id pmid title circrna_id circrna_synonyms circ_rna_name host_gene species Disease_Details Disease_MONDO_id Disease_MONDO_name Disease_DO_id Cell_Type expression_pattern description Dataset_Accession 1 21151960 Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. hsa_circ_ANRIL ANRIL Homo sapiens atherosclerotic vascular disease MONDO:1060134 atherosclerotic cardiovascular disease primary human peripheral blood T-lymphocyte (PBTL) samples down-regulated "ANRIL14-5, a circular ANRIL species, was detected by TaqMan qRT-PCR in isolated primary human peripheral blood T lymphocytes and showed decreased expression in individuals carrying the ASVD risk G allele." 2 26931159 Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation. hsa_circ_0023404 circRNA_100876 hsa_circ_RNF121 RNF121 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated "In isolated primary human chondrocytes, circRNA-CER expression increased after IL-1 and TNF¦Á stimulation compared with unstimulated controls. Functional experiments in chondrocytes linked circRNA-CER knockdown to reduced MMP13 expression and increased ECM-related gene/protein expression." 3 26998750 The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression. Cdr1as / CiRS-7 mmu_circ_CDR1 CDR1 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 Primary cardiomyocytes up-regulated "Cdr1as was up-regulated in primary mouse cardiomyocytes after hypoxia treatment, an in vitro simulation of myocardial infarction injury, based on qRT-PCR analysis." 4 27113499 A Comprehensive Analysis of Cell Type-Specific Nuclear RNA From Neurons and Glia of the Brain. mmu_circ_Hnrnpu Hnrnpu Mus musculus psychiatric disorder MONDO:0002025 psychiatric disorder DOID:150 neurons up-regulated "ciHnrnpu is a circular RNA from the Hnrnpu 3¡¯UTR that was detected almost exclusively in sorted neuronal nuclei and was about 30-fold more abundant in neurons than in oligodendrocyte and astrocyte nuclei. Its circularity, nuclear enrichment, and neuronal expression were validated using RT-PCR, Sanger sequencing, RNase R resistance, oligo-dT/random hexamer priming, and RT-qPCR." GSE73391 5 27539542 Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. circANRIL hsa_circ_CDKN2B-AS1 CDKN2B-AS1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 SMC unknown "circANRIL was detected in smooth muscle cells in human atherosclerotic plaques by RNA in situ hybridization with cell marker co-localization. In primary human SMC, circANRIL overexpression induced apoptosis and decreased proliferation." 6 27539542 Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. circANRIL hsa_circ_CDKN2B-AS1 CDKN2B-AS1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 CD68-positive macrophages unknown "circANRIL was detected in CD68-positive macrophages in human atherosclerotic plaques by RNA in situ hybridization with cell marker co-localization. In iPSC-derived macrophages, circANRIL overexpression caused pre-rRNA accumulation and induced apoptosis." 7 27713910 The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression. circ-Foxo3 mmu_circ_Foxo3 Foxo3 Mus musculus cardiomyopathy MONDO:0004994 cardiomyopathy DOID:0050700 mouse cardiac fibroblasts down-regulated "In cultured mouse cardiac fibroblasts under hydrogen peroxide-induced oxidative stress, Ganoderma spore oil treatment decreased circ-Foxo3 levels relative to controls in a concentration- and time-dependent manner." 8 27713910 The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression. circ-Foxo3 mmu_circ_Foxo3 Foxo3 Mus musculus heart failure MONDO:0005252 heart failure mouse cardiac fibroblasts down-regulated "In cultured mouse cardiac fibroblasts under hydrogen peroxide-induced oxidative stress, Ganoderma spore oil treatment decreased circ-Foxo3 levels relative to controls in a concentration- and time-dependent manner." 9 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. circRNA_003780 mmu_circ_Cdyl Cdyl Mus musculus others others others bone marrow-derived macrophages (BMDMs) up-regulated "circRNA-003780 was overexpressed in M1-polarized primary murine BMDMs compared with M2-polarized BMDMs, validated by RT-qPCR after circRNA microarray screening." 10 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. circRNA_010056 mmu_circ_Ube3a Ube3a Mus musculus others others others bone marrow-derived macrophages (BMDMs) up-regulated "circRNA-010056 was overexpressed in M1-polarized primary murine BMDMs compared with M2-polarized BMDMs, validated by RT-qPCR after circRNA microarray screening." 11 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. circRNA_010231 mmu_circ_Fut8 Fut8 Mus musculus others others others bone marrow-derived macrophages (BMDMs) up-regulated "circRNA-010231 was overexpressed in M1-polarized primary murine BMDMs compared with M2-polarized BMDMs, validated by RT-qPCR after circRNA microarray screening." 12 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. circRNA_003424 mmu_circ_Dgkb Dgkb Mus musculus others others others bone marrow-derived macrophages (BMDMs) down-regulated "circRNA-003424 was underexpressed in M1-polarized primary murine BMDMs compared with M2-polarized BMDMs, validated by RT-qPCR after circRNA microarray screening." 13 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. circRNA_013630 mmu_circ_Thada Thada Mus musculus others others others bone marrow-derived macrophages (BMDMs) down-regulated "circRNA-013630 was underexpressed in M1-polarized primary murine BMDMs compared with M2-polarized BMDMs, validated by RT-qPCR after circRNA microarray screening." 14 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. circRNA_001489 mmu_circ_Rnf2 Rnf2 Mus musculus others others others bone marrow-derived macrophages (BMDMs) down-regulated "circRNA-001489 was underexpressed in M1-polarized primary murine BMDMs compared with M2-polarized BMDMs, validated by RT-qPCR after circRNA microarray screening." 15 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. circRNA_018127 mmu_circ_Ipo11 Ipo11 Mus musculus others others others bone marrow-derived macrophages (BMDMs) down-regulated "circRNA-018127 was underexpressed in M1-polarized primary murine BMDMs compared with M2-polarized BMDMs, validated by RT-qPCR after circRNA microarray screening." 16 28272342 The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis. hsa_circ_0106803 hsa_circ_GSDMB GSDMB Homo sapiens relapsing remitting multiple sclerosis MONDO:0005314 relapsing-remitting multiple sclerosis DOID:2378 PBMCs up-regulated "GSDMB ecircRNA, annotated as hsa_circ_0106803, was measured by real-time RT-PCR in isolated PBMCs and was significantly up-regulated in relapsing-remitting MS cases compared with healthy controls." 17 28276108 CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR-26a. hsa_circ_0005105 Homo sapiens Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated "hsa_circ_0005105 is up-regulated in human articular chondrocytes after IL-1¦Â stimulation, as measured by real-time PCR. In chondrocytes, hsa_circ_0005105 promotes ECM degradation and inflammatory factor expression through the miR-26a/NAMPT pathway." 18 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. hsc-80 Homo sapiens amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 human iPSC-derived MNs down-regulated hsc-80 was measured in FACS-sorted human iPSC-derived motor neurons and was downregulated in FUSP525L/P525L motor neurons compared with FUSWT/WT motor neurons. 19 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. hsc-84 Homo sapiens amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 human iPSC-derived MNs down-regulated hsc-84 was measured in FACS-sorted human iPSC-derived motor neurons and was downregulated in FUSP525L/P525L motor neurons compared with FUSWT/WT motor neurons. 20 28412345 "A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-¦Â1." circRNA_010567 Mus musculus myocardial fibrosis MONDO:0004994 cardiomyopathy DOID:0050700 cardiac fibroblasts (CFs) up-regulated circRNA_010567 was increased in isolated and cultured mouse cardiac fibroblasts after Ang II induction. Knockdown of circRNA_010567 reduced fibrosis-associated protein expression in CFs. 21 28498369 Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression. mm9circ-016597 mmu_circ_Smyd4 Smyd4 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 Cardiomyocytes up-regulated MFACR/mm9circ-016597 is up-regulated in isolated mouse cardiomyocytes after anoxia/reoxygenation compared with control. MFACR knockdown attenuates A/R-induced mitochondrial fission and apoptosis in cardiomyocytes. 22 28624198 Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis. hsa_circ_0005567 hsa_circ_100226 hsa_circ_EPS15 EPS15 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated circRNA-MSR is up-regulated in primary cultured human chondrocytes exposed to cyclic tensile strain compared with control. Knockdown of circRNA-MSR in chondrocytes suppressed TNF-¦Á expression and increased extracellular matrix formation. 23 28644873 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. hsa_circRNA_103829 hsa_circ_HMGCS1 HMGCS1 Homo sapiens ovarian aging MONDO:0005387 primary ovarian failure DOID:5426 granulosa cells up-regulated "circRNA_103829 was significantly up-regulated in isolated human granulosa cells from women of advanced age compared with young women, validated by qRT-PCR." GSE97193 24 28644873 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. hsa_circRNA_103827 hsa_circ_HMGCS1 HMGCS1 Homo sapiens ovarian aging MONDO:0005387 primary ovarian failure DOID:5426 granulosa cells up-regulated "circRNA_103827 was significantly up-regulated in isolated human granulosa cells from women of advanced age compared with young women, and remained positively associated with maternal age after adjustment for gonadotropin treatment. Bioinformatics analysis predicted involvement in glucose metabolism, mitotic cell cycle, and ovarian steroidogenesis." GSE97193 25 28644873 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. hsa_circRNA_104816 hsa_circ_IARS IARS Homo sapiens ovarian aging MONDO:0005387 primary ovarian failure DOID:5426 granulosa cells up-regulated "circRNA_104816 was significantly up-regulated in isolated human granulosa cells from women of advanced age compared with young women, and remained positively associated with maternal age after adjustment for gonadotropin treatment. Bioinformatics analysis predicted involvement in glucose metabolism, mitotic cell cycle, and ovarian steroidogenesis." GSE97193 26 28644873 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. hsa_circRNA_101889 hsa_circ_USP10 USP10 Homo sapiens ovarian aging MONDO:0005387 primary ovarian failure DOID:5426 granulosa cells down-regulated "circRNA_101889 was remarkably down-regulated in isolated human granulosa cells from women of advanced age compared with young women, validated by qRT-PCR." GSE97193 27 28683453 Effect of Circular ANRIL on the Inflammatory Response of Vascular Endothelial Cells in a Rat Model of Coronary Atherosclerosis. cANRIL rno_circ_ANRIL ANRIL Rattus norvegicus coronary atherosclerosis MONDO:0021661 coronary atherosclerosis vascular endothelial cells down-regulated "In a rat coronary atherosclerosis model, cANRIL expression was measured by qRT-PCR in isolated vascular endothelial cells, and cANRIL levels decreased in the cANRIL inhibitor-treated group compared with model and empty-vector groups. The study links reduced cANRIL in endothelial cells with decreased EC apoptosis and inflammatory response." 28 28786753 Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. circHIPK2 / circHipk2 mmu_circ_Hipk2 Hipk2 Mus musculus methamphetamine-induced neurotoxicity MONDO:0005527 toxic encephalopathy DOID:3602 primary mouse astrocytes up-regulated "circHIPK2 was detected in primary mouse astrocytes and was significantly increased after methamphetamine treatment by qRT-PCR using divergent primers. Knockdown studies linked circHIPK2 to astrocyte activation, autophagy, and ER stress in astrocytes." 29 28786753 Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. circHIPK2 hsa_circ_HIPK2 HIPK2 Homo sapiens methamphetamine-induced neurotoxicity MONDO:0005527 toxic encephalopathy DOID:3602 primary mouse astrocytes up-regulated "circHIPK2 was detected in primary mouse astrocytes and was significantly increased after methamphetamine treatment by qRT-PCR using divergent primers. Knockdown studies linked circHIPK2 to astrocyte activation, autophagy, and ER stress in astrocytes." 30 28795385 "Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R." hsa_circ_0045714 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes down-regulated "In human articular chondrocytes, TNF-a treatment downregulated hsa_circ_0045714 expression compared with unstimulated controls. Functional experiments in chondrocytes indicated that hsa_circ_0045714 regulates extracellular matrix synthesis, proliferation and apoptosis through the miR-193b/IGF1R axis." 31 28798046 Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Cdr1as Mus musculus neuropsychiatric disorders MONDO:0002025 psychiatric disorder DOID:150 neurons up-regulated "RNA FISH with neural marker costaining showed that Cdr1as is highly expressed in neurons in adult mouse brain and absent from glial cells. The study links loss of Cdr1as to altered neuronal activity, synaptic transmission, and prepulse inhibition deficits associated with neuropsychiatric disorders." GSE93130 32 28798046 Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Cdr1as Mus musculus neuropsychiatric disorders MONDO:0002025 psychiatric disorder DOID:150 excitatory neurons up-regulated RNA FISH/ISH with excitatory and inhibitory neuronal markers showed that Cdr1as is predominantly expressed in excitatory neurons in mouse brain. The paper reports that loss of Cdr1as disrupts excitatory synaptic transmission and causes prepulse inhibition deficits. GSE93130 33 28824721 Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction. cZNF609 hsa_circ_ZNF609 ZNF609 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 HUVECs up-regulated "cZNF609 was up-regulated in HUVEC endothelial cells under high-glucose diabetic-like stress. Functional assays in endothelial cells showed that cZNF609 silencing affected viability, proliferation, migration, tube formation, and stress-induced apoptosis." 34 28860123 Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus. hsa_circ_0000284 circHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 retinal endothelial cells up-regulated "circHIPK3 is up-regulated in retinal endothelial cells after high-glucose treatment mimicking diabetic conditions. Functional experiments in HRVECs showed that circHIPK3 regulates endothelial viability, proliferation, migration, and tube formation." 35 28860123 Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus. mmu_circ_0001052 circHIPK3 mmu_circ_Hipk3 Hipk3 Mus musculus diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 retinal endothelial cells up-regulated "circHIPK3 is up-regulated in retinal endothelial cells after high-glucose treatment mimicking diabetic conditions. Functional experiments in HRVECs showed that circHIPK3 regulates endothelial viability, proliferation, migration, and tube formation." 36 28971903 Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia. hsa_circ_0100163 hsa_circ_FLT3 FLT3 Homo sapiens acute myeloid leukemia MONDO:0018874 acute myeloid leukemia DOID:9119 leukemia cells up-regulated "FLT3 circRNA expression was higher in AML leukemia cells than in healthy hematopoietic control cells based on ribosomal RNA-depleted RNA-seq with circRNA backsplice-junction analysis. FLT3 circular-derived reads mainly mapped to hsa_circ_0100163, hsa_circ_0100164, and one novel FLT3 circRNA variant." 37 28971903 Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia. hsa_circ_0100164 hsa_circ_FLT3 FLT3 Homo sapiens acute myeloid leukemia MONDO:0018874 acute myeloid leukemia DOID:9119 leukemia cells up-regulated "FLT3 circRNA expression was higher in AML leukemia cells than in healthy hematopoietic control cells based on ribosomal RNA-depleted RNA-seq with circRNA backsplice-junction analysis. FLT3 circular-derived reads mainly mapped to hsa_circ_0100163, hsa_circ_0100164, and one novel FLT3 circRNA variant." 38 29162050 Transcriptome profiling of aging Drosophila photoreceptors reveals gene expression trends that correlate with visual senescence. Eps-15 dme_circ_Eps-15 Eps-15 Drosophila melanogaster visual senescence MONDO:0021084 vision disorder photoreceptor neurons no change "In affinity-enriched Drosophila photoreceptor neuron nuclear transcriptome data comparing day 10 and day 40 flies, the Eps-15 circRNA was examined by RT-qPCR but did not show a significant decrease." GSE93128; GSE83431 39 29221160 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. chr14:97312431|97327072 hsa_circ_VRK1 VRK1 Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 BCSCs down-regulated "circVRK1 was downregulated in breast cancer stem cells compared with non-BCSCs/adherent cells after cell sorting and RNA-seq, with Q-PCR validation. Silencing circVRK1 increased mammosphere and colony formation, CD44+CD24- proportions, and stemness marker levels." 40 29221160 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. chr17:59853761|59861785 hsa_circ_BRIP1 BRIP1 Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 BCSCs down-regulated "circBRIP was downregulated in breast cancer stem cells compared with non-BCSCs/adherent cells after cell sorting and RNA-seq, with Q-PCR validation." 41 29221160 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. chr2:174987907|175006728 hsa_circ_OLA1 OLA1 Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 BCSCs down-regulated "circOLA was downregulated in breast cancer stem cells compared with non-BCSCs/adherent cells after cell sorting and RNA-seq, with Q-PCR validation." 42 29221160 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. chr15:76566752|76588078 hsa_circ_ETFA ETFA Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 BCSCs down-regulated "circETFA was downregulated in breast cancer stem cells compared with non-BCSCs/adherent cells after cell sorting and RNA-seq, with Q-PCR validation." 43 29221160 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. chr17:60061531|60062451 hsa_circ_MED13 MED13 Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 BCSCs down-regulated "circMED13 was downregulated in breast cancer stem cells compared with non-BCSCs/adherent cells after cell sorting and RNA-seq, with Q-PCR validation." 44 29221160 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. chr14:99723807|99724176 hsa_circ_BCL11B BCL11B Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 BCSCs down-regulated "circBCL11B was downregulated in breast cancer stem cells compared with non-BCSCs/adherent cells after cell sorting and RNA-seq, with Q-PCR validation." 45 29247798 Circular RNA expression profile of articular chondrocytes in an IL-1¦Â-induced mouse model of osteoarthritis. mmu-circRNA-30365 Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 mouse articular chondrocytes (MACs) dys-regulated "mmu-circRNA-30365 was differentially expressed in IL-1¦Â-treated mouse articular chondrocytes compared with untreated controls, based on circRNA sequencing and qRT-PCR validation." 46 29247798 Circular RNA expression profile of articular chondrocytes in an IL-1¦Â-induced mouse model of osteoarthritis. mmu-circRNA-36866 Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 mouse articular chondrocytes (MACs) dys-regulated "mmu-circRNA-36866 was differentially expressed in IL-1¦Â-treated mouse articular chondrocytes compared with untreated controls, based on circRNA sequencing and qRT-PCR validation." 47 29260931 Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition. circHECW2 hsa_circ_HECW2 HECW2 Homo sapiens drug abuse MONDO:0002491 substance abuse DOID:302 Primary human brain microvascular endothelial cells (HBMECs) up-regulated circHECW2 expression was increased in primary human brain microvascular endothelial cells after Meth treatment. Knockdown of circHECW2 in HBMECs inhibited Meth-induced EndoMT. 48 29260931 Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition. circHECW2 hsa_circ_HECW2 HECW2 Homo sapiens neuroinflammatory disorders MONDO:0021166 inflammatory disease Primary human brain microvascular endothelial cells (HBMECs) up-regulated circHECW2 expression was increased in primary human brain microvascular endothelial cells after LPS treatment. Knockdown of circHECW2 in HBMECs inhibited LPS-induced EndoMT. 49 29290828 circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination. mmu_circ_0000375 mm9_circ_002888 mmu_circ_HECTD1 HECTD1 Mus musculus silicosis MONDO:0005960 silicosis DOID:10325 macrophages isolated from SiO2-treated mouse BALF down-regulated circHECTD1 was significantly decreased in macrophages isolated from BALF of SiO2-treated mice compared with NS-treated mice. Functional experiments in macrophages linked circHECTD1 to SiO2-induced macrophage activation and downstream fibroblast proliferation and migration. 50 29305974 "Circular RNA Atp9b, a competing endogenous RNA, regulates the progression of osteoarthritis by targeting miR-138-5p." circ_15898 mmu_circ_Atp9b Atp9b Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 mouse chondrocytes up-regulated circRNA_Atp9b is up-regulated in IL-1¦Â-induced mouse articular chondrocytes compared with untreated control chondrocytes based on qRT-PCR after primary chondrocyte isolation. Knockdown experiments in these chondrocytes indicate roles in ECM catabolism and inflammation. GSE107009 51 29343508 Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein. hsa_circ_0091702 hsa_circ_VMA21 VMA21 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 NPCs down-regulated "circVMA21 is decreased in inflammatory cytokine-treated nucleus pulposus cells, a cellular model related to IVDD. In these cells, circVMA21 overexpression restrains apoptosis and catabolic responses through the miR-200c-XIAP pathway." 52 29499945 circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways. hsa_circ_0000936 hsa_circ_SHKBP1 SHKBP1 Homo sapiens glioma MONDO:0021042 glioma human glioma microvessels up-regulated circ-SHKBP1 was up-regulated in glioma microvessel endothelial-enriched samples compared with normal brain microvessels. Functional experiments in glioma-exposed endothelial cells showed that circ-SHKBP1 knockdown inhibited angiogenesis-related phenotypes. 53 29499945 circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways. hsa_circ_0000936 hsa_circ_SHKBP1 SHKBP1 Homo sapiens glioma MONDO:0021042 glioma human glioma microvessels up-regulated circ-SHKBP1 was more highly expressed in high-grade glioma microvessel endothelial-enriched samples than in low-grade glioma microvessels. Functional experiments in glioma-exposed endothelial cells showed that circ-SHKBP1 knockdown inhibited angiogenesis-related phenotypes. 54 29643944 Competing endogenous RNA expression profiling in pre-eclampsia identifies hsa_circ_0036877 as a potential novel blood biomarker for early pre-eclampsia. hsa_circ_0036877 hsa_circ_Furin Furin Homo sapiens pre-eclampsia MONDO:0005081 preeclampsia DOID:10591 syncytial trophoblasts down-regulated "RNA FISH showed hsa_circ_0036877 expression in the cytoplasm of syncytial trophoblasts, with lower expression in PE placenta than normal placenta." 55 29651107 Circular RNA circ-4099 is induced by TNF-¦Á and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration. hsa_circ_0004099 circ-4099 / hsa_circRNA_100759 hsa_circ_DENND5A DENND5A Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 NP cells up-regulated "In isolated human NP cells used as an in vitro IVDD model, TNF-¦Á treatment upregulated circ-4099 expression by qRT-PCR. Functional experiments in hNP cells showed circ-4099 affected ECM-related markers and pro-inflammatory cytokine expression." 56 29657280 CirComPara: A Multi-Method Comparative Bioinformatics Pipeline to Detect and Study circRNAs from RNA-seq Data. 11:33286413-33287511:+ hsa_circ_HIPK3 HIPK3 Homo sapiens QKI haploinsufficiency MONDO:0000001 disease DOID:4 (CD14+) monocytes from peripheral blood down-regulated The HIPK3-associated circRNA 11:33286413-33287511:+ was detected by RNA-seq in primary CD14+ monocytes and showed lower expression in QKI haploinsufficient monocytes than in control monocytes. GSE74978; SRR2923169; SRR2923170 57 29657280 CirComPara: A Multi-Method Comparative Bioinformatics Pipeline to Detect and Study circRNAs from RNA-seq Data. 11:33286413-33287511:+ hsa_circ_HIPK3 HIPK3 Homo sapiens QKI haploinsufficiency MONDO:0000001 disease DOID:4 differentiated CD14+ cells (macrophages) down-regulated The HIPK3-associated circRNA 11:33286413-33287511:+ was detected by RNA-seq in differentiated CD14+ macrophages and showed lower expression in QKI haploinsufficient macrophages than in control macrophages. GSE74978; SRR2923171; SRR2923172 58 29700819 Circular RNA expression profile and potential function of hsa_circ_0045272 in systemic lupus erythematosus. hsa_circ_0045272 hsa_circRNA_102165 hsa_circ_ERN1 ERN1 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 T cells down-regulated "hsa_circ_0045272 was significantly down-regulated in isolated T cells from SLE patients compared with healthy controls, as validated by qRT-PCR after cell isolation." GSE84655 59 29700819 Circular RNA expression profile and potential function of hsa_circ_0045272 in systemic lupus erythematosus. hsa_circ_0000694 hsa_circRNA_000694 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 T cells no change "hsa_circ_0000694 was measured by qRT-PCR in isolated T cells from SLE patients and healthy controls, but no significant difference was observed." GSE84655 60 29739336 Circular RNA expression and regulatory network prediction in posterior cingulate astrocytes in elderly subjects. CDR1as / CiRS-7 Homo sapiens Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 PC astrocyte pools no change "CDR1as was detected in laser-capture microdissected human posterior cingulate astrocyte RNA-seq samples from both late-onset Alzheimer¡¯s disease and no-disease controls, with no CDR1as reduction observed in this PC astrocyte dataset." 61 29739336 Circular RNA expression and regulatory network prediction in posterior cingulate astrocytes in elderly subjects. "1:201,452,657-201,736,927" Homo sapiens Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 PC astrocyte pools dys-regulated "The circRNA 1:201,452,657-201,736,927 showed a trend toward differential expression in human posterior cingulate astrocytes when comparing late-onset Alzheimer¡¯s disease and no-disease control samples, but the direction was not reported in the provided text." 62 29739336 Circular RNA expression and regulatory network prediction in posterior cingulate astrocytes in elderly subjects. "16:1,583,657-2,204,141" Homo sapiens Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 PC astrocyte pools dys-regulated "The circRNA 16:1,583,657-2,204,141 showed a trend toward differential expression in human posterior cingulate astrocytes when comparing late-onset Alzheimer¡¯s disease and no-disease control samples, but the direction was not reported in the provided text." 63 29902450 Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/¦Â-catenin pathway. hsa_circ_0000707 circ-CBFB hsa_circ_CBFB CBFB Homo sapiens chronic lymphocytic leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 CLL cells up-regulated circ-CBFB was significantly upregulated in purified CLL cells from patients compared with sorted normal control B cells. Functional assays in fresh primary CLL cells showed that circ-CBFB knockdown suppressed proliferation and induced apoptosis. 64 29928876 Circular RNA HIPK3 promotes gallbladder cancer cell growth by sponging microRNA-124. hsa_circ_0000284 circHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens gallbladder cancer MONDO:0005411 gallbladder cancer DOID:3121 primary human gallbladder cancer cells up-regulated circHIPK3 is over-expressed in isolated primary human gallbladder cancer cells compared with primary human gallbladder epithelial cells. Functional experiments in primary gallbladder cancer cells showed effects on proliferation and apoptosis. 65 29938598 Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke. mm9_circ_008488 mmu_circ_Hectd1 Hectd1 Mus musculus cerebral ischemic stroke MONDO:1060198 ischemic stroke primary mouse astrocytes up-regulated circHECTD1/circHectd1 expression is increased in primary mouse astrocytes after OGD-R treatment compared with control culture conditions. Knockdown of circHECTD1 attenuated OGD-R-induced astrocyte activation and autophagy-related changes in primary mouse astrocytes. 66 29941867 Association of microRNA-7 and its binding partner CDR1-AS with the prognosis and prediction of 1st-line tamoxifen therapy in breast cancer. CDR1-AS / ciRS-7 Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 stromal fibroblast strain up-regulated "CDR1-AS was detected in a stromal fibroblast strain derived from a primary breast cancer tumour, with especially high expression relative to other assessed cell types." 67 29949786 Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells. hg19_circ_0005033 Homo sapiens laryngeal squamous cell carcinoma MONDO:0005595 laryngeal squamous cell carcinoma DOID:2876 CD133+CD44+ LSCC stem cells up-regulated "hg19_circ_0005033 was upregulated in MACS-isolated CD133+CD44+ LSCC stem cells compared with parental TU-177 cells, supported by RNA-seq and qPCR validation. Knockdown experiments in TDP cells linked hg19_circ_0005033 to proliferation, migration, invasion, and cisplatin resistance." GSE106280; GSE106283 68 29949786 Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells. hsa_circ_0004481 hg19_ circ_0004481 Homo sapiens laryngeal squamous cell carcinoma MONDO:0005595 laryngeal squamous cell carcinoma DOID:2876 CD133+CD44+ LSCC stem cells dys-regulated "hg19_ circ_0004481 was among circRNAs assessed in MACS-isolated CD133+CD44+ LSCC stem cells, with qPCR results consistent with sequencing data in TDP cells." GSE106280; GSE106283 69 29949786 Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells. hsa_circ_0003610 hg19_circ_0003610 Homo sapiens laryngeal squamous cell carcinoma MONDO:0005595 laryngeal squamous cell carcinoma DOID:2876 CD133+CD44+ LSCC stem cells dys-regulated "hg19_circ_0003610 was among circRNAs assessed in MACS-isolated CD133+CD44+ LSCC stem cells, with qPCR results consistent with sequencing data in TDP cells." GSE106280; GSE106283 70 29949786 Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells. hsa_circ_0003081 hg19_circ_0003081 Homo sapiens laryngeal squamous cell carcinoma MONDO:0005595 laryngeal squamous cell carcinoma DOID:2876 CD133-CD44-cells up-regulated "hg19_circ_0003081 was upregulated in MACS-isolated CD133-CD44- LSCC cells, with qPCR results agreeing with sequencing data." GSE106280; GSE106283 71 29949786 Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells. hsa_circ_0008472 hg19_circ_0008472 Homo sapiens laryngeal squamous cell carcinoma MONDO:0005595 laryngeal squamous cell carcinoma DOID:2876 CD133-CD44-cells up-regulated "hg19_circ_0008472 was upregulated in MACS-isolated CD133-CD44- LSCC cells, with qPCR results agreeing with sequencing data." GSE106280; GSE106283 72 29949792 Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease. hsa_circ_0085020 circ_0085020 hsa_circ_LAPTM4B LAPTM4B Homo sapiens pterygium MONDO:0005085 pterygium DOID:0002116 pterygium epithelial cells down-regulated "In pterygium epithelial cells, circ_0085020 expression was down-regulated after siRNA treatment. Functional assays in these cells linked circ_0085020 silencing to reduced viability, proliferation, and migration and increased UV-induced apoptosis." 73 29959922 Circular RNA HIPK3 regulates human lens epithelial cells proliferation and apoptosis by targeting the miR-193a/CRYAA axis. hsa_circ_HIPK3 HIPK3 Homo sapiens age-related cataract MONDO:0004847 senile cataract DOID:9669 human lens epithelial cells (HLECs) down-regulated "circHIPK3 was down-regulated in lens epithelial samples from age-related cataract patients compared with control lens epithelial samples, based on circRNA sequencing and qRT-PCR validation. Functional experiments in primary cultured HLECs showed circHIPK3 involvement in viability, apoptosis, proliferation and EMT." 74 30098504 Silencing of circRNA.2837 Plays a Protective Role in Sciatic Nerve Injury by Sponging the miR-34 Family via Regulating Neuronal Autophagy. circRNA.2837 rno_circ_Slc25a16 Slc25a16 Rattus norvegicus sciatic nerve injury MONDO:0001543 lesion of sciatic nerve DOID:12528 spinal neurons down-regulated "In primary rat spinal neurons, circRNA.2837 was downregulated after OGD treatment used to mimic injury in vitro. Functional experiments in these neurons indicated that circRNA.2837 negatively regulates autophagy under injured conditions." 75 30159442 Molecular functions and specific roles of circRNAs in the cardiovascular system. circANRIL hsa_circ_ANRIL ANRIL Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 whole blood-derived T-cells down-regulated circANRIL isoforms were reduced in whole blood-derived T cells in association with atherosclerosis risk genotypes and disease severity. 76 30159442 Molecular functions and specific roles of circRNAs in the cardiovascular system. circANRIL hsa_circ_ANRIL ANRIL Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 blood mononuclear cells (PBMCs) down-regulated circANRIL isoforms were reduced in PBMCs in association with atherosclerosis risk genotypes and disease severity. 77 30159442 Molecular functions and specific roles of circRNAs in the cardiovascular system. hsa_circ_0124644 Homo sapiens coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 PBMCs up-regulated hsa_circ_0124644 was reported as up-regulated in PBMCs in coronary artery disease. 78 30159442 Molecular functions and specific roles of circRNAs in the cardiovascular system. hsa_circ_0082081 Homo sapiens coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 PBMCs up-regulated hsa_circ_0082081 was reported as up-regulated in PBMCs in coronary artery disease. 79 30159442 Molecular functions and specific roles of circRNAs in the cardiovascular system. hsa_circ_0113854 Homo sapiens coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 PBMCs up-regulated hsa_circ_0113854 was reported as up-regulated in PBMCs in coronary artery disease. 80 30159442 Molecular functions and specific roles of circRNAs in the cardiovascular system. hsa_circ_0098964 Homo sapiens coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 PBMCs up-regulated hsa_circ_0098964 was reported as up-regulated in PBMCs in coronary artery disease. 81 30159442 Molecular functions and specific roles of circRNAs in the cardiovascular system. hsa_circRNA5974-1 Homo sapiens coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 PBMCs up-regulated hsa_circRNA5974-1 was reported as up-regulated in PBMCs in coronary artery disease. 82 30237316 "The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous." hsa_circ_0012919 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4+ T cells up-regulated hsa_circ_0012919 is up-regulated in magnetically isolated CD4+ T cells from SLE patients compared with healthy controls and was validated by RT-PCR. 83 30237316 "The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous." hsa_circ_0012919 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4+ T cells up-regulated hsa_circ_0012919 expression is higher in CD4+ T cells from active SLE patients than inactive SLE patients based on RT-PCR after magnetic-bead isolation. 84 30237316 "The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous." hsa_circ_0006239 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4+ T cells up-regulated hsa_circ_0006239 is up-regulated in magnetically isolated CD4+ T cells from SLE patients compared with healthy controls and was validated by RT-PCR. 85 30237316 "The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous." hsa_circ_0006239 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4+ T cells up-regulated hsa_circ_0006239 expression is higher in CD4+ T cells from active SLE patients than inactive SLE patients based on RT-PCR after magnetic-bead isolation. 86 30237316 "The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous." hsa_circ_0002227 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4+ T cells up-regulated hsa_circ_0002227 is up-regulated in magnetically isolated CD4+ T cells from SLE patients compared with healthy controls and was validated by RT-PCR. 87 30237316 "The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous." hsa_circ_0002227 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4+ T cells no change hsa_circ_0002227 showed no significant expression difference between CD4+ T cells from inactive and active SLE patients. 88 30307766 "circDiaph3 regulates rat vascular smooth muscle cell differentiation, proliferation, and migration." rno-circ_005717 rno_circ_Diaph3 Diaph3 Rattus norvegicus intimal hyperplasia MONDO:0005385 vascular disorder DOID:178 rat vascular smooth muscle cells (VSMCs) down-regulated circDiaph3 expression was measured by real-time qPCR in primary rat VSMCs after siRNA-mediated knockdown. Knockdown of circDiaph3 reduced VSMC proliferation and migration and increased contractile differentiation markers. 89 30349076 The circular RNA ACR attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway. mmu_circRNA_006636 Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury cardiomyocytes down-regulated "ACR expression is decreased in primary mouse cardiomyocytes after anoxia/re-oxygenation treatment. Functional experiments in cardiomyocytes showed that ACR overexpression reduced A/R-induced autophagy, mitophagy, and cell death." 90 30352682 Circular RNA HIPK3 exerts oncogenic properties through suppression of miR-124 in lung cancer. hsa_circ_HIPK3 HIPK3 Homo sapiens lung cancer MONDO:0008903 lung cancer DOID:1324 primary human lung cancer cells up-regulated "circHIPK3 is up-regulated in primary human lung cancer cells compared with primary human lung epithelial cells, measured by qPCR after primary cell isolation and culture. Functional experiments in these primary lung cancer cells showed that circHIPK3 silencing reduced viability and induced apoptosis, while overexpression enhanced viability and proliferation." 91 30368217 Circular RNAs as Potential Theranostics in the Cardiovascular System. cZNF292 hsa_circ_ZNF292 ZNF292 Homo sapiens Cardiovascular disease MONDO:0004995 cardiovascular disorder DOID:1287 human umbilical vein endothelial cells (HUVECs) up-regulated "cZNF292 is increased in hypoxia-treated HUVEC endothelial cells, and silencing cZNF292 reduced endothelial sprouting, tube formation, and proliferation." 92 30368217 Circular RNAs as Potential Theranostics in the Cardiovascular System. cAFF1 hsa_circ_AFF1 AFF1 Homo sapiens Cardiovascular disease MONDO:0004995 cardiovascular disorder DOID:1287 human umbilical vein endothelial cells (HUVECs) up-regulated cAFF1 is increased in hypoxia-treated HUVEC endothelial cells. 93 30368217 Circular RNAs as Potential Theranostics in the Cardiovascular System. cDENND4C hsa_circ_DENND4C DENND4C Homo sapiens Cardiovascular disease MONDO:0004995 cardiovascular disorder DOID:1287 human umbilical vein endothelial cells (HUVECs) up-regulated cDENND4C is increased in hypoxia-treated HUVEC endothelial cells. 94 30368217 Circular RNAs as Potential Theranostics in the Cardiovascular System. cTHSD1 hsa_circ_THSD1 THSD1 Homo sapiens Cardiovascular disease MONDO:0004995 cardiovascular disorder DOID:1287 human umbilical vein endothelial cells (HUVECs) down-regulated cTHSD1 is decreased in hypoxia-treated HUVEC endothelial cells. 95 30368217 Circular RNAs as Potential Theranostics in the Cardiovascular System. hsa_circ_0010729 Homo sapiens Cardiovascular disease MONDO:0004995 cardiovascular disorder DOID:1287 HUVECs up-regulated "hsa_circ_0010729 is increased in hypoxia-treated HUVEC endothelial cells and regulates endothelial cell proliferation, migration, and apoptosis." 96 30368217 Circular RNAs as Potential Theranostics in the Cardiovascular System. hsa_circ_ZNF609 ZNF609 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 HUVECs up-regulated "cZNF609 is upregulated in high glucose-treated HUVEC endothelial cells and regulates endothelial viability, proliferation, migration, tube formation, and apoptosis." 97 30403769 circCTIC1 promotes the self-renewal of colon TICs through BPTF-dependent c-Myc expression. hsa_circRNA_103809 hsa_circ_CTIC1 CTIC1 Homo sapiens colon tumor MONDO:0005401 colonic neoplasm colon TICs up-regulated "circCTIC1 was enriched in FACS-isolated colon TICs compared with non-TICs, as measured by realtime PCR. Functional experiments showed circCTIC1 promoted colon TIC self-renewal through c-Myc." 98 30413800 CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination. mmu_circ_DYM DYM Mus musculus major depressive disorder MONDO:0002009 major depressive disorder DOID:1470 primary mouse microglia down-regulated "circDYM expression was significantly decreased in LPS-treated primary mouse microglia. In the same primary microglial system, circDYM overexpression inhibited LPS- or miR-9-induced microglial activation." 99 30442201 Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells. hsa-circRNA8881-21 hsa_circ_ASPM ASPM Homo sapiens endometrial damage MONDO:0000931 endometrial disorder DOID:1005 damaged ESCs up-regulated hsa-circRNA8881-21 was significantly upregulated in primary cultured damaged endometrial stromal cells cocultured with WJ-MSCs compared with non-cocultured damaged ESCs. 100 30442201 Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells. hsa_circ_0020492 hsa_circ_MKI67 MKI67 Homo sapiens endometrial damage MONDO:0000931 endometrial disorder DOID:1005 damaged ESCs up-regulated hsa_circ_0020492 was significantly upregulated in primary cultured damaged endometrial stromal cells cocultured with WJ-MSCs compared with non-cocultured damaged ESCs. 101 30442201 Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells. hsa_circ_0026141 hsa_circ_TROAP TROAP Homo sapiens endometrial damage MONDO:0000931 endometrial disorder DOID:1005 damaged ESCs up-regulated hsa_circ_0026141 was significantly upregulated in primary cultured damaged endometrial stromal cells cocultured with WJ-MSCs compared with non-cocultured damaged ESCs. 102 30442201 Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells. hsa-circRNA4049-38 hsa_circ_WDR62 WDR62 Homo sapiens endometrial damage MONDO:0000931 endometrial disorder DOID:1005 damaged ESCs up-regulated hsa-circRNA4049-38 was significantly upregulated in primary cultured damaged endometrial stromal cells cocultured with WJ-MSCs compared with non-cocultured damaged ESCs. 103 30442201 Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells. hsa_circ_0015825 hsa_circ_KIF14 KIF14 Homo sapiens endometrial damage MONDO:0000931 endometrial disorder DOID:1005 damaged ESCs up-regulated hsa_circ_0015825 was significantly upregulated in primary cultured damaged endometrial stromal cells cocultured with WJ-MSCs compared with non-cocultured damaged ESCs. 104 30442201 Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells. hsa-circRNA5028-15 hsa_circ_MYBL2 MYBL2 Homo sapiens endometrial damage MONDO:0000931 endometrial disorder DOID:1005 damaged ESCs up-regulated hsa-circRNA5028-15 was significantly upregulated in primary cultured damaged endometrial stromal cells cocultured with WJ-MSCs compared with non-cocultured damaged ESCs. 105 30442201 Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells. hsa_circ_0111659 hsa_circ_KIF14 KIF14 Homo sapiens endometrial damage MONDO:0000931 endometrial disorder DOID:1005 damaged ESCs up-regulated hsa_circ_0111659 was significantly upregulated in primary cultured damaged endometrial stromal cells cocultured with WJ-MSCs compared with non-cocultured damaged ESCs. 106 30455306 Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA. hsa_circ_0001400 hsa_circ_RELL1 RELL1 Homo sapiens KSHV infection MONDO:0005550 infectious disease DOID:0050117 primary human umbilical vein endothelial cells (HUVECs) up-regulated "hsa_circ_0001400 was up-regulated after KSHV infection in primary HUVEC endothelial cells, supported by circRNA-Seq/microarray profiling and divergent-primer qPCR." GSE119608; GSE120045; GSE121756 107 30455306 Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA. hsa_circ_0001741 Homo sapiens KSHV infection MONDO:0005550 infectious disease DOID:0050117 primary human umbilical vein endothelial cells (HUVECs) up-regulated "hsa_circ_0001741 was up-regulated after KSHV infection in primary HUVEC endothelial cells, supported by circRNA-Seq/microarray profiling and divergent-primer qPCR." GSE119608; GSE120045; GSE121756 108 30481761 Thymosin-¦Â4 Mediates Hepatic Stellate Cell Activation by Interfering with CircRNA-0067835/miR-155/FoxO3 Signaling Pathway. circRNA-0067835 Mus musculus liver fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 HSCs up-regulated "circRNA-0067835 was increased in primary mouse hepatic stellate cells cultured for 7 days compared with freshly isolated HSCs, supporting altered expression during HSC activation associated with liver fibrosis." 109 30497053 circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide. hsa_circ_02838 / circGprc5a Homo sapiens bladder cancer MONDO:0004986 urinary bladder carcinoma DOID:4007 bladder CSCs up-regulated circGprc5a was highly expressed in bladder cancer stem cells enriched by surface markers/FACS and measured by real-time PCR. Functional experiments showed circGprc5a supported bladder CSC self-renewal and metastasis. 110 30497055 Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli. hsa_circ_0000395 hg38_circ_0000395 Homo sapiens bacterial meningitis MONDO:0006670 bacterial meningitis DOID:9470 primary hBMECs down-regulated hg38_circ_0000395 was significantly downregulated in primary human brain microvascular endothelial cells after meningitic E. coli infection compared with uninfected control cells. SRP116604 111 30497055 Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli. hsa_circ_0008815 hg38_circ_0008815 Homo sapiens bacterial meningitis MONDO:0006670 bacterial meningitis DOID:9470 primary hBMECs down-regulated hg38_circ_0008815 was significantly downregulated in primary human brain microvascular endothelial cells after meningitic E. coli infection compared with uninfected control cells. SRP116604 112 30497055 Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli. hsa_circ_0033002 hg38_circ_0033002 Homo sapiens bacterial meningitis MONDO:0006670 bacterial meningitis DOID:9470 primary hBMECs down-regulated hg38_circ_0033002 was significantly downregulated in primary human brain microvascular endothelial cells after meningitic E. coli infection compared with uninfected control cells. SRP116604 113 30497055 Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli. hsa_circ_0014254 hg38_circ_0014254 Homo sapiens bacterial meningitis MONDO:0006670 bacterial meningitis DOID:9470 primary hBMECs up-regulated hg38_circ_0014254 was significantly upregulated in primary human brain microvascular endothelial cells after meningitic E. coli infection compared with uninfected control cells. SRP116604 114 30497055 Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli. hsa_circ_0019064 hg38_circ_0019064 Homo sapiens bacterial meningitis MONDO:0006670 bacterial meningitis DOID:9470 primary hBMECs up-regulated hg38_circ_0019064 was significantly upregulated in primary human brain microvascular endothelial cells after meningitic E. coli infection compared with uninfected control cells. SRP116604 115 30497055 Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli. hsa_circ_0035876 hg38_circ_0035876 Homo sapiens bacterial meningitis MONDO:0006670 bacterial meningitis DOID:9470 primary hBMECs up-regulated hg38_circ_0035876 was significantly upregulated in primary human brain microvascular endothelial cells after meningitic E. coli infection compared with uninfected control cells. SRP116604 116 30582454 "Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function." hsa_circ_LRP6 LRP6 Homo sapiens vascular diseases MONDO:0005385 vascular disorder DOID:178 vascular smooth muscle cells (VSMCs) up-regulated "circ_Lrp6 is enriched in vascular smooth muscle cells and its VSMC localization was supported by in situ hybridization with smooth muscle marker staining. Functional experiments showed that circ_Lrp6 modulates VSMC migration, proliferation, and differentiation through miR-145." GSE99318 117 30582454 "Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function." hsa_circ_LRP6 LRP6 Homo sapiens vascular diseases MONDO:0005385 vascular disorder DOID:178 VSMCs down-regulated "In VSMCs, PDGF-BB treatment downregulated circ_Lrp6 after 24 hours as measured by RT-qPCR. The study relates this regulation to cytokine-driven modulation of VSMC differentiation." 118 30582454 "Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function." hsa_circ_LRP6 LRP6 Homo sapiens vascular diseases MONDO:0005385 vascular disorder DOID:178 VSMCs down-regulated "In VSMCs, TGF-¦Â treatment downregulated circ_Lrp6 after 24 hours as measured by RT-qPCR. The authors reported an inverse correlation between circ_Lrp6 and miR-145 expression in TGF-¦Â-treated cells." 119 30582454 "Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function." hsa_circ_LRP6 Lrp6; LRP6 Homo sapiens vascular diseases MONDO:0005385 vascular disorder DOID:178 VSMCs no change "In VSMCs grown under hypoxic conditions, circ_Lrp6 expression did not change by RT-qPCR, whereas miR-145 was strongly downregulated. The hypoxia experiment was presented in the context of vascular disease mechanisms." 120 30582454 "Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function." mmu_circ_Lrp6 Lrp6 Mus musculus vascular diseases MONDO:0005385 vascular disorder DOID:178 vascular smooth muscle cells (VSMCs) up-regulated "circ_Lrp6 is enriched in vascular smooth muscle cells and its VSMC localization was supported by in situ hybridization with smooth muscle marker staining. Functional experiments showed that circ_Lrp6 modulates VSMC migration, proliferation, and differentiation through miR-145." GSE99318 121 30582454 "Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function." mmu_circ_Lrp6 Lrp6 Mus musculus vascular diseases MONDO:0005385 vascular disorder DOID:178 VSMCs down-regulated "In VSMCs, PDGF-BB treatment downregulated circ_Lrp6 after 24 hours as measured by RT-qPCR. The study relates this regulation to cytokine-driven modulation of VSMC differentiation." 122 30582454 "Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function." mmu_circ_Lrp6 Lrp6 Mus musculus vascular diseases MONDO:0005385 vascular disorder DOID:178 VSMCs down-regulated "In VSMCs, TGF-¦Â treatment downregulated circ_Lrp6 after 24 hours as measured by RT-qPCR. The authors reported an inverse correlation between circ_Lrp6 and miR-145 expression in TGF-¦Â-treated cells." 123 30582454 "Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function." mmu_circ_Lrp6 Lrp6 Mus musculus vascular diseases MONDO:0005385 vascular disorder DOID:178 VSMCs no change "In VSMCs grown under hypoxic conditions, circ_Lrp6 expression did not change by RT-qPCR, whereas miR-145 was strongly downregulated. The hypoxia experiment was presented in the context of vascular disease mechanisms." 124 30613267 A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p. circNCX1 rno_circ_ncx1 ncx1 Rattus norvegicus ischemic myocardial injury MONDO:0024644 myocardial ischemia neonatal rat cardiomyocytes up-regulated "circNCX1 was enriched in primary neonatal rat cardiomyocytes compared with cardiac fibroblasts, as measured by qRT-PCR after primary cell isolation." 125 30613267 A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p. circNCX1 rno_circ_ncx1 ncx1 Rattus norvegicus ischemic myocardial injury MONDO:0024644 myocardial ischemia neonatal cardiomyocytes up-regulated "In primary neonatal rat cardiomyocytes, circNCX1 expression increased under H2O2 or hypoxia-reoxygenation treatment. Functional experiments in neonatal cardiomyocytes supported a role for circNCX1 in promoting cardiomyocyte apoptosis." 126 30651325 MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5. mmu_circ_0000691 CircRNA-005252 mmu_circ_Filip1l Filip1l Mus musculus chronic inflammatory pain MONDO:0024317 chronic pain syndrome spinal neurons up-regulated "circRNA-Filip1l is increased in spinal neurons of mice under CFA-induced chronic inflammatory pain, supported by neuronal marker co-localization with NeuN." 127 30651325 MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5. mmu_circ_0000691 CircRNA-005252 mmu_circ_Filip1l Filip1l Mus musculus chronic inflammatory pain MONDO:0024317 chronic pain syndrome spinal neuron cells up-regulated circRNA-Filip1l is enriched in primary cultured spinal neurons compared with cultured microglial cells and astrocyte cells. 128 30664808 Mesenchymal stem cells in psoriatic lesions affect the skin microenvironment through circular RNA. chr2:206992521|206994966 Homo sapiens psoriasis MONDO:0005083 psoriasis DOID:8893 S-MSCs down-regulated chr2:206992521|206994966 was down-regulated in skin-derived mesenchymal stem cells from psoriatic lesions compared with normal S-MSCs. Knockdown experiments indicated that this circRNA affects S-MSC immunoregulatory activity toward T lymphocytes and cytokine secretion. GSE81106 129 30692016 circRNA.33186 Contributes to the Pathogenesis of Osteoarthritis by Sponging miR-127-5p. circRNA.33186 mmu_circ_Umad1 Umad1 Mus musculus Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated circRNA.33186 is up-regulated in IL-1b-treated primary mouse chondrocytes compared with control chondrocytes by qRT-PCR. Knockdown experiments in chondrocytes support roles in proliferation and apoptosis regulation. 130 30815012 CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome. 17:77402059-77402703:+ hsa_circ_SEPT9 SEPT9 Homo sapiens MLL rearranged acute leukemia MONDO:0850156 B-lymphoblastic leukemia/lymphoma MLL rearranged DOID:0080644 monocytes up-regulated circSEPT9 17:77402059-77402703:+ was detected in FACS-sorted blood cell RNA-seq and showed marked overexpression in monocytes. GSE110159 131 30815012 CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome. 2:100006632-100008932:- hsa_circ_AFF3 AFF3 Homo sapiens MLL rearranged acute leukemia MONDO:0850156 B-lymphoblastic leukemia/lymphoma MLL rearranged DOID:0080644 B-cells up-regulated circAFF3 2:100006632-100008932:- was detected by RNA-seq of sorted blood cell populations and was upregulated in B cells. GSE110159 132 30815012 CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome. 5:132892164-132893118:- hsa_circ_AFF4 AFF4 Homo sapiens MLL rearranged acute leukemia MONDO:0850156 B-lymphoblastic leukemia/lymphoma MLL rearranged DOID:0080644 B-cells up-regulated circAFF4 5:132892164-132893118:- was detected by RNA-seq of sorted blood cell populations and was upregulated in B cells. GSE110159 133 30815012 CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome. 11:86007542-86026367:- hsa_circ_PICALM PICALM Homo sapiens MLL rearranged acute leukemia MONDO:0850156 B-lymphoblastic leukemia/lymphoma MLL rearranged DOID:0080644 stem cells up-regulated circPICALM 11:86007542-86026367:- was detected in sorted blood cell RNA-seq and was more abundant in stem cells. GSE110159 134 30815012 CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome. 11:86022367-86031611:- hsa_circ_PICALM PICALM Homo sapiens MLL rearranged acute leukemia MONDO:0850156 B-lymphoblastic leukemia/lymphoma MLL rearranged DOID:0080644 stem cells up-regulated circPICALM 11:86022367-86031611:- was detected in sorted blood cell RNA-seq and was more abundant in stem cells. GSE110159 135 30815012 CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome. 5:65528452-65529145:- hsa_circ_CENPK CENPK Homo sapiens MLL rearranged acute leukemia MONDO:0850156 B-lymphoblastic leukemia/lymphoma MLL rearranged DOID:0080644 stem cells up-regulated circCENPK 5:65528452-65529145:- was detected in sorted blood cell RNA-seq and was stem-cell-specific among the examined blood populations. GSE110159 136 30815012 CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome. 17:59668941-59669222:+ hsa_circ_CLTC CLTC Homo sapiens MLL rearranged acute leukemia MONDO:0850156 B-lymphoblastic leukemia/lymphoma MLL rearranged DOID:0080644 stem cells up-regulated circCLTC 17:59668941-59669222:+ was detected in sorted blood cell RNA-seq and was specific to stem cells in the analyzed populations. GSE110159 137 30815012 CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome. 1:51402435-51408332:- hsa_circ_EPS15 EPS15 Homo sapiens MLL rearranged acute leukemia MONDO:0850156 B-lymphoblastic leukemia/lymphoma MLL rearranged DOID:0080644 stem cells up-regulated circEPS15 1:51402435-51408332:- was detected in all sorted blood cell types and showed slight upregulation in stem cells. GSE110159 138 30815012 CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome. 1:51394381-51448135:- hsa_circ_EPS15 EPS15 Homo sapiens MLL rearranged acute leukemia MONDO:0850156 B-lymphoblastic leukemia/lymphoma MLL rearranged DOID:0080644 monocytes up-regulated circEPS15 1:51394381-51448135:- was detected by RNA-seq in sorted blood cells and was upregulated only in monocytes. GSE110159 139 30815012 CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome. 4:87046166-87047594:+ hsa_circ_AFF1 AFF1 Homo sapiens MLL rearranged acute leukemia MONDO:0850156 B-lymphoblastic leukemia/lymphoma MLL rearranged DOID:0080644 stem cells up-regulated circAFF1 4:87046166-87047594:+ was detected by RNA-seq of sorted blood populations and showed remarkable upregulation in stem cells compared with mature cells. GSE110159 140 30815012 CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome. 11:118481715-118482495:+ hsa_circ_KMT2A KMT2A Homo sapiens MLL rearranged acute leukemia MONDO:0850156 B-lymphoblastic leukemia/lymphoma MLL rearranged DOID:0080644 B- and T-cells up-regulated circKMT2A 11:118481715-118482495:+ was detected in sorted mature blood populations and was upregulated in B and T cells while absent from the stem population. GSE110159 141 30820544 circ-Sirt1 controls NF-¦ÊB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells. hsa_circ_0093887 hsa_circ_SIRT1 SIRT1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 VSMCs down-regulated "circ-Sirt1 expression is decreased in TNF-¦Á- or PDGF-BB-treated VSMCs, supporting down-regulation during inflammatory phenotypic switching relevant to atherosclerosis and neointimal formation. Functional experiments in VSMCs showed circ-Sirt1 suppresses inflammatory gene expression and NF-¦ÊB activation." 142 30820544 circ-Sirt1 controls NF-¦ÊB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells. circ-Sirt1 Sirt1 Rattus norvegicus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 VSMCs up-regulated circ-Sirt1 is primarily enriched in VSMCs compared with other vascular cells examined. This supports VSMC-associated expression of circ-Sirt1 in the context of vascular disease biology. 143 30824182 Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA/NF-¦ÊB pathway. hsa_circ_0075932 Homo sapiens burn injury MONDO:0043519 burn dermal keratinocytes up-regulated "In primary human dermal keratinocytes, circ_0075932 was significantly up-regulated after heat stimulation used to simulate burn injury, although its absolute abundance remained low." 144 30824182 Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA/NF-¦ÊB pathway. hsa_circ_0075932 Homo sapiens burn injury MONDO:0043519 burn matured adipocytes up-regulated "In primary human adipose-derived cells induced to mature adipocytes, circ_0075932 was up-regulated after pLL-circ_0075932 transfection, and its level also increased in adipocyte-derived exosomes." 145 30838031 Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation. hsa_circ_0030569 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 lymphocytes up-regulated hsa_circ_0030569 was up-regulated in lymphocytes from atrial fibrillation patients compared with healthy donors based on RNA-seq circRNA detection. SRP093226 146 30838031 Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation. chr9:15474007-15490122 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 lymphocytes dys-regulated "chr9:15474007-15490122 was identified among dysregulated circRNAs in lymphocytes from atrial fibrillation patients compared with healthy donors, and was enriched in cytokine-cytokine receptor interaction by KEGG analysis." SRP093226 147 30838031 Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation. chr16:75445723-75448593 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 lymphocytes dys-regulated "chr16:75445723-75448593 was identified among dysregulated circRNAs in lymphocytes from atrial fibrillation patients compared with healthy donors, and was enriched in cytokine-cytokine receptor interaction by KEGG analysis." SRP093226 148 30838031 Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation. hsa_circ_0007256 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 lymphocytes dys-regulated "hsa_circ_0007256 was identified among dysregulated circRNAs in lymphocytes from atrial fibrillation patients compared with healthy donors, and was enriched in cytokine-cytokine receptor interaction by KEGG analysis." SRP093226 149 30838031 Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation. chr12:56563313-56563992 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 lymphocytes dys-regulated "chr12:56563313-56563992 was identified among dysregulated circRNAs in lymphocytes from atrial fibrillation patients compared with healthy donors, and was enriched in cytokine-cytokine receptor interaction by KEGG analysis." SRP093226 150 30838031 Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation. hsa_circ_0003533 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 lymphocytes dys-regulated "hsa_circ_0003533 was identified among dysregulated circRNAs in lymphocytes from atrial fibrillation patients compared with healthy donors, and was enriched in RIG-I like receptor signaling pathway by KEGG analysis." SRP093226 151 30876857 Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b. circ-Ttc3 rno_circ_Ttc3 Ttc3 Rattus norvegicus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 primary cardiomyocytes up-regulated "circ-Ttc3 expression was elevated in primary rat cardiomyocytes exposed to hypoxia, an in vitro ischemic injury model. Functional experiments in cardiomyocytes showed effects on hypoxia-induced ATP depletion and apoptosis." 152 30898701 Expression patterns of novel circular RNAs in chicken cells after avian leukosis virus subgroup J infection. circRNA2494 Gallus gallus avian leukosis virus subgroup J infection MONDO:0005108 viral infectious disease DOID:934 CEF cells up-regulated "circRNA2494 expression increased over time in primary chicken embryo fibroblast cells after ALV-J infection, based on RNA-seq analysis." 153 30898701 Expression patterns of novel circular RNAs in chicken cells after avian leukosis virus subgroup J infection. circRNA5516 Gallus gallus avian leukosis virus subgroup J infection MONDO:0005108 viral infectious disease DOID:934 CEF cells up-regulated "circRNA5516 expression increased over time in primary chicken embryo fibroblast cells after ALV-J infection, based on RNA-seq analysis." 154 30898701 Expression patterns of novel circular RNAs in chicken cells after avian leukosis virus subgroup J infection. circRNA7419 gga_circ_KDM4C KDM4C Gallus gallus avian leukosis virus subgroup J infection MONDO:0005108 viral infectious disease DOID:934 CEF cells up-regulated "circRNA7419 expression increased over time in primary chicken embryo fibroblast cells after ALV-J infection, based on RNA-seq analysis. Its host gene was identified as KDM4C." 155 30898701 Expression patterns of novel circular RNAs in chicken cells after avian leukosis virus subgroup J infection. circRNA6679 gga_circ_TNFAIP6 TNFAIP6 Gallus gallus avian leukosis virus subgroup J infection MONDO:0005108 viral infectious disease DOID:934 CEF cells down-regulated "circRNA6679, derived from TNFAIP6, was highly expressed under normal conditions but down-regulated in primary chicken embryo fibroblast cells during ALV-J infection." 156 30898701 Expression patterns of novel circular RNAs in chicken cells after avian leukosis virus subgroup J infection. circRNA6680 gga_circ_TNFAIP6 TNFAIP6 Gallus gallus avian leukosis virus subgroup J infection MONDO:0005108 viral infectious disease DOID:934 CEF cells down-regulated "circRNA6680, derived from TNFAIP6, was highly expressed under normal conditions but down-regulated in primary chicken embryo fibroblast cells during ALV-J infection." 157 30908647 Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray. hsa_circRNA_100797 hsa_circ_CD44 CD44 Homo sapiens ultraviolet B stress-induced human fibroblast premature senescence others others human fibroblasts down-regulated "hsa_circRNA_100797 was down-regulated in senescent human fibroblasts in the UVB-SIPS model compared with normal fibroblasts, validated by qRT-PCR after primary fibroblast isolation and culture. Overexpression of circRNA_100797 increased fibroblast viability and alleviated UVB-induced cell cycle arrest." 158 30908647 Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray. hsa_circRNA_100686 Homo sapiens ultraviolet B stress-induced human fibroblast premature senescence others others human fibroblasts down-regulated "hsa_circRNA_100686 was down-regulated in senescent human fibroblasts in the UVB-SIPS model compared with normal fibroblasts, validated by qRT-PCR after primary fibroblast isolation and culture." 159 30908647 Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray. hsa_circRNA_400036 Homo sapiens ultraviolet B stress-induced human fibroblast premature senescence others others human fibroblasts up-regulated "hsa_circRNA_400036 was up-regulated in senescent human fibroblasts in the UVB-SIPS model compared with normal fibroblasts, validated by qRT-PCR after primary fibroblast isolation and culture." 160 30908647 Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray. hsa_circRNA_101755 Homo sapiens ultraviolet B stress-induced human fibroblast premature senescence others others human fibroblasts up-regulated "hsa_circRNA_101755 was up-regulated in senescent human fibroblasts in the UVB-SIPS model compared with normal fibroblasts, validated by qRT-PCR after primary fibroblast isolation and culture." 161 30908647 Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray. hsa_circRNA_003794 Homo sapiens ultraviolet B stress-induced human fibroblast premature senescence others others human fibroblasts up-regulated "hsa_circRNA_003794 was up-regulated in senescent human fibroblasts in the UVB-SIPS model compared with normal fibroblasts, validated by qRT-PCR after primary fibroblast isolation and culture." 162 30923232 CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene. hsa_circ_00008667 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes (HCs) down-regulated hsa_circ_00008667 was downregulated in IL-1¦Â- and TNF-¦Á-treated primary human chondrocytes in an osteoarthritis-related inflammatory context. 163 30923232 CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene. hsa_circ_0072568 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes (HCs) down-regulated hsa_circ_0072568 was downregulated in IL-1¦Â- and TNF-¦Á-treated primary human chondrocytes in an osteoarthritis-related inflammatory context. 164 30923232 CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene. hsa_circ_0008365 CircSERPINE2 hsa_circ_SERPINE2 SERPINE2 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes (HCs) down-regulated hsa_circ_0008365 / CircSERPINE2 was downregulated in IL-1¦Â- and TNF-¦Á-treated primary human chondrocytes. Functional experiments in HCs indicated that CircSERPINE2 regulates apoptosis and extracellular matrix metabolism. 165 30923232 CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene. hsa_circ_0020093 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes (HCs) down-regulated hsa_circ_0020093 was downregulated in IL-1¦Â- and TNF-¦Á-treated primary human chondrocytes in an osteoarthritis-related inflammatory context. 166 30923232 CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene. hsa_circ_0110251 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes (HCs) down-regulated hsa_circ_0110251 was downregulated in IL-1¦Â- and TNF-¦Á-treated primary human chondrocytes in an osteoarthritis-related inflammatory context. 167 30923232 CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene. hsa_circ_0001103 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes (HCs) down-regulated hsa_circ_0001103 was downregulated in IL-1¦Â- and TNF-¦Á-treated primary human chondrocytes in an osteoarthritis-related inflammatory context. 168 30925324 "Role of the ciRS-7/miR-7 axis in the regulation of proliferation, apoptosis and inflammation of chondrocytes induced by IL-1¦Â." ciRS-7 / Cdr1as Homo sapiens Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 Monocytes down-regulated ciRS-7 expression was measured by qRT-PCR after isolation of monocyte-containing blood fractions and was significantly downregulated in OA patients compared with healthy subjects. 169 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0020093 hsa_circ_ATRNL1 ATRNL1 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0020093 was down-regulated by RNA-seq and confirmed by qRT-PCR." 170 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0000284 hsa_circ_HIPK3 HIPK3 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0000284 was down-regulated by RNA-seq." 171 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0001922 hsa_circ_HUWE1 HUWE1 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0001922 was down-regulated by RNA-seq." 172 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0000839 hsa_circ_TTC39C TTC39C Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0000839 was down-regulated by RNA-seq." 173 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0004032 hsa_circ_ATXN1 ATXN1 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0004032 was down-regulated by RNA-seq." 174 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0050277 hsa_circ_CTC-513N18.7 CTC-513N18.7 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0050277 was down-regulated by RNA-seq." 175 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0002483 hsa_circ_PTK2(FAK) PTK2(FAK) Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0002483 was down-regulated by RNA-seq." 176 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0002484 hsa_circ_ZBTB44 ZBTB44 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0002484 was down-regulated by RNA-seq." 177 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0001414 hsa_circ_TMEM165 TMEM165 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0001414 was down-regulated by RNA-seq." 178 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0002290 hsa_circ_RSF1 RSF1 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0002290 was down-regulated by RNA-seq." 179 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0070039 hsa_circ_NUP54 NUP54 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0070039 was down-regulated by RNA-seq." 180 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0005782 hsa_circ_HP1BP3 HP1BP3 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0005782 was down-regulated by RNA-seq." 181 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0006595 hsa_circ_ST3GAL3 ST3GAL3 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0006595 was down-regulated by RNA-seq." 182 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0004711 hsa_circ_VWA8 VWA8 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0004711 was down-regulated by RNA-seq." 183 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0001103 hsa_circ_SERPINE2 SERPINE2 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0001103 was down-regulated by RNA-seq." 184 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0005777 hsa_circ_ARHGEF28 ARHGEF28 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0005777 was down-regulated by RNA-seq." 185 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0009061 hsa_circ_KDM1A KDM1A Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0009061 was down-regulated by RNA-seq." 186 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0018281 hsa_circ_ZFAND4 ZFAND4 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0018281 was down-regulated by RNA-seq." 187 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0008012 hsa_circ_NFKB1 NFKB1 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0008012 was down-regulated by RNA-seq." 188 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0009022 hsa_circ_PPP4R1 PPP4R1 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0009022 was down-regulated by RNA-seq." 189 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0123212 hsa_circ_UBXN7 UBXN7 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0123212 was down-regulated by RNA-seq." 190 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0005600 hsa_circ_YPEL2 YPEL2 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0005600 was down-regulated by RNA-seq." 191 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0024604 hsa_circ_ARHGEF12 ARHGEF12 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells up-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0024604 was up-regulated by RNA-seq." 192 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0137905 hsa_circ_DENND1A DENND1A Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells up-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0137905 was up-regulated by RNA-seq." 193 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0005925 hsa_circ_PILRB PILRB Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells up-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0005925 was up-regulated by RNA-seq." 194 30937532 Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. hsa_circ_0001577 hsa_circ_RANBP9 RANBP9 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells up-regulated "In isolated granulosa cells from women with PCOS versus controls, hsa_circ_0001577 was up-regulated by RNA-seq and confirmed by qRT-PCR." 195 30941555 Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome. hsa_circ_0043533 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 cumulus cells up-regulated "hsa_circ_0043533 was significantly up-regulated in isolated cumulus cells from PCOS patients compared with non-PCOS controls, validated by qRT-PCR." 196 30941555 Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome. hsa_circ_0097636 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 cumulus cells down-regulated "hsa_circ_0097636 was significantly down-regulated in isolated cumulus cells from PCOS patients compared with non-PCOS controls, validated by qRT-PCR." 197 30941555 Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome. hsa_circ_0043532 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 cumulus cells up-regulated hsa_circ_0043532 was reported as significantly up-regulated in isolated cumulus cells from PCOS patients compared with non-PCOS controls after qRT-PCR validation. 198 30947518 Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice. mmu_circ_0001704 circRNA_Nfix mmu_circ_Nfix Nfix Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 cardiomyocytes up-regulated "circNfix is enriched in cardiomyocytes compared with other cardiac cell types isolated from adult mouse hearts. In myocardial infarction models, loss of circNfix promoted cardiomyocyte proliferation and cardiac repair." 199 30967276 Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p. mmu_circ_0001052 circHIPK3 mmu_circ_HIPK3 HIPK3 Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 CFs up-regulated "circHIPK3 is up-regulated in cardiac fibroblasts after Ang II or TGF-¦Â treatment and in cardiac fibroblasts isolated from Ang II pump-treated mouse hearts compared with saline controls. Functional experiments in CFs showed that circHIPK3 regulates proliferation, migration and fibrosis-associated marker expression." 200 31051333 Circular RNA SNX29 Sponges miR-744 to Regulate Proliferation and Differentiation of Myoblasts by Activating the Wnt5a/Ca2+ Signaling Pathway. circRNA243 / circSNX29 bta_circ_SNX29 SNX29 Bos taurus others others others primary bovine myoblasts up-regulated "In primary bovine myoblasts, circSNX29 expression increased over the course of differentiation. Functional experiments showed that circSNX29 promoted myoblast differentiation and inhibited proliferation by regulating miR-744-associated Wnt5a/Ca2+ signaling." 201 31114845 Targeting the highly abundant circular RNA circSlc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy. circSlc8a1 mmu_circ_Slc8a1 Slc8a1 Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 isolated cardiomyocytes no change "In isolated mouse cardiomyocytes from the TAC pressure-overload hypertrophy model, circSlc8a1 abundance was reported to be consistently unchanged compared with Sham controls." 202 31140741 Cigarette smoke extract alters genome-wide profiles of circular RNAs and mRNAs in primary human small airway epithelial cells. hsa_circ_0010023 Homo sapiens chronic obstructive pulmonary disease MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 primary human small airway epithelial cells (HSAECs) up-regulated "hsa_circ_0010023 was overexpressed in primary human small airway epithelial cells after CSE treatment compared with untreated control cells, with RNA-seq findings validated by RT-qPCR." 203 31140741 Cigarette smoke extract alters genome-wide profiles of circular RNAs and mRNAs in primary human small airway epithelial cells. hsa_circ_0040929 Homo sapiens chronic obstructive pulmonary disease MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 primary human small airway epithelial cells (HSAECs) up-regulated "hsa_circ_0040929 was overexpressed in primary human small airway epithelial cells after CSE treatment compared with untreated control cells, with RNA-seq findings validated by RT-qPCR." 204 31140741 Cigarette smoke extract alters genome-wide profiles of circular RNAs and mRNAs in primary human small airway epithelial cells. hsa_circ_0060927 Homo sapiens chronic obstructive pulmonary disease MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 primary human small airway epithelial cells (HSAECs) down-regulated "hsa_circ_0060927 was underexpressed in primary human small airway epithelial cells after CSE treatment compared with untreated control cells, with RNA-seq findings validated by RT-qPCR." 205 31140741 Cigarette smoke extract alters genome-wide profiles of circular RNAs and mRNAs in primary human small airway epithelial cells. hsa_circ_0002472 Homo sapiens chronic obstructive pulmonary disease MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 primary human small airway epithelial cells (HSAECs) down-regulated "hsa_circ_0002472 was underexpressed in primary human small airway epithelial cells after CSE treatment compared with untreated control cells, with RNA-seq findings validated by RT-qPCR." 206 31140741 Cigarette smoke extract alters genome-wide profiles of circular RNAs and mRNAs in primary human small airway epithelial cells. hsa_circ_0002153 Homo sapiens chronic obstructive pulmonary disease MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 primary human small airway epithelial cells (HSAECs) down-regulated "hsa_circ_0002153 was underexpressed in primary human small airway epithelial cells after CSE treatment compared with untreated control cells, with RNA-seq findings validated by RT-qPCR." 207 31140741 Cigarette smoke extract alters genome-wide profiles of circular RNAs and mRNAs in primary human small airway epithelial cells. hsa_circ_0001573 Homo sapiens chronic obstructive pulmonary disease MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 primary human small airway epithelial cells (HSAECs) down-regulated "hsa_circ_0001573 was underexpressed in primary human small airway epithelial cells after CSE treatment compared with untreated control cells, with RNA-seq findings validated by RT-qPCR." 208 31141496 circFADS2 protects LPS-treated chondrocytes from apoptosis acting as an interceptor of miR-498/mTOR cross-talking. hsa_circ_0022387 circFADS2 hsa_circ_FADS2 FADS2 Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 LPS-treated chondrocytes up-regulated "circFADS2 was up-regulated in primary rat chondrocytes after LPS treatment compared with untreated chondrocytes, measured by qPCR. Functional experiments in LPS-treated chondrocytes linked circFADS2 to ECM catabolism, inflammation, proliferation and apoptosis." 209 31148290 Hsa_circ_0005519 increases IL-13/IL-6 by regulating hsa-let-7a-5p in CD4+ T cells to affect asthma. hsa_circ_0005519 hsa_circ_SNX13 SNX13 Homo sapiens asthma MONDO:0004979 asthma DOID:2841 CD4 + T cells up-regulated "hsa_circ_0005519 was increased in isolated CD4+ T cells from asthmatic patients compared with healthy subjects, with qRT-PCR validation after magnetic-bead isolation. In CD4+ T cells from asthmatic patients, knockdown of hsa_circ_0005519 decreased IL-13 and IL-6 protein levels." 210 31195953 CircRNA-9119 suppresses poly I:C induced inflammation in Leydig and Sertoli cells via TLR3 and RIG-I signal pathways. circRNA-9119 Mus musculus orchitis MONDO:0006882 orchitis DOID:2518 Leydig cells up-regulated circRNA-9119 was increased in isolated Leydig cells after poly I:C-induced inflammatory stimulation and was measured by qRT-PCR. Inhibition of circRNA-9119 reduced inflammatory cytokine responses in these testicular cells. 211 31195953 CircRNA-9119 suppresses poly I:C induced inflammation in Leydig and Sertoli cells via TLR3 and RIG-I signal pathways. circRNA-9119 Mus musculus orchitis MONDO:0006882 orchitis DOID:2518 Sertoli cells up-regulated circRNA-9119 was increased in isolated Sertoli cells after poly I:C-induced inflammatory stimulation and was measured by qRT-PCR. Inhibition of circRNA-9119 reduced inflammatory cytokine responses in these testicular cells. 212 31204558 CircRNA_28313/miR-195a/CSF1 axis modulates osteoclast differentiation to affect OVX-induced bone absorption in mice. circRNA_28313 Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 bone marrow monocyte cells up-regulated circRNA_28313 was up-regulated in primary mouse BMM cells after RANKL + CSF1-induced osteoclast differentiation compared with non-treated BMM cells. Knockdown experiments supported that circRNA_28313 modulates osteoclast differentiation in BMM cells. 213 31204558 CircRNA_28313/miR-195a/CSF1 axis modulates osteoclast differentiation to affect OVX-induced bone absorption in mice. circRNA_28313 Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 bone marrow macrophage cells up-regulated circRNA_28313 was up-regulated in primary mouse BMM cells after RANKL + CSF1-induced osteoclast differentiation compared with non-treated BMM cells. Knockdown experiments supported that circRNA_28313 modulates osteoclast differentiation in BMM cells. 214 31209250 Intragenic antagonistic roles of protein and circRNA in tumorigenesis. mmu_circ_Zbtb7a Zbtb7a Mus musculus mesenchymal tumors MONDO:0002616 mesenchymal cell neoplasm DOID:3350 primary p53 -/-MSCs down-regulated "Mouse circPOK was detected in primary p53-/- MSCs, and shRNA targeting its back-splice junction decreased circPOK levels in MSCs. Functional experiments in these MSC-based mesenchymal tumor models linked circPOK to proliferation and tumor formation." 215 31242973 Dexamethasone-induced cytotoxicity in human osteoblasts is associated with circular RNA HIPK3 downregulation. hsa_circ_0000284 hsa_circ_HIPK3 HIPK3 Homo sapiens osteonecrosis MONDO:0005380 osteonecrosis DOID:0080008; DOID:10159 primary human osteoblasts down-regulated "circHIPK3 expression is downregulated in primary human osteoblasts after dexamethasone treatment compared with untreated control cells. Functional experiments in primary human osteoblasts showed that circHIPK3 overexpression attenuated DEX-induced viability reduction, cell death, apoptosis, and mitochondrial injury, while circHIPK3 silencing potentiated DEX-induced cytotoxicity." 216 31281495 Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma. hsa_circ_0001727 circZKSCAN1 hsa_circ_ZKSCAN1 ZKSCAN1 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 sorted EpCAM+ primary HCC cells down-regulated "circZKSCAN1 was downregulated in sorted EpCAM+ primary HCC cells compared with EpCAM- cells, supporting reduced expression in the cancer stem-like cell population." 217 31295021 Identification of Circular RNA Related to Inflammation-Induced Lymphangiogenesis by Microarray Analysis. cZNF609 hsa_circ_ZNF609 ZNF609 Homo sapiens inflammation-induced lymphangiogenesis MONDO:0021166 inflammatory disease HLECs up-regulated "cZNF609 was upregulated in primary human lymphatic endothelial cells after macrophage co-culture inflammatory stimulation, supported by microarray profiling and qRT-PCR validation. The authors proposed that cZNF609 may regulate lymphangiogenesis-related mediators as an endogenous miRNA sponge." 218 31311824 Circular RNA TLK1 Aggravates Neuronal Injury and Neurological Deficits after Ischemic Stroke via miR-335-3p/TIPARP. mmu_circRNA_009932 mmu_circ_TLK1 TLK1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke primary cortical neurons up-regulated "circTLK1 colocalized with the neuronal marker NeuN and was detected in primary cultured cortical neurons. In primary cortical neurons, circTLK1 expression increased after OGD/R treatment." 219 31311824 Circular RNA TLK1 Aggravates Neuronal Injury and Neurological Deficits after Ischemic Stroke via miR-335-3p/TIPARP. mmu_circRNA_009932 mmu_circ_TLK1 TLK1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke neurons up-regulated circTLK1 colocalized with NeuN in mouse cortex and showed higher expression in neurons than other primary cultured brain cell types including astrocytes and microglia. 220 31312211 Genome-Wide Identification of Circular RNAs Revealed the Dominant Intergenic Region Circularization Model in Apostichopus japonicus. AJAPsacffold254:100722| 267769 Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 coelomocytes dys-regulated "AJAPsacffold254:100722| 267769 was included among differentially expressed exonic circRNAs analyzed in coelomocytes from SUS-diseased versus healthy sea cucumbers, based on circRNA RNA-seq junction-read analysis." PRJNA512578 221 31316543 Upregulation of Circular RNA CircNFIB Attenuates Cardiac Fibrosis by Sponging miR-433. mmu_circ_0011794 circNFIB mmu_circ_Nfib Nfib Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 primary adult cardiac fibroblasts down-regulated circNFIB expression is reduced in TGF-¦Â-treated primary adult cardiac fibroblasts. Functional experiments in primary adult cardiac fibroblasts showed that circNFIB attenuates fibroblast proliferation. 222 31325635 Circ_1639 induces cells inflammation responses by sponging miR-122 and regulating TNFRSF13C expression in alcoholic liver disease. circ_1639 Mus musculus alcoholic liver disease MONDO:0043693 alcoholic liver diseases Kupffer cells up-regulated "circ_1639 is up-regulated in primary Kupffer cells isolated from ethanol-fed mice compared with control diet-fed mice, based on qRT-PCR after Kupffer cell isolation." 223 31357500 Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons. circ-0000604 mmu_circ_Pvt1 Pvt1 Mus musculus others others others primary cortical neurons up-regulated circ-0000604 from Pvt1 is up-regulated during in vitro maturation of primary mouse cortical neurons. 224 31357500 Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons. circ-0005721 mmu_circ_Pvt1 Pvt1 Mus musculus others others others primary cortical neurons up-regulated circ-0005721 from Pvt1 is up-regulated during in vitro maturation of primary mouse cortical neurons. 225 31357500 Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons. circ-0005724 mmu_circ_Pvt1 Pvt1 Mus musculus others others others primary cortical neurons up-regulated "circ-0005724 from Pvt1 is up-regulated during in vitro maturation of primary mouse cortical neurons, peaking at DIV10." 226 31357500 Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons. circ-0009172 mmu_circ_Ano3 Ano3 Mus musculus others others others primary cortical neurons up-regulated "circ-0009172 from Ano3 is up-regulated during in vitro maturation of primary mouse cortical neurons, mainly between DIV10 and DIV14." 227 31357500 Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons. circ-0009174 mmu_circ_Ano3 Ano3 Mus musculus others others others primary cortical neurons up-regulated "circ-0009174 from Ano3 is up-regulated during in vitro maturation of primary mouse cortical neurons, mainly between DIV10 and DIV14." 228 31357500 Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons. circ-0009175 mmu_circ_Ano3 Ano3 Mus musculus others others others primary cortical neurons up-regulated "circ-0009175 from Ano3 is up-regulated during in vitro maturation of primary mouse cortical neurons, mainly between DIV10 and DIV14." 229 31357500 Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons. circ-0009176 mmu_circ_Ano3 Ano3 Mus musculus others others others primary cortical neurons no change circ-0009176 from Ano3 showed no substantial change during in vitro maturation of primary mouse cortical neurons. 230 31357500 Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons. circ-0013703 mmu_circ_Rnf169 Rnf169 Mus musculus others others others primary cortical neurons down-regulated circ-0013703 from Rnf169 is down-regulated during in vitro maturation of primary mouse cortical neurons. 231 31357500 Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons. circ-0013704 mmu_circ_Rnf169 Rnf169 Mus musculus others others others primary cortical neurons down-regulated circ-0013704 from Rnf169 is down-regulated during in vitro maturation of primary mouse cortical neurons. 232 31357500 Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons. circ-0001605 mmu_circ_Rnf169 Rnf169 Mus musculus others others others primary cortical neurons no change circ-0001605 from Rnf169 showed no change during in vitro maturation of primary mouse cortical neurons. 233 31373242 "Circular RNA circ_0000950 promotes neuron apoptosis, suppresses neurite outgrowth and elevates inflammatory cytokines levels via directly sponging miR-103 in Alzheimer's disease." circ_0000950 Rattus norvegicus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 primary cerebral cortex neurons from rat embryo cells no change "In primary cerebral cortex neurons from rat embryo used to construct a cellular AD model, circ_0000950 expression was not influenced by A¦Â-42 insult compared with control. Functional experiments in the cellular AD model of cerebral cortex neurons showed circ_0000950 promoted apoptosis, suppressed neurite outgrowth, and elevated inflammatory cytokines via miR-103." 234 31397348 Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery. novel_circ_0003760 Rattus norvegicus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary brain microvascular endothelial cells up-regulated "novel_circ_0003760 was up-regulated in primary rat brain microvascular endothelial cells after OGD/R treatment versus control, supported by circRNA RNA-seq and qRT-PCR validation." 235 31397348 Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery. novel_circ_0002086 Rattus norvegicus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary brain microvascular endothelial cells up-regulated "novel_circ_0002086 was up-regulated in primary rat brain microvascular endothelial cells after OGD/R treatment versus control, supported by circRNA RNA-seq and qRT-PCR validation." 236 31397348 Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery. novel_circ_0001606 Rattus norvegicus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary brain microvascular endothelial cells up-regulated "novel_circ_0001606 was up-regulated in primary rat brain microvascular endothelial cells after OGD/R treatment versus control, supported by circRNA RNA-seq and qRT-PCR validation." 237 31397348 Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery. novel_circ_0002023 Rattus norvegicus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary brain microvascular endothelial cells up-regulated "novel_circ_0002023 was up-regulated in primary rat brain microvascular endothelial cells after OGD/R treatment versus control, supported by circRNA RNA-seq and qRT-PCR validation." 238 31397348 Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery. novel_circ_0000173 Rattus norvegicus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary brain microvascular endothelial cells down-regulated "novel_circ_0000173 was down-regulated in primary rat brain microvascular endothelial cells after OGD/R treatment versus control, supported by circRNA RNA-seq and qRT-PCR validation." 239 31397348 Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery. novel_circ_0004586 Rattus norvegicus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary brain microvascular endothelial cells down-regulated "novel_circ_0004586 was down-regulated in primary rat brain microvascular endothelial cells after OGD/R treatment versus control, supported by circRNA RNA-seq and qRT-PCR validation." 240 31397348 Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery. novel_circ_0003342 Rattus norvegicus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary brain microvascular endothelial cells down-regulated "novel_circ_0003342 was down-regulated in primary rat brain microvascular endothelial cells after OGD/R treatment versus control, supported by circRNA RNA-seq and qRT-PCR validation." 241 31397348 Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery. novel_circ_0004860 Rattus norvegicus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary brain microvascular endothelial cells down-regulated "novel_circ_0004860 was down-regulated in primary rat brain microvascular endothelial cells after OGD/R treatment versus control, supported by circRNA RNA-seq and qRT-PCR validation." 242 31397837 Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4. circRNA_000203 mmu_circ_Myo9a Myo9a Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 neonatal mouse ventricular cardiomyocytes (NMVCs) up-regulated "circRNA_000203 is up-regulated in Ang-II-treated neonatal mouse ventricular cardiomyocytes, a primary cardiomyocyte model of cardiac hypertrophy. Overexpression of circRNA_000203 increased NMVC cell size and hypertrophic marker expression." 243 31409777 Circular RNA PRKCI promotes glioma cell progression by inhibiting microRNA-545. hsa_circ_PRKCI PRKCI Homo sapiens glioma MONDO:0021042 glioma primary human glioma cells up-regulated "circPRKCI is upregulated in primary human glioma cells compared with normal primary neuronal cultures and astrocytes. In primary human glioma cells, circPRKCI silencing reduced viability, proliferation and migration and induced apoptosis." 244 31411002 Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis-induced acute lung injury. chr17:71273374_71275287_ Mus musculus sepsis-induced acute lung injury MONDO:0015796 acute lung injury pulmonary macrophages up-regulated "chr17:71273374_71275287_ was up-regulated in isolated pulmonary macrophages from CLP-induced sepsis-associated acute lung injury mice compared with sham controls, based on circRNA RNA-seq and qRT-PCR validation." 245 31411002 Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis-induced acute lung injury. chr14:57733878_57734418_ Mus musculus sepsis-induced acute lung injury MONDO:0015796 acute lung injury pulmonary macrophages up-regulated "chr14:57733878_57734418_ was up-regulated in isolated pulmonary macrophages from CLP-induced sepsis-associated acute lung injury mice compared with sham controls, based on circRNA RNA-seq and qRT-PCR validation." 246 31411002 Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis-induced acute lung injury. chr18:10119885_10132272_ Mus musculus sepsis-induced acute lung injury MONDO:0015796 acute lung injury pulmonary macrophages up-regulated "chr18:10119885_10132272_ was up-regulated in isolated pulmonary macrophages from CLP-induced sepsis-associated acute lung injury mice compared with sham controls, based on circRNA RNA-seq and qRT-PCR validation." 247 31439031 Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2. circHIPK2 mmu_circ_HIPK2 HIPK2 Mus musculus depression MONDO:0002050 depressive disorder DOID:1596 GFAP-positive cells unknown circHIPK2 was detected in GFAP-positive astrocytes in mouse hippocampi by in situ hybridization combined with immunostaining. The study links circHIPK2 to astrocyte dysfunction in CUS-induced depressive-like behavior. 248 31511040 circPTN sponges miR-145-5p/miR-330-5p to promote proliferation and stemness in glioma. hsa_circ_0003949 circPTN hsa_circ_PTN PTN Homo sapiens glioma MONDO:0021042 glioma glioma stem cells up-regulated circPTN was approximately 10-fold higher in patient-derived G15 glioma stem cells than in serum-induced S15 cells. Functional assays in G15 cells indicated that circPTN promoted glioma stem cell self-renewal and stemness marker expression via sponging miR-145-5p. 249 31511520 CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain. circ:chr20:7561057-7573740 rno_circ_Anks1a Anks1a Rattus norvegicus neuropathic pain MONDO:0021667 neuralgia dorsal horn neurons up-regulated "circAnks1a is increased in dorsal horn neurons after spinal nerve ligation in a rodent neuropathic pain model, with FISH/qPCR evidence showing expression in neuronal cytoplasm and nucleus. Functional experiments indicate circAnks1a contributes to dorsal horn neuronal excitability and pain-like hypersensitivity, but this function is outside the predefined function categories." 250 31541092 Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. circFndc3b mmu_circ_Fndc3b Fndc3b Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 endothelial cells down-regulated circFndc3b is significantly down-regulated in isolated cardiac endothelial cells from post-MI mouse LV tissue compared with sham controls. Functional experiments indicate circFndc3b overexpression enhances endothelial angiogenic activity and reduces endothelial cell apoptosis. 251 31541092 Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis. circFndc3b mmu_circ_Fndc3b Fndc3b Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 cardiomyocytes down-regulated circFndc3b is significantly down-regulated in isolated cardiomyocytes from post-MI mouse LV tissue compared with sham controls. Functional experiments indicate circFndc3b overexpression reduces stress-induced cardiomyocyte apoptosis. 252 31582895 circRNA CDR1as Regulated the Proliferation of Human Periodontal Ligament Stem Cells under a Lipopolysaccharide-Induced Inflammatory Condition. CDR1as / CiRS-7 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 PDLSCs down-regulated CDR1as was significantly down-regulated in FACS-sorted human PDLSCs under LPS-induced inflammatory conditions compared with normal untreated PDLSCs. Functional experiments showed that CDR1as regulated PDLSC proliferation under this inflammatory condition through the miR-7/ERK pathway. 253 31605010 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. circIL4R hsa_circ_IL4R IL4R Homo sapiens pediatric B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemic cells down-regulated circIL4R was significantly less expressed in BCP-ALL leukemic cells than in healthy donor B-cells based on qRT-PCR of patient-derived xenograft samples. 254 31605010 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. circZCCHC7 hsa_circ_ZCCHC7 ZCCHC7 Homo sapiens pediatric B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemic cells down-regulated circZCCHC7 was significantly less expressed in BCP-ALL leukemic cells than in healthy donor B-cells based on qRT-PCR of patient-derived xenograft samples. 255 31605010 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. circX(intergenic) Homo sapiens pediatric B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemic cells down-regulated circX(intergenic) was significantly less expressed in BCP-ALL leukemic cells than in healthy donor B-cells based on qRT-PCR of patient-derived xenograft samples. 256 31605010 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. circAFF3 hsa_circ_AFF3 AFF3 Homo sapiens pediatric B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemic cells up-regulated circAFF3 was overexpressed in BCP-ALL leukemic cells compared with healthy donor B-cells based on qRT-PCR of patient-derived xenograft samples. 257 31605010 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. circHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens pediatric B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemic cells up-regulated circHIPK3 was overexpressed in BCP-ALL leukemic cells compared with healthy donor B-cells based on qRT-PCR of patient-derived xenograft samples. 258 31605010 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. circPVT1 hsa_circ_PVT1 PVT1 Homo sapiens pediatric B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemic cells up-regulated circPVT1 was overexpressed in BCP-ALL leukemic cells compared with healthy donor B-cells based on qRT-PCR of patient-derived xenograft samples. 259 31605010 Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. circPAX5 hsa_circ_PAX5 PAX5 Homo sapiens pediatric B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemic cells up-regulated circPAX5 was overexpressed in BCP-ALL leukemic cells compared with healthy donor B-cells based on qRT-PCR of patient-derived xenograft samples. 260 31607223 circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cells via ER stress. hsa_circ_DLGAP4 DLGAP4 Homo sapiens myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury Human umbilical vein endothelial cells (HUVECs) down-regulated "circDLGAP4 was significantly decreased in HUVEC endothelial cells after I/R exposure, with qRT-PCR detection and FISH confirmation. circDLGAP4 overexpression attenuated I/R-induced endothelial cell migration." 261 31621141 Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration. circ_4099 hsa_circ_DENND5A DENND5A Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 human NP cells up-regulated "circ_4099 was upregulated in human nucleus pulposus cells isolated from degenerated discs compared with non-degenerated discs, and this was confirmed by RT-qPCR. In NP cells, circ_4099 was also reported to modulate inflammatory cytokine and extracellular matrix-related gene expression." 262 31621141 Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration. circ_2069 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 human NP cells up-regulated "circ_2069 was upregulated in human nucleus pulposus cells isolated from degenerated discs compared with non-degenerated discs, with RT-qPCR confirmation." 263 31621141 Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration. circ_92328 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 human NP cells up-regulated "circ_92328 was upregulated in human nucleus pulposus cells isolated from degenerated discs compared with non-degenerated discs, with RT-qPCR confirmation." 264 31621141 Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration. circ_68610 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 human NP cells up-regulated "circ_68610 was upregulated in human nucleus pulposus cells isolated from degenerated discs compared with non-degenerated discs, with RT-qPCR confirmation." 265 31636010 Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI. hsa_circ_0059802 hsa_circ_DNMT3B DNMT3B Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 human retinal microvascular endothelial cells (HRMECs) down-regulated "circDNMT3B is reduced in HRMECs after high-glucose treatment, an in vitro diabetic-condition model. In the same cell type, circDNMT3B overexpression alleviated high-glucose-induced proliferation, migration, and tube formation." 266 31646606 Characterization of hsa_circ_0000594 as a new biomarker and therapeutic target for hepatoblastoma. hsa_circ_0000594 hsa_circ_TTBK2 TTBK2 Homo sapiens hepatoblastoma MONDO:0018666 hepatoblastoma DOID:687 HB epithelial cells up-regulated "hsa_circ_0000594 is up-regulated in hepatoblastoma specimens and is mainly expressed in epithelial rather than mesenchymal tissues, with ISH/IHC evidence showing a shared pattern with glypican-3 and ¦Â-catenin in HB epithelial cells." 267 31690252 Circulating Circular RNAs as Biomarkers for the Diagnosis and Prediction of Outcomes in Acute Ischemic Stroke. hsa_circ_PDS5B PDS5B Homo sapiens ischemic stroke MONDO:1060198 ischemic stroke lymphocytes up-regulated circPDS5B was significantly higher in lymphocytes from acute ischemic stroke patients than in controls after separation of blood cells and qRT-PCR analysis. 268 31690252 Circulating Circular RNAs as Biomarkers for the Diagnosis and Prediction of Outcomes in Acute Ischemic Stroke. hsa_circ_PDS5B PDS5B Homo sapiens ischemic stroke MONDO:1060198 ischemic stroke granulocytes up-regulated circPDS5B was significantly higher in granulocytes from acute ischemic stroke patients than in controls after separation of blood cells and qRT-PCR analysis. 269 31690252 Circulating Circular RNAs as Biomarkers for the Diagnosis and Prediction of Outcomes in Acute Ischemic Stroke. hsa_circ_CDC14A CDC14A Homo sapiens ischemic stroke MONDO:1060198 ischemic stroke granulocytes up-regulated circCDC14A was significantly increased in granulocytes from acute ischemic stroke patients compared with controls after separation of blood cells and qRT-PCR analysis. 270 31734859 Cross-Talk Between circRNAs and mRNAs Modulates MiRNA-mediated Circuits and Affects Melanoma Plasticity. hsa_circ_0004907 hsa_circ_ZEB1 ZEB1 Homo sapiens melanoma MONDO:0005105 melanoma DOID:1909 human melanoma cells (IgR39) no change "In flow-sorted IgR39 melanoma cells negative for CSC markers, circZEB1 was measured by qRT-PCR during phenotypic switching and remained high and relatively constant at both the CSC-marker re-expression overshoot and steady state." 271 31778958 Suppression of circDcbld1 Alleviates Intimal Hyperplasia in Rat Carotid Artery by Targeting miR-145-3p/Neuropilin-1. rno-circRNA_009723 rno_circ_Dcbld1 Dcbld1 Rattus norvegicus intimal hyperplasia MONDO:0005385 vascular disorder DOID:178 rat vascular smooth muscle cells (VSMCs) down-regulated "In primary cultured rat VSMCs, circDcbld1 was knocked down by siRNA and verified by quantitative real-time PCR. Suppression of circDcbld1 increased contractile smooth muscle cell markers and reduced VSMC migration." 272 31782248 CircNr1h4 regulates the pathological process of renal injury in salt-sensitive hypertensive mice by targeting miR-155-5p. circRNA1350 mmu_circ_Nr1h4 Nr1h4 Mus musculus hypertensive kidney injury MONDO:0005300 chronic kidney disease DOID:784 tubular cells of kidneys up-regulated FISH evidence indicates that circNr1h4 is most highly expressed in kidney tubular cells in the context of DOCA-salt-induced hypertensive kidney injury. 273 31790973 Characterization of Circular RNAs in Vascular Smooth Muscle Cells with Vascular Calcification. circSp140 rno_circ_Sp140 Sp140 Rattus norvegicus vascular calcification MONDO:0005311 atherosclerosis DOID:1936 RVSMCs up-regulated circSp140 was up-regulated in primary rat vascular smooth muscle cells after phosphate-induced vascular calcification based on circRNA RNA-seq analysis. 274 31790973 Characterization of Circular RNAs in Vascular Smooth Muscle Cells with Vascular Calcification. circUxs1 rno_circ_Uxs1 Uxs1 Rattus norvegicus vascular calcification MONDO:0005311 atherosclerosis DOID:1936 RVSMCs up-regulated "circUxs1 was up-regulated in primary rat vascular smooth muscle cells after phosphate-induced vascular calcification, with RNA-seq results validated by PCR." 275 31790973 Characterization of Circular RNAs in Vascular Smooth Muscle Cells with Vascular Calcification. circSamd4a rno_circ_Samd4a Samd4a Rattus norvegicus vascular calcification MONDO:0005311 atherosclerosis DOID:1936 RVSMCs down-regulated "circSamd4a was down-regulated in primary rat vascular smooth muscle cells after phosphate-induced vascular calcification, with RNA-seq results validated by PCR. Functional assays in vascular smooth muscle cells indicated an anti-calcification role for circSamd4a." 276 31790973 Characterization of Circular RNAs in Vascular Smooth Muscle Cells with Vascular Calcification. circSmoc1-1 rno_circ_Smoc1 Smoc1 Rattus norvegicus vascular calcification MONDO:0005311 atherosclerosis DOID:1936 RVSMCs down-regulated "circSmoc1-1 was down-regulated in primary rat vascular smooth muscle cells after phosphate-induced vascular calcification, with RNA-seq results validated by PCR." 277 31790973 Characterization of Circular RNAs in Vascular Smooth Muscle Cells with Vascular Calcification. circSmoc1-2 rno_circ_Smoc1 Smoc1 Rattus norvegicus vascular calcification MONDO:0005311 atherosclerosis DOID:1936 RVSMCs down-regulated circSmoc1-2 was down-regulated in primary rat vascular smooth muscle cells after phosphate-induced vascular calcification based on circRNA RNA-seq analysis. 278 31790973 Characterization of Circular RNAs in Vascular Smooth Muscle Cells with Vascular Calcification. circMettl9 rno_circ_Mettl9 Mettl9 Rattus norvegicus vascular calcification MONDO:0005311 atherosclerosis DOID:1936 RVSMCs down-regulated "circMettl9 was down-regulated in primary rat vascular smooth muscle cells after phosphate-induced vascular calcification, with RNA-seq results validated by PCR." 279 31811527 "circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan." circAFF1 hsa_circ_AFF1 AFF1 Homo sapiens cellular senescence others others Astrocytes up-regulated circAFF1 was significantly increased in late-passage senescent primary human astrocytes compared with early-passage astrocytes. 280 31811527 "circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan." circCDYL hsa_circ_CDYL CDYL Homo sapiens cellular senescence others others Astrocytes up-regulated circCDYL was significantly increased in late-passage senescent primary human astrocytes compared with early-passage astrocytes. 281 31811527 "circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan." circMIB1 hsa_circ_MIB1 MIB1 Homo sapiens cellular senescence others others Astrocytes up-regulated circMIB1 was significantly increased in late-passage senescent primary human astrocytes compared with early-passage astrocytes. 282 31811527 "circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan." circFOXO3 hsa_circ_FOXO3 FOXO3 Homo sapiens cellular senescence others others Cardiomyocytes down-regulated circFOXO3 was significantly decreased in late-passage senescent primary human cardiomyocytes compared with early-passage cardiomyocytes. 283 31811527 "circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan." circZC3H18 hsa_circ_ZC3H18 ZC3H18 Homo sapiens cellular senescence others others Endothelial cells up-regulated circZC3H18 was significantly increased in late-passage senescent primary human endothelial cells compared with early-passage endothelial cells. 284 31811527 "circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan." circAFF1 hsa_circ_AFF1 AFF1 Homo sapiens cellular senescence others others Fibroblasts down-regulated circAFF1 was significantly decreased in late-passage senescent primary human fibroblasts compared with early-passage fibroblasts. 285 31811527 "circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan." circEP300 hsa_circ_EP300 EP300 Homo sapiens cellular senescence others others Fibroblasts down-regulated circEP300 was significantly decreased in late-passage senescent primary human fibroblasts compared with early-passage fibroblasts. 286 31811527 "circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan." circFOXO3 hsa_circ_FOXO3 FOXO3 Homo sapiens cellular senescence others others Fibroblasts down-regulated circFOXO3 was significantly decreased in late-passage senescent primary human fibroblasts compared with early-passage fibroblasts. 287 31811527 "circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan." circMETTL3 hsa_circ_METTL3 METTL3 Homo sapiens cellular senescence others others Fibroblasts up-regulated circMETTL3 was significantly increased in late-passage senescent primary human fibroblasts compared with early-passage fibroblasts. 288 31815137 Identification of Circular RNAs Regulating Islet ¦Â-Cell Autophagy in Type 2 Diabetes Mellitus. rno_circRNA_011190 Rattus norvegicus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 islet ¦Â-cells up-regulated rno_circRNA_011190 was up-regulated in flow-sorted islet ¦Â-cells from T2DM rats compared with control rats and was included among qRT-PCR-validated circRNAs. 289 31815137 Identification of Circular RNAs Regulating Islet ¦Â-Cell Autophagy in Type 2 Diabetes Mellitus. rno_circRNA_014301 Rattus norvegicus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 islet ¦Â-cells up-regulated rno_circRNA_014301 was up-regulated in flow-sorted islet ¦Â-cells from T2DM rats compared with control rats and was included among qRT-PCR-validated circRNAs. 290 31815137 Identification of Circular RNAs Regulating Islet ¦Â-Cell Autophagy in Type 2 Diabetes Mellitus. rno_circRNA_000793 Rattus norvegicus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 islet ¦Â-cells up-regulated rno_circRNA_000793 was up-regulated in flow-sorted islet ¦Â-cells from T2DM rats compared with control rats and was included among qRT-PCR-validated circRNAs. 291 31815137 Identification of Circular RNAs Regulating Islet ¦Â-Cell Autophagy in Type 2 Diabetes Mellitus. mmu_circRNA_31436 Mus musculus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 islet ¦Â-cells up-regulated mmu_circRNA_31436 was up-regulated in flow-sorted islet ¦Â-cells from T2DM rats compared with control rats and was included among qRT-PCR-validated circRNAs. 292 31815137 Identification of Circular RNAs Regulating Islet ¦Â-Cell Autophagy in Type 2 Diabetes Mellitus. rno_circRNA_008695 Rattus norvegicus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 islet ¦Â-cells up-regulated rno_circRNA_008695 was up-regulated in flow-sorted islet ¦Â-cells from T2DM rats compared with control rats and was included among qRT-PCR-validated circRNAs. 293 31815137 Identification of Circular RNAs Regulating Islet ¦Â-Cell Autophagy in Type 2 Diabetes Mellitus. rno_circRNA_001731 Rattus norvegicus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 islet ¦Â-cells down-regulated rno_circRNA_001731 was down-regulated in flow-sorted islet ¦Â-cells from T2DM rats compared with control rats and was included among qRT-PCR-validated circRNAs. 294 31815137 Identification of Circular RNAs Regulating Islet ¦Â-Cell Autophagy in Type 2 Diabetes Mellitus. rno_circRNA_017447 Rattus norvegicus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 islet ¦Â-cells down-regulated rno_circRNA_017447 was down-regulated in flow-sorted islet ¦Â-cells from T2DM rats compared with control rats and was included among qRT-PCR-validated circRNAs. 295 31815137 Identification of Circular RNAs Regulating Islet ¦Â-Cell Autophagy in Type 2 Diabetes Mellitus. rno_circRNA_008565 Rattus norvegicus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 islet ¦Â-cells down-regulated rno_circRNA_008565 was down-regulated in flow-sorted islet ¦Â-cells from T2DM rats compared with control rats and was identified as the circRNA with the highest autophagy relevance score. 296 31815137 Identification of Circular RNAs Regulating Islet ¦Â-Cell Autophagy in Type 2 Diabetes Mellitus. rno_circRNA_011560 Rattus norvegicus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 islet ¦Â-cells down-regulated rno_circRNA_011560 was down-regulated in flow-sorted islet ¦Â-cells from T2DM rats compared with control rats and was included among qRT-PCR-validated circRNAs. 297 31815137 Identification of Circular RNAs Regulating Islet ¦Â-Cell Autophagy in Type 2 Diabetes Mellitus. mmu_circRNA_24828 Mus musculus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 islet ¦Â-cells down-regulated mmu_circRNA_24828 was down-regulated in flow-sorted islet ¦Â-cells from T2DM rats compared with control rats and was included among qRT-PCR-validated circRNAs. 298 31837293 Knock-down of circular RNA H19 induces human adipose-derived stem cells adipogenic differentiation via a mechanism involving the polypyrimidine tract-binding protein 1. hsa_circ_0095570 hsa_circ_H19 H19 Homo sapiens Metabolic syndrome MONDO:0000816 abdominal obesity-metabolic syndrome DOID:0060611 human adipose-derived stem cells down-regulated "In primary human adipose-derived stem cells, siRNA treatment decreased hsa_circH19 expression as measured by qRT-PCR. Knockdown of hsa_circH19 promoted adipogenic differentiation and lipid accumulation in hADSCs." 299 31857645 hsa_circ_0006459 and hsa_circ_0015962 affect prognosis of Dengue fever. hsa_circ_0015962 hsa_circ_RNPEP RNPEP Homo sapiens Dengue fever MONDO:0005502 dengue disease DOID:12205 peripheral blood leukocytes; PBMCs up-regulated hsa_circ_0015962 was up-regulated in isolated peripheral blood leukocytes/PBMCs from post-treatment dengue fever samples compared with pretreatment samples. 300 31857645 hsa_circ_0006459 and hsa_circ_0015962 affect prognosis of Dengue fever. hsa_circ_0006459 hsa_circ_GNAQ GNAQ Homo sapiens Dengue fever MONDO:0005502 dengue disease DOID:12205 peripheral blood leukocytes; PBMCs down-regulated hsa_circ_0006459 was down-regulated in isolated peripheral blood leukocytes/PBMCs from post-treatment dengue fever samples compared with pretreatment samples. 301 31860870 Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice. mmu_circ_0003411 mmu_circ_NF1 NF1 Mus musculus senile dementia MONDO:0004975 Alzheimer disease DOID:10652 astrocytes up-regulated "circNF1-419 was identified and up-regulated in D-galactose-induced senescent astrocytes compared with untreated astrocytes. In astrocytes, circNF1-419 overexpression enhanced autophagy." 302 31860870 Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice. mmu_circ_0003411 Rattus norvegicus senile dementia MONDO:0004975 Alzheimer disease DOID:10652 astrocytes up-regulated "circNF1-419 was identified and up-regulated in D-galactose-induced senescent astrocytes compared with untreated astrocytes. In astrocytes, circNF1-419 overexpression enhanced autophagy." 303 31885817 Exosomal circHIPK3 Released from Hypoxia-Pretreated Cardiomyocytes Regulates Oxidative Damage in Cardiac Microvascular Endothelial Cells via the miR-29a/IGF-1 Pathway. mmu_circ_0001052 circHIPK3 mmu_circ_HIPK3 HIPK3 Mus musculus ischemia reperfusion injury / IRI MONDO:0005203 ischemia reperfusion injury CMVECs down-regulated "In primary mouse cardiac microvascular endothelial cells, circHIPK3 was reduced after H2O2-induced oxidative stress compared with control cells, and hypoxia-pretreated cardiomyocyte exosomes rescued its level." 304 31885817 Exosomal circHIPK3 Released from Hypoxia-Pretreated Cardiomyocytes Regulates Oxidative Damage in Cardiac Microvascular Endothelial Cells via the miR-29a/IGF-1 Pathway. mmu_circ_0001052 circHIPK3 mmu_circ_HIPK3 HIPK3 Mus musculus ischemia reperfusion injury / IRI MONDO:0005203 ischemia reperfusion injury CMs up-regulated "In exosomes released by primary mouse cardiomyocytes, circHIPK3 was increased after hypoxia pretreatment compared with normoxic exosomes." 305 31894303 Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let_7a_5p/IGF2BP3 in cardiomyocytes. circRNA_101237 mmu_circ_CDK8 CDK8 Mus musculus anoxia/reoxygenation injury MONDO:0005203 ischemia reperfusion injury primary cardiomyocytes up-regulated "In mouse primary cardiomyocytes, circRNA_101237 was increased after A/R treatment and rose in a time-dependent manner. Knockdown experiments linked circRNA_101237 to A/R-induced cardiomyocyte apoptosis and autophagy." 306 31894303 Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let_7a_5p/IGF2BP3 in cardiomyocytes. circRNA_400095 Mus musculus anoxia/reoxygenation injury MONDO:0005203 ischemia reperfusion injury primary cardiomyocytes down-regulated "In mouse primary cardiomyocytes, circRNA_400095 was decreased after A/R treatment as confirmed by RT-qPCR." 307 31894303 Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let_7a_5p/IGF2BP3 in cardiomyocytes. circRNA_101512 Mus musculus anoxia/reoxygenation injury MONDO:0005203 ischemia reperfusion injury primary cardiomyocytes down-regulated "In mouse primary cardiomyocytes, circRNA_101512 was decreased after A/R treatment as confirmed by RT-qPCR." 308 31894303 Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let_7a_5p/IGF2BP3 in cardiomyocytes. circRNA_100714 Mus musculus anoxia/reoxygenation injury MONDO:0005203 ischemia reperfusion injury primary cardiomyocytes up-regulated "In mouse primary cardiomyocytes, circRNA_100714 was increased after A/R treatment as confirmed by RT-qPCR." 309 31894303 Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let_7a_5p/IGF2BP3 in cardiomyocytes. circRNA_405755 Mus musculus anoxia/reoxygenation injury MONDO:0005203 ischemia reperfusion injury primary cardiomyocytes up-regulated "In mouse primary cardiomyocytes, circRNA_405755 was increased after A/R treatment as confirmed by RT-qPCR." 310 31904383 Expression profile and bioinformatics analyses of circular RNAs in keloid and normal dermal fibroblasts. hsa_circ_0008259 Homo sapiens keloid MONDO:0005348 keloid keloid dermal fibroblasts (KDFs) down-regulated "hsa_circ_0008259 was significantly downregulated in primary cultured keloid dermal fibroblasts compared with normal dermal fibroblasts, supported by circRNA RNA-seq and qRT-PCR validation. Overexpression of hsa_circ_0008259 in KDFs inhibited type I and III collagen expression." 311 31904383 Expression profile and bioinformatics analyses of circular RNAs in keloid and normal dermal fibroblasts. hsa_circ_0005480 Homo sapiens keloid MONDO:0005348 keloid keloid dermal fibroblasts (KDFs) down-regulated "hsa_circ_0005480 was significantly downregulated in primary cultured keloid dermal fibroblasts compared with normal dermal fibroblasts, consistent with RNA-seq data and qRT-PCR validation." 312 31904383 Expression profile and bioinformatics analyses of circular RNAs in keloid and normal dermal fibroblasts. hsa_circ_0002198 Homo sapiens keloid MONDO:0005348 keloid keloid dermal fibroblasts (KDFs) up-regulated "hsa_circ_0002198 was significantly upregulated in primary cultured keloid dermal fibroblasts compared with normal dermal fibroblasts, consistent with RNA-seq data and qRT-PCR validation." 313 31931709 Transcriptome-wide map of m6A circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension. circXpo6 rno_circ_Xpo6 Xpo6 Rattus norvegicus Hypoxia mediated pulmonary hypertension MONDO:0017157 pulmonary hypertension owing to lung disease and/or hypoxia PASMCs down-regulated "In isolated and cultured rat pulmonary artery smooth muscle cells, m6A-modified circXpo6 was decreased after hypoxia exposure compared with normoxia, as measured by MeRIP-RT-PCR and MeRIP-qRT-PCR." 314 31931709 Transcriptome-wide map of m6A circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension. circXpo6 rno_circ_Xpo6 Xpo6 Rattus norvegicus Hypoxia mediated pulmonary hypertension MONDO:0017157 pulmonary hypertension owing to lung disease and/or hypoxia PAECs down-regulated "In isolated and cultured rat pulmonary artery endothelial cells, m6A-modified circXpo6 was decreased after hypoxia exposure compared with normoxia, as measured by MeRIP-RT-PCR and MeRIP-qRT-PCR." 315 31931709 Transcriptome-wide map of m6A circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension. circTmtc3 rno_circ_Tmtc3 Tmtc3 Rattus norvegicus Hypoxia mediated pulmonary hypertension MONDO:0017157 pulmonary hypertension owing to lung disease and/or hypoxia PASMCs down-regulated "In isolated and cultured rat pulmonary artery smooth muscle cells, m6A-modified circTmtc3 was decreased after hypoxia exposure compared with normoxia, as measured by MeRIP-RT-PCR and MeRIP-qRT-PCR." 316 31931709 Transcriptome-wide map of m6A circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension. circTmtc3 rno_circ_Tmtc3 Tmtc3 Rattus norvegicus Hypoxia mediated pulmonary hypertension MONDO:0017157 pulmonary hypertension owing to lung disease and/or hypoxia PAECs down-regulated "In isolated and cultured rat pulmonary artery endothelial cells, m6A-modified circTmtc3 was decreased after hypoxia exposure compared with normoxia, as measured by MeRIP-RT-PCR and MeRIP-qRT-PCR." 317 31938060 Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia. cZFP609 mmu_circ_ZFP609 ZFP609 Mus musculus hindlimb ischemia MONDO:0000491 limb ischemia DOID:0050852 VSMCs up-regulated cZFP609 was increased in hypoxic SIRT1-Tg VSMCs and their exosomes compared with WT and SIRT1-KO VSMCs. VSMC-derived exosomal cZFP609 was implicated in reprogramming endothelial angiogenic function. 318 31938060 Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia. cZFP609 mmu_circ_ZFP609 ZFP609 Mus musculus hindlimb ischemia MONDO:0000491 limb ischemia DOID:0050852 ECs down-regulated Endothelial cZFP609 expression was decreased under hypoxia compared with normoxia in primary mouse ECs. This establishes a hypoxia-associated down-regulation context in endothelial cells. 319 31938060 Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia. cZFP609 mmu_circ_ZFP609 ZFP609 Mus musculus hindlimb ischemia MONDO:0000491 limb ischemia DOID:0050852 ECs up-regulated "cZFP609 increased in primary mouse ECs after incubation with exosomes from hypoxic SIRT1-Tg VSMCs, and this increase was abolished when cZFP609 was knocked down in donor VSMCs. The delivered cZFP609 suppressed VEGFA expression and endothelial angiogenic functions." 320 31948430 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0005273 hsa_circRNA_104700 hsa_circ_PTK2 PTK2 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells up-regulated "circ-PTK2 was up-regulated in purified bone marrow plasma cells from multiple myeloma patients compared with healthy controls, validated by qPCR after CD138 magnetic bead purification." 321 31948430 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0077765 hsa_circRNA_104181 hsa_circ_RNF217 RNF217 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells up-regulated "circ-RNF217 was up-regulated in purified bone marrow plasma cells from multiple myeloma patients compared with healthy controls, validated by qPCR after CD138 magnetic bead purification." 322 31948430 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0009581 hsa_circRNA_100033 hsa_circ_RERE RERE Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells up-regulated "circ-RERE was up-regulated in purified bone marrow plasma cells from multiple myeloma patients compared with healthy controls, validated by qPCR after CD138 magnetic bead purification." 323 31948430 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0007146 hsa_circRNA_101695 hsa_circ_NAGPA NAGPA Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells up-regulated "circ-NAGPA was up-regulated in purified bone marrow plasma cells from multiple myeloma patients compared with healthy controls, validated by qPCR after CD138 magnetic bead purification." 324 31948430 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0004136 hsa_circRNA_104134 hsa_circ_KCNQ5 KCNQ5 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells up-regulated "circ-KCNQ5 was up-regulated in purified bone marrow plasma cells from multiple myeloma patients compared with healthy controls, validated by qPCR after CD138 magnetic bead purification." 325 31948430 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0001947 hsa_circRNA_105034 hsa_circ_AFF2 AFF2 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells down-regulated "circ-AFF2 was down-regulated in purified bone marrow plasma cells from multiple myeloma patients compared with healthy controls, validated by qPCR after CD138 magnetic bead purification." 326 31948430 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0001910 hsa_circRNA_104980 hsa_circ_WWC3 WWC3 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells down-regulated "circ-WWC3 was down-regulated in purified bone marrow plasma cells from multiple myeloma patients compared with healthy controls, validated by qPCR after CD138 magnetic bead purification." 327 31948430 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0007609 hsa_circRNA_103106 hsa_circ_DNAJC5 DNAJC5 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells down-regulated "circ-DNAJC5 was down-regulated in purified bone marrow plasma cells from multiple myeloma patients compared with healthy controls, validated by qPCR after CD138 magnetic bead purification." 328 31948430 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0071375 hsa_circRNA_103765 hsa_circ_KLHL2 KLHL2 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells down-regulated "circ-KLHL2 was down-regulated in purified bone marrow plasma cells from multiple myeloma patients compared with healthy controls, validated by qPCR after CD138 magnetic bead purification." 329 31948430 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0000651 hsa_circRNA_101648 hsa_circ_IQGAP1 IQGAP1 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells down-regulated "circ-IQGAP1 was down-regulated in purified bone marrow plasma cells from multiple myeloma patients compared with healthy controls, validated by qPCR after CD138 magnetic bead purification." 330 31948430 Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma. hsa_circ_0020594 hsa_circRNA_100731 hsa_circ_AL137655 AL137655 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells down-regulated "circ-AL137655 was down-regulated in purified bone marrow plasma cells from multiple myeloma patients compared with healthy controls, validated by qPCR after CD138 magnetic bead purification." 331 31949130 circRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma. hsa-circRNA-002178 hsa_circ_RPPH1 RPPH1 Homo sapiens lung adenocarcinoma MONDO:0005061 lung adenocarcinoma DOID:3910 CD8+ T cells up-regulated circRNA-002178 was reported to be significantly enriched in CD8+ T cells among immune cells isolated from lung cancer tissues. 332 31949130 circRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma. hsa-circRNA-002178 hsa_circ_RPPH1 RPPH1 Homo sapiens lung adenocarcinoma MONDO:0005061 lung adenocarcinoma DOID:3910 CD8+ T cells up-regulated circRNA-002178 increased in primary CD8+ T cells after incubation with exosomes from LUAD cancer cells or LUAD patient serum compared with control exosomes. The study further linked transferred circRNA-002178 to increased PD1 expression in CD8+ T cells via miR-28-5p. 333 31950540 "Circ_LAS1L regulates cardiac fibroblast activation, growth, and migration through miR-125b/SFRP5 pathway." hsa_circ_0090876 circ_LAS1L hsa_circ_LAS1L LAS1L Homo sapiens acute myocardial infarction MONDO:0004781 acute myocardial infarction DOID:9408 cardiac fibroblasts (CFs) down-regulated "circ_LAS1L was down-regulated in activated human cardiac fibroblasts after TGF-¦Â1 or Ang II stimulation. Functional experiments in CFs showed circ_LAS1L overexpression inhibited CF activation, proliferation and migration and promoted apoptosis through the miR-125b/SFRP5 pathway." 334 31954666 Circular RNA-ZNF609 regulates corneal neovascularization by acting as a sponge of miR-184. cZNF609 rno_circ_ZNF609 ZNF609 Rattus norvegicus corneal neovascularization MONDO:0006713 corneal neovascularization DOID:11382 corneal epithelium up-regulated cZNF609 was up-regulated in rat corneal epithelium after corneal suture surgery compared with normal controls in a corneal neovascularization model. 335 31954666 Circular RNA-ZNF609 regulates corneal neovascularization by acting as a sponge of miR-184. cZNF609 hsa_circ_ZNF609 ZNF609 Homo sapiens corneal neovascularization MONDO:0006713 corneal neovascularization DOID:11382 HCEK cells up-regulated "cZNF609 was significantly up-regulated in inflammatory HCEKs after TNF-a and IL-4 treatment compared with untreated HCEK controls. Functional assays in HCEKs indicated effects on proliferation and migration, and HCEK-conditioned media affected endothelial tube formation." 336 31973814 The circular RNA hsa_circ_0007623 acts as a sponge of microRNA-297 and promotes cardiac repair. hsa_circ_0007623 Homo sapiens myocardial ischemia MONDO:0024644 myocardial ischemia human umbilical vein endothelial cells (HUVECs) up-regulated "hsa_circ_0007623 was significantly and time-dependently upregulated in hypoxia-exposed HUVEC endothelial cells compared with normoxic conditions. Knockdown experiments in hypoxia-induced HUVECs showed reduced proliferation, migration, and tube formation." 337 31974620 CircRNA expression profiles in human visceral preadipocytes and adipocytes. hsa_circ_0136134 hsa_circ_LPL LPL Homo sapiens visceral obesity MONDO:0011122 obesity disorder DOID:9970 adipocytes up-regulated hsa_circ_0136134 was detected exclusively in differentiated human visceral adipocytes compared with HPA-v preadipocytes by qPCR. 338 31974620 CircRNA expression profiles in human visceral preadipocytes and adipocytes. hsa_circ_0017650 hsa_circ_ITIH5 ITIH5 Homo sapiens visceral obesity MONDO:0011122 obesity disorder DOID:9970 adipocytes up-regulated hsa_circ_0017650 was upregulated 30.0-fold in differentiated human visceral adipocytes compared with HPA-v preadipocytes by qPCR. 339 31974620 CircRNA expression profiles in human visceral preadipocytes and adipocytes. hsa-circRNA9227-1 Homo sapiens visceral obesity MONDO:0011122 obesity disorder DOID:9970 adipocytes up-regulated hsa-circRNA9227-1 was upregulated 2.3-fold in differentiated human visceral adipocytes compared with HPA-v preadipocytes by qPCR. 340 31988434 A psychiatric disease-related circular RNA controls synaptic gene expression and cognition. circHomer1a hsa_circ_HOMER1 HOMER1 Homo sapiens schizophrenia MONDO:0005090 schizophrenia DOID:5419 iPS cell-derived neuronal cultures down-regulated "circHomer1a was downregulated in iPS cell-derived differentiated neurons from schizophrenia patients compared with controls, while neuronal progenitors did not show this change." 341 31988434 A psychiatric disease-related circular RNA controls synaptic gene expression and cognition. circHomer1a hsa_circ_HOMER1 HOMER1 Homo sapiens bipolar disorder MONDO:0004985 bipolar disorder DOID:3312 iPS cell-derived neuronal cultures down-regulated "circHomer1a was downregulated in iPS cell-derived neuronal cultures from bipolar disorder patients compared with unaffected controls, with a more robust reduction reported in 6-week patient-derived neurons." 342 31990052 Circular RNA circTET3 mediates migration of rat vascular smooth muscle cells by targeting miR-351-5p. chr4_115106428_115104274_-2154-Tet3 rno_circ_tet3 tet3 Rattus norvegicus vein graft disease MONDO:0004634 vein disorder DOID:866 VSMCs up-regulated "circTET3 was increased in rat grafted vein compared with control vein, and FISH with smooth muscle ¦Á-actin indicated localization of circTET3 in the cytoplasm of VSMCs. Knockdown experiments in VSMCs showed that circTET3 promotes VSMC migration." 343 32003753 Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3. hsa_circ_0070963 hsa_circ_SCLT1 SCLT1 Homo sapiens liver fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 primary HSCs down-regulated hsa_circ_0070963 was reduced in activated hepatic stellate cells isolated from CCl4-induced fibrotic mouse livers compared with quiescent hepatic stellate cells from control mice. Functional experiments in HSC systems indicated that hsa_circ_0070963 inhibits HSC activation and proliferation through the miR-223-3p-LEMD3 axis. 344 32018039 Circular RNA CDR1as promotes adipogenic and suppresses osteogenic differentiation of BMSCs in steroid-induced osteonecrosis of the femoral head. hsa_circ_0001946 circRNA CDR1as / CDR1as Homo sapiens Steroid-induced osteonecrosis of the femoral head MONDO:0012126 familial avascular necrosis of femoral head SONFH-BMSCs up-regulated "CDR1as/hsa_circ_0001946 was up-regulated in primary cultured BMSCs from SONFH patients compared with control BMSCs, with circRNA microarray data validated by qRT-PCR. Functional experiments in BMSCs showed that CDR1as promotes adipogenic differentiation and suppresses osteogenic differentiation." 345 32052645 Circular RNA cZNF292 silence alleviates OGD/R-induced injury through up-regulation of miR-22 in rat neural stem cells (NSCs). cZNF292 rno_circ_ZNF292 ZNF292 Rattus norvegicus Hypoxic-ischaemic encephalopathy MONDO:0006663 perinatal asphyxia DOID:11088 neural stem cells (NSCs) up-regulated "In primary rat neural stem cells, OGD/R treatment up-regulated cZNF292 expression as measured by qRT-PCR. Functional experiments showed that silencing cZNF292 protected OGD/R-treated NSCs from injury through miR-22-related effects." 346 32062357 Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke. circHIPK2 mmu_circ_HIPK2 HIPK2 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke NSCs down-regulated "In primary mouse neural stem cells cultured under differentiation conditions, circHIPK2 expression decreased over time from day 1 to day 14. The study links this cell-specific circHIPK2 expression change to NSC differentiation in an ischaemic stroke research context." 347 32062357 Silencing of circular RNA HIPK2 in neural stem cells enhances functional recovery following ischaemic stroke. circHIPK2 mmu_circ_HIPK2 HIPK2 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke NSCs down-regulated "In primary mouse NSCs, circHIPK2 siRNA lentiviral transduction significantly decreased circHIPK2 expression compared with control-transduced NSCs. Silencing circHIPK2 in NSCs promoted neuronal differentiation and was evaluated as a therapeutic strategy in tMCAO-induced ischaemic stroke." 348 32099534 Circular RNA-CDR1as acts as the sponge of microRNA-641 to promote osteoarthritis progression. circRNA-CDR1as / CDR1as / circCDR1as Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 OA chondrocytes up-regulated circRNA-CDR1as was significantly up-regulated in primary chondrocytes isolated from osteoarthritis patients compared with normal chondrocytes. Functional experiments in OA chondrocytes showed that circRNA-CDR1as regulates ECM-related markers and IL-6 through the miR-641/FGF-2/MEK/ERK pathway. 349 32099751 Circ-MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self-Renewal of Hepatocellular Cancer Stem Cells. hsa_circ_0002082 circ_MALAT1 hsa_circ_MALAT1 MALAT1 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 hepatocellular CSCs up-regulated "circ_MALAT1 / hsa_circ_0002082 is up-regulated in hepatocellular cancer stem cells compared with matched adherent HCC cells, supported by circRNA-seq of patient-derived primary samples and qRT-PCR validation. The paper reports that circ_MALAT1 promotes hepatocellular CSC self-renewal." 350 32114390 CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. hsa_circ_0044722 circRNA-CIDN hsa_circ_TRIM25 TRIM25 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 human NP cells down-regulated "hsa_circ_0044722 / circRNA-CIDN was down-regulated in compression-treated human nucleus pulposus cells compared with untreated control cells, as supported by qRT-PCR validation after circRNA microarray screening. Functional assays in these cells showed that circRNA-CIDN inhibited compression-induced apoptosis and extracellular matrix degradation." 351 32162171 CircMACF1 Attenuates Acute Myocardial Infarction Through miR-500b-5p-EMP1 Axis. circMACF1 mmu_circ_MACF1 MACF1 Mus musculus acute myocardial infarction MONDO:0004781 acute myocardial infarction DOID:9408 primary cardiomyocytes down-regulated circMACF1 was down-regulated in isolated primary mouse cardiomyocytes exposed to hypoxic/ischemic injury in an AMI-related experimental context. Functional experiments in primary cardiomyocytes indicated that circMACF1 overexpression inhibited cardiomyocyte apoptosis via the miR-500b-5p/EMP1 axis. 352 32220601 Loss of hsa_circ_0118530 inhibits human granulosa-like tumor cell line KGN cell injury by sponging miR-136. hsa_circ_0118530 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 GCs up-regulated "hsa_circ_0118530 was up-regulated in isolated ovarian granulosa cells from PCOS patients compared with healthy controls, as measured by RT-qPCR." 353 32242002 "The regulatory network among CircHIPK3, LncGAS5, and miR-495 promotes Th2 differentiation in allergic rhinitis." CircHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens allergic rhinitis MONDO:0011786 allergic rhinitis DOID:4481 OVA and Th2 differentiation-induced CD4+ T cells unknown "CircHIPK3 was detected by FISH in OVA and Th2 differentiation-induced CD4+ T cells, with cytoplasmic localization in the same pattern as miR-495. Functional assays in isolated CD4+ T cells indicated that CircHIPK3 promoted Th2 differentiation via the miR-495/GATA-3 pathway." 354 32242002 "The regulatory network among CircHIPK3, LncGAS5, and miR-495 promotes Th2 differentiation in allergic rhinitis." mmu_circ_Hipk3 Hipk3 Mus musculus allergic rhinitis MONDO:0011786 allergic rhinitis DOID:4481 OVA and Th2 differentiation-induced CD4+ T cells unknown "CircHIPK3 was detected by FISH in OVA and Th2 differentiation-induced CD4+ T cells, with cytoplasmic localization in the same pattern as miR-495. Functional assays in isolated CD4+ T cells indicated that CircHIPK3 promoted Th2 differentiation via the miR-495/GATA-3 pathway." 355 32256118 hsa_circRNA_101237: A Novel Diagnostic and Prognostic Biomarker and Potential Therapeutic Target for Multiple Myeloma. hsa_circ_0003489 hsa_circRNA_101237 hsa_circ_CDK8 CDK8 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 Plasma cells up-regulated "CD138 MACS-enriched plasma cells from bone marrow samples were analyzed by qRT-PCR, showing hsa_circRNA_101237 was significantly up-regulated in multiple myeloma compared with the control group." 356 32256118 hsa_circRNA_101237: A Novel Diagnostic and Prognostic Biomarker and Potential Therapeutic Target for Multiple Myeloma. hsa_circ_0003489 hsa_circRNA_101237 hsa_circ_CDK8 CDK8 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 Plasma cells up-regulated "In CD138 MACS-enriched plasma cells from multiple myeloma bone marrow samples, hsa_circRNA_101237 was higher in recurrent/refractory patients than in first-episode treatment-naive patients." 357 32283545 Overexpression of miR-10a-5p facilitates the progression of osteoarthritis. hsa_circ_0010029 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 Human primary chondrocytes (HC-a) down-regulated "In human primary chondrocytes, whole-transcriptome sequencing after miR-10a-5p overexpression identified dysregulated circRNAs, and RT-qPCR validation listed hsa_circ_0010029 among selected downregulated genes. The comparison context was miR-10a-5p mimic treatment versus negative control in an osteoarthritis-related chondrocyte model." 358 32292524 Circular RNA SAMD4A controls adipogenesis in obesity through the miR-138-5p/EZH2 axis. hsa_circ_0004846 circSAMD4A hsa_circ_SAMD4A SAMD4A Homo sapiens obesity MONDO:0011122 obesity disorder DOID:9970 preadipocytes unknown "circSAMD4A was detected and characterized in isolated human preadipocytes from obese patient tissue, with Sanger sequencing, RNase R resistance, RNA-FISH localization, and qRT-PCR-based knockdown validation. Functional assays in these preadipocytes showed that circSAMD4A knockdown inhibited differentiation." 359 32297303 CircRNA BIRC6 promotes non-small cell lung cancer cell progression by sponging microRNA-145. hsa_circ_BIRC6 BIRC6 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 primary human NSCLC cells up-regulated "circBIRC6 is up-regulated in primary human NSCLC cells compared with primary human lung epithelial cells, based on qRT-PCR analysis of primary cultured cells. In primary NSCLC cells, circBIRC6 perturbation affected cell growth and proliferation." 360 32304667 Engineered Circular RNA Sponges Act as miRNA Inhibitors to Attenuate Pressure Overload-Induced Cardiac Hypertrophy. circmiR Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocytes up-regulated "Engineered circmiR was delivered specifically to cardiomyocytes in a mouse TAC model using AAV9-cTnT, and qPCR analysis of isolated cardiomyocytes validated targeted expression. In this cardiomyocyte-targeted system, circmiR treatment attenuated pressure overload-induced hypertrophy and preserved cardiac function." 361 32308754 Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis. mm9_circ_000338 mmu_circ_FBXW4 FBXW4 Mus musculus hepatic fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 primary HSCs down-regulated "circFBXW4 was downregulated in primary hepatic stellate cells isolated from hepatic fibrosis mice compared with vehicle controls, based on circRNA sequencing and qRT-PCR validation." 362 32308754 Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis. mm9_circ_000338 mmu_circ_FBXW4 FBXW4 Mus musculus hepatic fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 HSCs up-regulated circFBXW4 expression in isolated hepatic stellate cells was restored during hepatic fibrosis recovery compared with the fibrogenesis stage. 363 32308754 Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis. mm9_circ_000338 mmu_circ_FBXW4 FBXW4 Mus musculus hepatic fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 liver macrophages no change circFBXW4 showed no detectable disease-associated expression change in isolated liver macrophages from hepatic fibrosis mice compared with vehicle controls. 364 32319627 Circular RNA hsa_circ_0001380 in peripheral blood as a potential diagnostic biomarker for active pulmonary tuberculosis. hsa_circ_0001380 hsa_circUBXN7_006 hsa_circ_UBXN7 UBXN7 Homo sapiens pulmonary tuberculosis / TB MONDO:0006052 pulmonary tuberculosis DOID:2957 PBMCs down-regulated hsa_circ_0001380 was measured by RT-qPCR in isolated PBMCs and was significantly downregulated in PBMCs from patients with active pulmonary tuberculosis compared with healthy volunteers. 365 32321304 Circular RNA circ-CDYL sponges miR-1180 to elevate yes-associated protein in multiple myeloma. circ-CDYL hsa_circ_CDYL CDYL Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 multiple myeloma cells in the bone marrow up-regulated "circ-CDYL was up-regulated in multiple myeloma patient samples after sorting multiple myeloma cells from bone marrow, with expression assessed by qRT-PCR. Functional assays in MM cells showed that circ-CDYL knockdown reduced DNA synthesis and viability and increased apoptosis." 366 32321346 Hsa_circ_0012919 regulates expression of MDA5 by miR-125a-3p in CD4+ T cells of systemic lupus erythematous. hsa_circ_0012919 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4_ T cells up-regulated "Magnetic bead-isolated CD4+ T cells from SLE patients and healthy controls were analyzed by RT-PCR, showing that hsa_circ_0012919 was significantly up-regulated in SLE CD4+ T cells compared with healthy control CD4+ T cells. The study further showed that hsa_circ_0012919 regulated MDA5 expression in lupus CD4+ T cells." 367 32329819 CircPSM3 inhibits the proliferation and differentiation of OA chondrocytes by targeting miRNA-296-5p. CircPSM3 / circPSMC3 Homo sapiens Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 OA chondrocytes up-regulated CircPSM3 was up-regulated in OA chondrocytes compared with normal chondrocytes/cells based on qRT-PCR. Functional experiments in OA chondrocytes indicated that CircPSM3 inhibits proliferation and differentiation through targeting miR-296-5p. 368 32332704 CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-¦Á in TMJ osteoarthritis. hsa_circ_0000448 circGCN1L1 hsa_circ_GCN1L1 GCN1L1 Homo sapiens temporomandibular joint osteoarthritis / TMJOA MONDO:0005473 temporomandibular joint disorder synoviocyte up-regulated "circGCN1L1 was upregulated in primary TMJ synoviocytes from TMJOA compared with control synoviocytes, as validated by RT-qPCR. Functional experiments linked synoviocyte circGCN1L1 to synoviocyte proliferation, inflammatory TNF-¦Á signaling, and effects on co-cultured chondrocytes." 369 32332879 Circ-camk4 involved in cerebral ischemia/reperfusion induced neuronal injury. rno_circ_camk4 camk4 Rattus norvegicus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary cultured neuron cells up-regulated "In primary cultured rat cortical neurons, circ-camk4 expression was increased after OGD/R treatment compared with untreated control neurons, supporting neuronal up-regulation of circ-camk4 in an in vitro cerebral ischemia/reperfusion injury model." 370 32337768 The regulated profile of noncoding RNAs associated with inflammation by tanshinone IIA on atherosclerosis. circ-Cd84 mmu_circ_Cd84 Cd84 Mus musculus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 M__s down-regulated circ-Cd84 was significantly down-regulated by tanshinone IIA in FACS-purified plaque macrophages from ApoE-/- atherosclerosis mice compared with model controls. 371 32337768 The regulated profile of noncoding RNAs associated with inflammation by tanshinone IIA on atherosclerosis. circ-Wdr91 mmu_circ_Wdr91 Wdr91 Mus musculus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 M__s down-regulated circ-Wdr91 was significantly down-regulated by tanshinone IIA in FACS-purified plaque macrophages from ApoE-/- atherosclerosis mice compared with model controls. 372 32337768 The regulated profile of noncoding RNAs associated with inflammation by tanshinone IIA on atherosclerosis. circ-Tns3 mmu_circ_Tns3 Tns3 Mus musculus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 M__s down-regulated circ-Tns3 was significantly down-regulated by tanshinone IIA in FACS-purified plaque macrophages from ApoE-/- atherosclerosis mice compared with model controls. 373 32343678 Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. circ_0047814 hsa_circ_ZNF532 ZNF532 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 human retinal pericytes up-regulated "cZNF532/circ_0047814 is up-regulated in human retinal pericytes after high-glucose treatment, a diabetic-stress model relevant to diabetic retinopathy. Functional experiments indicate cZNF532 supports pericyte viability, proliferation, differentiation, recruitment toward endothelial cells, and resistance to apoptosis." GSE14367 374 32343678 Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. circ_0001757 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 human retinal pericytes up-regulated circ_0001757 is up-regulated in human retinal pericytes after high-glucose treatment. GSE14367 375 32343678 Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. circ_0002085 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 human retinal pericytes up-regulated circ_0002085 is up-regulated in human retinal pericytes after high-glucose treatment. GSE14367 376 32343678 Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. circ_0002404 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 human retinal pericytes up-regulated circ_0002404 is up-regulated in human retinal pericytes after high-glucose treatment. GSE14367 377 32343678 Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. circ_0004588 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 human retinal pericytes up-regulated circ_0004588 is up-regulated in human retinal pericytes after high-glucose treatment. GSE14367 378 32343678 Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. circ_0090921 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 human retinal pericytes down-regulated circ_0090921 is down-regulated in human retinal pericytes after high-glucose treatment. GSE14367 379 32343678 Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. circ_0086414 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 human retinal pericytes down-regulated circ_0086414 is down-regulated in human retinal pericytes after high-glucose treatment. GSE14367 380 32343678 Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. circ_0084156 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 human retinal pericytes down-regulated circ_0084156 is down-regulated in human retinal pericytes after high-glucose treatment. GSE14367 381 32343678 Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. circ_0084062 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 human retinal pericytes down-regulated circ_0084062 is down-regulated in human retinal pericytes after high-glucose treatment. GSE14367 382 32343678 Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. circ_0082423 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 human retinal pericytes down-regulated circ_0082423 is down-regulated in human retinal pericytes after high-glucose treatment. GSE14367 383 32343678 Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. cZNF532 hsa_circ_ZNF532 ZNF532 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 HRVECs no change "cZNF532 expression showed no significant change in HRVECs after diabetic-stress treatments, in contrast to its induction in pericytes." 384 32369647 Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells. hsa_circ_0021086 CircRIC3 hsa_circ_RIC3 RIC3 Homo sapiens Calcific aortic valve disease MONDO:0005463 aortic valve calcification hVICs up-regulated CircRIC3 was detected at high levels in isolated human valvular interstitial cells compared with human valvular endothelial cells by qRT-PCR. 385 32369647 Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells. hsa_circ_0021086 CircRIC3 hsa_circ_RIC3 RIC3 Homo sapiens Calcific aortic valve disease MONDO:0005463 aortic valve calcification hVICs down-regulated "Melatonin treatment significantly decreased CircRIC3 levels in isolated human valvular interstitial cells from CAVD patients and non-CAVD controls, measured by qRT-PCR." 386 32369647 Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells. hsa_circ_0021086 CircRIC3 hsa_circ_RIC3 RIC3 Homo sapiens aortic valve calcification MONDO:0005463 aortic valve calcification hVICs up-regulated "CircRIC3 increased over time in human valvular interstitial cells after osteogenesis induction, supporting association with osteogenic differentiation." 387 32387133 N6-Methyladenosine Modification of Fatty Acid Amide Hydrolase Messenger RNA in Circular RNA STAG1-Regulated Astrocyte Dysfunction and Depressive-like Behaviors. mm9_circ_0015149 circSTAG1 mmu_circ_STAG1 STAG1 Mus musculus major depressive disorder MONDO:0002009 major depressive disorder DOID:1470 astrocytes down-regulated Flow cytometric cell sorting followed by real-time PCR showed that circSTAG1 was downregulated in astrocyte-derived lysates in the CUS depression model compared with microglia or neurons. In situ hybridization further confirmed circSTAG1 expression in astrocytes and mainly in astrocyte cytoplasm. GSE135343 388 32392088 "The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a." hsa_circ_0001141 CircITCH hsa_circ_ITCH ITCH Homo sapiens DOX-induced cardiotoxicity MONDO:0023006 doxorubicin induced cardiomyopathy hiPSC-CMs down-regulated CircITCH/hsa_circ_0001141 is expressed in human iPSC-derived cardiomyocytes and is reduced after DOX treatment; RNA FISH with cardiomyocyte marker staining supports localization in cardiomyocytes. Functional experiments in hiPSC-CMs indicate that CircITCH overexpression ameliorates DOX-induced cardiomyocyte injury and dysfunction. 389 32423804 Matrine reduces the secretion of exosomal circSLC7A6 from cancer-associated fibroblast to inhibit tumorigenesis of colorectal cancer by regulating CXCR5. hsa_circ_0039943 circSLC7A6 hsa_circ_SLC7A6 SLC7A6 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 cancer-associated fibroblasts down-regulated "In isolated cancer-associated fibroblast cultures from colorectal cancer, matrine treatment reduced exosomal circSLC7A6 secretion compared with mock treatment. Exosomal circSLC7A6 from CAF-conditioned medium promoted CRC cell proliferation and invasion and inhibited apoptosis." 390 32441115 Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models. mmu_circ_SCMH1 SCMH1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke neurons down-regulated "Flow-cytometry-sorted neurons from sham and PT stroke mice were analyzed by qPCR, and circSCMH1 showed a decrease in the PT model that was mitigated by RVG-circSCMH1-EV treatment. In sham mice, circSCMH1 was most abundant in neurons." 391 32441115 Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models. mmu_circ_SCMH1 SCMH1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke astrocytes down-regulated "Flow-cytometry-sorted astrocytes from sham and PT stroke mice were included in qPCR analysis of circSCMH1 expression, and ISH also showed circSCMH1 accumulation in astrocytes. The PT-associated decrease in circSCMH1 was mitigated by RVG-circSCMH1-EV treatment." 392 32441115 Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models. mmu_circ_SCMH1 SCMH1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke microglia down-regulated "Flow-cytometry-sorted microglia from sham and PT stroke mice were included in qPCR analysis of circSCMH1 expression, and ISH also showed circSCMH1 accumulation in microglia. The PT-associated decrease in circSCMH1 was mitigated by RVG-circSCMH1-EV treatment." 393 32450169 Circular RNA circHIPK3 modulates the proliferation of airway smooth muscle cells by miR-326/STIM1 axis. hsa_circ_0000284 hsa_circ_HIPK3 HIPK3 Homo sapiens asthma MONDO:0004979 asthma DOID:2841 airway smooth muscle cells (ASMCs) up-regulated circHIPK3 is up-regulated in PDGF-induced primary cultured human airway smooth muscle cells. Knockdown of circHIPK3 represses ASMC proliferation and migration and increases apoptosis via the miR-326/STIM1 axis. 394 32463418 Dicalcium silicate microparticles modulate the differential expression of circRNAs and mRNAs in BMSCs and promote osteogenesis via circ_1983-miR-6931-Gas7 interaction. mmu_circ_0014738 circ_1983 mmu_circ_Tacc1 Tacc1 Mus musculus cranial bone defect MONDO:0002081 musculoskeletal system disorder DOID:17 BMSCs up-regulated "In cultured mouse BMSCs undergoing osteogenic differentiation, C2S treatment upregulated circ_1983 compared with osteogenic medium control. Functional knockdown experiments indicated circ_1983 contributes to C2S-induced osteogenic differentiation via the circ_1983-miR-6931-Gas7 interaction." GSE140273 395 32468088 CiRS-126 inhibits proliferation of ovarian granulosa cells through targeting the miR-21-PDCD4-ROS axis in a polycystic ovarian syndrome model. CiRS-126 Mus musculus polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 ovarian granulosa cells isolated from mice down-regulated "In primary mouse ovarian granulosa cells, qPCR showed that ciRS-126 was decreased after insulin stimulation, a PCOS-related cell model. Overexpression experiments in insulin-treated granulosa cells linked ciRS-126 to reduced proliferation and increased apoptosis through the miR-21-PDCD4-ROS axis." 396 32522972 Circular RNA (circRNA) CDYL Induces Myocardial Regeneration by ceRNA After Myocardial Infarction. mmu_circ_CDYL CDYL Mus musculus acute myocardial infarction MONDO:0004781 acute myocardial infarction DOID:9408 cardiomyocytes down-regulated "circCDYL was detected by RT-PCR in isolated mouse cardiomyocytes and was downregulated in hypoxic myocardial cells in the acute myocardial infarction-related model. Functional experiments in cardiomyocytes showed that circCDYL overexpression promoted proliferation, whereas knockdown inhibited proliferation." 397 32540374 circPUM1 promotes polycystic ovary syndrome progression by sponging to miR-760. circPUM1 hsa_circ_PUM1 PUM1 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 GCs up-regulated "circPUM1 was highly expressed in insulin-treated granulosa cells in the PCOS study context, measured by qRT-PCR after primary GCs were collected." 398 32547599 Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells. circRNA-4452 Homo sapiens Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 Primary human aortic smooth muscle cells up-regulated circRNA-4452 was significantly up-regulated in PDGF-BB-treated primary human aortic smooth muscle cells compared with untreated controls. PRJNA607375 399 32547599 Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells. hsa_circ_0003341 CircRNA13360 hsa_circ_GIGYF2 GIGYF2 Homo sapiens Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 Primary human aortic smooth muscle cells up-regulated circRNA13360 / hsa_circ_0003341 was up-regulated in PDGF-BB-treated primary human aortic smooth muscle cells and was predicted to have miRNA response element binding sites. PRJNA607375 400 32547599 Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells. circRNA-1698 Homo sapiens Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 Primary human aortic smooth muscle cells up-regulated circRNA-1698 was significantly up-regulated in PDGF-BB-treated primary human aortic smooth muscle cells compared with untreated controls. PRJNA607375 401 32547599 Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells. CircRNA8979 hsa_circ_HPCAL1 HPCAL1 Homo sapiens Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 Primary human aortic smooth muscle cells up-regulated circRNA8979 was significantly up-regulated in PDGF-BB-treated primary human aortic smooth muscle cells compared with untreated controls. PRJNA607375 402 32547599 Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells. circRNA-14411 Homo sapiens Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 Primary human aortic smooth muscle cells up-regulated circRNA-14411 was significantly up-regulated in PDGF-BB-treated primary human aortic smooth muscle cells compared with untreated controls. PRJNA607375 403 32547599 Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells. circRNA-3041 Homo sapiens Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 Primary human aortic smooth muscle cells down-regulated circRNA-3041 was significantly down-regulated in PDGF-BB-treated primary human aortic smooth muscle cells compared with untreated controls. PRJNA607375 404 32547599 Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells. circRNA-5780 Homo sapiens Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 Primary human aortic smooth muscle cells down-regulated circRNA-5780 was significantly down-regulated in PDGF-BB-treated primary human aortic smooth muscle cells compared with untreated controls. PRJNA607375 405 32547599 Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells. circRNA-1848 Homo sapiens Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 Primary human aortic smooth muscle cells down-regulated circRNA-1848 was significantly down-regulated in PDGF-BB-treated primary human aortic smooth muscle cells compared with untreated controls. PRJNA607375 406 32547599 Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells. circRNA3875 Homo sapiens Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 Primary human aortic smooth muscle cells down-regulated circRNA3875 / circRNA-3875 was significantly down-regulated in PDGF-BB-treated primary human aortic smooth muscle cells compared with untreated controls. PRJNA607375 407 32547599 Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells. hsa_circ_0008776 circRNA160 hsa_circ_THSD1 THSD1 Homo sapiens Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 VSMC down-regulated circRNA160 / hsa_circ_0008776 was significantly down-regulated in PDGF-BB-treated vascular smooth muscle cells and had the highest connectivity in the predicted circRNA-miRNA network. PRJNA607375 408 32584784 hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis. hsa_circ_0004018 Homo sapiens liver fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 HSCs down-regulated "In FACS-sorted primary HSCs from mouse liver, hsa_circ_0004018 RNA levels were significantly downregulated after IL-6 treatment. Functional experiments in primary HSCs showed that hsa_circ_0004018 overexpression suppressed HSC proliferation and activation." 409 32584784 hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis. hsa_circ_0004018 Homo sapiens liver fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 HSCs up-regulated "In FACS-sorted primary HSCs from fibrotic mouse liver, hsa_circ_0004018 RNA levels were significantly upregulated after Sal B treatment in a time- and concentration-associated manner. Functional experiments in primary HSCs showed that hsa_circ_0004018 overexpression suppressed HSC proliferation and activation." 410 32593303 Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma. hsa_circ_0048677 circUHRF1 hsa_circ_UHRF1 UHRF1 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 NK cells up-regulated "In purified healthy donor NK cells cocultured with HCC cell lines, circUHRF1 expression was significantly increased via an exosome-dependent mechanism. HCC-derived exosomal circUHRF1 impaired NK cell IFN-¦Ã and TNF-¦Á secretion and contributed to NK cell exhaustion." 411 32593303 Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma. hsa_circ_0048677 circUHRF1 hsa_circ_UHRF1 UHRF1 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 CD8+ T cells up-regulated "In purified healthy donor CD8+ T cells cocultured with HCC cell lines, circUHRF1 expression was significantly increased. Unlike NK cells, the study reported no significant impairment of IFN-¦Ã and TNF-¦Á secretion in these CD8+ T cells." 412 32616775 Identification of circRNA-associated ceRNA network in BMSCs of OVX models for postmenopausal osteoporosis. circRNA 0020 Mus musculus postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis BMSCs up-regulated "Novel_circRNA 0020/circRNA 0020 was up-regulated in isolated BMSCs from OVX osteoporosis-model mice compared with control mice, based on RNA-seq and qRT-PCR validation." 413 32616775 Identification of circRNA-associated ceRNA network in BMSCs of OVX models for postmenopausal osteoporosis. mmu_circ_0009625 circRNA 3832 Mus musculus postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis BMSCs down-regulated "circRNA 3832/circRNA_3832/mmu_circ_0009625 was down-regulated in isolated BMSCs from OVX osteoporosis-model mice compared with control mice, based on RNA-seq and qRT-PCR validation." 414 32621951 "Down-regulation of circ_0061140 attenuates ectopic endometrial cell proliferation, migration and invasion in endometriosis via inactivating Notch2." circ_0061140 Homo sapiens endometriosis MONDO:0005133 endometriosis DOID:289 ectopic endometrial cells down-regulated "In primary ectopic endometrial cells isolated from endometriosis tissue, circ_0061140 siRNA reduced circ_0061140 expression. Loss of circ_0061140 suppressed proliferation, migration and invasion and induced apoptosis in these cells." 415 32626912 Circular RNA derived from TIMP2 functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR_185_5p and matrix metalloproteinase 2. hsa_circ_0045942 circ-TIMP2 hsa_circ_TIMP2 TIMP2 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 NP cells up-regulated "In primary cultured human NP cells, TNF-¦Á and IL-1¦Â treatment upregulated circ-TIMP2 expression by RT-qPCR. Functional experiments in NP cells indicated that circ-TIMP2 modulated miR-185-5p and MMP2 expression and affected ECM anabolism/catabolism." 416 32629000 circPAN3 exerts a profibrotic role via sponging miR-221 through FoxO3/ATG7-activated autophagy in a rat model of myocardial infarction. circPAN3 rno_circ_PAN3 PAN3 Rattus norvegicus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 Cardiac fibroblasts (CFs) up-regulated "In primary rat cardiac fibroblasts, TGF¦Â1 stimulation used to simulate cardiac fibrosis significantly increased circPAN3 expression by qPCR. circPAN3 knockdown reduced profibrotic phenotype, proliferation, migration, and excessive autophagy in these fibroblasts." 417 32651991 Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome. hsa_circ_0006877 circLDLR hsa_circ_LDLR LDLR Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells down-regulated "circLDLR expression was significantly decreased in primary granulosa cells from PCOS patients compared with control patients, as measured by qRT-PCR." 418 32660590 The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis. chr5: 83519349-83522309 hsa_circ_VCAN VCAN Homo sapiens sepsis due to community-acquired pneumonia MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 monocytes up-regulated circVCAN was significantly more abundant in FACS-sorted monocytes from patients with sepsis due to community-acquired pneumonia relative to monocytes from healthy subjects. GSE136200 419 32660590 The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis. chr15: 93000512-93014909 hsa_circ_CHD2 CHD2 Homo sapiens sepsis due to community-acquired pneumonia MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 monocytes up-regulated circCHD2 was significantly more abundant in FACS-sorted monocytes from patients with sepsis due to community-acquired pneumonia relative to monocytes from healthy subjects. GSE136200 420 32661238 Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p. hsa_circ_0001791 hsa_circ_ADAM9 ADAM9 Homo sapiens diabetes mellitus MONDO:0005015 diabetes mellitus DOID:9351 endothelial progenitor cells (EPCs) up-regulated circ-ADAM9 was significantly increased in human umbilical cord blood-derived EPCs exposed to high glucose. Functional experiments in EPCs showed that circ-ADAM9 promotes apoptosis and autophagy and suppresses angiogenic function under high-glucose conditions. 421 32671065 hsa_circ_0026827 Promotes Osteoblast Differentiation of Human Dental Pulp Stem Cells Through the Beclin1 and RUNX1 Signaling Pathways by Sponging miR-188-3p. hsa_circ_0026827 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 human dental pulp stem cells (DPSCs) up-regulated "In primary cultured human dental pulp stem cells, hsa_circ_0026827 expression significantly increased during osteogenic differentiation as measured by RT-qPCR. Functional experiments showed that hsa_circ_0026827 promotes osteoblast differentiation of DPSCs via miR-188-3p, Beclin1 and RUNX1 pathways." 422 32673817 Hsa_circ_0088036 promotes the proliferation and migration of fibroblast-like synoviocytes by sponging miR-140-3p and upregulating SIRT 1 expression in rheumatoid arthritis. hsa_circ_0088036 circRNA-104871 hsa_circ_SUSD1 SUSD1 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 fibroblast-like synoviocytes (FLSs) up-regulated circ0088036 was significantly upregulated in primary RA fibroblast-like synoviocytes compared with OA fibroblast-like synoviocytes by RT-qPCR. Functional assays in RA-FLSs showed that circ0088036 promoted proliferation and migration. 423 32674051 IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome. hsa_circ_0029589 circ_0029589 Homo sapiens acute coronary syndrome MONDO:0005542 acute coronary syndrome human PBMC-derived macrophages down-regulated hsa_circ_0029589 was significantly decreased in ox-LDL-stimulated PBMC-derived macrophages from ACS patients compared with CPS and SA groups. Functional experiments in macrophages indicated that circ_0029589 is involved in IRF-1-induced macrophage pyroptosis and inflammation. 424 32681011 CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis. circGRIA1 mml_circ_Gria1 Gria1 Macaca mulatta brain aging others others neurons up-regulated "In primary male fetal macaque hippocampal neuron cultures, circGRIA1 expression increased at DIV28 compared with DIV14, based on BASEscope ISH and RT-qPCR." 425 32681834 Circular RNA circSnx5 Controls Immunogenicity of Dendritic Cells through the miR-544/SOCS1 Axis and PU.1 Activity Regulation. circRNA-015445 mmu_circ_Snx5 snx5 Mus musculus cardiac allograft rejection MONDO:1010185 transplant rejection BM-derived DCs dys-regulated "circSnx5 was detected in mouse BM-derived dendritic cells by qRT-PCR and FISH, and its expression changed in LPS-stimulated DCs compared with unstimulated DCs. Functional experiments linked circSnx5 to regulation of DC activation and tolerogenic versus inflammatory phenotypes." 426 32692763 Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation. circ-1376 / novel_circ_0001376 PLXNA1 Anas platyrhynchos others others others duck pre-adipocytes; duck adipocytes up-regulated "circ-PLXNA1 was up-regulated during differentiation of primary duck pre-adipocytes into adipocytes, supported by RNA-seq and qRT-PCR. Knockdown experiments indicated that circ-PLXNA1 promotes duck adipocyte differentiation." 427 32692763 Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation. circ-1044 / novel_circ_0001044 MTCL1 Anas platyrhynchos others others others duck pre-adipocytes; duck adipocytes up-regulated circ-1044 was up-regulated in differentiated duck adipocytes compared with primary duck pre-adipocytes based on RNA-seq. 428 32692763 Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation. circ-0365 ARHGAP21 Anas platyrhynchos others others others duck pre-adipocytes; duck adipocytes down-regulated circ-0365 was down-regulated in differentiated duck adipocytes compared with primary duck pre-adipocytes based on RNA-seq. 429 32692763 Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation. circ-1526 METRNL Anas platyrhynchos others others others duck pre-adipocytes; duck adipocytes down-regulated circ-1526 was down-regulated in differentiated duck adipocytes compared with primary duck pre-adipocytes based on RNA-seq. 430 32692763 Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation. circ-3377 FBLN2 Anas platyrhynchos others others others duck pre-adipocytes; duck adipocytes down-regulated circ-3377 was down-regulated in differentiated duck adipocytes compared with primary duck pre-adipocytes based on RNA-seq. 431 32692763 Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation. circ-5802 SPSB4 Anas platyrhynchos others others others duck pre-adipocytes; duck adipocytes down-regulated circ-5802 was down-regulated in differentiated duck adipocytes compared with primary duck pre-adipocytes based on RNA-seq. 432 32692763 Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation. circ-6050 ZBTB1 Anas platyrhynchos others others others duck pre-adipocytes; duck adipocytes down-regulated circ-6050 was down-regulated in differentiated duck adipocytes compared with primary duck pre-adipocytes based on RNA-seq. 433 32692763 Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation. circ-6443 MBNL1 Anas platyrhynchos others others others duck pre-adipocytes; duck adipocytes down-regulated circ-6443 was down-regulated in differentiated duck adipocytes compared with primary duck pre-adipocytes based on RNA-seq. 434 32692763 Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation. circ-8371 AHNAK Anas platyrhynchos others others others duck pre-adipocytes; duck adipocytes down-regulated circ-8371 was down-regulated in differentiated duck adipocytes compared with primary duck pre-adipocytes based on RNA-seq. 435 32692763 Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation. circ-8614 MAPKBP1 Anas platyrhynchos others others others duck pre-adipocytes; duck adipocytes up-regulated circ-8614 was up-regulated in differentiated duck adipocytes compared with primary duck pre-adipocytes based on RNA-seq. 436 32692763 Circular RNA expression profiling reveals that circ-PLXNA1 functions in duck adipocyte differentiation. circ-8890 LCMT2 Anas platyrhynchos others others others duck pre-adipocytes; duck adipocytes up-regulated circ-8890 was up-regulated in differentiated duck adipocytes compared with primary duck pre-adipocytes based on RNA-seq. 437 32694641 Adipose circular RNAs exhibit dynamic regulation in obesity and functional role in adipogenesis. circTshz2-1 mmu_circ_Tshz2 Tshz2 Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 primary mouse white pre-adipocytes up-regulated "In primary mouse adipocyte differentiation culture, circTshz2-1 was up-regulated during differentiation, increasing fourfold by day 6. Knockdown experiments in the same primary adipocyte system showed that circTshz2-1 supports adipogenesis." 438 32694641 Adipose circular RNAs exhibit dynamic regulation in obesity and functional role in adipogenesis. circArhgap5-2 mmu_circ_Arhgap5 Arhgap5 Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 primary mouse white pre-adipocytes up-regulated "In primary mouse adipocyte differentiation culture, circArhgap5-2 was strongly up-regulated during differentiation, increasing 33-fold over 6 days. Knockdown in primary adipocytes showed that circArhgap5-2 is required for adipogenesis and maintenance of the adipocyte gene programme." GSE118762 439 32698139 Estrogen-decreased hsa_circ_0001649 promotes stromal cell invasion in endometriosis. hsa_circ_0001649 hsa_circ_SHPRH SHPRH Homo sapiens endometriosis MONDO:0005133 endometriosis DOID:289 human primary endometrial stromal cells (ESCs) down-regulated "In isolated human primary endometrial stromal cells, E2 treatment decreased hsa_circ_0001649 expression in a concentration- and time-dependent manner as measured by qRT-PCR." 440 32700752 "Circulating RNAs, circ_4911 and circ_4302, are novel regulators of endothelial cell function under a hepatocellular carcinoma microenvironment." circ_4911 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 human umbilical vein endothelial cells (HUVECs) down-regulated "circ_4911 was down-regulated in primary HUVECs exposed to an HCC microenvironment compared with naive HUVECs, based on RNA-seq and RT-qPCR validation. Overexpression experiments in HCC-conditioned HUVECs showed effects on proliferation and migration." GSE77661 441 32700752 "Circulating RNAs, circ_4911 and circ_4302, are novel regulators of endothelial cell function under a hepatocellular carcinoma microenvironment." circ_4302 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 human umbilical vein endothelial cells (HUVECs) down-regulated "circ_4302 was down-regulated in primary HUVECs exposed to an HCC microenvironment compared with naive HUVECs, based on RNA-seq and RT-qPCR validation. Overexpression experiments in HCC-conditioned HUVECs showed effects on proliferation and migration." GSE77661 442 32732957 LEF1 mediates osteoarthritis progression through circRNF121/miR-665/MYD88 axis via NF-§ÜB signaling pathway. hsa_circ_0023404 hsa_circ_RNF121 RNF121 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated "Primary human chondrocytes isolated from cartilage were used for q-PCR-based circRNF121 analysis, and circRNF121 expression was increased in LEF1-overexpressing chondrocytes. Functional experiments in chondrocytes showed that circRNF121 regulated ECM degradation, proliferation, and apoptosis." 443 32733638 Exosomal CircHIPK3 Released from Hypoxia-Induced Cardiomyocytes Regulates Cardiac Angiogenesis after Myocardial Infarction. circHIPK3 mmu_circ_HIPK3 HIPK3 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 hypoxia-induced CMs up-regulated "In primary mouse cardiomyocytes, hypoxia increased circHIPK3 and promoted its release in exosomes. These cardiomyocyte-derived exosomal circHIPK3 signals to cardiac endothelial cells during myocardial infarction-related angiogenesis." 444 32733638 Exosomal CircHIPK3 Released from Hypoxia-Induced Cardiomyocytes Regulates Cardiac Angiogenesis after Myocardial Infarction. circHIPK3 mmu_circ_HIPK3 HIPK3 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 cardiac endothelial cells down-regulated "In primary mouse cardiac endothelial cells, H2O2-induced oxidative stress significantly reduced circHIPK3 expression compared with untreated control cells." 445 32733638 Exosomal CircHIPK3 Released from Hypoxia-Induced Cardiomyocytes Regulates Cardiac Angiogenesis after Myocardial Infarction. circHIPK3 mmu_circ_HIPK3 HIPK3 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 cardiac endothelial cells up-regulated "In primary mouse cardiac endothelial cells exposed to oxidative stress, exosome pretreatment increased circHIPK3 levels, with hypoxic cardiomyocyte-derived exosomes producing higher circHIPK3 expression than normoxic exosomes." 446 32750152 "A Circular RNA, Cholangiocarcinoma-Associated Circular RNA 1, Contributes to Cholangiocarcinoma Progression, Induces Angiogenesis, and Disrupts Vascular Endothelial Barriers." hsa_circRNA_102064 / circ-CCAC1 hsa_circ_ERBB2 ERBB2 Homo sapiens cholangiocarcinoma MONDO:0019087 cholangiocarcinoma DOID:4947 tumor cells up-regulated ISH of paired iCCA and adjacent normal tissues showed higher circ-CCAC1 expression in the cytoplasm of tumor cells. 447 32750152 "A Circular RNA, Cholangiocarcinoma-Associated Circular RNA 1, Contributes to Cholangiocarcinoma Progression, Induces Angiogenesis, and Disrupts Vascular Endothelial Barriers." hsa_circRNA_102064 / circ-CCAC1 hsa_circ_ERBB2 ERBB2 Homo sapiens cholangiocarcinoma MONDO:0019087 cholangiocarcinoma DOID:4947 vascular endothelial cells up-regulated ISH of paired iCCA and adjacent normal tissues showed higher circ-CCAC1 expression in vascular endothelial cells. Functional experiments in endothelial cells supported a role in disrupting endothelial barriers and inducing angiogenesis. 448 32767318 CircTMBIM6 promotes osteoarthritis-induced chondrocyte extracellular matrix degradation via miR-27a/MMP13 axis. circTMBIM6 hsa_circ_TMBIM6 TMBIM6 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated Primary isolated chondrocytes stimulated with IL-1¦Â or TNF-¦Á to model osteoarthritis showed increased circTMBIM6 expression by qRT-PCR. The study further links circTMBIM6 to miR-27a/MMP13-mediated chondrocyte extracellular matrix degradation. 449 32767319 Low expression of CircRNA HIPK3 promotes osteoarthritis chondrocyte apoptosis by serving as a sponge of miR-124 to regulate SOX8. hsa_circ_HIPK3 HIPK3 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 OA chondrocytes up-regulated CircHIPK3 was highly expressed in OA chondrocytes compared with normal chondrocytes/cells based on RT-qPCR. Functional assays in OA chondrocytes showed that CircHIPK3 affected apoptosis through the miR-124/SOX8 axis. 450 32782441 Circ_0007841 promotes the progression of multiple myeloma through targeting miR-338-3p/BRD4 signaling cascade. circ_0007841 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 BM-derived plasma cells up-regulated "circ_0007841 is up-regulated in BM-derived plasma cells from multiple myeloma patients compared with plasma cells from healthy individuals, based on qRT-PCR of collected plasma cells." 451 32782441 Circ_0007841 promotes the progression of multiple myeloma through targeting miR-338-3p/BRD4 signaling cascade. circ_0007841 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 MSCs up-regulated circ_0007841 is higher in isolated MSCs and MSC-derived exosomes from MM-associated adjacent tissues than in normal tissues. MSC-derived exosomes promoted malignant behaviors of MM cells via circ_0007841. 452 32792505 The circular RNA circ-GRB10 participates in the molecular circuitry inhibiting human intervertebral disc degeneration. hsa_circ_GRB10 GRB10 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 nucleus pulposus (NP) cells down-regulated circ-GRB10 is reduced in nucleus pulposus cells from IDD patients compared with control-derived NP cells. The study links circ-GRB10 regulation in NP cells to ERBB2/Erk signaling and extracellular matrix-related NP cell function. 453 32796851 An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution. mmu_circ_0000084 mmu_circRNA_012594 mmu_circ_Kcnt2 Kcnt2 Mus musculus innate colitis MONDO:0005292 colitis DOID:0060180 ILC3s up-regulated "circKcnt2 is up-regulated in FACS-isolated ILC3s during mouse innate colitis, supported by circRNA microarray and qRT-PCR validation. Functional experiments indicate that circKcnt2 suppresses ILC3 activation and IL-17 production to facilitate colitis resolution." GSE142106 454 32801258 CircPlekha7 plays an anti-fibrotic role in intrauterine adhesions by modulating endometrial stromal cell proliferation and apoptosis. chr1:185495031|185495489 rno_circ_Plekha7 Plekha7 Rattus norvegicus intrauterine adhesions MONDO:0015299 Asherman syndrome endometrial stromal cells up-regulated "circPlekha7 was up-regulated in SIS3-treated fibrosis-induced rat endometrial stromal cells compared with the IUA model group. Functional assays in ESCs showed that circPlekha7 promoted apoptosis, reduced viability, and suppressed fibrosis-related proteins." 455 32801258 CircPlekha7 plays an anti-fibrotic role in intrauterine adhesions by modulating endometrial stromal cell proliferation and apoptosis. chr16:26755422|26780008 Rattus norvegicus intrauterine adhesions MONDO:0015299 Asherman syndrome endometrial stromal cells up-regulated chr16:26755422|26780008 was up-regulated in SIS3-treated fibrosis-induced rat endometrial stromal cells compared with the IUA model group. 456 32801258 CircPlekha7 plays an anti-fibrotic role in intrauterine adhesions by modulating endometrial stromal cell proliferation and apoptosis. chr5:158071477|158074209 Rattus norvegicus intrauterine adhesions MONDO:0015299 Asherman syndrome endometrial stromal cells up-regulated chr5:158071477|158074209 was up-regulated in SIS3-treated fibrosis-induced rat endometrial stromal cells compared with the IUA model group. 457 32801258 CircPlekha7 plays an anti-fibrotic role in intrauterine adhesions by modulating endometrial stromal cell proliferation and apoptosis. chr5: 74954384|74956829 Rattus norvegicus intrauterine adhesions MONDO:0015299 Asherman syndrome endometrial stromal cells up-regulated chr5: 74954384|74956829 was up-regulated in SIS3-treated fibrosis-induced rat endometrial stromal cells compared with the IUA model group. 458 32801258 CircPlekha7 plays an anti-fibrotic role in intrauterine adhesions by modulating endometrial stromal cell proliferation and apoptosis. chr9:52047552|52053503 Rattus norvegicus intrauterine adhesions MONDO:0015299 Asherman syndrome endometrial stromal cells down-regulated chr9:52047552|52053503 was down-regulated in SIS3-treated fibrosis-induced rat endometrial stromal cells compared with the IUA model group. 459 32802182 CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2. hsa_circ_0001722 CircCDK14 hsa_circ_CDK14 CDK14 Homo sapiens Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human chondrocytes (HC) down-regulated "CircCDK14 was reduced in primary human chondrocytes after inflammatory stimulation with IL-1¦Â, LPS or TNF-¦Á. Functional experiments in chondrocytes showed that CircCDK14 regulated ECM metabolism, proliferation and apoptosis in the OA-related inflammatory context." 460 32808450 CircPSMC3 alleviates the symptoms of PCOS by sponging miR-296-3p and regulating PTEN expression. circPSMC3 hsa_circ_PSMC3 PSMC3 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 ovarian granulosa cells down-regulated "circPSMC3 was down-regulated in isolated ovarian granulosa cells from PCOS patients compared with granulosa cells from normal individuals, as measured by qRT-PCR." 461 32814879 CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin ¦Á5 expression. CircRNA-0879 rno_circ_vgll3 vgll3 Rattus norvegicus cranial bone defect MONDO:0002081 musculoskeletal system disorder DOID:17 ADSCs up-regulated "In rat ADSCs, circRNA-vgll3 was detected by rRNA-depleted RNA-seq and qPCR and was gradually up-regulated during BMP2-induced osteogenic differentiation compared with naive ADSCs. Functional experiments showed circRNA-vgll3 enhanced ADSC osteogenic differentiation through the circRNA-vgll3/miR-326-5p/Itga5 pathway." SRP165832 462 32830397 Circ-SLC8A1 regulates osteoporosis through blocking the inhibitory effect of miR-516b-5p on AKAP2 expression. mmu_circ_SLC8A1 SLC8A1 Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 BMSCs up-regulated "circ-SLC8A1 was up-regulated in BMSCs derived from OVX osteoporosis-model mice compared with sham-derived BMSCs, as measured by RT-qPCR after primary cell isolation. Functional assays in BMSCs indicated that circ-SLC8A1 modulated osteogenic differentiation-related phenotypes." 463 32831141 Circular RNA SIPA1L1 promotes osteogenesis via regulating the miR-617/Smad3 axis in dental pulp stem cells. hsa_circ_SIPA1L1 SIPA1L1 Homo sapiens bone defects MONDO:0002081 musculoskeletal system disorder DOID:17 dental pulp stem cells; DPSCs up-regulated "circSIPA1L1 is up-regulated during osteogenic differentiation of primary cultured DPSCs, measured after primary DPSC isolation and RT-PCR. Functional experiments in DPSCs support that circSIPA1L1 stimulates osteogenic differentiation through the miR-617/Smad3 axis." 464 32846020 CircC3P1 attenuated pro-inflammatory cytokine production and cell apoptosis in acute lung injury induced by sepsis through modulating miR-21. mmu_circ_C3P1 C3P1 Mus musculus sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 Primary murine pulmonary microvascular endothelial cells (MPVECs) down-regulated circC3P1 expression was decreased in LPS-treated primary murine pulmonary microvascular endothelial cells compared with untreated control cells. circC3P1 overexpression reduced apoptosis and pro-inflammatory cytokine levels in this MPVEC inflammatory injury model. 465 32847498 "Integrative analysis of circRNAs, miRNAs, and mRNAs profiles to reveal ceRNAs networks in chicken intramuscular and abdominal adipogenesis." gga_circ_FNDC3AL FNDC3AL Gallus gallus others others others differentiated-mature intramuscular adipocytes up-regulated "circFNDC3AL was significantly up-regulated in differentiated-mature intramuscular adipocytes compared with intramuscular preadipocytes, supported by RNA-Seq and RT-qPCR in primary chicken adipogenic cultures." PRJNA429489; PRJNA453673 466 32847498 "Integrative analysis of circRNAs, miRNAs, and mRNAs profiles to reveal ceRNAs networks in chicken intramuscular and abdominal adipogenesis." gga_circ_LCLAT1 LCLAT1 Gallus gallus others others others differentiated-mature intramuscular adipocytes down-regulated "circLCLAT1 was significantly down-regulated in differentiated-mature intramuscular adipocytes compared with preadipocytes, supported by RNA-Seq and qRT-PCR data in primary chicken adipogenic cultures." PRJNA429489; PRJNA453673 467 32847498 "Integrative analysis of circRNAs, miRNAs, and mRNAs profiles to reveal ceRNAs networks in chicken intramuscular and abdominal adipogenesis." gga_circ_CLEC19A CLEC19A Gallus gallus others others others abdominal adipocytes up-regulated circCLEC19A expression increased during the late stage of abdominal adipogenesis in primary chicken adipogenic cultures. PRJNA429489; PRJNA453673 468 32847498 "Integrative analysis of circRNAs, miRNAs, and mRNAs profiles to reveal ceRNAs networks in chicken intramuscular and abdominal adipogenesis." gga_circ_ARMH1 ARMH1 Gallus gallus others others others abdominal adipocytes down-regulated circARMH1 expression decreased during abdominal adipogenesis in primary chicken adipogenic cultures. PRJNA429489; PRJNA453673 469 32850833 Circular RNA cMTO1 Promotes PTEN Expression Through Sponging miR-181b-5p in Liver Fibrosis. mmu_circ_0015911 cMTO1 mmu_circ_MTO1 MTO1 Mus musculus liver fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 isolated primary HSCs down-regulated "In isolated primary mouse HSCs, cMTO1/mmu_circ_0015911 decreased during culture-associated HSC activation. Functional experiments in primary HSCs showed that cMTO1 reduced HSC proliferation and activation-associated fibrotic markers." 470 32879441 Aberrant expression of a novel circular RNA in pancreatic cancer. circPDAC RNA LOC107987178; LOC100507377 Homo sapiens pancreatic cancer MONDO:0009831 malignant pancreatic neoplasm DOID:1793 acinar cells unknown "RNA in situ hybridization detected circPDAC RNA in acinar cells adjacent to pancreatic intraepithelial neoplasia lesions, while expression was not detected in the lesions themselves." 471 32894165 The U2AF2 /circRNA ARF1/miR-342-3p/ISL2 feedback loop regulates angiogenesis in glioma stem cells. hsa_circ_0016767 hsa_circ_ARF1 ARF1 Homo sapiens glioma MONDO:0021042 glioma glioma stem cells / GSCs dys-regulated "In patient-derived glioma stem cells, qPCR showed that cARF1 expression was altered by miR-342-3p mimic/inhibitor treatment and by U2AF2 overexpression/knockdown. Functional assays using GSC-conditioned medium indicated that cARF1 promoted hBMEC proliferation, invasion and angiogenesis." 472 32904464 "CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-¦Â2 axis under hypoxia." mmu_circ_0001052 circHIPK3 mmu_circ_Hipk3 Hipk3 Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 cardiac fibroblasts up-regulated "circHIPK3 (mmu_circ_0001052) was significantly upregulated in primary mouse cardiac fibroblasts exposed to hypoxia compared with untreated normal cardiac fibroblasts. Functional assays in CFs indicated that circHIPK3 promoted proliferation, migration, and fibrotic phenotypic switching via the miR-152-3p/TGF-¦Â2 axis." 473 32917870 Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory. ciRS-7 / CDR1as hsa_circ_LINC00632 LINC00632 Homo sapiens colon cancer MONDO:0021063 malignant colon neoplasm DOID:219 stromal cells within the tumors up-regulated "ciRS-7 is highly expressed in tumor stromal cells relative to cancer cells in colon cancer, supported by CISH and laser capture microdissection followed by NanoString analysis." 474 32917870 Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory. ciRS-7 / CDR1as hsa_circ_LINC00632 LINC00632 Homo sapiens colon cancer MONDO:0021063 malignant colon neoplasm DOID:219 colon cancer cells down-regulated "ciRS-7 is absent or markedly depleted in colon cancer cells compared with stromal cells within colon cancer tissues, based on CISH and microdissected-cell expression analysis." 475 32922589 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. hsa_circ_0008737 circRNA_0031 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 peripheral blood monocytes up-regulated circRNA_0031 / hsa_circ_0008737 was up-regulated in purified peripheral blood monocytes from atrial fibrillation patients compared with healthy controls and was validated by qRT-PCR. 476 32922589 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. circRNA_1837 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 peripheral blood monocytes up-regulated circRNA_1837 was up-regulated in purified peripheral blood monocytes from atrial fibrillation patients compared with healthy controls and was validated by qRT-PCR. 477 32922589 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. hsa_circ_0001240 circRNA_5901 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 peripheral blood monocytes up-regulated circRNA_5901 / hsa_circ_0001240 was up-regulated in purified peripheral blood monocytes from atrial fibrillation patients compared with healthy controls and was validated by qRT-PCR. 478 32922589 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. circRNA_7571 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 peripheral blood monocytes up-regulated circRNA_7571 was up-regulated in purified peripheral blood monocytes from atrial fibrillation patients compared with healthy controls and was validated by qRT-PCR. 479 32922589 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. hsa_circ_0062426 circRNA_5801 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 peripheral blood monocytes down-regulated circRNA_5801 / hsa_circ_0062426 was down-regulated in purified peripheral blood monocytes from atrial fibrillation patients compared with healthy controls and was validated by qRT-PCR. 480 32922589 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. circRNA_7386 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 peripheral blood monocytes down-regulated circRNA_7386 was down-regulated in purified peripheral blood monocytes from atrial fibrillation patients compared with healthy controls and was validated by qRT-PCR. 481 32922589 Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation. hsa_circ_0006109 circRNA_7577 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 peripheral blood monocytes down-regulated circRNA_7577 / hsa_circ_0006109 was down-regulated in purified peripheral blood monocytes from atrial fibrillation patients compared with healthy controls and was validated by qRT-PCR. 482 32929177 CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression. circPAN3 hsa_circ_Pan3 Pan3 Homo sapiens myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury Primary human cardiac myocytes (HCMs) down-regulated "circPAN3 expression was decreased in primary human cardiac myocytes after hypoxia/reoxygenation treatment, an in vitro model of myocardial I/R injury. Overexpression of circPAN3 alleviated H/R-induced cardiomyocyte damage by suppressing autophagy and apoptosis." 483 32931733 Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output. hsa_circ_0089762 hsa_circ_JA760602 JA760602 Homo sapiens nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 primary fibroblasts down-regulated circRNA SCAR/hsa_circ_0089762 is down-regulated in primary liver fibroblasts from patients with NASH cirrhosis compared with fibroblasts from patients without NAFLD. FISH with co-immunofluorescence further showed circRNA SCAR is predominantly detected in fibroblasts in liver tissue. GSE134146 484 32931733 Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output. hsa_circ_0089763 Homo sapiens nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 primary fibroblasts down-regulated hsa_circ_0089763 is one of three mitochondrial circRNAs whose suppression in primary liver fibroblasts from NASH patients was validated by qRT-PCR. GSE134146 485 32931733 Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output. hsa_circ_0008882 Homo sapiens nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 primary fibroblasts down-regulated hsa_circ_0008882 is one of three mitochondrial circRNAs whose suppression in primary liver fibroblasts from NASH patients was validated by qRT-PCR. GSE134146 486 32950633 Quietness of circular RNA circ_0054633 alleviates the inflammation and proliferation in lipopolysaccharides-induced acute lung injury model through NF-¦ÊB signaling pathway. circ_0054633 Mus musculus acute lung injury MONDO:0015796 acute lung injury primary murine pulmonary microvascular endothelial cells (MPVECs) up-regulated "circ_0054633 was overexpressed in LPS-treated primary murine pulmonary microvascular endothelial cells, and siCirc reduced circ_0054633 expression in LPS-induced MPVECs. Silencing circ_0054633 decreased inflammatory cytokine production and repressed MPVEC proliferation and apoptosis in the LPS-induced ALI model." 487 32960511 Circ_0007331 knock-down suppresses the progression of endometriosis via miR-200c-3p/HiF-1¦Á axis. circ_0007331 Homo sapiens endometriosis MONDO:0005133 endometriosis DOID:289 ectopic endometrial (EE) cells up-regulated circ_0007331 was significantly up-regulated in ectopic endometrial cells from patients with endometriosis compared with normal endometrial cells from patients without endometriosis. Knock-down experiments in EE cells supported roles in proliferation and invasion. 488 32977365 Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF-¦ÊB activation. circ_0060745 Mus musculus acute myocardial infarction MONDO:0004781 acute myocardial infarction DOID:9408 myocardial fibroblasts up-regulated circ_0060745 was increased in isolated myocardial fibroblasts from AMI mice compared with sham controls. 489 32977365 Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF-¦ÊB activation. circ_0060745 Mus musculus acute myocardial infarction MONDO:0004781 acute myocardial infarction DOID:9408 myocardial fibroblasts up-regulated circ_0060745 was enriched in isolated myocardial fibroblasts relative to cardiomyocytes in the AMI mouse myocardium analysis. 490 32977365 Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF-¦ÊB activation. circ_0060745 Mus musculus acute myocardial infarction MONDO:0004781 acute myocardial infarction DOID:9408 cardiomyocytes no change circ_0060745 showed no significant expression difference in isolated cardiomyocytes from AMI mice compared with sham controls. 491 32977365 Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF-¦ÊB activation. circ_0060745 Mus musculus acute myocardial infarction MONDO:0004781 acute myocardial infarction DOID:9408 cardiac fibroblasts up-regulated "circ_0060745 was induced in primary neonatal cardiac fibroblasts under hypoxia, an in vitro AMI-related stress condition. Knockdown in cardiac fibroblasts reduced inflammatory factor expression and affected macrophage migration and cardiomyocyte apoptosis assays." 492 32978798 CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia. hsa_circ_0003489 circCDK8 hsa_circ_CDK8 CDK8 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 PDLSCs up-regulated "circCDK8/hsa_circ_0003489 was significantly increased in primary cultured human PDLSCs treated with CoCl2 compared with untreated controls, supporting hypoxia-induced up-regulation in this cell type. Functional experiments in PDLSCs indicated that circCDK8 regulates osteogenic differentiation and apoptosis through ER stress/autophagy-related pathways." 493 33002329 CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures. mmu_circ_0000146 mmu_circ_Hivep2 Hivep2 Mus musculus epileptic seizures MONDO:0005027 epilepsy DOID:1826 Iba_1_positive microglia up-regulated "FISH combined with Iba-1 immunohistochemical labeling showed increased circHivep2 expression in Iba1+ microglia in the hippocampal CA3 region of circHivep2+ exosome-treated KA-induced epileptic mice, while circHivep2 was undetectable in PBS-KA-treated mice. The authors linked this increase to repression of microglial activation." 494 33027196 Circ-HIPK2 Accelerates Cell Apoptosis and Autophagy in Myocardial Oxidative Injury by Sponging miR-485-5p and Targeting ATG101. circ-HIPK2 mmu_circ_HIPK2 HIPK2 Mus musculus myocardial oxidative injury MONDO:0024643 myocardial disorder primary mouse neonatal cardiomyocytes (MNCs) up-regulated circ-HIPK2 was up-regulated in H2O2-treated primary mouse neonatal cardiomyocytes as measured by RT-qPCR after primary cardiomyocyte isolation. Functional experiments in MNCs showed circ-HIPK2 promoted apoptosis and affected proliferation through the miR-485-5p/ATG101 axis. 495 33028811 CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089/AKT1/NF-¦ÊB axis. circRNA_09505 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 peripheral monocytes up-regulated circRNA_09505 expression was significantly increased in CD14 microbead-isolated peripheral monocytes from RA patients compared with controls. 496 33037617 Circular RNA CircCDH13 contributes to the pathogenesis of osteoarthritis via CircCDH13/miR-296-3p/PTEN axis. hsa_circ_0040646 CircCDH13 hsa_circ_CDH13 CDH13 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human chondrocytes (HCs) up-regulated "CircCDH13 was upregulated in primary human chondrocytes after IL-1¦Â and TNF-¦Á treatment, an in vitro OA model. Functional assays in HCs showed proapoptotic and procatabolic effects." 497 33042261 Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus. hsa_circ_0062444 circPPM1F hsa_circ_PPM1F PPM1F Homo sapiens type 1 diabetes mellitus MONDO:0005147 type 1 diabetes mellitus DOID:9744 monocytes up-regulated "After magnetic sorting of CD14+, CD3+, and CD19+ PBMC subsets followed by qRT-PCR, circPPM1F was mainly expressed in monocytes rather than T and B cells in the context of type 1 diabetes mellitus research." 498 33042405 Overexpression of circRNA chr7:154954255-154998784+ in cancer-associated pancreatic stellate cells promotes the growth and metastasis of pancreatic cancer by targeting the miR-4459/KIAA0513 axis. chr7:154954255-154998784+ Homo sapiens pancreatic cancer MONDO:0009831 malignant pancreatic neoplasm DOID:1793 cancer-associated pancreatic stellate cells up-regulated "chr7:154954255-154998784+ was up-regulated in isolated cancer-associated pancreatic stellate cells compared with normal-associated pancreatic stellate cells, based on RNA-seq and qRT-PCR validation. Silencing this circRNA in CaPSCs reduced their cancer-promoting effects on PANC-1 proliferation, migration and invasion in co-culture." unclear 499 33070258 CircRNA TGFBR2/MiR-25-3p/TWIST1 axis regulates osteoblast differentiation of human aortic valve interstitial cells. hsa_circ_TGFBR2 TGFBR2 Homo sapiens Calcific aortic valve disease MONDO:0005463 aortic valve calcification human aortic valve interstitial cells (VICs) down-regulated circRNA TGFBR2 was gradually decreased in human aortic valve interstitial cells after osteogenic induction. Functional experiments indicated that TGFBR2 overexpression suppressed osteoblast differentiation of osteogenic VICs. 500 33090019 Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients. hsa_circ_0072391 hsa circ 0072391 hsa_circ_HMGCS1 HMGCS1 Homo sapiens endometriosis-associated infertility MONDO:0005133 endometriosis DOID:289 cumulus cells up-regulated "hsa circ 0072391 was significantly overexpressed in isolated cumulus cells from endometriosis-associated infertility patients compared with control cumulus cells, based on circRNA sequencing and qRT-PCR validation." 501 33090019 Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients. hsa_circ_0007299 hsa circ 0007299 hsa_circ_CYP51A1 CYP51A1 Homo sapiens endometriosis-associated infertility MONDO:0005133 endometriosis DOID:289 cumulus cells up-regulated "hsa circ 0007299 was significantly overexpressed in isolated cumulus cells from endometriosis-associated infertility patients compared with control cumulus cells, based on circRNA sequencing and qRT-PCR validation." 502 33090019 Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients. hsa_circ_0057799 hsa circ 0057799 hsa_circ_BMPR2 BMPR2 Homo sapiens endometriosis-associated infertility MONDO:0005133 endometriosis DOID:289 cumulus cells up-regulated "hsa circ 0057799 was significantly overexpressed in isolated cumulus cells from endometriosis-associated infertility patients compared with control cumulus cells, based on circRNA sequencing and qRT-PCR validation." 503 33090019 Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients. hsa_circ_001533 hsa_circ_FKBP5 FKBP5 Homo sapiens endometriosis-associated infertility MONDO:0005133 endometriosis DOID:289 cumulus cells down-regulated "hsa circ 001533 was significantly downregulated in isolated cumulus cells from endometriosis-associated infertility patients compared with control cumulus cells, based on circRNA sequencing and qRT-PCR validation." 504 33125858 Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18. circPDE4D hsa_circ_PDE4D PDE4D Homo sapiens Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 OA cartilage chondrocytes down-regulated "circPDE4D is decreased in OA cartilage chondrocytes compared with non-OA control cartilage, and the decrease is associated with higher OA stages." 505 33125858 Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18. circPDE4D hsa_circ_PDE4D PDE4D Homo sapiens Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes down-regulated "In primary human chondrocytes, inflammatory TNF-¦Á stimulation reduces circPDE4D expression in a dose-dependent manner." 506 33131417 Circ_0008450 downregulates Runx3 to promote the proliferation and epithelial-mesenchymal transition of human keratinized epithelial cells. hsa_circ_0008450 circ_0008450 Homo sapiens Keloid MONDO:0005348 keloid keratinized epithelial cells up-regulated "circ_0008450 was up-regulated in keratinized epithelial samples from keloid compared with normal epithelial samples by qRT-PCR. In primary human keratinized epithelial cells, circ_0008450 silencing inhibited proliferation, migration and EMT-related changes and promoted apoptosis." 507 33133095 Hsa_circ_0060450 Negatively Regulates Type I Interferon-Induced Inflammation by Serving as miR-199a-5p Sponge in Type 1 Diabetes Mellitus. hsa_circ_0060450 hsa_circ_MYBL2 MYBL2 Homo sapiens type 1 diabetes mellitus MONDO:0005147 type 1 diabetes mellitus DOID:9744 monocytes up-regulated hsa_circ_0060450 expression was higher in monocytes than in T cells and B cells from separated human PBMCs in the context of T1DM pathogenesis. 508 33135071 CircRNA_0092516 regulates chondrocyte proliferation and apoptosis in osteoarthritis through the miR-337-3p/PTEN axis. hsa_circ_0092516 hsa_circ_NT5C2 NT5C2 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated "circRNA_0092516 was up-regulated in IL-1¦Â-stimulated primary chondrocytes used as an in vitro osteoarthritis model. Functional experiments in primary chondrocytes linked circRNA_0092516 interference to altered proliferation, apoptosis, inflammatory factor release, and miR-337-3p/PTEN signaling." 509 33138854 Circular RNA SIPA1L1 regulates osteoblastic differentiation of stem cells from apical papilla via miR-204-5p/ALPL pathway. hsa_circ_SIPA1L1 SIPA1L1 Homo sapiens others others others stem cells from apical papilla (SCAPs) up-regulated circSIPA1L1 expression was significantly increased in primary human SCAPs during osteogenic induction as measured by qRT-PCR. Functional assays in SCAPs showed that circSIPA1L1 promotes osteogenic differentiation via the miR-204-5p/ALPL pathway. 510 33151455 CircRNA-23525 regulates osteogenic differentiation of adipose-derived mesenchymal stem cells via miR-30a-3p. circRNA-23525 Mus musculus others others others adipose-derived mesenchymal stem cells up-regulated circRNA-23525 is up-regulated in primary murine ADSCs during osteogenic induction compared with non-induced controls. Functional assays in ADSCs indicate that circRNA-23525 promotes osteogenic differentiation through the miR-30a-3p/Runx2 axis. 511 33154349 A circular RNA generated from an intron of the insulin gene controls insulin secretion. ci-Ins2 rno_circ_Ins2 Ins2 Rattus norvegicus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 ¦Â-cells up-regulated ci-Ins2 was detected by qPCR after FACS enrichment of rat islet ¦Á- and ¦Â-cell fractions and was highly enriched in ¦Â-cells relative to the ¦Á-cell-enriched fraction. The study further links reduced ci-Ins2 levels in islets to type 2 diabetes models and impaired ¦Â-cell insulin secretion. 512 33159017 CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1. hsa_circ_GLCE GLCE Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 nucleus pulposus (NP) cells down-regulated CircGLCE was detected in the cytoplasm of nucleus pulposus cells and was downregulated in IDD compared with controls. Functional assays in NP cells showed that CircGLCE knockdown increased apoptosis and matrix-degrading enzyme expression. 513 33177084 Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline. circEx3-6 hsa_circ_BOULE BOULE Homo sapiens asthenozoospermia MONDO:0850098 oligoasthenoteratozoospermia DOID:0070311 sperm down-regulated "Human circBoule circEx3-6 is significantly lower in purified sperm from asthenozoospermic patients compared with normozoospermic sperm, measured by RT-qPCR." 514 33177084 Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline. circEx2-7 hsa_circ_BOULE BOULE Homo sapiens asthenozoospermia MONDO:0850098 oligoasthenoteratozoospermia DOID:0070311 sperm down-regulated "Human circBoule circEx2-7 is significantly lower in purified sperm from asthenozoospermic patients compared with normozoospermic sperm, measured by RT-qPCR." 515 33192092 Effect of the Up-Regulation of Circular RNA Hsa_circ_0069767 Derived from C-KIT on the Biological Behavior of Multiple Myeloma Cells. Hsa_circ_0069767 hsa_circ_C-KIT C-KIT Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 MM cells up-regulated "circ_0069767 was measured by qRT-PCR in magnetically sorted MM bone marrow samples and was higher in MM samples than in normal control bone marrow samples. Functional assays in MM cells indicated reduced viability, migration and invasion and increased apoptosis after circ_0069767 overexpression." 516 33195225 CircCOG8 Downregulation Contributes to the Compression-Induced Intervertebral Disk Degeneration by Targeting miR-182-5p and FOXO3. hsa_circ_0040060 circCOG8 hsa_circ_COG8 COG8 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 disk NP cells down-regulated "circCOG8 was down-regulated in primary human disk nucleus pulposus cells after 1.0 MPa mechanical compression compared with untreated control cells, based on circRNA microarray screening and qRT-PCR validation. Functional experiments in disk NP cells showed that circCOG8 attenuated compression-induced apoptosis, ROS accumulation, and ECM degradation." 517 33205602 Circular RNA circANKRD36 regulates Casz1 by targeting miR-599 to prevent osteoarthritis chondrocyte apoptosis and inflammation. circANKRD36 hsa_circ_ANKRD36 ANKRD36 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human chondrocytes down-regulated "In primary human chondrocytes used as an IL-1¦Â-induced osteoarthritis model, circANKRD36 expression was decreased after IL-1¦Â treatment. Functional assays in chondrocytes showed that circANKRD36 overexpression alleviated IL-1¦Â-induced apoptosis and inflammation." 518 33207953 Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation. hsa_circ_0009034 CircMAP3K5 hsa_circ_MAP3K5 MAP3K5 Homo sapiens coronary heart disease MONDO:0005010 coronary artery disorder DOID:3393 human SMC down-regulated CircMAP3K5/hsa_circ_0009034 was significantly down-regulated in human smooth muscle cells from CHD patients compared with non-CHD subjects. 519 33207953 Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation. CircMAP3K5 hsa_circ_MAP3K5 MAP3K5 Homo sapiens intimal hyperplasia MONDO:0005385 vascular disorder DOID:178 human coronary artery smooth muscle cells (HCASMCs) down-regulated "CircMAP3K5 was down-regulated in PDGF-BB-treated human coronary artery smooth muscle cells, a model of SMC phenotypic modulation relevant to intimal hyperplasia." 520 33207953 Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation. CircMAP3K5 hsa_circ_MAP3K5 MAP3K5 Homo sapiens intimal hyperplasia MONDO:0005385 vascular disorder DOID:178 human coronary artery smooth muscle cells (HCASMCs) up-regulated CircMAP3K5 was up-regulated in RepSox-treated human coronary artery smooth muscle cells under a VSMC differentiation-promoting condition. 521 33230455 circRNA CDR1as Promotes Pulmonary Artery Smooth Muscle Cell Calcification by Upregulating CAMK2D and CNN3 via Sponging miR-7-5p. hsa_circ_0001946 CDR1as / ciRS-7 hsa_circ_CDR1 CDR1 Homo sapiens pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 HPASMCs up-regulated "CDR1as was up-regulated in hypoxia-exposed human pulmonary artery smooth muscle cells compared with normoxic HPASMCs, as measured by qPCR. Functional experiments in HPASMCs support a role for CDR1as in hypoxia-induced osteogenic differentiation and calcification." 522 33230464 Exosome-Shuttled circSHOC2 from IPASs Regulates Neuronal Autophagy and Ameliorates Ischemic Brain Injury via the miR-7670-3p/SIRT1 Axis. mmu_circ_0092670 mmu_circ_SHOC2 SHOC2 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke ischemic-preconditioned astrocyte-derived exosomes up-regulated circSHOC2 was increased in exosomes derived from ischemic-preconditioned primary astrocytes compared with exosomes from normal astrocytes. Functional experiments indicated that IPAS-EXO-mediated circSHOC2 transfer reduced OGD-induced neuronal apoptosis via autophagy-related mechanisms. 523 33230464 Exosome-Shuttled circSHOC2 from IPASs Regulates Neuronal Autophagy and Ameliorates Ischemic Brain Injury via the miR-7670-3p/SIRT1 Axis. circRCL1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke ischemic-preconditioned astrocyte-derived exosomes up-regulated circRCL1 was upregulated in exosomes from ischemic-preconditioned primary astrocytes compared with the control group by qRT-PCR validation of circRNA microarray results. 524 33230464 Exosome-Shuttled circSHOC2 from IPASs Regulates Neuronal Autophagy and Ameliorates Ischemic Brain Injury via the miR-7670-3p/SIRT1 Axis. circPOLR2A Mus musculus ischemic stroke MONDO:1060198 ischemic stroke ischemic-preconditioned astrocyte-derived exosomes up-regulated circPOLR2A was upregulated in exosomes from ischemic-preconditioned primary astrocytes compared with the control group by qRT-PCR validation of circRNA microarray results. 525 33230464 Exosome-Shuttled circSHOC2 from IPASs Regulates Neuronal Autophagy and Ameliorates Ischemic Brain Injury via the miR-7670-3p/SIRT1 Axis. circPANK4 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke ischemic-preconditioned astrocyte-derived exosomes up-regulated circPANK4 was upregulated in exosomes from ischemic-preconditioned primary astrocytes compared with the control group by qRT-PCR validation of circRNA microarray results. 526 33257975 Circular RNA Sequencing of Maternal Platelets: A Novel Tool for the Identification of Pregnancy-Specific Biomarkers. hsa_circ_NRIP1 NRIP1 Homo sapiens pregnancy MONDO:0024575 pregnancy disorder first-trimester maternal platelets up-regulated "NRIP1 circRNA was detected in isolated maternal platelets and was significantly up-regulated in platelets from first-trimester pregnant women compared with nonpregnant controls, with confirmation by RT-qPCR." 527 33257975 Circular RNA Sequencing of Maternal Platelets: A Novel Tool for the Identification of Pregnancy-Specific Biomarkers. ZEB2 circRNA hsa_circ_ZEB2 ZEB2 Homo sapiens pregnancy MONDO:0024575 pregnancy disorder maternal platelets down-regulated ZEB2 circRNA was reported as significantly down-regulated in maternal platelets from normal pregnancies based on the platelet circRNA sequencing analysis. 528 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circZNF609 hsa_circ_ZNF609 ZNF609 Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circZNF609 was ectopically up-regulated in immature T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. Silencing experiments indicated a pro-proliferative role in T-ALL cells. GSE110636; GSE142179 529 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circCEP70 hsa_circ_CEP70 CEP70 Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circCEP70 was ectopically up-regulated in immature T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. GSE110636; GSE142179 530 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circKPNA5 hsa_circ_KPNA5 KPNA5 Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circKPNA5 was ectopically up-regulated in immature T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. GSE110636; GSE142179 531 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circPSEN1 hsa_circ_PSEN1 PSEN1 Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circPSEN1 was ectopically up-regulated in immature T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. GSE110636; GSE142179 532 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circESYT2(4-8) hsa_circ_ESYT2 ESYT2 Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circESYT2(4-8) was ectopically up-regulated in TLX3-subtype T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. GSE110636; GSE142179 533 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circKDM1A(2-9) hsa_circ_KDM1A KDM1A Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circKDM1A(2-9) was ectopically up-regulated in TLX3-subtype T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. GSE110636; GSE142179 534 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circTASP1(4-7) hsa_circ_TASP1 TASP1 Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circTASP1(4-7) was ectopically up-regulated in TLX3-subtype T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. GSE110636; GSE142179 535 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circ-TASP1(5-8) hsa_circ_TASP1 TASP1 Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circ-TASP1(5-8) was ectopically up-regulated in TLX3-subtype T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. GSE110636; GSE142179 536 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circBACH1 hsa_circ_BACH1 BACH1 Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circBACH1 was ectopically up-regulated in TLX3-subtype T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. GSE110636; GSE142179 537 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circSTAM hsa_circ_STAM STAM Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circSTAM was ectopically up-regulated in HOXA-subtype T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. GSE110636; GSE142179 538 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circHACD1 hsa_circ_HACD1 HACD1 Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circHACD1 was ectopically up-regulated in HOXA-subtype T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. GSE110636; GSE142179 539 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circCAMSAP1 hsa_circ_CAMSAP1 CAMSAP1 Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circCAMSAP1 was ectopically up-regulated in TLX1-subtype T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. GSE110636; GSE142179 540 33259601 Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. circCASC15 hsa_circ_CASC15 CASC15 Homo sapiens T-cell acute lymphoblastic leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 malignant T cells up-regulated circCASC15 was ectopically up-regulated in TAL-LMO-subtype T-ALL malignant T cells compared with normal thymocyte counterparts and other T-ALL subtypes. GSE110636; GSE142179 541 33298186 circAKT3 positively regulates osteogenic differentiation of human dental pulp stromal cells via miR-206/CX43 axis. circAKT3 hsa_circ_AKT3 AKT3 Homo sapiens others others others human dental pulp stromal cells up-regulated "In isolated and cultured human dental pulp stromal cells, circAKT3 was up-regulated during osteogenic differentiation. Knockdown of circAKT3 inhibited osteogenic differentiation of hDPSCs." 542 33318297 Identification of the ceRNA networks in ¦Á-MSH-induced melanogenesis of melanocytes. hsa_circ_0091223 circ_0091223 Homo sapiens skin pigmentation disorders MONDO:0019288 skin pigmentation disorder DOID:10123 human skin primary melanocytes up-regulated "circ_0091223 is up-regulated in ¦Á-MSH-treated primary human melanocytes compared with untreated control melanocytes, supported by qRT-PCR after primary melanocyte isolation. Functional experiments in melanocytes showed that si-circ_0091223 affected TYR expression and melanin production." 543 33326955 Diagnostic and Therapeutic Value of Hsa_circ_0002594 for T Helper 2-Mediated Allergic Asthma. hsa_circ_0002594 Homo sapiens asthma MONDO:0004979 asthma DOID:2841 CD4 + T cells up-regulated "hsa_circ_0002594 was markedly increased in isolated CD4+ T cells from asthmatic patients compared with healthy subjects, validated by qRT-PCR after CD4+ T cell isolation." 544 33326955 Diagnostic and Therapeutic Value of Hsa_circ_0002594 for T Helper 2-Mediated Allergic Asthma. hsa_circ_0002594 Homo sapiens asthma MONDO:0004979 asthma DOID:2841 CD4 + T cells up-regulated "In isolated CD4+ T cells from asthmatic patients, hsa_circ_0002594 expression was higher in the Th2-high subgroup than in the Th2-low subgroup." 545 33326955 Diagnostic and Therapeutic Value of Hsa_circ_0002594 for T Helper 2-Mediated Allergic Asthma. hsa_circ_0002594 Homo sapiens asthma MONDO:0004979 asthma DOID:2841 CD4 + T cells down-regulated "In isolated CD4+ T cells from asthmatic subjects, hsa_circ_0002594 levels decreased after 4 weeks of inhaled corticosteroid treatment compared with the first visit." 546 33372369 CircASPH promotes KGN cells proliferation through miR-375/MAP2K6 axis in Polycystic Ovary Syndrome. hsa_circ_ASPH ASPH Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 Ovarian granulosa cells up-regulated "circASPH was up-regulated in isolated ovarian granulosa cells from PCOS patients compared with granulosa cells from non-PCOS controls, as measured by RT-qPCR." 547 33382168 Circular RNA Foxo3 in cardiac ischemia-reperfusion injury in heart transplantation: A new regulator and target. mmu_circ_Foxo3 Foxo3 Mus musculus ischemia reperfusion injury / IRI MONDO:0005203 ischemia reperfusion injury PCMs up-regulated "circFoxo3 was significantly increased in primary cardiomyocytes isolated from neonatal mice after hypoxia/reoxygenation compared with normoxic control cells, as measured by qRT-PCR." 548 33394311 Circ_0045714 alleviates TNF-¦Á-induced chondrocyte injury and extracellular matrix degradation through miR-218-5p/HRAS axis. hsa_circ_0045714 circ_0045714 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 normal chondrocytes down-regulated "circ_0045714 was decreased in TNF-¦Á-treated primary human articular chondrocytes compared with untreated chondrocytes. Functional experiments in the same chondrocyte model showed circ_0045714 overexpression reduced TNF-¦Á-induced growth inhibition, apoptosis, inflammation and ECM degradation." 549 33398455 Involvement of circHIPK3 in the pathogenesis of diabetic cardiomyopathy in mice. mmu_circ_0001052 circHIPK3 mmu_circ_Hipk3 Hipk3 Mus musculus diabetic cardiomyopathy MONDO:0004994 cardiomyopathy DOID:0050700 cardiac fibroblasts up-regulated "In primary mouse cardiac fibroblast culture, circHIPK3 was upregulated after high glucose or Ang II treatment. circHIPK3 knockdown suppressed Ang II-induced fibroblast proliferation and reduced COL1A1 and COL3A1 expression." 550 33402817 Silencing of circHIPK3 Inhibits Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction by Sponging miR-185-3p. circHIPK3 mmu_circ_HIPK3 HIPK3 Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocytes up-regulated "In primary neonatal mouse cardiomyocytes, Ang II treatment induced an in vitro hypertrophy model and increased circHIPK3 expression compared with control cells. circHIPK3 knockdown reduced Ang II-induced cardiomyocyte hypertrophic phenotypes." 551 33408787 Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress. hsa_circ_0006577 circRSU1 hsa_circ_RSU1 RSU1 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human articular chondrocytes up-regulated "circRSU1 / hsa_circ_0006577 was up-regulated in primary human articular chondrocytes after H2O2 or IL-1¦Â stimulation, supported by circRNA RNA-seq and qRT-PCR validation. Functional experiments in human chondrocytes linked circRSU1 to oxidative stress-triggered inflammation and extracellular matrix maintenance." 552 33408787 Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress. hsa_circ_0006577 circRSU1 hsa_circ_RSU1 RSU1 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 HCs from OA cartilage up-regulated "circRSU1 was up-regulated in human articular chondrocytes from osteoarthritic cartilage, with highest expression reported in medial cartilage of older patients. The study linked circRSU1 in chondrocytes to oxidative stress-triggered inflammation and ECM maintenance." 553 33417289 Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy. circIgf1r mmu_circ_Igf1r Igf1r Mus musculus epilepsy MONDO:0005027 epilepsy DOID:1826 primary astrocytes up-regulated "In primary mouse astrocytes, circIgf1r was up-regulated after 4-AP treatment as measured by QPCR. Functional experiments showed that astrocytic circIgf1r knockdown altered astrocyte polarization and reduced neuronal toxicity in conditioned-medium assays." 554 33425489 CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells. CircMEG3 hsa_circ_MEG3 MEG3 Homo sapiens liver cancer MONDO:0002691 liver cancer DOID:3571 human liver CSCs up-regulated "Human liver cancer stem cells were isolated from Huh7 cells using MACS microbeads, and CircMEG3 expression was detected by back-to-back RT-PCR. CircMEG3 was increased after DOX induction in rLV-Tet-on-CircMEG3-hLCSCs and inhibited growth and malignant differentiation of human liver CSCs." 555 33425899 CircHmbox1 Targeting miRNA-1247-5p Is Involved in the Regulation of Bone Metabolism by TNF-¦Á in Postmenopausal Osteoporosis. mmu_circ_0000549 mmu_circ_Hmbox1 Hmbox1 Mus musculus postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis osteoclasts down-regulated circHmbox1/mmu_circ_0000549 was decreased during TNF-¦Á-enhanced RANKL-induced osteoclast differentiation in primary mouse BMM-derived osteoclast cultures. 556 33425899 CircHmbox1 Targeting miRNA-1247-5p Is Involved in the Regulation of Bone Metabolism by TNF-¦Á in Postmenopausal Osteoporosis. mmu_circ_0000549 mmu_circ_Hmbox1 Hmbox1 Mus musculus postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis osteoclasts down-regulated "BMM-derived osteoclasts from OVX mice showed significantly decreased circHmbox1 expression compared with controls, and anti-TNF-¦Á treatment alleviated this decrease." 557 33425899 CircHmbox1 Targeting miRNA-1247-5p Is Involved in the Regulation of Bone Metabolism by TNF-¦Á in Postmenopausal Osteoporosis. mmu_circ_0000549 mmu_circ_Hmbox1 Hmbox1 Mus musculus postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis osteoblasts down-regulated circHmbox1 expression was reduced in osteoblasts after exposure to exosomes from RANKL-induced osteoclasts and was further reduced by exosomes from TNF-¦Á-treated osteoclasts. 558 33425899 CircHmbox1 Targeting miRNA-1247-5p Is Involved in the Regulation of Bone Metabolism by TNF-¦Á in Postmenopausal Osteoporosis. mmu_circ_0000550 mmu_circ_Hmbox1 Hmbox1 Mus musculus postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis pre-osteoblasts no change TNF-¦Á treatment did not significantly alter circHmbox1 expression in pre-osteoblasts. 559 33436852 CircRNA_103765 acts as a proinflammatory factor via sponging miR-30 family in Crohn's disease. hsa_circRNA_103765 hsa_circ_KLHL2 KLHL2 Homo sapiens Crohn's disease MONDO:0005011 Crohn disease DOID:8778 peripheral blood mononuclear cells (PBMCs) up-regulated circRNA_103765 was up-regulated in isolated PBMCs from Crohn¡¯s disease patients compared with healthy controls based on qRT-PCR analysis. 560 33436852 CircRNA_103765 acts as a proinflammatory factor via sponging miR-30 family in Crohn's disease. hsa_circRNA_103765 hsa_circ_KLHL2 KLHL2 Homo sapiens ulcerative colitis MONDO:0005101 ulcerative colitis DOID:8577 peripheral blood mononuclear cells (PBMCs) up-regulated circRNA_103765 was up-regulated in isolated PBMCs from ulcerative colitis patients compared with healthy controls based on qRT-PCR analysis. 561 33436852 CircRNA_103765 acts as a proinflammatory factor via sponging miR-30 family in Crohn's disease. hsa_circRNA_103765 hsa_circ_KLHL2 KLHL2 Homo sapiens Crohn's disease MONDO:0005011 Crohn disease DOID:8778 peripheral blood mononuclear cells (PBMCs) up-regulated circRNA_103765 expression was higher in isolated PBMCs from active Crohn¡¯s disease patients than in PBMCs from Crohn¡¯s disease patients in remission. 562 33436852 CircRNA_103765 acts as a proinflammatory factor via sponging miR-30 family in Crohn's disease. hsa_circRNA_103765 hsa_circ_KLHL2 KLHL2 Homo sapiens ulcerative colitis MONDO:0005101 ulcerative colitis DOID:8577 peripheral blood mononuclear cells (PBMCs) up-regulated circRNA_103765 expression was higher in isolated PBMCs from active ulcerative colitis patients than in PBMCs from ulcerative colitis patients in remission. 563 33436852 CircRNA_103765 acts as a proinflammatory factor via sponging miR-30 family in Crohn's disease. hsa_circRNA_103765 hsa_circ_KLHL2 KLHL2 Homo sapiens Crohn's disease MONDO:0005011 Crohn disease DOID:8778 PBMCs down-regulated "In isolated PBMCs from active Crohn¡¯s disease patients, circRNA_103765 decreased after effective infliximab therapy compared with before induction therapy." 564 33450597 Expression and clinical significance of circular RNAs related to immunity and inflammation in patients with rheumatoid arthritis. hsa_circ_0003353 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLS up-regulated "hsa_circ_0003353 was significantly up-regulated in rheumatoid arthritis fibroblast-like synoviocytes compared with normal control FLS by RT-qPCR. Functional assays in RA-FLS linked hsa_circ_0003353 to inflammation, proliferation, apoptosis, migration, and invasion." 565 33450597 Expression and clinical significance of circular RNAs related to immunity and inflammation in patients with rheumatoid arthritis. hsa_circ_0003353 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLS up-regulated "hsa_circ_0003353 expression was significantly elevated in TNF-¦Á-stimulated RA-FLS. Functional assays in RA-FLS linked hsa_circ_0003353 to inflammation, proliferation, apoptosis, migration, and invasion." 566 33524877 Circ_0081572 inhibits the progression of periodontitis through regulating the miR-378h/RORA axis. hsa_circ_0081572 hsa_circ_SERPINE1 SERPINE1 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 periodontal ligament cells (PDLCs) down-regulated "circ_0081572 was reduced in primary PDLCs after LPS treatment, an in vitro periodontitis cell model. Overexpression of circ_0081572 alleviated LPS-induced PDLC injury through effects on viability, apoptosis, inflammatory response and oxidative stress." 567 33526034 "CircTM7SF3 contributes to oxidized low-density lipoprotein-induced apoptosis, inflammation and oxidative stress through targeting miR-206/ASPH axis in atherosclerosis cell model in vitro." hsa_circ_0007478 hsa_circ_TM7SF3 TM7SF3 Homo sapiens Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 Human monocyte-derived macrophages (hMDMs) up-regulated "In primary human monocyte-derived macrophages used to establish an ox-LDL-induced AS cell model, circTM7SF3 expression was up-regulated by ox-LDL and reduced by si-circTM7SF3. CircTM7SF3 interference attenuated ox-LDL-induced inflammatory cytokine secretion in these differentiated hMDMs." 568 33573240 "Novel Identified Circular Transcript of RCAN2, circ-RCAN2, Shows Deviated Expression Pattern in Pig Reperfused Infarcted Myocardium and Hypoxic Porcine Cardiac Progenitor Cells In Vitro." circ-RCAN2 ssc_circ_RCAN2 RCAN2 Sus scrofa acute myocardial infarction MONDO:0004781 acute myocardial infarction DOID:9408 porcine cardiac progenitor cells up-regulated circ-RCAN2 was up-regulated in hypoxic porcine cardiac progenitor cells compared with normoxic pCPCs based on qPCR after primary pCPC isolation and culture. 569 33573240 "Novel Identified Circular Transcript of RCAN2, circ-RCAN2, Shows Deviated Expression Pattern in Pig Reperfused Infarcted Myocardium and Hypoxic Porcine Cardiac Progenitor Cells In Vitro." circ-C12orf29 Sus scrofa acute myocardial infarction MONDO:0004781 acute myocardial infarction DOID:9408 porcine cardiac progenitor cells no change "circ-C12orf29 was measured in hypoxic versus normoxic porcine cardiac progenitor cells by qPCR, but showed no significant up- or down-regulation in vitro." 570 33579365 Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p/TLR4 axis in cerebral infarction. mmu_circ_TTC3 TTC3 Mus musculus cerebral infarction MONDO:0002679 cerebral infarction DOID:3526 OGD-treated astrocytes up-regulated "circTTC3 was upregulated in primary mouse astrocytes after OGD treatment. circTTC3 depletion reduced OGD-induced astrocyte apoptosis, LDH release, inflammatory cytokines, and senescence." 571 33579365 Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p/TLR4 axis in cerebral infarction. rno_circ_TTC3 TTC3 Rattus norvegicus cerebral infarction MONDO:0002679 cerebral infarction DOID:3526 astrocytes down-regulated "In primary rat NSC-derived differentiation cultures, circTTC3 expression decreased during differentiation into astrocytes. The study also showed circTTC3 knockdown promoted NSC proliferation and differentiation markers." 572 33579365 Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p/TLR4 axis in cerebral infarction. rno_circ_TTC3 TTC3 Rattus norvegicus cerebral infarction MONDO:0002679 cerebral infarction DOID:3526 neurons down-regulated "In primary rat NSC-derived differentiation cultures, circTTC3 expression decreased during differentiation into neurons. The study also showed circTTC3 knockdown promoted NSC proliferation and differentiation markers." 573 33614234 Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p/Smad7 axis. mmu_circ_0001682 mm9_circ_006613 mmu_circ_PSD3 PSD3 Mus musculus hepatic fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 primary HSCs down-regulated circPSD3 (mmu_circ_0001682/mm9_circ_006613) was downregulated in isolated primary HSCs from mice with CCl4-induced hepatic fibrosis compared with vehicle controls. Functional analyses indicated circPSD3 restrained HSC activation and proliferation. 574 33637685 Inhibition of intervertebral disc disease progression via the circPKNOX1-miR-370-3p-KIAA0355 axis. hsa_circ_0061853 circPKNOX1 hsa_circ_PKNOX1 PKNOX1 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 NP cells down-regulated "circPKNOX1 / hsa_circ_0061853 is decreased in degenerative NP cells from IVDD patients compared with normal NP cells, supported by isolated NP cell expression analysis and RT-qPCR validation. Functional experiments in NP cells showed that circPKNOX1 regulates extracellular matrix synthesis and decomposition through the miR-370-3p-KIAA0355 axis." 575 33649815 circNRIP1 facilitates keloid progression via FXR1_mediated upregulation of miR_503_3p and miR_503_5p. hsa_circ_NRIP1 NRIP1 Homo sapiens keloid MONDO:0005348 keloid keloid-derived fibroblasts up-regulated "circNRIP1 was up-regulated in primary cultured keloid-derived fibroblasts compared with normal human fibroblasts, as measured by qPCR. Loss-of-function assays in keloid-derived fibroblasts indicated roles in proliferation, apoptosis and extracellular matrix accumulation." 576 33653372 "Circ-AFF2/miR-650/CNP axis promotes proliferation, inflammatory response, migration, and invasion of rheumatoid arthritis synovial fibroblasts." hsa_circ_0001947 hsa_circ_AFF2 AFF2 Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 rheumatoid arthritis fibroblast-like synoviocytes up-regulated "circ-AFF2 is up-regulated in fibroblast-like synoviocytes isolated from rheumatoid arthritis synovial tissues compared with normal synovial fibroblast-like cells. In RAFLSs, circ-AFF2 promotes proliferation, inflammatory response, migration, and invasion and represses apoptosis." 577 33657879 Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis. mmu_circ_Calm4 Calm4 Mus musculus pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 pulmonary arterial smooth muscle cells up-regulated "circ-Calm4 is up-regulated in primary cultured mouse pulmonary arterial smooth muscle cells under hypoxia, a pulmonary hypertension-related condition, based on qRT-PCR after PASMC isolation. Functional experiments in PASMCs showed that circ-Calm4 silencing mitigated hypoxia-induced pyroptosis-related inflammatory phenotypes." 578 33658002 Knockdown of circROBO2 attenuates acute myocardial infarction through regulating the miR-1184/TRADD axis. circROBO2 mmu_circ_ROBO2 ROBO2 Mus musculus acute myocardial infarction MONDO:0004781 acute myocardial infarction DOID:9408 primary myocardial cells up-regulated circROBO2 was up-regulated in isolated primary mouse cardiomyocytes exposed to hypoxic/ischemic injury. Knockdown of circROBO2 enhanced cardiomyocyte viability and inhibited apoptosis through the miR-1184/TRADD axis. 579 33658057 Knockdown of Circ_SLC39A8 protects against the progression of osteoarthritis by regulating miR-591/IRAK3 axis. hsa_circ_0002782 hsa_circ_SLC39A8 SLC39A8 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 OA chondrocytes down-regulated "Primary OA chondrocytes were isolated and cultured, and qRT-PCR showed reduced circ-SLC39A8 expression after si-circ-SLC39A8 transfection. In these OA chondrocytes, circ_SLC39A8 knockdown affected viability, apoptosis, inflammation, and ECM degradation-related markers." 580 33664496 Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling. hsa_circ_0039992 hsa_circ_CDH1 CDH1 Homo sapiens glioblastoma MONDO:0018177 glioblastoma DOID:3068 CD133 + GSCs up-regulated "circ-E-Cad RNA is upregulated in CD133+ glioma stem cells compared with paired CD133_ non-GSCs in glioblastoma. Functional perturbation in GSCs showed that C-E-Cad/circ-E-Cad supports stemness, proliferation, invasion and apoptosis resistance." 581 33679417 "CircMAP3K11 Contributes to Proliferation, Apoptosis and Migration of Human Periodontal Ligament Stem Cells in Inflammatory Microenvironment by Regulating TLR4 via miR-511 Sponging." hsa_circ_002284 hsa_circ_MAP3K11 MAP3K11 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 hPDLSCs dys-regulated "In primary cultured hPDLSCs used as an inflammatory microenvironment model for periodontitis, circMAP3K11 expression was experimentally increased by circMAP3K11 plasmid transfection and reduced by si-circMAP3K11. Functional assays in hPDLSCs linked circMAP3K11 to proliferation, apoptosis and migration." 582 33683343 Deregulated expression of circular RNAs in acute myeloid leukemia. circBCL11B hsa_circ_BCL11B BCL11B Homo sapiens acute myeloid leukemia MONDO:0018874 acute myeloid leukemia DOID:9119 AML blasts up-regulated "circBCL11B was exclusively detected in AML blasts/patient AML samples and not in healthy CD34+ HSPCs using ribosomal RNA-depleted RNA-seq, with validation by Oxford Nanopore sequencing and an independent AML cohort." GSE158596; GSE137851 583 33687273 UVB-Induced ciRS-7 Activates Melanogenesis by Paracrine Effects. CDR1as / ciRS-7 Homo sapiens pigmented skin diseases MONDO:0000001 disease DOID:4 primary human dermal fibroblasts (FBs) up-regulated "In primary human dermal fibroblasts, ciRS-7 expression was significantly upregulated after UVB irradiation as measured by qRT-PCR. Inhibition of ciRS-7 reduced fibroblast secretion of FGF2 and affected melanogenesis through paracrine effects." 584 33692802 Circ_0088194 Promotes the Invasion and Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the miR-766-3p/MMP2 Axis. Hsa_circ_0088194 Circ_0088194 hsa_circ_TNC TNC Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA fibroblast-like synoviocytes (RA-FLSs) up-regulated "Circ_0088194 is up-regulated in primary cultured RA fibroblast-like synoviocytes compared with OA-FLSs. In RA-FLSs, Circ_0088194 promotes migration and invasion through the miR-766-3p/MMP2 axis." 585 33692802 Circ_0088194 Promotes the Invasion and Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the miR-766-3p/MMP2 Axis. Hsa_circ_0088200 Circ_0088200 hsa_circ_TNC TNC Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs up-regulated Circ_0088200 is up-regulated in primary cultured RA fibroblast-like synoviocytes compared with OA-FLSs based on qRT-PCR validation. 586 33692802 Circ_0088194 Promotes the Invasion and Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the miR-766-3p/MMP2 Axis. Hsa_circ_0012103 Circ_0012103 hsa_circ_ST3GAL3 ST3GAL3 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs no change Circ_0012103 showed no significant expression difference between primary cultured RA-FLSs and OA-FLSs in qRT-PCR validation. 587 33692802 Circ_0088194 Promotes the Invasion and Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the miR-766-3p/MMP2 Axis. Hsa_circ_0034953 Circ_0034953 hsa_circ_TUBGCP4 TUBGCP4 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs no change Circ_0034953 showed no significant expression difference between primary cultured RA-FLSs and OA-FLSs in qRT-PCR validation. 588 33708807 The Emerging Role of Long Non-coding RNAs and Circular RNAs in Coronary Artery Disease. hsa_circ_0029589 circ_0029589 Homo sapiens coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 human peripheral blood mononuclear cell-originated macrophages down-regulated hsa_circ_0029589 was reported to be down-regulated in PBMC-originated macrophages from CAD patients. The review links circ_0029589 obstruction to macrophage pyroptosis and inflammatory responses in acute coronary syndrome and atherosclerotic patients. 589 33710445 Circ_0085289 Alleviates the Progression of Periodontitis by Regulating let-7f-5p/SOCS6 Pathway. hsa_circ_0085289 circ_0085289 hsa_circ_CTHRC1 CTHRC1 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 Periodontal ligament cells (PDLCs) down-regulated circ_0085289 was down-regulated in primary cultured PDLCs after LPS stimulation compared with untreated PDLCs. Functional experiments indicated that circ_0085289 overexpression alleviated LPS-triggered inflammatory cytokine release and apoptosis-related injury in PDLCs. 590 33719821 Circular RNA circ_0003420 mediates inflammation in sepsis-induced liver damage by downregulating neuronal PAS domain protein 4. hsa_circ_0003420 circ_0003420 Homo sapiens sepsis-induced liver damage MONDO:0005154 liver disorder DOID:409 Kupffer cells up-regulated circ_0003420 was significantly up-regulated in primary isolated Kupffer cells after LPS treatment compared with untreated controls. Functional experiments in LPS-treated Kupffer cells showed that circ_0003420 silencing attenuated apoptosis and inflammatory cytokine expression. 591 33733589 CircPVT1 up-regulation attenuates steroid-induced osteonecrosis of the femoral head through regulating miR-21-5p-mediated Smad7/TGF¦Â signalling pathway. CircPVT1 hsa_circ_PVT1 PVT1 Homo sapiens steroid-induced osteonecrosis of the femoral head MONDO:0012126 familial avascular necrosis of femoral head BMSCs down-regulated CircPVT1 was down-regulated in GC-treated BMSCs compared with untreated control BMSCs. CircPVT1 overexpression promoted BMSC differentiation and proliferation and inhibited apoptosis in the GC-treated model. 592 33737085 The mechanism of aerobic exercise combined with glucosamine therapy and circUNK in improving knee osteoarthritis in rabbits. hsa_circ_0045714 CircUNK hsa_circ_UNK UNK Homo sapiens knee osteoarthritis MONDO:0005416 "osteoarthritis, knee" MIA-induced rabbit chondrocytes down-regulated "In primary rabbit chondrocytes, MIA-induced osteoarthritis modeling significantly inhibited circUNK expression compared with normal chondrocytes. Overexpressed circUNK alleviated MIA-induced effects on chondrocyte viability, apoptosis, and cartilage differentiation-related molecules." 593 33737085 The mechanism of aerobic exercise combined with glucosamine therapy and circUNK in improving knee osteoarthritis in rabbits. CircUNK UNK Oryctolagus cuniculus knee osteoarthritis MONDO:0005416 "osteoarthritis, knee" MIA-induced rabbit chondrocytes down-regulated "In primary rabbit chondrocytes, MIA-induced osteoarthritis modeling significantly inhibited circUNK expression compared with normal chondrocytes. Overexpressed circUNK alleviated MIA-induced effects on chondrocyte viability, apoptosis, and cartilage differentiation-related molecules." 594 33751650 CircSEC24A promotes IL-1¦Â-induced apoptosis and inflammation in chondrocytes by regulating miR-142-5p/SOX5 axis. hsa_circ_0005105 hsa_circ_SEC24A SEC24A Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 OA chondrocytes up-regulated "circSEC24A was up-regulated in isolated OA chondrocytes compared with normal chondrocytes, measured by qRT-PCR after primary chondrocyte isolation. Functional experiments in chondrocytes linked circSEC24A to reduced proliferation and increased apoptosis and inflammation." 595 33751650 CircSEC24A promotes IL-1¦Â-induced apoptosis and inflammation in chondrocytes by regulating miR-142-5p/SOX5 axis. hsa_circ_0005105 hsa_circ_SEC24A SEC24A Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 IL-1¦Â-treated chondrocytes up-regulated circSEC24A was up-regulated in IL-1¦Â-treated primary chondrocytes compared with untreated control chondrocytes. Overexpression of circSEC24A aggravated IL-1¦Â-induced chondrocyte injury by decreasing proliferation and increasing apoptosis and inflammatory cytokine expression. 596 33799408 Circular RNA UVRAG Mediated by Alternative Splicing Factor NOVA1 Regulates Adhesion and Migration of Vascular Smooth Muscle Cells. rno_circ_Uvrag Uvrag Rattus norvegicus vein graft disease MONDO:0004634 vein disorder DOID:866 VSMCs down-regulated "In primary rat VSMCs, circUVRAG was detected by FISH and qPCR, and siRNA targeting the back-splicing junction reduced circUVRAG expression by 70%. Knockdown of circUVRAG decreased VSMC adhesion and migration." 597 33824287 CircHIPK3 regulates the autophagy and apoptosis of hypoxia/reoxygenation-stimulated cardiomyocytes via the miR-20b-5p/ATG7 axis. mmu_circ_HIPK3 HIPK3 Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury cardiomyocytes up-regulated circHIPK3 is up-regulated in primary mouse cardiomyocytes after hypoxia/reoxygenation stimulation. Functional experiments in cardiomyocytes showed that circHIPK3 promotes H/R-induced apoptosis via the miR-20b-5p/ATG7 axis. 598 33858489 The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway. hsa_circ_0027068 hsa_circ_ATP5B ATP5B Homo sapiens glioma MONDO:0021042 glioma patient-derived primary GSCs up-regulated "In patient-derived primary glioma stem cells, circATP5B expression was higher in WHO grade IV GSCs than in grade III and grade II GSCs. Functional assays in GSCs showed that circATP5B promoted GSC proliferation." 599 33859754 Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A3. hsa_circ_0030042 hsa_circ_FOXO1 FOXO1 Homo sapiens coronary heart disease MONDO:0005010 coronary artery disorder DOID:3393 endothelial cells up-regulated "hsa_circ_0030042 was enriched in endothelial cells compared with other vascular cell types, and FISH in human coronary artery showed primary localization in endothelial cells." 600 33859754 Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A3. hsa_circ_0030042 hsa_circ_FOXO1 FOXO1 Homo sapiens coronary heart disease MONDO:0005010 coronary artery disorder DOID:3393 HUVECs down-regulated "In HUVEC endothelial cells, ox-LDL treatment reduced hsa_circ_0030042 expression. Overexpression experiments showed that hsa_circ_0030042 mitigated ox-LDL-induced autophagosome accumulation and reduced Annexin V-positive cells." 601 33864191 "Circular RNA_0000190 and its target microRNA-767-5p are dysregulated, and they are related to risk stratification as well as prognosis in multiple myeloma patients." hsa_circ_0000190 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 plasma cells down-regulated CD138-coated magnetic bead-purified plasma cells from bone marrow samples were analyzed by RT-qPCR. circ_0000190 was decreased in plasma cells from multiple myeloma patients compared with healthy donors. 602 33868781 Circular RNA circMYBPC1 promotes skeletal muscle differentiation by targeting MyHC. circRNA0007120 bta_circ_MYBPC1 MYBPC1 Bos taurus others others others bovine primary myoblasts up-regulated "circMYBPC1 expression is higher in differentiated bovine myoblasts than in proliferating myoblasts, based on qRT-PCR after primary muscle cell isolation. Functional experiments in bovine primary myoblasts support a role in muscle cell differentiation." 603 33875631 Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts. hsa_circ_0021739 Homo sapiens postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis PBMCs down-regulated hsa_circ_0021739 was significantly down-regulated in isolated PBMCs from patients with postmenopausal osteoporosis compared with controls. 604 33875631 Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts. hsa_circ_0019693 Homo sapiens postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis PBMCs no change hsa_circ_0019693 showed no significant expression difference in isolated PBMCs between postmenopausal osteoporosis patients and controls by RT-qPCR. 605 33875631 Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts. hsa_circ_0013121 Homo sapiens postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis PBMCs no change hsa_circ_0013121 showed no significant expression difference in isolated PBMCs between postmenopausal osteoporosis patients and controls by RT-qPCR. 606 33875631 Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts. hsa_circ_0002332 Homo sapiens postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis PBMCs no change hsa_circ_0002332 showed no significant expression difference in isolated PBMCs between postmenopausal osteoporosis patients and controls by RT-qPCR. 607 33875631 Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts. hsa_circ_0021739 Homo sapiens postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis osteoclasts down-regulated "During monocyte-derived osteoclast differentiation, hsa_circ_0021739 expression visibly decreased. Overexpression of hsa_circ_0021739 reduced osteoclast formation, supporting a role in differentiation." 608 33880592 Hsa_circ_0010957 level is increased and sponges microRNA_125b in CD4+ T cells of patients with systemic lupus erythematosus. hsa_circ_0010957 hsa_circ_SEPN1 SEPN1 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4+ T cells up-regulated "hsa_circ_0010957 is up-regulated in sorted CD4+ T cells from patients with SLE compared with healthy individuals, as assessed by RT-qPCR. Functional experiments in CD4+ T cells support involvement in inflammatory cytokine secretion via miR-125b/STAT3 signaling." 609 33880592 Hsa_circ_0010957 level is increased and sponges microRNA_125b in CD4+ T cells of patients with systemic lupus erythematosus. hsa_circ_0010957 hsa_circ_SEPN1 SEPN1 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4+ T cells up-regulated "hsa_circ_0010957 expression differs in sorted CD4+ T cells between active and inactive SLE, supporting association with disease activity. Functional experiments in CD4+ T cells support involvement in inflammatory cytokine secretion via miR-125b/STAT3 signaling." 610 33884524 LLLI promotes BMSC proliferation through circRNA_0001052/miR-124-3p. circRNA_0001052 Mus musculus Osteoporosis MONDO:0005298 osteoporosis DOID:11476 BMSCs down-regulated "In primary mouse BMSCs, circRNA_0001052 expression was detected by RT-PCR and decreased after LLLI treatment. Functional experiments indicate circRNA_0001052 regulates BMSC proliferation through the miR-124-3p/Wnt4/¦Â-catenin pathway." 611 33885378 circACTA2 mediates Ang II-induced VSMC senescence by modulation of the interaction of ILF3 with CDK4 mRNA. circACTA2 hsa_circ_ACTA2 ACTA2 Homo sapiens hypertension MONDO:0005044 hypertensive disorder DOID:10763 VSMCs up-regulated circACTA2 is up-regulated in Ang II-stimulated vascular smooth muscle cells relative to vehicle-treated controls. Functional experiments in VSMCs showed that circACTA2 knockdown reduced Ang II-induced VSMC senescence. 612 33901012 Construction and topological analysis of an endometriosis-related exosomal circRNA-miRNA-mRNA regulatory network. hsa_circ_0026129 Homo sapiens endometriosis MONDO:0005133 endometriosis DOID:289 endometrial stromal cells dys-regulated "circ_0026129 was detected as a differentially expressed exosomal circRNA in endometrial stromal cell-derived exosomes from endometriosis patients compared with controls, and its expression was validated by RT-PCR." 613 33924932 The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells. hsa_circ_0087960 hsa_circ_LPAR1 LPAR1 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 human periodontal ligament stem cells (hPDLSCs) up-regulated hsa_circ_0087960 was increased in exosomes from hPDLSCs during osteogenic differentiation and was linked to miRNA-sponging pathways relevant to osteogenesis. 614 33924932 The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells. hsa_circ_0000437 hsa_circ_CORO1C CORO1C Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 human periodontal ligament stem cells (hPDLSCs) up-regulated hsa_circ_0000437 was up-regulated in hPDLSCs during osteogenic differentiation based on RNA sequencing and RT-qPCR evidence. 615 33924932 The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells. hsa_circ_0001946 CDR1as Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 hPDLSCs up-regulated "CDR1as/hsa_circ_0001946 was enhanced during osteogenic differentiation of primary hPDLSCs and affected osteogenesis through miR-7, TGF-¦Â/Smad and MAPK-related pathways." 616 33924932 The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells. circNCOA3 hsa_circ_NCOA3 NCOA3 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 hPDLSCs up-regulated "circNCOA3 was increased in primary hPDLSCs after osteogenic induction, with proposed roles in circRNA-miRNA-mRNA networks during osteogenesis." 617 33924932 The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells. hsa_circ_0124534 circRNA124534 hsa_circ_FRMD4B FRMD4B Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 human dental pulp stem cells (hDPSCs) up-regulated circRNA124534/hsa_circ_0124534 increased during osteogenic differentiation of primary hDPSCs and promoted osteogenesis via the miR-496/¦Â-catenin axis. 618 33924932 The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells. hsa_circ_0026827 hsa_circ_RPL41 RPL41 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 hDPSCs up-regulated hsa_circ_0026827 was increased in osteogenic differentiated hDPSCs and promoted osteoblastic differentiation through miR-188-3p-related targets. 619 33924932 The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells. hsa_circ_0003611 circLPAR1 hsa_circ_LPAR1 LPAR1 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 hDPSCs up-regulated Exosomal hsa_circ_0003611/circLPAR1 increased during hDPSC osteogenesis and promoted osteogenic differentiation by interacting with hsa-miR-31. 620 33924932 The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells. circSIPA1L1 hsa_circ_SIPA1L1 SIPA1L1 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 hDPSCs up-regulated circSIPA1L1 was upregulated during osteogenic differentiation of primary hDPSCs and promoted osteogenesis via the miR-617/Smad3 pathway. 621 33924932 The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells. circFgfr2 rno_circ_Fgfr2 Fgfr2 Rattus norvegicus periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 rat dental follicle cells (rDFCs) up-regulated circFgfr2 was upregulated in primary rat dental follicle cells during osteogenic differentiation and promoted osteogenic differentiation via the miR-133/BMP6 pathway. 622 33951696 Circular RNA circ_0010729 Knockdown Attenuates Oxygen-Glucose Deprivation-Induced Human Cardiac Myocytes Injury by miR-338-3p/CALM2 Axis. hsa_circ_0010729 circ_0010729 hsa_circ_HSPG2 HSPG2 Homo sapiens cardiovascular disease MONDO:0004995 cardiovascular disorder DOID:1287 primary cardiac myocytes up-regulated circ_0010729 was increased in primary cardiac myocytes after OGD treatment compared with normoxic control conditions. Knockdown of circ_0010729 mitigated OGD-induced viability suppression and promotion of apoptosis and autophagy in primary cardiac myocytes. 623 33959635 "Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells." hsa_circ_0025992 Homo sapiens preeclampsia MONDO:0005081 preeclampsia DOID:10591 HUVECs down-regulated "hsa_circ_0025992 was validated by qRT-PCR in primary HUVECs from PE patients and normal pregnancies, and the selected genes were decreased in HUVECs from the PE group." GSE165324 624 33959635 "Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells." hsa_circ_0090396 Homo sapiens preeclampsia MONDO:0005081 preeclampsia DOID:10591 HUVECs down-regulated "hsa_circ_0090396 was validated by qRT-PCR in primary HUVECs from PE patients and normal pregnancies, and the selected genes were decreased in HUVECs from the PE group." GSE165324 625 33959635 "Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells." hsa_circ_0066955 Homo sapiens preeclampsia MONDO:0005081 preeclampsia DOID:10591 HUVECs down-regulated "hsa_circ_0066955 was validated by qRT-PCR in primary HUVECs from PE patients and normal pregnancies, and the selected genes were decreased in HUVECs from the PE group." GSE165324 626 33959635 "Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells." hsa_circ_0041203 Homo sapiens preeclampsia MONDO:0005081 preeclampsia DOID:10591 HUVECs down-regulated "hsa_circ_0041203 was validated by qRT-PCR in primary HUVECs from PE patients and normal pregnancies, and the selected genes were decreased in HUVECs from the PE group." GSE165324 627 33959635 "Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells." hsa_circ_0018116 Homo sapiens preeclampsia MONDO:0005081 preeclampsia DOID:10591 HUVECs down-regulated "hsa_circ_0018116 was validated by qRT-PCR in primary HUVECs from PE patients and normal pregnancies, and the selected genes were decreased in HUVECs from the PE group." GSE165324 628 33960555 CircSLC7A2 protects against osteoarthritis through inhibition of the miR-4498/TIMP3 axis. hsa_circ_0005805 hsa_circSLC7A2_010 hsa_circ_SLC7A2 SLC7A2 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human chondrocytes down-regulated circSLC7A2 expression was confirmed in human chondrocytes and was reduced after FUS knockdown in HC cells by RT-qPCR. Functional experiments in chondrocytes linked circSLC7A2 loss to inflammatory responses and apoptosis in the osteoarthritis context. 629 33964939 CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis. hsa_circ_0083964 hsa_circ_ASH2L ASH2L Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA fibroblast-like synoviocytes (RA-FLSs) up-regulated "FACS-separated RA-FLSs showed elevated circASH2L expression compared with normal FLSs by qRT-PCR. circASH2L knockdown suppressed RA-FLS proliferation, migration, invasion, and inflammation and promoted apoptosis." 630 33971492 CircATRNL1 protects against osteoarthritis by targeting miR-153-3p and KLF5. hsa_circ_ATRNL1 ATRNL1 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes down-regulated circATRNL1 was decreased in IL-1¦Â-treated human chondrocytes compared with normal chondrocytes in an in vitro osteoarthritis model. Functional experiments in chondrocytes indicated that circATRNL1 overexpression attenuated IL-1¦Â-induced apoptosis and ECM degradation. 631 33975612 Circular RNA circ_0128846 promotes the progression of osteoarthritis by regulating miR-127-5p/NAMPT axis. hsa_circ_0128846 hsa_circ_ZFR ZFR Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 OA chondrocytes down-regulated "In primary OA chondrocytes, siRNA treatment reduced circ_0128846 expression compared with si-NC. Circ_0128846 knockdown was associated with increased cell viability and reduced apoptosis, inflammation, and ECM degradation in OA chondrocytes." 632 33995660 CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction. mmu_circ_0001572 mmu_circ_Ube3a Ube3a Mus musculus acute myocardial infarction MONDO:0004781 acute myocardial infarction DOID:9408 M2 macrophages (M2Ms) up-regulated "circUbe3a was elevated in M2 macrophage-derived small extracellular vesicles compared with M0 macrophage-derived small extracellular vesicles, based on circRNA microarray screening and RT-qPCR confirmation after primary macrophage isolation and polarization. Functional experiments supported that M2M-SEV-derived circUbe3a mediates communication with cardiac fibroblasts and promotes fibrosis-related fibroblast changes." 633 34017077 FMR1/circCHAF1A/miR-211-5p/HOXC8 feedback loop regulates proliferation and tumorigenesis via MDM2-dependent p53 signaling in GSCs. hsa_circ_0000876 hsa_circ_CHAF1A CHAF1A Homo sapiens glioblastoma MONDO:0018177 glioblastoma DOID:3068 glioma stem cells (GSCs) up-regulated "Patient-derived TP53wt GBM glioma stem cells were isolated and purified, and qPCR showed circCHAF1A expression was higher in GSCs than in differentiated GSCs. Functional experiments in GSCs supported roles in proliferation and self-renewing capacity." 634 34027234 Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis. circRNA3503 hsa_circ_ZNF430 ZNF430 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated RNA-seq of rRNA-depleted total RNA from chondrocytes showed that circRNA3503 was increased after melatonin-induced cell sleep. The study further indicates that circRNA3503 helps maintain cartilage homeostasis in osteoarthritis-related chondrocyte models. 635 34027234 Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis. circRNA3503 hsa_circ_ZNF430 ZNF430 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes down-regulated "In an osteoarthritis-related inflammatory chondrocyte model, TNF-¦Á or IL-1¦Â treatment inhibited circRNA3503 expression. Functional experiments showed that circRNA3503 overexpression rescued IL-1¦Â-induced apoptosis and ECM-related changes in chondrocytes." 636 34035858 circSKIL promotes the ossification of cervical posterior longitudinal ligament by activating the JNK/STAT3 pathway. hsa_circ_SKIL SKIL Homo sapiens ossification of the posterior longitudinal ligament MONDO:0011230 ossification of the posterior longitudinal ligament of the spine DOID:0060887 primary cervical posterior longitudinal ligament cells up-regulated circSKIL was significantly up-regulated in primary cervical posterior longitudinal ligament cells from OPLL patients compared with control ligament cells. Functional experiments in these primary ligament cells linked circSKIL to proliferation and osteogenic differentiation through the JNK/STAT3 pathway. 637 34052126 Preventing alloimmune rejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation. mmu_circ_FSCN1 FSCN1 Mus musculus alloimmune rejection MONDO:1010185 transplant rejection mDCs up-regulated "In mouse bone marrow-derived dendritic cells, circFSCN1 was higher in mature/LPS-stimulated DCs than in immature immunosuppressant-treated DC states. Functional experiments showed that circFSCN1 knockdown induced immunosuppressive DCs that reduced T-cell activation and promoted Treg induction in heart transplantation rejection models." 638 34058990 CircHYBID regulates hyaluronan metabolism in chondrocytes via hsa-miR-29b-3p/TGF-¦Â1 axis. hsa_circ_0003893 hsa_circ_KIAA1199 KIAA1199 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary chondrocytes down-regulated "In isolated primary chondrocytes, IL-1¦Â stimulation used to model OA reduced circHYBID expression as measured by qRT-PCR. Functional experiments in the same chondrocyte system showed that circHYBID overexpression increased HA accumulation and modulated HYBID, HAS2, and inflammatory factor expression." 639 34074294 The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway. hsa_circ_0004104 circSPARC hsa_circ_SPARC SPARC Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 epithelial marker E-Cadherin up-regulated circSPARC/hsa_circ_0004104 was co-localized with the epithelial marker E-Cadherin by FISH-IF and showed higher expression in colorectal cancer tumour tissue than adjacent non-tumoral tissue. 640 34097558 Hsa_circ_0044235 regulates the pyroptosis of rheumatoid arthritis via MiR-135b-5p-SIRT1 axis. hsa_circ_0044235 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 Fibroblast-like synoviocytes (FLSs) down-regulated "In extracted fibroblast-like synoviocytes, LPS/ATP treatment reduced hsa_circ_0044235 expression by RT-qPCR, while hsa_circ_0044235 overexpression inhibited caspase-1 content and the NLRP3-mediated pyroptosis pathway." 641 34098776 Gastric Cancer Cell-Derived Exosomes Can Regulate the Biological Functions of Mesenchymal Stem Cells by Inducing the Expression of Circular RNA circ_0004303. hsa_circ_0004303 hsa_circ_DDX60 DDX60 Homo sapiens gastric cancer MONDO:0001056 gastric cancer DOID:10534 human adipose-derived MSCs up-regulated "In primary human adipose-derived MSCs, AGS gastric cancer cell-derived exosome treatment increased hsa_circ_0004303 expression as verified by qRT-PCR and microarray analysis. Functional assays in these MSCs showed that circ_0004303 promoted migration and invasion via the miR-148a-3p/ALCAM axis." 642 34100377 "circ-PTTG1IP/miR-671-5p/TLR4 axis regulates proliferation, migration, invasion and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis." hsa_circ_0001200 hsa_circ_PTTG1IP PTTG1IP Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 fibroblast-like synoviocytes from RA patients (RA-FLSs) up-regulated "circ-PTTG1IP was up-regulated in fibroblast-like synoviocytes from rheumatoid arthritis patients compared with normal fibroblast-like synoviocytes, as measured by RT-qPCR. Knockdown experiments in RA-FLSs linked circ-PTTG1IP to proliferation, apoptosis, migration, invasion and inflammatory response." 643 34100450 Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury. circPrkcsh mmu_circ_Prkcsh Prkcsh Mus musculus spinal cord injury MONDO:0043797 spinal cord injury primary mouse astrocytes up-regulated circPrkcsh expression was elevated in TNF-¦Á-treated primary mouse astrocytes used to simulate the inflammatory response after spinal cord injury. circPrkcsh knockdown reduced inflammatory cytokine secretion in these astrocytes. 644 34116030 Circular RNA CircHIPK3 Promotes Homeostasis of the Intestinal Epithelium by Reducing MicroRNA 29b Function. circHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens Crohn's disease MONDO:0005011 Crohn disease DOID:8778 epithelial cells down-regulated "RNA-FISH showed circHIPK3 predominantly in intestinal epithelial cells, and circHIPK3-FITC intensity was decreased in Crohn¡¯s disease mucosal tissue compared with controls." 645 34116030 Circular RNA CircHIPK3 Promotes Homeostasis of the Intestinal Epithelium by Reducing MicroRNA 29b Function. circHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens ulcerative colitis MONDO:0005101 ulcerative colitis DOID:8577 epithelial cells down-regulated "RNA-FISH showed circHIPK3 predominantly in intestinal epithelial cells, and circHIPK3-FITC intensity was decreased in ulcerative colitis mucosal tissue compared with controls." 646 34116030 Circular RNA CircHIPK3 Promotes Homeostasis of the Intestinal Epithelium by Reducing MicroRNA 29b Function. circHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 epithelial cells down-regulated "RNA-FISH showed circHIPK3 predominantly in intestinal epithelial cells, and circHIPK3-FITC intensity was decreased in sepsis mucosal tissue compared with controls." 647 34117589 Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis. hsa_circ_0075503 hsa_circ_SLC22A23 SLC22A23 Homo sapiens endometriosis MONDO:0005133 endometriosis DOID:289 ectopic ESCs up-regulated circ_0075503 was up-regulated in primary ectopic endometrial stromal cells compared with eutopic cells from patients with endometriosis. 648 34117589 Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis. hsa_circ_0075503 hsa_circ_SLC22A23 SLC22A23 Homo sapiens endometriosis MONDO:0005133 endometriosis DOID:289 eutopic ESCs up-regulated circ_0075503 was up-regulated in primary eutopic endometrial stromal cells after E2 treatment. Knockdown of circ_0075503 inhibited E2-induced migration and invasion in these cells. 649 34120145 Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress. hsa_circ_0032138 hsa_circ_HIF1A HIF1A Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 cancer-associated fibroblasts (CAFs) up-regulated circHIF1A was significantly up-regulated in exosomes from hypoxic breast cancer CAFs compared with normoxic CAFs. Functional experiments showed that hypoxic CAF exosomal circHIF1A promoted breast cancer cell proliferation and stemness via miR-580-5p/CD44. 650 34132637 circPTPN12/miR-21-5 p/_Np63¦Á pathway contributes to human endometrial fibrosis. hsa_circ_0003764 circPTPN12 hsa_circ_PTPN12 PTPN12 Homo sapiens endometrial fibrosis MONDO:0000931 endometrial disorder DOID:1005 endometrial epithelial cells (EECs) up-regulated "hsa_circ_0003764, termed circPTPN12, is significantly up-regulated in IUA-associated fibrotic endometrium and is mainly expressed in endometrial epithelial cells by RNA-scope assay. Functional experiments in EECs support that circPTPN12 promotes EEC-EMT through the miR-21-5p/¦¤Np63¦Á pathway." GSE165321 651 34145212 Circular RNA AFF4 modulates osteogenic differentiation in BM-MSCs by activating SMAD1/5 pathway through miR-135a-5p/FNDC5/Irisin axis. hsa_circ_AFF4 AFF4 Homo sapiens bone formation-related diseases MONDO:0005076 periodontitis DOID:824; DOID:9893 BM-MSCs up-regulated "In human BM-MSC primary cell culture, circ_AFF4 was markedly upregulated during osteogenic differentiation induction compared with non-induced conditions. Functional experiments showed that circ_AFF4 knockdown inhibited osteogenic differentiation potential in BM-MSCs." 652 34154526 Circular RNA mmu_circ_0005019 inhibits fibrosis of cardiac fibroblasts and reverses electrical remodeling of cardiomyocytes. mmu_circ_0005019 Mus musculus atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 cardiac fibroblasts up-regulated "In primary mouse cardiac fibroblasts, mmu_circ_0005019 was experimentally overexpressed and confirmed by qRT-PCR. Overexpression inhibited cardiac fibroblast proliferation and migration." 653 34154526 Circular RNA mmu_circ_0005019 inhibits fibrosis of cardiac fibroblasts and reverses electrical remodeling of cardiomyocytes. mmu_circ_0005019 Mus musculus atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 cardiac fibroblasts down-regulated "In primary mouse cardiac fibroblasts, mmu_circ_0005019 was knocked down with siRNAs and confirmed by qRT-PCR. Knockdown promoted cardiac fibroblast migration." 654 34154607 CircMAPK9 promotes the progression of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-140-3p/PPM1A axis. hsa_circ_0001566 circMAPK9 hsa_circ_MAPK9 MAPK9 Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 FLSs from RA patients (RA-FLSs) up-regulated "circMAPK9 is up-regulated in fibroblast-like synoviocytes from rheumatoid arthritis patients compared with FLSs from normal subjects, based on qRT-PCR after primary cell isolation/culture. Functional experiments in RA-FLSs showed that circMAPK9 knockdown suppressed proliferation, migration, invasion and inflammatory response and promoted apoptosis." 655 34157123 NOVA2 regulates neural circRNA biogenesis. circ0015034 mmu_circ_Efnb2 Efnb2 Mus musculus NOVA2 deficiency MONDO:0000001 disease DOID:4 excitatory cortical neurons down-regulated circEfnb2 was identified as a NOVA2-regulated circRNA reduced in NOVA2-deficient FACS-sorted Emx1+ excitatory cortical neurons by RNA-seq circRNA analysis. GSE103316 656 34157123 NOVA2 regulates neural circRNA biogenesis. circ0015034 mmu_circ_Efnb2 Efnb2 Mus musculus NOVA2 deficiency MONDO:0000001 disease DOID:4 inhibitory cortical neurons down-regulated circEfnb2 was identified as a NOVA2-regulated circRNA reduced in NOVA2-deficient FACS-sorted Gad2+ inhibitory cortical neurons by RNA-seq circRNA analysis. GSE103316 657 34158864 Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer. hsa_circ_0007444 hsa_circ_RHOBTB3 RHOBTB3 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 CAFs and NFs no change Primary cancer-associated fibroblasts from CRC tissues and normal fibroblasts from paired adjacent tissues showed no significant difference in circRHOBTB3 expression. 658 34193158 Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis. hsa_circ_HIPK3 HIPK3 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated "Primary mouse chondrocytes showed increased circHIPK3 expression after co-culture with MSC-derived extracellular vesicles, as measured by qRT-PCR. MSCs-circHIPK3-EVs promoted chondrocyte proliferation and migration and suppressed apoptosis in osteoarthritis-related chondrocyte injury models." 659 34193158 Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis. mmu_circ_Hipk3 Hipk3 Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated "Primary mouse chondrocytes showed increased circHIPK3 expression after co-culture with MSC-derived extracellular vesicles, as measured by qRT-PCR. MSCs-circHIPK3-EVs promoted chondrocyte proliferation and migration and suppressed apoptosis in osteoarthritis-related chondrocyte injury models." 660 34197029 Silencing of circTASP1 inhibits proliferation and induces apoptosis of acute myeloid leukaemia cells through modulating miR-515-5p/HMGA2 axis. hsa_circ_0007340 hsa_circRNA_406083 hsa_circ_TASP1 TASP1 Homo sapiens acute myeloid leukemia MONDO:0018874 acute myeloid leukemia DOID:9119 CD34+ cells up-regulated circTASP1 was up-regulated in isolated CD34+ cells from peripheral blood of patients with AML compared with healthy individuals. 661 34237642 Cadmium promotes apoptosis and inflammation via the circ08409/miR-133a/TGFB2 axis in bovine mammary epithelial cells and mouse mammary gland. circ08409 Bos taurus cadmium damage MONDO:0043523 cadmium poisoning bovine mammary epithelial cells (BMECs) up-regulated "In bovine mammary epithelial cells, circ08409 expression was higher after cadmium treatment than in the blank group. Functional assays in BMECs showed that circ08409 increased apoptosis, reduced proliferation-related readouts, and altered inflammatory factor expression via the miR-133a/TGFB2 axis." 662 34256841 Exosome-transported circRNA_0001236 enhances chondrogenesis and suppress cartilage degradation via the miR-3677-3p/Sox9 axis. hsa_circ_0001236 hsa_circ_ZC3H7B ZC3H7B Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human bone marrow-derived MSCs (hMSCs) up-regulated Exosomal circ_0001236 was up-regulated in exosomes from chondro-differentiated primary hMSCs compared with undifferentiated MSC exosomes. Functional experiments indicated that exosomal circ_0001236 promoted chondrogenic differentiation through the miR-3677-3p/Sox9 axis. 663 34256841 Exosome-transported circRNA_0001236 enhances chondrogenesis and suppress cartilage degradation via the miR-3677-3p/Sox9 axis. hsa_circ_0001236 hsa_circ_ZC3H7B ZC3H7B Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes down-regulated "circ_0001236 was detected in human chondrocytes and showed lower expression in OA cartilage-associated chondrocyte context than in normal chondrocytes. In OA chondrocytes, exosomal circ_0001236 promoted cartilage-related matrix expression and maintained cartilage function." 664 34257163 CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9. circFUT10 mmu_circ_FUT10 FUT10 Mus musculus degenerative muscle disease MONDO:0000001 disease DOID:4 SkMSCs up-regulated circRNA FUT10 is up-regulated in aged mouse skeletal muscle stem cells compared with adult skeletal muscle stem cells after isolation by flow cytometry/FACS and qRT-PCR validation. Functional experiments in SkMSCs showed that circRNA FUT10 suppresses proliferation and differentiation. 665 34258151 circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation. hsa_circ_0001461 hsa_circ_FAT1 FAT1 Homo sapiens head and neck squamous cell carcinoma / HNSCC MONDO:0010150 head and neck squamous cell carcinoma DOID:5520 ALDHhigh CSCs; EpCAM+ALDHhigh CSCs up-regulated circFAT1 is up-regulated in ALDHhigh or EpCAM+ALDHhigh HNSCC cancer stem cell populations compared with ALDHlow nonstem tumor cells based on sorted-cell qRT-PCR. circFAT1 knockdown reduced stemness-related gene expression and tumorsphere/tumorigenic potential in these CSC populations. 666 34262589 Analysis of Age-Related Circular RNA Expression Profiles in Mesenchymal Stem Cells of Rat Bone Marrow. rno_circ_Phldb2 Phldb2 Rattus norvegicus age-associated MSC senescence others others bone marrow MSCs up-regulated "Circ-Phldb2 was significantly up-regulated in senescent MSCs isolated from old rat bone marrow compared with young rat MSCs, validated by RT-qPCR after high-throughput circRNA sequencing." SUB9796502; SRP322768; PRJNA735212 667 34262589 Analysis of Age-Related Circular RNA Expression Profiles in Mesenchymal Stem Cells of Rat Bone Marrow. rno_circ_Mdm2 Mdm2 Rattus norvegicus age-associated MSC senescence others others bone marrow MSCs down-regulated "circ-Mdm2 was down-regulated in senescent MSCs isolated from old rat bone marrow compared with young rat MSCs, validated by RT-qPCR after high-throughput circRNA sequencing." SUB9796502; SRP322768; PRJNA735212 668 34262589 Analysis of Age-Related Circular RNA Expression Profiles in Mesenchymal Stem Cells of Rat Bone Marrow. circ-Rab31 rno_circ_Rab31 Rab31 Rattus norvegicus age-associated MSC senescence others others bone marrow MSCs down-regulated "circ-Rab31 was down-regulated in senescent MSCs isolated from old rat bone marrow compared with young rat MSCs, validated by RT-qPCR after high-throughput circRNA sequencing." SUB9796502; SRP322768; PRJNA735212 669 34262589 Analysis of Age-Related Circular RNA Expression Profiles in Mesenchymal Stem Cells of Rat Bone Marrow. Circ-Cd2ap rno_circ_Cd2ap Cd2ap Rattus norvegicus age-associated MSC senescence others others bone marrow MSCs down-regulated "Circ-Cd2ap was down-regulated by RT-qPCR in senescent MSCs isolated from old rat bone marrow compared with young rat MSCs, although the authors noted a conflict with high-throughput sequencing results." SUB9796502; SRP322768; PRJNA735212 670 34263675 Circular RNA circZNF652 is overexpressed in osteoarthritis and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN. hsa_circ_ZNF652 ZNF652 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated "In primary chondrocytes used as an OA cell model, circZNF652 expression increased after LPS treatment in a dose-dependent manner by RT-qPCR. Functional assays further showed that circZNF652 positively regulated LPS-induced apoptosis of chondrocytes." 671 34276603 Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs. vIRF4 Human herpesvirus 8 / KSHV KSHV infection MONDO:0005550 infectious disease DOID:0050117 primary vascular and lymphatic endothelial cells (LECs) down-regulated KSHV circvIRF4 was analyzed in de novo infected primary LECs by RNA-seq-based circRNA detection and was lower than in the KSHV-positive patient lymph node sample. PRJEB31253 672 34276603 Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs. circT0.7 T0.7 Human herpesvirus 8 / KSHV KSHV infection MONDO:0005550 infectious disease DOID:0050117 LECs up-regulated "KSHV circT0.7 was detected in primary LECs after de novo KSHV infection, increasing with viral dose by RT-ddPCR." 673 34276603 Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs. circORF72 ORF72 Human herpesvirus 8 / KSHV KSHV infection MONDO:0005550 infectious disease DOID:0050117 LECs up-regulated "KSHV circORF72 was detected in primary LECs after de novo KSHV infection, increasing with viral dose by RT-ddPCR." 674 34276603 Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs. PAN Human herpesvirus 8 / KSHV KSHV infection MONDO:0005550 infectious disease DOID:0050117 LECs up-regulated "KSHV circK7/PAN was detected as many BSJ reads in infected primary LECs by RNA-seq-based circRNA analysis, and circPAN was also quantified in infected primary LECs by RT-ddPCR." PRJEB31253 675 34276603 Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs. hsa_circ_0001400 hsa_circ_RELL1 RELL1 Homo sapiens KSHV infection MONDO:0005550 infectious disease DOID:0050117 primary endothelial cells (HUVECs) up-regulated "Human hsa_circ_0001400/circRELL1 was reported as highly upregulated in KSHV-infected primary endothelial cells compared with non-infected primary endothelial cells, based on RNase R-treated sequencing analysis." GSE120045 676 34326381 Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit. circPTK2 hsa_circ_PTK2 PTK2 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 M2 macrophages up-regulated "circPTK2 was enriched in M2-like macrophage subpopulations isolated from NSCLC patient samples, with enrichment observed in primary lung and metastatic lymph node/blood regions." 677 34326381 Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit. circHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 M2 macrophages up-regulated circHIPK3 expression was described as mainly M2-related in macrophage-associated regions of NSCLC patient tumors. 678 34326381 Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit. circHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 M1 macrophages up-regulated circHIPK3 showed augmented expression in M1 macrophages and was co-expressed in M1/M2 macrophage subpopulations isolated from NSCLC patient samples. 679 34330307 Circ_0025908 regulates cell vitality and proliferation via miR-137/HIPK2 axis of rheumatic arthritis. hsa_circ_0025908 circ_0025908 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 FLS-RA cell up-regulated "circ_0025908 was upregulated in FLS-RA cells compared with FLS-Normal cells, based on qRT-PCR after isolation of cells from RA and normal samples. In FLS-RA cells, circ_0025908 knockdown affected viability, proliferation, apoptosis, and inflammatory cytokine production." 680 34345300 Upregulation of circular and linear METTL3 and USP3 in colorectal cancer. hsa_circ_0000523 hsa_circ_METTL3 METTL3 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 leukocytes up-regulated "circMETTL3 was significantly up-regulated in leukocytes from patients with colorectal cancer compared with controls, based on leukocyte RNA extraction followed by RT-qPCR." 681 34345300 Upregulation of circular and linear METTL3 and USP3 in colorectal cancer. hsa_circ_0002138 hsa_circ_USP3 USP3 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 leukocytes up-regulated "circUSP3 was significantly up-regulated in leukocytes from patients with colorectal cancer compared with controls, based on leukocyte RNA extraction followed by RT-qPCR." 682 34363030 The circular RNA circINPP4B acts as a sponge of miR-30a to regulate Th17 cell differentiation during progression of experimental autoimmune encephalomyelitis. circ_3998 / circINPP4B mmu_circ_INPP4B INPP4B Mus musculus experimental autoimmune encephalomyelitis MONDO:0005134 experimental autoimmune encephalomyelitis peripheral blood CD4 + lymphocytes up-regulated "circINPP4B was increased in peripheral blood CD4+ T cells from mice with EAE, with expression rising as EAE severity increased." PRJNA725306; PRJNA725350 683 34363030 The circular RNA circINPP4B acts as a sponge of miR-30a to regulate Th17 cell differentiation during progression of experimental autoimmune encephalomyelitis. circ_3998 / circINPP4B mmu_circ_INPP4B INPP4B Mus musculus experimental autoimmune encephalomyelitis MONDO:0005134 experimental autoimmune encephalomyelitis CD4 + IL-17 + T cells / Ror¦Ãt + Th17 cells up-regulated "circINPP4B was up-regulated in Th17-like CD4+ IL-17+ cells from EAE mice and during in vitro Th17 differentiation, with FISH showing cytoplasmic expression in Ror¦Ãt+ Th17 cells. Functional experiments showed that circINPP4B promoted Th17 differentiation." PRJNA725306; PRJNA725350 684 34375168 CircTYW1 serves as a sponge for microRNA-380 in accelerating neurological recovery following spinal cord injury via regulating FGF9. hsa_circ_0003962 Homo sapiens spinal cord injury MONDO:0043797 spinal cord injury neurons up-regulated RNA-FISH combined with NeuN immunofluorescence showed that circTYW1 was expressed mainly in neurons of rat spinal cord tissues in the context of spinal cord injury research. 685 34375168 CircTYW1 serves as a sponge for microRNA-380 in accelerating neurological recovery following spinal cord injury via regulating FGF9. rno_circ_TYW1 TYW1 Rattus norvegicus spinal cord injury MONDO:0043797 spinal cord injury neurons up-regulated RNA-FISH combined with NeuN immunofluorescence showed that circTYW1 was expressed mainly in neurons of rat spinal cord tissues in the context of spinal cord injury research. 686 34402627 Hsa_circ_0066523 promotes the proliferation and osteogenic differentiation of bone mesenchymal stem cells by repressing PTEN. hsa_circ_0066523 hsa_circ_FOXP1 FOXP1 Homo sapiens osteonecrosis MONDO:0005380 osteonecrosis DOID:0080008; DOID:10159 bone mesenchymal stem cells (BMSCs) up-regulated "hsa_circ_0066523/circFOXP1 expression increases in human BMSCs during osteogenic differentiation induction, as measured by qRT-PCR. Functional assays showed that circ_0066523 supports BMSC proliferation and osteogenic differentiation through PTEN/PI3K/AKT-related mechanisms." 687 34403373 Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF. cia-MAF Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 liver TICs up-regulated "cia-MAF is highly expressed in human liver tumor-initiating cells enriched from HCC primary cells, compared with CD44-negative non-TICs. Functional experiments indicate that cia-MAF promotes liver TIC self-renewal, invasion, tumor initiation, and metastasis." GSE78520 688 34403373 Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF. cia-maf Mus musculus liver cancer MONDO:0002691 liver cancer DOID:3571 mouse liver TICs up-regulated "The mouse homolog cia-maf is increased in CD44-high liver tumor clones and tumor spheres, supporting elevated expression in mouse liver TIC-like cells. cia-maf loss impairs liver TIC sphere formation and tumorigenic self-renewal." 689 34412616 Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214/PD-L1 axis. circEIF3K hsa_circ_EIF3K EIF3K Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 cancer-associated fibroblasts up-regulated "Hypoxia-treated cancer-associated fibroblasts showed increased exosomal circEIF3K by RT-qPCR. CAF-derived circEIF3K-containing exosomes promoted colorectal cancer cell proliferation, invasion, and tube formation in the reported functional assays." 690 34413269 Hsa_circ_0134111 promotes osteoarthritis progression by regulating miR-224-5p/CCL1 interaction. hsa_circ_0134111 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human primary chondrocytes up-regulated "hsa_circ_0134111 is up-regulated in IL-1¦Â-stimulated human primary chondrocytes used to mimic osteoarthritis in vitro. Knockdown of hsa_circ_0134111 in these chondrocytes reverses IL-1¦Â-induced effects on viability, proliferation, and apoptosis." 691 34416901 N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. hsa_circ_0079587 circIGF2BP3 hsa_circ_IGF2BP3 IGF2BP3 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 CD45+ cells down-regulated "Flow-sorted CD45+ immune cells from PBMCs of NSCLC patients were assessed by qPCR, and circIGF2BP3 was lower in these immune cells than in NSCLC cells." 692 34416901 N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. hsa_circ_0079587 circIGF2BP3 hsa_circ_IGF2BP3 IGF2BP3 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 CD3+ cells down-regulated "Flow-sorted CD3+ T cells from PBMCs of NSCLC patients were assessed by qPCR, and circIGF2BP3 was lower in these immune cells than in NSCLC cells." 693 34416901 N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. hsa_circ_0079587 circIGF2BP3 hsa_circ_IGF2BP3 IGF2BP3 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 CD4+ cells down-regulated "Flow-sorted CD4+ T cells from PBMCs of NSCLC patients were assessed by qPCR, and circIGF2BP3 was lower in these immune cells than in NSCLC cells." 694 34416901 N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. hsa_circ_0079587 circIGF2BP3 hsa_circ_IGF2BP3 IGF2BP3 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 CD8+ cells down-regulated "Flow-sorted CD8+ T cells from PBMCs of NSCLC patients were assessed by qPCR, and circIGF2BP3 was lower in these immune cells than in NSCLC cells." 695 34422839 Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma. hsa_circ_0006935 Homo sapiens nasopharyngeal carcinoma / NPC MONDO:0015459 nasopharyngeal carcinoma DOID:9261 T cells up-regulated "hsa_circ_0006935 was among five selected circRNAs assayed by qRT-PCR after isolation of CD4-positive and CD4-negative cells from recurrent nasopharyngeal carcinoma samples, and the five circRNAs were reported to be highly expressed in T cells." 696 34422839 Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma. hsa_circ_0001730 Homo sapiens nasopharyngeal carcinoma / NPC MONDO:0015459 nasopharyngeal carcinoma DOID:9261 T cells up-regulated "hsa_circ_0001730 was among five selected circRNAs assayed by qRT-PCR after isolation of CD4-positive and CD4-negative cells from recurrent nasopharyngeal carcinoma samples, and the five circRNAs were reported to be highly expressed in T cells." 697 34422839 Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma. hsa_circ_0000831 Homo sapiens nasopharyngeal carcinoma / NPC MONDO:0015459 nasopharyngeal carcinoma DOID:9261 T cells up-regulated "hsa_circ_0000831 was among five selected circRNAs assayed by qRT-PCR after isolation of CD4-positive and CD4-negative cells from recurrent nasopharyngeal carcinoma samples, and the five circRNAs were reported to be highly expressed in T cells." 698 34422839 Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma. hsa_circ_0031584 Homo sapiens nasopharyngeal carcinoma / NPC MONDO:0015459 nasopharyngeal carcinoma DOID:9261 T cells up-regulated "hsa_circ_0031584 was among five selected circRNAs assayed by qRT-PCR after isolation of CD4-positive and CD4-negative cells from recurrent nasopharyngeal carcinoma samples, and the five circRNAs were reported to be highly expressed in T cells." 699 34422839 Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma. hsa_circ_0005019 Homo sapiens nasopharyngeal carcinoma / NPC MONDO:0015459 nasopharyngeal carcinoma DOID:9261 T cells up-regulated "hsa_circ_0005019 was among five selected circRNAs assayed by qRT-PCR after isolation of CD4-positive and CD4-negative cells from recurrent nasopharyngeal carcinoma samples, and the five circRNAs were reported to be highly expressed in T cells." 700 34423389 Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis. hsa_circ_0003972 circ-FAM120A hsa_circ_FAM120A FAM120A Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA fibroblast-like synoviocytes (RA-FLSs) up-regulated "circ-FAM120A is up-regulated in RA fibroblast-like synoviocytes compared with control FLSs. Knockdown experiments in RA-FLSs support roles in proliferation, migration, invasion and inflammation." 701 34423389 Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis. hsa_circ_0003972 circ-FAM120A hsa_circ_FAM120A FAM120A Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs down-regulated "Paeoniflorin treatment down-regulates circ-FAM120A expression in RA-FLSs. circ-FAM120A overexpression counteracts paeoniflorin-mediated suppression of RA-FLS proliferation, migration, invasion and inflammatory response." 702 34458003 ceRNA regulatory network of FIH inhibitor as a radioprotector for gastrointestinal toxicity by activating the HIF-1 pathway. circRNA_2909 / Chr6:40713489_40747968_+ / circRNA2909 Mus musculus radiation-induced GI syndrome MONDO:0043459 radiation-induced disorder isolated crypts up-regulated "circRNA_2909 was up-regulated in isolated intestinal crypts from NOFD-pretreated irradiated mice compared with saline-treated irradiated mice, supported by RNA-seq and qRT-PCR validation." PRJNA728840 703 34458003 ceRNA regulatory network of FIH inhibitor as a radioprotector for gastrointestinal toxicity by activating the HIF-1 pathway. circRNA_0323 / Chr10:94043302_94045633_+ / circRNA0323 Mus musculus radiation-induced GI syndrome MONDO:0043459 radiation-induced disorder isolated crypts up-regulated "circRNA_0323 was up-regulated in isolated intestinal crypts from NOFD-pretreated irradiated mice compared with saline-treated irradiated mice, supported by RNA-seq and qRT-PCR validation." PRJNA728840 704 34462830 "Circular RNA circ_0008360 Inhibits the Proliferation, Migration, and Inflammation and Promotes Apoptosis of Fibroblast-Like Synoviocytes by Regulating miR-135b-5p/HDAC4 Axis in Rheumatoid Arthritis." hsa_circ_0008360 circ_0008360 hsa_circ_XPNPEP3 XPNPEP3 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA fibroblastlike synoviocytes (RA-FLSs) down-regulated "circ_0008360 was reduced in primary RA fibroblast-like synoviocytes compared with FLSs from normal subjects, as measured by qRT-PCR after isolation from patient synovial tissues. Functional assays in RA-FLSs showed that circ_0008360 suppressed proliferation, migration, and inflammation and promoted apoptosis." 705 34468254 Circ_nuclear factor I X (circNfix) attenuates pressure overload-induced cardiac hypertrophy via regulating miR-145-5p/ATF3 axis. hsa_circ_0005660 circNfix hsa_circ_Nfix Nfix Homo sapiens cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocytes down-regulated "circNfix expression was significantly downregulated in primary neonatal mouse cardiomyocytes treated with Ang II compared with control cardiomyocytes, as measured by RT-qPCR." 706 34477035 Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties. hsa_circ_0003420 Homo sapiens acute myeloid leukemia MONDO:0018874 acute myeloid leukemia DOID:9119 CD34 _ CD38_ AML cells down-regulated "hsa-circ_0003420 was decreased in CD34+CD38_ AML leukemia stem cells compared with normal hematopoietic stem cells or healthy CD34+CD38_ cells. The study also reports that hsa-circ_0003420 overexpression reduced LSC viability, induced apoptosis, and suppressed the LSC phenotype." 707 34478012 Exosomes Derived from ADSCs Attenuate Sepsis-Induced Lung Injury by Delivery of Circ-Fryl and Regulation of the miR-490-3p/SIRT3 Pathway. mmu_circ_0001356 mmu_circ_Fryl Fryl Mus musculus sepsis-induced lung injury MONDO:0015796 acute lung injury ADSCs up-regulated "circ-Fryl/mmu_circ_0001356 is enriched in ADSC-derived exosomes compared with fibroblast exosomes, based on high-throughput RNA-seq and RT-qPCR validation. The study links ADSC exosomal circ-Fryl delivery to attenuation of sepsis-induced lung injury through regulation of miR-490-3p/SIRT3-mediated autophagy." 708 34483137 Hsa-circ-0007292 promotes the osteogenic differentiation of posterior longitudinal ligament cells via regulating SATB2 by sponging miR-508-3p. hsa_circ_0007292 hsa_circ_ATP5C1 ATP5C1 Homo sapiens Ossification of the posterior longitudinal ligament MONDO:0011230 ossification of the posterior longitudinal ligament of the spine DOID:0060887 OPLL cells up-regulated "hsa_circ_0007292 is up-regulated in primary OPLL cells compared with non-OPLL cells, as detected by qRT-PCR after primary PLL cell isolation and culture. Functional experiments in PLL cells showed that hsa_circ_0007292 promotes osteogenic differentiation." 709 34490735 Emerging roles of circular RNAs in osteoporosis. circ_0020 Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 BMSCs up-regulated circ_0020 was overexpressed in BMSCs from ovariectomy mice compared with control mice based on RNA sequencing and confirmation assays. 710 34490735 Emerging roles of circular RNAs in osteoporosis. circ_3832 Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 BMSCs down-regulated circ_3832 was downregulated in BMSCs from ovariectomy mice compared with control mice based on RNA sequencing and confirmation assays. 711 34490735 Emerging roles of circular RNAs in osteoporosis. hsa_circ_0002770 circ_0002770 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 human BMSCs down-regulated circ_0002770 was downregulated in melatonin-treated human BMSCs compared with untreated BMSCs in an RNA-seq expression profiling study. 712 34490735 Emerging roles of circular RNAs in osteoporosis. hsa_circ_0073244 circ_0073244 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 human BMSCs down-regulated circ_0073244 was downregulated in melatonin-treated human BMSCs compared with untreated BMSCs in an RNA-seq expression profiling study. 713 34490735 Emerging roles of circular RNAs in osteoporosis. hsa_circ_0003126 circ_0003126 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 human BMSCs down-regulated circ_0003126 was downregulated in melatonin-treated human BMSCs compared with untreated BMSCs in an RNA-seq expression profiling study. 714 34490735 Emerging roles of circular RNAs in osteoporosis. hsa_circ_0002867 circ_0002867 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 human BMSCs down-regulated circ_0002867 was downregulated in melatonin-treated human BMSCs compared with untreated BMSCs in an RNA-seq expression profiling study. 715 34490735 Emerging roles of circular RNAs in osteoporosis. hsa_circ_0008210 circ_0008210 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 human BMSCs down-regulated circ_0008210 was downregulated in melatonin-treated human BMSCs compared with untreated BMSCs in an RNA-seq expression profiling study. 716 34490735 Emerging roles of circular RNAs in osteoporosis. hsa_circ_0037026 circ_0037026 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 human BMSCs down-regulated circ_0037026 was downregulated in melatonin-treated human BMSCs compared with untreated BMSCs in an RNA-seq expression profiling study. 717 34490735 Emerging roles of circular RNAs in osteoporosis. hsa_circ_0005015 circ_0005015 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 human BMSCs down-regulated circ_0005015 was downregulated in melatonin-treated human BMSCs compared with untreated BMSCs in an RNA-seq expression profiling study. 718 34490735 Emerging roles of circular RNAs in osteoporosis. hsa_circ_0003865 circ_0003865 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 human BMSCs down-regulated "circ_0003865 was downregulated in melatonin-treated BMSCs, and knock-down of circ_0003865 promoted osteogenic marker expression in BMSCs." 719 34490735 Emerging roles of circular RNAs in osteoporosis. hsa_circ_0006935 circ_0006935 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 human BMSCs down-regulated circ_0006935 was downregulated in melatonin-treated human BMSCs compared with untreated BMSCs in an RNA-seq expression profiling study. 720 34504314 Circular RNA Cwc27 contributes to Alzheimer's disease pathogenesis by repressing Pur-¦Á activity. mmu_circ_0004423 circCwc27 mmu_circ_Cwc27 Cwc27 Mus musculus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 neurons up-regulated "circCwc27 is enriched in neurons compared with glial cells in APP/PS1 and WT mouse brain, supported by BaseScope-ISH with cell-type marker immunostaining and qRT-PCR in mouse cortical neurons, astrocytes and microglia." 721 34504314 Circular RNA Cwc27 contributes to Alzheimer's disease pathogenesis by repressing Pur-¦Á activity. mmu_circ_0004423 circCwc27 mmu_circ_Cwc27 Cwc27 Mus musculus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 neuronal circCwc27 up-regulated "Neuronal circCwc27 is upregulated in APP/PS1 mice, as confirmed by BaseScope-ISH combined with immunostaining." 722 34522177 Downregulation of circ_0000673 Promotes Cell Proliferation and Migration in Endometriosis via the Mir-616-3p/PTEN Axis. hsa_circ_0000673 circ_0000673 hsa_circ_RSL1D1 RSL1D1 Homo sapiens endometriosis MONDO:0005133 endometriosis DOID:289 endometrial stromal cells down-regulated "In primary cultured endometrial stromal cells, hsa_circ_0000673 was experimentally knocked down and qPCR confirmed reduced circ_0000673 expression. Knockdown promoted proliferation and migration of endometrial stromal cells through the miR-616-3p/PTEN/PI3K/AKT axis." 723 34528447 Hsa_circ_0001021 regulates intestinal epithelial barrier function via sponging miR-224-5p in ulcerative colitis. hsa_circ_0001021 hsa_circ_AFTPH AFTPH Homo sapiens ulcerative colitis MONDO:0005101 ulcerative colitis DOID:8577 colonic epithelial cells unknown FISH in colonic mucosae showed that hsa circ 0001021 was expressed in the cytoplasm of colonic epithelial cells in the context of ulcerative colitis research. The same study reported that hsa circ 0001021 was associated with epithelial barrier-related molecules and regulated intestinal epithelial barrier function. 724 34528696 circ_Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS. mmu_circ_0001907 mmu_circ_Grm1 Grm1 Mus musculus hypoxic pulmonary hypertension MONDO:0017157 pulmonary hypertension owing to lung disease and/or hypoxia hypoxic PASMCs up-regulated circ-Grm1 is up-regulated in primary cultured mouse PASMCs under hypoxia compared with normoxia based on high-throughput transcriptome sequencing. Functional experiments showed that circ-Grm1 promotes proliferation and migration of hypoxic PASMCs. PRJNA753221; SRR15440746; SRR15403718 725 34532485 Involvement of ferroptosis in the granulosa cells proliferation of PCOS through the circRHBG/miR-515/SLC7A11 axis. hsa_circ_0014734 circRHBG hsa_circ_RHBG RHBG Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granular cells up-regulated "hsa_circ_0014734 / circRHBG was up-regulated in primary granulosa/granular cells from PCOS patients compared with non-PCOS controls, verified by qRT-PCR after circRNA chip screening. Knockdown experiments in granulosa cell lines indicated effects on cell proliferation and ferroptosis-related pathways." 726 34537436 Circ_0022382 ameliorated intervertebral disc degeneration by regulating TGF-¦Â3 expression through sponge adsorption of miR-4726-5p. hsa_circ_0022382 hsa_circ_FADS2 FADS2 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 human endplate chondrocytes down-regulated "In primary human endplate chondrocytes, circ_0022382 expression was reduced under intermittent cyclic mechanical tension compared with untreated control cells. Functional experiments in endplate chondrocytes indicated that circRNA_0022382 modulates chondrocyte morphology and ECM-related degeneration through the miR-4726-5p/TGF-¦Â3 axis." 727 34539405 Identification of Circular RNAs Circ_0005008 and Circ_0005198 in Plasma as Novel Biomarkers for New-Onset Rheumatoid Arthritis. hsa_circ_0005198 hsa_circ_PARP4 PARP4 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs up-regulated "circ_0005198 was significantly upregulated in primary cultured RA fibroblast-like synoviocytes compared with OA fibroblast-like synoviocytes, and its expression correlated positively with DAS28." 728 34547461 Circular RNA Cdyl promotes abdominal aortic aneurysm formation by inducing M1 macrophage polarization and M1-type inflammation. mmu_circ_0000451 circCdyl mmu_circ_Cdyl Cdyl Mus musculus abdominal aortic aneurysm MONDO:0005350 abdominal aortic aneurysm DOID:7693 primary macrophages up-regulated "circCdyl is highly expressed in mouse macrophages, including primary macrophages, compared with other vascular cell types examined in the AAA study. Functional experiments indicate that circCdyl promotes M1 macrophage polarization and M1-type inflammation." 729 34552819 "circGNAQ, a circular RNA enriched in vascular endothelium, inhibits endothelial cell senescence and atherosclerosis progression." hsa_circ_0006459 circGNAQ hsa_circ_GNAQ GNAQ Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 senescent ECs down-regulated circGNAQ was significantly downregulated in senescent human endothelial cells compared with young endothelial cells based on RNA-seq and qRT-PCR validation. Functional experiments showed circGNAQ suppressed endothelial cell senescence and supported proliferation and angiogenesis. GSE151475 730 34552819 "circGNAQ, a circular RNA enriched in vascular endothelium, inhibits endothelial cell senescence and atherosclerosis progression." hsa_circ_0006459 circGNAQ hsa_circ_GNAQ GNAQ Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 aortic intima down-regulated Endothelium-enriched aortic intimal RNA showed reduced circGNAQ expression during atherosclerotic progression in Ldlr_/_ mice after high-fat diet. This supports a decrease of circGNAQ in vascular endothelial cells in an atherosclerosis-related context. 731 34552819 "circGNAQ, a circular RNA enriched in vascular endothelium, inhibits endothelial cell senescence and atherosclerosis progression." hsa_circ_0006459 circGNAQ hsa_circ_GNAQ GNAQ Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 vascular endothelium up-regulated circGNAQ was enriched in vascular endothelium compared with aortic media and adventitia based on endothelium-enriched aortic intimal RNA and qRT-PCR. The study links this endothelial enrichment to endothelial function and atherosclerosis progression. 732 34572871 The Analysis of Platelet-Derived circRNA Repertoire as Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer. hsa_circ_NRIP1 NRIP1 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 platelets derived from NSCLC patients down-regulated "circNRIP1, derived from the NRIP1 gene, was significantly down-regulated in isolated platelets from NSCLC patients compared with platelets from asymptomatic individuals, supported by platelet RNA-seq and independent RT-qPCR validation." 733 34588633 The circRNA CNEACR regulates necroptosis of cardiomyocytes through Foxa2 suppression. mmu_circ_000338 Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury isolated neonatal mouse CMs down-regulated "CNEACR expression is reduced in isolated neonatal mouse cardiomyocytes after hypoxia-reoxygenation exposure, an in vitro model that mimics myocardial I/R injury." 734 34588633 The circRNA CNEACR regulates necroptosis of cardiomyocytes through Foxa2 suppression. mmu_circ_000338 Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury CMs up-regulated CNEACR is enriched in mouse cardiomyocytes compared with cardiac fibroblasts based on qPCR analysis of cells isolated from mouse hearts. 735 34611229 CircRNA_0079586 and circRNA_RanGAP1 are involved in the pathogenesis of intracranial aneurysms rupture by regulating the expression of MPO. hsa_circ_0079586 hsa_circ_IGF2BP3 IGF2BP3 Homo sapiens Intracranial aneurysm MONDO:0005291 brain aneurysm DOID:10941 endothelial cells up-regulated circRNA-0079586 was up-regulated in endothelial cells isolated from ruptured intracranial aneurysm patients compared with unruptured intracranial aneurysm patients. The study links circRNA-0079586 to an MPO-modulating circRNA_0079586/miR-183-5p/MPO pathway. 736 34611229 CircRNA_0079586 and circRNA_RanGAP1 are involved in the pathogenesis of intracranial aneurysms rupture by regulating the expression of MPO. hsa_circ_RanGAP1 RanGAP1 Homo sapiens Intracranial aneurysm MONDO:0005291 brain aneurysm DOID:10941 endothelial cells up-regulated circRNA-RanGAP1 was up-regulated in endothelial cells isolated from ruptured intracranial aneurysm patients compared with unruptured intracranial aneurysm patients. The study links circRNA-RanGAP1 to an MPO-modulating circRNA_RanGAP1/miR-877-3p/MPO pathway. 737 34611269 circSPG21 protects against intervertebral disc disease by targeting miR-1197/ATP1B3. hsa_circ_0035875 circSPG21 hsa_circ_SPG21 SPG21 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 degenerated nucleus pulposus cells (NPCs) down-regulated "circSPG21/hsa_circ_0035875 is decreased in degenerated nucleus pulposus cells in IVDD, with NPC isolation/culture and RT-qPCR-based cellular RNA analysis described. Functional experiments in NPCs indicate that circSPG21 regulates extracellular matrix metabolism and senescence-related phenotypes through the miR-1197/ATP1B3 axis." 738 34621049 Negative feedback of SNRK to circ-SNRK regulates cardiac function post-myocardial infarction. rno_circ_SNRK SNRK Rattus norvegicus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 NRCMs (neonatal rat cardiomyocytes) down-regulated "In primary neonatal rat cardiomyocytes, circ-SNRK decreases under hypoxia treatment, an in vitro condition used to model ischemic stress after myocardial infarction. Functional experiments in NRCMs indicate that circ-SNRK regulates ATP synthesis and apoptosis via the miR-33-SNRK axis." 739 34649567 Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. hsa_circ_0007915 circIPO11 hsa_circ_IPO11 IPO11 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 liver CSCs (CD13+CD133+) up-regulated "circIPO11 is more highly expressed in liver CSCs than non-CSCs in HCC, supported by flow-sorted CD13+CD133+ CSC analysis and qRT-PCR/Northern blot validation. Functional experiments indicate circIPO11 is required for liver CSC self-renewal." 740 34650036 CircNPHP4 in monocyte-derived small extracellular vesicles controls heterogeneous adhesion in coronary heart atherosclerotic disease. hsa_circ_0009135 circNPHP4 hsa_circ_NPHP4 NPHP4 Homo sapiens coronary heart disease MONDO:0005010 coronary artery disorder DOID:3393 monocytes up-regulated "circNPHP4/hsa_circ_0009135 was upregulated in small extracellular vesicles derived from monocytes of CAD patients compared with controls, based on circRNA profiling and qRT-PCR validation after monocyte isolation. Knockdown of circNPHP4 in CAD patient monocyte-derived sEVs reduced heterogeneous adhesion between monocytes and coronary artery endothelial cells." GSE166126 741 34670409 CircSOD2: A Novel Regulator for Smooth Muscle Proliferation and Neointima Formation. circSOD2 hsa_circ_SOD2 SOD2 Homo sapiens neointima formation MONDO:0000001 disease DOID:4 human aortic SMCs up-regulated "In human aortic smooth muscle cells, circSOD2 was identified by circRNA RNA-seq and was up-regulated after PDGF-BB treatment, with time-dependent validation by RT-qPCR. Functional experiments in HASMCs showed that circSOD2 promotes SMC proliferation." 742 34670409 CircSOD2: A Novel Regulator for Smooth Muscle Proliferation and Neointima Formation. circSOD2 rno_circ_SOD2 SOD2 Rattus norvegicus others others others neointimal SMCs up-regulated "In balloon-injured rat carotid arteries, circSOD2 was induced in neointimal smooth muscle cells compared with normal arteries. Knockdown of circSOD2 reduced neointimal SMC proliferation and attenuated injury-induced neointima formation." 743 34693745 CircRFWD2 Promotes Osteogenic Differentiation of human Dental Pulp Stem Cells by Targeting miR-6817-5p Through BMP-Smad and p38 MAPK Pathway. circRFWD2 hsa_circ_RFWD2 RFWD2 Homo sapiens bone defects MONDO:0002081 musculoskeletal system disorder DOID:17 hDPSCs up-regulated circRFWD2 was up-regulated in primary cultured human dental pulp stem cells after osteogenic induction. Knockdown of circRFWD2 suppressed osteogenic differentiation of hDPSCs. 744 34695392 The circRNA circ-Nbea participates in regulating diabetic encephalopathy. chr2: 131511984-131516443 mmu_circ_Smox Smox Mus musculus diabetic encephalopathy MONDO:0000489 diabetic encephalopathy DOID:0050850 primary hippocampal neurons down-regulated "circ-Smox was downregulated in AGE-treated primary hippocampal neurons compared with untreated control neurons, based on RNA-seq and qRT-PCR validation." 745 34695392 The circRNA circ-Nbea participates in regulating diabetic encephalopathy. chr3: 56079859-56091120 mmu_circ_Nbea Nbea Mus musculus diabetic encephalopathy MONDO:0000489 diabetic encephalopathy DOID:0050850 primary hippocampal neurons down-regulated "circ-Nbea was downregulated in AGE-treated primary hippocampal neurons compared with untreated control neurons, with RNA-seq followed by qRT-PCR validation. The study also reported that circ-Nbea bound miR-128-3p, but did not perform circ-Nbea gain- or loss-of-function validation in neurons." 746 34695392 The circRNA circ-Nbea participates in regulating diabetic encephalopathy. chr18: 79086551-79087180 mmu_circ_Setbp1 Setbp1 Mus musculus diabetic encephalopathy MONDO:0000489 diabetic encephalopathy DOID:0050850 primary hippocampal neurons down-regulated "circ-Setbp1 was downregulated in AGE-treated primary hippocampal neurons compared with untreated control neurons, based on RNA-seq and qRT-PCR validation." 747 34717918 Comprehensive analysis of differentially expressed mRNA and circRNA in Ankylosing spondylitis patients' platelets. hsa_circ_0000110 circPTPN22 hsa_circ_PTPN22 PTPN22 Homo sapiens Ankylosing spondylitis MONDO:0005306 ankylosing spondylitis DOID:7147 platelets down-regulated "hsa_circ_0000110 / circPTPN22 was down-regulated in isolated platelets from Ankylosing spondylitis patients compared with healthy controls, supported by platelet RNA-seq and qRT-PCR validation." 748 34717918 Comprehensive analysis of differentially expressed mRNA and circRNA in Ankylosing spondylitis patients' platelets. hsa_circ_0005918 circFCHSD2 hsa_circ_FCHSD2 FCHSD2 Homo sapiens Ankylosing spondylitis MONDO:0005306 ankylosing spondylitis DOID:7147 platelets down-regulated "hsa_circ_0005918 / circFCHSD2 was down-regulated in isolated platelets from Ankylosing spondylitis patients compared with healthy controls, supported by platelet RNA-seq and qRT-PCR validation." 749 34740363 Circ_0043532 regulates miR-182/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome. circ_0043532 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 GCs up-regulated "circ_0043532 was up-regulated in granulosa cells isolated from PCOS patients compared with control granulosa cells, as measured by qRT-PCR. In PCOS granulosa cells, circ_0043532 knockdown suppressed proliferation and promoted apoptosis." 750 34750830 Silencing of circARHGAP12 inhibits the progression of atherosclerosis via miR-630/EZH2/TIMP2 signal axis. circARHGAP12 mmu_circ_ARHGAP12 ARHGAP12 Mus musculus Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 MASMCs up-regulated "circARHGAP12 was up-regulated in ox-LDL-treated mouse aortic smooth muscle cells, a cell model related to atherosclerosis. Silencing circARHGAP12 inhibited proliferation and migration of MASMCs." GSE107522 751 34751080 Circular RNA circCTNNA1 is downregulated in osteoarthritis and sponges miR-29a to suppress LPS-induced apoptosis of synoviocytes. circCTNNA1 hsa_circ_CTNNA1 CTNNA1 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 "Synoviocytes (type B, primary cells)" down-regulated "In primary type B synoviocytes derived from an OA patient, LPS treatment significantly downregulated circCTNNA1 as measured by RT-qPCR. circCTNNA1 overexpression reduced LPS-induced synoviocyte apoptosis via interaction with miR-29a." 752 34751973 "CircPrkcsh, a circular RNA, contributes to the polarization of microglia towards the M1 phenotype induced by spinal cord injury and acts via the JNK/p38 MAPK pathway." circPrkcsh mmu_circ_Prkcsh Prkcsh Mus musculus spinal cord injury MONDO:0043797 spinal cord injury microglia up-regulated FISH on mouse spinal cord sections with the microglia marker Iba1 showed that circPrkcsh is expressed in microglia and is up-regulated in SCI mice compared with sham-operated mice. The study further reports that circPrkcsh promotes M1 microglia polarization via the miR-488/MEKK1/JNK/p38 MAPK pathway. 753 34753486 Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC. hsa_circ_0005152 circUSP7 hsa_circ_USP7 USP7 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 CD8+ T cells from cancer tissues up-regulated circUSP7 is up-regulated in CD8+ T cells isolated from NSCLC cancer tissues compared with corresponding CD8+ T cells from adjacent tissues. The study links exosomal circUSP7 to CD8+ T cell dysfunction and anti-PD1 resistance through the miR-934/SHP2 axis. 754 34754888 RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathway. hsa_circ_0005752 hsa_circ_LPAR1 LPAR1 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 ADSCs up-regulated hsa_circ_0005752 was up-regulated in ADSCs during osteogenic differentiation after OM induction compared with day 0. Functional experiments in ADSCs supported that hsa_circ_0005752 promotes osteogenic differentiation. 755 34758510 IL-6-induced cGGNBP2 encodes a protein to promote cell growth and metastasis in intrahepatic cholangiocarcinoma. hsa_circ_0003930 hsa_circ_ggnbp2 ggnbp2 Homo sapiens intrahepatic cholangiocarcinoma MONDO:0003210 intrahepatic cholangiocarcinoma DOID:4928 ICC cells up-regulated cGGNBP2 expression was higher in ICC tumor cells than in noncancerous cholangiocytes in freshly isolated patient tissues. Functional assays in ICC cells showed that cGGNBP2 promoted cell growth and metastasis. 756 34758510 IL-6-induced cGGNBP2 encodes a protein to promote cell growth and metastasis in intrahepatic cholangiocarcinoma. hsa_circ_0003930 hsa_circ_ggnbp2 ggnbp2 Homo sapiens intrahepatic cholangiocarcinoma MONDO:0003210 intrahepatic cholangiocarcinoma DOID:4928 CAFs down-regulated cGGNBP2 expression was extremely low in cancer-associated fibroblasts from freshly isolated ICC tissues. 757 34763084 Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion. hsa_circ_0006404 circ-FoxO3 hsa_circ_FoxO3 FoxO3 Homo sapiens ischemia reperfusion injury / IRI MONDO:0005203 ischemia reperfusion injury brain microvessel endothelial cells up-regulated "In patient hemorrhagic transformation brain tissue, circ-FoxO3 was upregulated in BMECs, supported by FISH co-localization with the endothelial marker CD31. Functional experiments linked circ-FoxO3 in BMECs to endothelial barrier protection and tube formation." 758 34763084 Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion. mmu_circ_0002207 circ-FoxO3 mmu_circ_FoxO3 FoxO3 Mus musculus ischemia reperfusion injury / IRI MONDO:0005203 ischemia reperfusion injury brain microvessel endothelial cells up-regulated "In MCAO/R mouse brain tissue, circ-FoxO3 was upregulated in BMECs, supported by FISH co-localization with CD31. BMEC functional assays showed circ-FoxO3 protected endothelial barrier integrity and promoted tube formation." 759 34763084 Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion. hsa_circ_0006404 circ-FoxO3 hsa_circ_FoxO3 FoxO3 Homo sapiens ischemia reperfusion injury / IRI MONDO:0005203 ischemia reperfusion injury astrocyte up-regulated "In hemorrhagic transformation brain tissue, circ-FoxO3 co-localized with the astrocyte marker GFAP and was described as upregulated especially in astrocytes after I/R. No astrocyte-specific function was experimentally assigned." 760 34763084 Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion. mmu_circ_0002207 circ-FoxO3 mmu_circ_FoxO3 FoxO3 Mus musculus ischemia reperfusion injury / IRI MONDO:0005203 ischemia reperfusion injury astrocyte up-regulated "In MCAO/R mouse brain tissue, circ-FoxO3 co-localized with the astrocyte marker GFAP and was described as upregulated especially in astrocytes after I/R. No astrocyte-specific function was experimentally assigned." 761 34764783 Knockdown of circular RNA hsa_circ_0003204 inhibits oxidative stress and apoptosis through the miR-330-5p/Nod2 axis to ameliorate endothelial cell injury induced by low-density lipoprotein. hsa_circ_0003204 hsa_circ_USP36 USP36 Homo sapiens Atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 Human primary aortic endothelial cells (HAECs) up-regulated "In human primary aortic endothelial cells used as an atherosclerosis cell model, hsa_circ_0003204 was up-regulated after ox-LDL treatment compared with untreated control cells. Knockdown experiments in ox-LDL-induced HAECs showed that hsa_circ_0003204 downregulation reduced apoptosis through the miR-330-5p/Nod2 axis." 762 34764979 Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout. hsa_circ_0069977 hsa_circRNA_103657 Homo sapiens primary gout MONDO:0005393 gout DOID:13189 peripheral blood mononuclear cells (PBMCs) up-regulated "hsa_circRNA_103657 was significantly up-regulated in isolated PBMCs from primary gout patients compared with healthy controls, validated by qRT-PCR." GSE178825 763 34764979 Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout. hsa_circ_0000241 hsa_circRNA_000241 Homo sapiens primary gout MONDO:0005393 gout DOID:13189 peripheral blood mononuclear cells (PBMCs) up-regulated "hsa_circRNA_000241 was significantly up-regulated in isolated PBMCs from primary gout patients compared with healthy controls, validated by qRT-PCR." GSE178825 764 34776969 Angiogenesis is Inhibited by Arsenic Trioxide Through Downregulation of the CircHIPK3/miR-149-5p/FOXO1/VEGF Functional Module in Rheumatoid Arthritis. hsa_circ_0000284 circHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA fibroblast-like synoviocytes up-regulated circHIPK3 was up-regulated in RA fibroblast-like synoviocytes after TNF-¦Á induction compared with control RA-FLS. Knockdown of circHIPK3 reduced VEGF production and impaired RA-FLS-induced angiogenesis. 765 34776969 Angiogenesis is Inhibited by Arsenic Trioxide Through Downregulation of the CircHIPK3/miR-149-5p/FOXO1/VEGF Functional Module in Rheumatoid Arthritis. hsa_circ_0000284 circHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLS down-regulated "ATO treatment down-regulated circHIPK3 in RA-FLS, with a stronger decrease under TNF-¦Á induction. The study linked this suppression to reduced FOXO1/VEGF expression and antiangiogenic effects in RA-FLS." 766 34779488 circPhc3 sponging microRNA_93_3p is involved in the regulation of chondrocyte function by mechanical instability in osteoarthritis. mmu_circ_0010621 mmu_circ_Phc3 Phc3 Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes down-regulated circPhc3 expression is reduced in primary cultured chondrocytes exposed to mechanical stimuli compared with untreated control conditions. The study further shows that circPhc3 is involved in mechanical loading-regulated chondrocyte matrix metabolism. 767 34784951 Knockdown of circ-FURIN suppresses the proliferation and induces apoptosis of granular cells in polycystic ovary syndrome via miR-195-5p/BCL2 axis. Hsa_circ_0036881 hsa_circ_FURIN FURIN Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 cumulus cells (CCs) up-regulated "circ-FURIN was up-regulated in isolated cumulus cells from patients with PCOS compared with cumulus cells from healthy women, based on RT-qPCR after primary cell isolation." 768 34789275 A nanodrug system overexpressed circRNA_0001805 alleviates nonalcoholic fatty liver disease via miR-106a-5p/miR-320a and ABCA1/CPT1 axis. hsa_circ_0001805 Homo sapiens nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 primary hepatocytes down-regulated "circRNA_0001805 was downregulated in FFA-treated primary human hepatocytes used as an in vitro NAFLD model, with expression measured by qRT-PCR." 769 34789642 "Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells." hsa_circ_0006156 hsa_circ_FNDC3B FNDC3B Homo sapiens abdominal aortic aneurysm MONDO:0005350 abdominal aortic aneurysm DOID:7693 VSMCs up-regulated "circ-FNDC3B was up-regulated in primary VSMCs isolated from AAA aortic tissues compared with normal controls. Functional experiments in VSMCs showed that circ-FNDC3B silencing relieved Ang-II-triggered injury involving proliferation, apoptosis, and inflammation." 770 34795497 circ_TGFBR2 Inhibits Vascular Smooth Muscle Cells Phenotypic Switch and Suppresses Aortic Dissection Progression by Sponging miR-29a. hsa_circ_TGFBR2 TGFBR2 Homo sapiens Aortic dissection MONDO:0022470 aortic dissection lentiginosis AD-VSMCs cells down-regulated circ_TGFBR2 was significantly down-regulated in primary cultured AD-derived vascular smooth muscle cells compared with normal aorta-derived vascular smooth muscle cells. Functional experiments in AD-VSMCs showed that circ_TGFBR2 overexpression inhibited proliferation and migration and regulated phenotypic switch. 771 34850997 CircSmg5 stimulates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting the miR-194-5p/Fzd6 axis and beta-catenin signaling. mmu_circ_0001145 mm9_circ_008622 mmu_circ_Smg5 Smg5 Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 bone marrow mesenchymal stem cells (BMSCs) up-regulated "CircSmg5/mmu_circ_0001145 expression is elevated during osteogenic differentiation of mouse BMSCs, as measured by RT-qPCR over 0-3 weeks of induction. Functional assays in BMSCs showed that CircSmg5 promotes osteogenic differentiation through the miR-194-5p/Fzd6 axis and Wnt/¦Â-catenin signaling." 772 34868028 CircRNA75 and CircRNA72 Function as the Sponge of MicroRNA-200 to Suppress Coelomocyte Apoptosis Via Targeting Tollip in Apostichopus japonicus. circRNA75 fibrinogen-like protein A Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 primary coelomocytes up-regulated circRNA75 was significantly up-regulated in LPS-exposed primary coelomocytes of Apostichopus japonicus. Functional experiments in primary coelomocytes indicated that circRNA75 suppressed apoptosis via the miR-200/Tollip axis. 773 34868028 CircRNA75 and CircRNA72 Function as the Sponge of MicroRNA-200 to Suppress Coelomocyte Apoptosis Via Targeting Tollip in Apostichopus japonicus. circRNA72 HSP97 Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 primary coelomocytes up-regulated circRNA72 was significantly up-regulated in LPS-exposed primary coelomocytes of Apostichopus japonicus. Functional experiments in primary coelomocytes indicated that circRNA72 suppressed apoptosis via the miR-200/Tollip axis. 774 34868028 CircRNA75 and CircRNA72 Function as the Sponge of MicroRNA-200 to Suppress Coelomocyte Apoptosis Via Targeting Tollip in Apostichopus japonicus. circRNA75 fibrinogen-like protein A Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 coelomocyte up-regulated circRNA75 was up-regulated in coelomocytes from SUS-affected Apostichopus japonicus compared with healthy controls. The paper further functionally linked circRNA75 to suppression of primary coelomocyte apoptosis. 775 34868028 CircRNA75 and CircRNA72 Function as the Sponge of MicroRNA-200 to Suppress Coelomocyte Apoptosis Via Targeting Tollip in Apostichopus japonicus. circRNA72 HSP97 Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 coelomocyte up-regulated circRNA72 was up-regulated in coelomocytes from SUS-affected Apostichopus japonicus compared with healthy controls. The paper further functionally linked circRNA72 to suppression of primary coelomocyte apoptosis. 776 34876161 Down-regulation of circular RNA CDC14A peripherally ameliorates brain injury in acute phase of ischemic stroke. circCDC14A mmu_circ_CDC14A CDC14A Mus musculus ischemic stroke MONDO:1060198 ischemic stroke neutrophils up-regulated "In tMCAO mice, elevated circCDC14A was mainly localized to peripheral neutrophils based on FISH combined with Ly6g immunofluorescence. Peripheral knockdown of circCDC14A modulated infiltrated neutrophil polarization and improved acute ischemic stroke outcomes." 777 34876161 Down-regulation of circular RNA CDC14A peripherally ameliorates brain injury in acute phase of ischemic stroke. circCDC14A mmu_circ_CDC14A CDC14A Mus musculus ischemic stroke MONDO:1060198 ischemic stroke astrocytes up-regulated "In peri-infarct cortex of tMCAO mice, elevated circCDC14A was mainly colocalized with astrocytes and its astrocyte colocalization increased compared with sham-operated mice. Peripheral circCDC14A knockdown relieved astrocyte activation in peri-infarct cortex." 778 34887661 Therapeutic Potential of Exosomal circRNA Derived from Synovial Mesenchymal Cells via Targeting circEDIL3/miR-485-3p/PIAS3/STAT3/VEGF Functional Module in Rheumatoid Arthritis. hsa_circ_0073244 circEDIL3 hsa_circ_EDIL3 EDIL3 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 normal synovial MSCs (SMSCs) up-regulated hsa_circ_0073244 / circEDIL3 was detected by qRT-PCR as highly expressed in primary human synovial mesenchymal stem cells and enriched in SMSC-derived exosomes compared with RA-FLS. The study links SMSC-exosomal circEDIL3 to suppression of VEGF-associated angiogenic activity in an RA model. 779 34887753 Circular RNA CREBBP Suppresses Hepatic Fibrosis Via Targeting the hsa-miR-1291/LEFTY2 Axis. mmu_circ_0006288 circCREBBP mmu_circ_CREBBP CREBBP Mus musculus hepatic fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 primary hepatic stellate cells (HSCs) down-regulated circCREBBP was significantly down-regulated in primary hepatic stellate cells from CCl4-induced hepatic fibrosis mice compared with vehicle controls. The study further reports that circCREBBP inhibited HSC activation and proliferation. 780 34907911 Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation. mmu_circ_Esyt2 Esyt2 Mus musculus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 VSMCs up-regulated FISH combined with immunofluorescence showed that circEsyt2 was significantly upregulated in ¦Á-SMA+ VSMCs within atherosclerotic plaques in ApoE-/- mice compared with C57BL/6J controls. The study links this VSMC expression to vascular remodeling and VSMC functional regulation. GSE133269 781 34907911 Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation. mmu_circ_Esyt2 Esyt2 Mus musculus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 VSMCs up-regulated "In a Tagln-CreERT2/tdTomato VSMC-lineage tracing mouse carotid injury model, FISH showed circEsyt2 upregulation in VSMCs of injured carotid arteries compared with sham controls. Functional experiments indicated that circEsyt2 promotes VSMC proliferation and migration and suppresses apoptosis and differentiation." 782 34917303 Circular RNA mmu_circ_0001598 Contributes to IL-1¦Â-Induced Osteoarthritis Progression by Regulating miR-127-3p. mmu_circ_0001598 Mus musculus Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated "circ_0001598 is up-regulated in primary mouse chondrocytes after IL-1¦Â treatment compared with controls, as measured by qRT-PCR. Knockdown experiments in chondrocytes support roles in proliferation and apoptosis." 783 34933019 CircARHGAP12 Triggers Mesenchymal Stromal Cell Autophagy to Facilitate its Effect on Repairing Diabetic Wounds by Sponging miR-301b-3p/ATG16L1 and miR-301b-3p/ULK2. hsa_circ_0018103 hsa_circ_ARHGAP12 ARHGAP12 Homo sapiens diabetic wounds MONDO:0005015 diabetes mellitus DOID:9351 MSCs down-regulated "In primary human MSCs cultured under high-glucose conditions relevant to diabetic wounds, whole-transcriptome sequencing followed by qRT-PCR showed that circARHGAP12 was the most downregulated circRNA. Functional experiments in MSCs indicated that circARHGAP12 promoted autophagy, suppressed high glucose-triggered apoptosis, and improved MSC repairability in diabetic wounds." GSE168890 784 34934923 Circ-Hdgfrp3 shuttles along neurites and is trapped in aggregates formed by ALS-associated mutant FUS. mmu_circ_Hdgfrp3 Hdgfrp3 Mus musculus amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 MNs up-regulated Basescope-FISH combined with ISLET immunofluorescence showed that circ-Hdgfrp3 signals were almost exclusively present in murine motor neurons compared with non-MN cells. 785 34934923 Circ-Hdgfrp3 shuttles along neurites and is trapped in aggregates formed by ALS-associated mutant FUS. mmu_circ_Hdgfrp3 Hdgfrp3 Mus musculus amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 MNs dys-regulated "Basescope-FISH with neuronal marker immunofluorescence showed that circ-Hdgfrp3 was present in the soma and neurites of WT and FUS-P517L motor neurons, but oxidative stress altered its neurite localization and caused retention in soma/perinuclear regions." 786 34938195 Long Noncoding RNA and Circular RNA Expression Profiles of Monocyte-Derived Dendritic Cells in Autoimmune Hepatitis. hsa_circ_0000279 hsa_circ_HPS5 HPS5 Homo sapiens Autoimmune hepatitis MONDO:0016264 autoimmune hepatitis DOID:2048 monocyte-derived DCs up-regulated "hsa_circ_0000279 was upregulated in monocyte-derived dendritic cells from autoimmune hepatitis patients compared with healthy controls, based on RNA-seq and qRT-PCR validation." unclear 787 34938195 Long Noncoding RNA and Circular RNA Expression Profiles of Monocyte-Derived Dendritic Cells in Autoimmune Hepatitis. hsa_circ_0005076 hsa_circ_MRPS6 MRPS6 Homo sapiens Autoimmune hepatitis MONDO:0016264 autoimmune hepatitis DOID:2048 monocyte-derived DCs down-regulated "hsa_circ_0005076 was downregulated in monocyte-derived dendritic cells from autoimmune hepatitis patients compared with healthy controls, based on RNA-seq and qRT-PCR validation." unclear 788 34938195 Long Noncoding RNA and Circular RNA Expression Profiles of Monocyte-Derived Dendritic Cells in Autoimmune Hepatitis. hsa_circ_0006719 Homo sapiens Autoimmune hepatitis MONDO:0016264 autoimmune hepatitis DOID:2048 moDCs down-regulated hsa_circ_0006719 was identified by RNA-seq as the most downregulated circRNA in monocyte-derived dendritic cells from autoimmune hepatitis patients compared with healthy controls. unclear 789 34938599 circRNA-DURSA regulates trophoblast apoptosis via miR-760-HIST1H2BE axis in unexplained recurrent spontaneous abortion. hsa_circ_0050703 hsa_circ_WDR62 WDR62 Homo sapiens Recurrent Spontaneous Abortion MONDO:0013727 "pregnancy loss, recurrent, susceptibility to, 1" human primary trophoblast cells down-regulated "In isolated human primary trophoblast cells, siRNA-mediated targeting of the back-splice junction reduced circRNA-DURSA expression as assessed by qRT-PCR. circRNA-DURSA silencing promoted trophoblast apoptosis in the URSA-related experimental model." 790 34942001 Circular RNA Sequencing Reveals Serum Exosome Circular RNA Panel for High-Grade Astrocytoma Diagnosis. hsa_circ_0008285 Homo sapiens high-grade astrocytoma MONDO:0016680 high grade astrocytic tumor primary HGA cells up-regulated "hsa_circ_0008285 was highly expressed in primary cultured HGA tumor cells, supported by circRNA deep sequencing and qRT-PCR validation." 791 34942001 Circular RNA Sequencing Reveals Serum Exosome Circular RNA Panel for High-Grade Astrocytoma Diagnosis. hsa_circ_0001900 Homo sapiens high-grade astrocytoma MONDO:0016680 high grade astrocytic tumor primary HGA cells up-regulated "hsa_circ_0001900 was highly expressed in primary cultured HGA tumor cells, supported by circRNA deep sequencing and qRT-PCR validation." 792 34948079 New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer. hsa_circ_0001445 circSMARcA5 hsa_circ_SMARCA5 SMARCA5 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 malignant cells down-regulated "In colorectal cancer single-cell transcriptome profiles from TISCH, hsa_circ_0001445 expression was lower in malignant cells than in stromal cells and lower in tumor cells than in the TME." CRC_GSE146771_Smartseq2 793 34948079 New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer. hsa_circ_0001445 circSMARcA5 hsa_circ_SMARCA5 SMARCA5 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 fibroblast up-regulated TISCH single-cell transcriptome profile analysis indicated that hsa_circ_0001445 expression was highest in fibroblast and endothelial cells among stromal cells in colorectal cancer. CRC_GSE146771_Smartseq2 794 34948079 New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer. hsa_circ_0001445 circSMARcA5 hsa_circ_SMARCA5 SMARCA5 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 endothelial cells up-regulated TISCH single-cell transcriptome profile analysis indicated that hsa_circ_0001445 expression was highest in fibroblast and endothelial cells among stromal cells in colorectal cancer. CRC_GSE146771_Smartseq2 795 34948079 New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer. hsa_circ_0007915 circIPO11 hsa_circ_IPO11 IPO11 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 malignant cells down-regulated "In colorectal cancer single-cell transcriptome profiles from TISCH, hsa_circ_0007915 expression was lower in malignant cells than in stromal cells and lower in tumor cells than in the TME." CRC_GSE146771_Smartseq2 796 34948079 New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer. hsa_circ_0007915 circIPO11 hsa_circ_IPO11 IPO11 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 endothelial cells up-regulated TISCH single-cell transcriptome profile analysis indicated that hsa_circ_0007915 expression was highest only in endothelial cells in colorectal cancer. CRC_GSE146771_Smartseq2 797 34953789 Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine-dependent manner in atopic dermatitis and psoriasis. hsa_circ_0004287 circ4287 hsa_circ_MALAT1 MALAT1 Homo sapiens atopic dermatitis MONDO:0004980 atopic eczema DOID:3310 CD14 1 monocyte-derived macrophages; CD68 1 macrophages up-regulated hsa_circ_0004287 is increased in human PBMC-derived macrophages after inflammatory stimulation and colocalizes with CD68+ macrophages in AD skin lesions. Functional experiments support an inhibitory role in M1 macrophage activation and skin inflammation. GSE168694; GSE168696 798 34953789 Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine-dependent manner in atopic dermatitis and psoriasis. hsa_circ_0004287 circ4287 hsa_circ_MALAT1 MALAT1 Homo sapiens psoriasis MONDO:0005083 psoriasis DOID:8893 macrophages; M1 macrophages up-regulated The study reports hsa_circ_0004287 upregulation in psoriasis patient PBMCs and macrophage-enriched expression under inflammatory conditions. Macrophage-specific hsa_circ_0004287 overexpression ameliorated inflammation in an IMQ-induced psoriatic mouse model. GSE168694; GSE168696 799 34976440 hsa_circ_0005358 suppresses cervical cancer metastasis by interacting with PTBP1 protein to destabilize CDCP1 mRNA. hsa_circ_0005358 hsa_circ_Gli1 Gli1 Homo sapiens cervical cancer MONDO:0002974 cervical cancer DOID:4362 cancer cells up-regulated RNA in situ hybridization in cervical cancer tissues showed hsa_circ_0005358 expression in cancer cells but not stromal cells. 800 34979511 Circular RNA CCDC66 Regulates Osteoarthritis Progression by Targeting miR-3622b-5p. hsa_circ_0001313 CircCCDC66 hsa_circ_CCDC66 CCDC66 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary chondrocytes up-regulated "Primary chondrocytes showed significantly increased circCCDC66 expression after pcDNA-circCCDC66 treatment, and circCCDC66 overexpression was linked to reduced viability, increased apoptosis, and increased IL-6 and TNF-¦Á levels in chondrocytes." 801 34987549 Systematic Analysis of mRNAs and ncRNAs in BMSCs of Senile Osteoporosis Patients. circRNA_008876 Homo sapiens senile osteoporosis MONDO:0005298 osteoporosis DOID:11476 hBMSCs down-regulated "circRNA008876 was down-regulated in hBMSCs from senile osteoporosis patients compared with hBMSCs from normal individuals, based on whole transcriptome sequencing and RT-qPCR validation. Functional experiments in hBMSCs showed that circRNA008876 promotes osteogenesis via miR-150-5p." SRP337202; PRJNA763497 802 34999209 Targeting circular RNA-MET for anti-angiogenesis treatment via inhibiting endothelial tip cell specialization. hsa_circ_0082002 hsa_circ_MET MET Homo sapiens pathological angiogenesis MONDO:0000001 disease DOID:4 Human retinal vascular endothelial cells (HRVECs) up-regulated circMET is up-regulated in hypoxic human retinal vascular endothelial cells compared with normoxic controls. Functional assays in HRVECs showed that circMET silencing reduced endothelial sprouting and migration. 803 34999209 Targeting circular RNA-MET for anti-angiogenesis treatment via inhibiting endothelial tip cell specialization. mmu_circ_0013214 mmu_circ_Met MET Mus musculus pathological angiogenesis MONDO:0000001 disease DOID:4 endothelial cells down-regulated "After endothelial-targeted circMET shRNA delivery in Cdh5-Cre mice, circ-MET expression decreased in endothelial cells but not in pericytes. This cell-resolved evidence supports endothelial-cell-specific circMET modulation in the angiogenesis model system." 804 35000524 Circular RNA Plasmacytoma Variant Translocation 1 (CircPVT1) knockdown ameliorates hypoxia-induced bladder fibrosis by regulating the miR-203/Suppressor of Cytokine Signaling 3 (SOCS3) signaling axis. hsa_circ_PVT1 PVT1 Homo sapiens bladder outlet obstruction / BOO MONDO:0006679 bladder neck obstruction DOID:13948 human BSMCs up-regulated "In primary cultured BSMCs, hypoxia treatment induced a fibrotic cell model and upregulated circPVT1 expression compared with control. circPVT1 silencing in hypoxia-induced BSMCs affected fibrotic gene expression, cell viability, and apoptosis." 805 35002536 CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis. circN4bp1 hsa_circ_N4bp1 N4bp1 Homo sapiens sepsis-induced ARDS MONDO:0006502 acute respiratory distress syndrome monocytes up-regulated "In sorted PBMC subsets from sepsis-induced ARDS patients and healthy controls, circN4bp1 was mainly expressed in monocytes and was higher in patient monocytes than healthy controls." 806 35002536 CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis. circN4bp1 mmu_circ_N4bp1 N4bp1 Mus musculus sepsis-induced ARDS MONDO:0006502 acute respiratory distress syndrome macrophages of the BALF and lung tissue up-regulated circN4bp1 was upregulated in isolated BALF and lung-tissue macrophages from CLP-induced sepsis-associated ARDS mice compared with sham controls. 807 35002536 CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis. circN4bp1 mmu_circ_N4bp1 N4bp1 Mus musculus sepsis-induced ARDS MONDO:0006502 acute respiratory distress syndrome alveolar macrophages down-regulated "In CLP-induced ARDS mice, circN4bp1 knockdown reduced circN4bp1 expression in alveolar macrophages compared with vector-treated CLP mice and was associated with reduced lung injury and inflammatory macrophage activation." 808 35003060 Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease. hsa_circ_0102898 Homo sapiens Vogt-Koyanagi-Harada disease MONDO:0018092 Vogt-Koyanagi-Harada disease DOID:12297 CD4+ T cells up-regulated hsa_circ_0102898 was the most upregulated circRNA in sorted CD4+ T cells from VKH patients compared with healthy controls by RNA-seq. unclear 809 35003060 Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease. hsa_circ_0087960 Homo sapiens Vogt-Koyanagi-Harada disease MONDO:0018092 Vogt-Koyanagi-Harada disease DOID:12297 CD4+ T cells down-regulated hsa_circ_0087960 was the most downregulated circRNA in sorted CD4+ T cells from VKH patients compared with healthy controls by RNA-seq. unclear 810 35003060 Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease. hsa_circ_0033144 Homo sapiens Vogt-Koyanagi-Harada disease MONDO:0018092 Vogt-Koyanagi-Harada disease DOID:12297 CD4+ T cells dys-regulated "hsa_circ_0033144 was differentially expressed in sorted CD4+ T cells from VKH patients compared with healthy controls, with RT-qPCR validation consistent with RNA-seq data." unclear 811 35003060 Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease. hsa_circ_0000233 Homo sapiens Vogt-Koyanagi-Harada disease MONDO:0018092 Vogt-Koyanagi-Harada disease DOID:12297 CD4+ T cells dys-regulated "hsa_circ_0000233 was differentially expressed in sorted CD4+ T cells from VKH patients compared with healthy controls, with RT-qPCR validation consistent with RNA-seq data." unclear 812 35003060 Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease. hsa_circ_0000396 Homo sapiens Vogt-Koyanagi-Harada disease MONDO:0018092 Vogt-Koyanagi-Harada disease DOID:12297 CD4+ T cells dys-regulated "hsa_circ_0000396 was differentially expressed in sorted CD4+ T cells from VKH patients compared with healthy controls, with RT-qPCR validation consistent with RNA-seq data." unclear 813 35003060 Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease. hsa_circ_0001924 Homo sapiens Vogt-Koyanagi-Harada disease MONDO:0018092 Vogt-Koyanagi-Harada disease DOID:12297 CD4+T cells up-regulated hsa_circ_0001924 showed higher expression in sorted CD4+ T cells from active VKH patients compared with healthy controls and was validated by RT-qPCR. unclear 814 35003060 Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease. hsa_circ_0001320 Homo sapiens Vogt-Koyanagi-Harada disease MONDO:0018092 Vogt-Koyanagi-Harada disease DOID:12297 CD4+ T cells dys-regulated "hsa_circ_0001320 was differentially expressed in sorted CD4+ T cells from VKH patients compared with healthy controls, with RT-qPCR validation consistent with RNA-seq data." unclear 815 35003269 CircRNA FAT1 Regulates Osteoblastic Differentiation of Periodontal Ligament Stem Cells via miR-4781-3p/SMAD5 Pathway. hsa_circ_FAT1 FAT1 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 human periodontal ligament stem cells (PDLSCs) down-regulated "In primary cultured human PDLSCs, siRNA-mediated circFAT1 silencing decreased circFAT1 expression by RT-qPCR and reduced osteogenic differentiation markers and mineralization. The evidence links circFAT1 to PDLSC osteogenic differentiation relevant to periodontal regeneration." 816 35029057 Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours. mm9_circ_0007509 CircDYM mmu_circ_DYM DYM Mus musculus Major depressive disorder MONDO:0002009 major depressive disorder DOID:1470 primary mouse microglia up-regulated "In primary mouse microglia, RVG-circDYM-EVs increased circDYM levels as measured by absolute qPCR. In the same primary microglial system, RVG-circDYM-EVs reduced LPS-induced inflammatory activation markers." 817 35030455 Circ_SEC61A1 contributes to the progression of multiple myeloma cells via regulating miR-660-5p/CDK6 axis. hsa_circ_0007841 hsa_circ_SEC61A1 SEC61A1 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 Plasma cells up-regulated "CD138/SDC1-positive plasma cells were magnetically selected from MM patients and controls, and qRT-PCR showed circ_SEC61A1 was elevated in MM samples compared with non-tumor controls." 818 35030971 Circ_0019693 promotes osteogenic differentiation of bone marrow mesenchymal stem cell and enhances osteogenesis-coupled angiogenesis via regulating microRNA-942-5p-targeted purkinje cell protein 4 in the development of osteoporosis. hsa_circ_0019693 hsa_circ_NOLC1 NOLC1 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 BMSCs up-regulated circ_0019693 was gradually upregulated during osteogenic differentiation of human BMSCs. Functional assays showed that circ_0019693 promoted BMSC osteogenic differentiation and angiogenesis. 819 35036070 Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome. hsa_circ_0050946 hsa_circ_SIRT2 SIRT2 Homo sapiens Rett syndrome MONDO:0010726 Rett syndrome DOID:1206 differentiating neural progenitor cells; neuronal marker TUJ1 unknown RNA ISH showed hsa_circ_0050946 localization in differentiating human neural progenitor cells with colocalization to the neuronal marker TUJ1 in a MeCP2/Rett syndrome cellular model. 820 35036071 Circular RNA circSmoc1-2 regulates vascular calcification by acting as a miR-874-3p sponge in vascular smooth muscle cells. circSmoc1-2 rno_circ_Smoc1 Smoc1 Rattus norvegicus vascular calcification MONDO:0005311 atherosclerosis DOID:1936 Primary rat VSMCs down-regulated "circSmoc1-2, generated from the Smoc1 gene, is down-regulated in primary rat vascular smooth muscle cells after inorganic phosphate-induced vascular calcification, as verified by RT-PCR." 821 35039758 Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration. hsa_circ_0040039 hsa_circ_SNTB2 SNTB2 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 primary human NPCs up-regulated "In primary human NPCs, circ_0040039 was up-regulated after TNF-¦Á treatment used to simulate the IVDD inflammatory microenvironment. Functional experiments in NPCs linked circ_0040039 to PAoptosis, inflammatory response, growth inhibition, and ECM degradation." 822 35039758 Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration. hsa_circ_0004354 hsa_circ_SNTB2 SNTB2 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 primary human NPCs up-regulated "In primary human NPCs, circ_0004354 was up-regulated after TNF-¦Á treatment used to simulate the IVDD inflammatory microenvironment. Functional experiments in NPCs linked circ_0004354 to PAoptosis, inflammatory response, growth inhibition, and ECM degradation." 823 35045883 circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis. hsa_circ_0002557 hsa_circ_FARP1 FARP1 Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 Cancer-associated fibroblasts up-regulated "circFARP1 was up-regulated in cancer-associated fibroblasts compared with paired normal fibroblasts in PDAC, supported by RNA-seq of isolated CAFs/NFs and qRT-PCR validation. Functional experiments in CAFs linked circFARP1 to LIF-mediated tumor cell stemness and gemcitabine resistance." GSE172096 824 35045883 circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis. hsa_circ_0002557 hsa_circ_FARP1 FARP1 Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 Cancer-associated fibroblasts up-regulated qRT-PCR showed circFARP1 was specifically expressed in CAFs but not in cancer cells or other stromal cells in PDAC-related samples. CAF circFARP1 promoted paracrine LIF signaling associated with tumor cell stemness and gemcitabine resistance. 825 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA6809 bta_circ_PLXDC2 PLXDC2 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage up-regulated circRNA6809 was up-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 826 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA6689 bta_circ_CRYBG1 CRYBG1 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage up-regulated circRNA6689 was up-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 827 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA6273 bta_circ_CRLF2 CRLF2 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage up-regulated circRNA6273 was up-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 828 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA5915 bta_circ_CD44 CD44 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage up-regulated circRNA5915 was up-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 829 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA6092 bta_circ_WDR7 WDR7 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage up-regulated circRNA6092 was up-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 830 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA5983 bta_circ_TEX2 TEX2 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage up-regulated circRNA5983 was up-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 831 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA6014 bta_circ_FTO FTO Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage up-regulated circRNA6014 was up-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 832 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA2357 bta_circ_LVRN LVRN Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage up-regulated circRNA2357 was up-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 833 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA4934 bta_circ_GPR137B GPR137B Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage up-regulated circRNA4934 was up-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 834 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA5096 bta_circ_PLXNC1 PLXNC1 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage up-regulated circRNA5096 was up-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 835 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA1008 bta_circ_PRIM2 PRIM2 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage down-regulated circRNA1008 was down-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 836 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA1154 bta_circ_TT+Z2:Z40C13 TT+Z2:Z40C13 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage down-regulated circRNA1154 was down-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 837 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA1863 bta_circ_BRWD1 BRWD1 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage down-regulated circRNA1863 was down-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 838 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA2814 bta_circ_PLEKHA2 PLEKHA2 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage down-regulated circRNA2814 was down-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 839 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA1459 bta_circ_FGD4 FGD4 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage down-regulated circRNA1459 was down-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 840 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA1943 bta_circ_ERMARD ERMARD Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage down-regulated circRNA1943 was down-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 841 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA413 bta_circ_ATP8B4 ATP8B4 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage down-regulated circRNA413 was down-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 842 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA1245 bta_circ_MYO1F MYO1F Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage down-regulated circRNA1245 was down-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 843 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA150 bta_circ_ZC3H13 ZC3H13 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage down-regulated circRNA150 was down-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 844 35046920 Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis. circRNA1762 bta_circ_UBR4 UBR4 Bos taurus Johne¡¯s disease / paratuberculosis MONDO:0025449 paratuberculosis bovine monocyte-macrophage down-regulated circRNA1762 was down-regulated in MAP-infected bovine monocyte-derived macrophages compared with control MDM samples at 6 hpi. GSE185609 845 35066205 Hsa_circ_0001020 accelerates the lower extremity deep vein thrombosis via sponging miR-29c-3p to promote MDM2 expression. hsa_circ_0001020 hsa_circ_UGP2 UGP2 Homo sapiens lower extremity deep vein thrombosis MONDO:0005399 venous thromboembolism EPCs up-regulated "Primary isolated EPCs from DVT and control samples were analyzed by qRT-PCR, showing increased hsa_circ_0001020 in EPCs in DVT. Functional experiments in EPCs showed that hsa_circ_0001020 knockdown promoted EPC migration, invasion, and angiogenesis." 846 35066205 Hsa_circ_0001020 accelerates the lower extremity deep vein thrombosis via sponging miR-29c-3p to promote MDM2 expression. hsa_circ_0001020 hsa_circ_UGP2 UGP2 Homo sapiens lower extremity deep vein thrombosis MONDO:0005399 venous thromboembolism neutrophil no change "Primary isolated neutrophils from DVT and control samples were analyzed by qRT-PCR, and no change in hsa_circ_0001020 expression was observed in neutrophils." 847 35074490 Mechanism of CircANKRD36 regulating cell heterogeneity and endothelial mesenchymal transition in aortic valve stromal cells by regulating miR-599 and TGF-¦Â signaling pathway. hsa_circ_ANKRD36 ANKRD36 Homo sapiens Calcific aortic valve disease / CAVD MONDO:0005463 aortic valve calcification human aortic VIC down-regulated "Primary human aortic VICs were isolated and analyzed by qRT-PCR, showing that circANKRD36 expression decreased gradually during OM-induced osteogenic differentiation. Functional experiments in VICs indicated that circANKRD36 inhibited osteogenic differentiation, calcium nodule formation, and TGF-¦Â signaling activation." 848 35093109 "Circ_0001947 promotes cell proliferation, invasion, migration and inflammation and inhibits apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes through miR-671-5p/STAT3 axis." hsa_circ_0001947 hsa_circ_AFF2 AFF2 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs up-regulated "circ_0001947 is increased in rheumatoid arthritis fibroblast-like synoviocytes compared with normal fibroblast-like synoviocytes, based on qRT-PCR after isolation of FLSs from synovial tissues. Functional assays in RA-FLSs support roles in proliferation, invasion, migration, apoptosis and inflammation." 849 35117187 Potential of circular RNA itchy E3 ubiquitin protein ligase as a biomarker and treatment target for multiple myeloma. hsa_circ_ITCH ITCH Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 CD138+ myeloma cells (plasma cells) down-regulated "circ-ITCH expression was measured by qPCR after CD138 immunomagnetic purification of myeloma/plasma cells from bone marrow samples, and was lower in multiple myeloma patients than in healthy controls." 850 35120971 CircZNF652 promotes the goblet cell metaplasia by targeting the miR-452-5p/JAK2 signaling pathway in allergic airway epithelia. hsa_circ_0000782 circZNF652 hsa_circ_ZNF652 ZNF652 Homo sapiens allergic asthma MONDO:0004784 allergic asthma DOID:9415 airway epithelia up-regulated "In children with allergic asthma, circZNF652 is up-regulated in airway epithelial cells, supported by RNA-FISH co-localization of circZNF652 with the epithelial marker CC10 in BALF cells. The paper reports that circZNF652 contributes to goblet cell metaplasia through the miR-452-5p/JAK2/STAT6 pathway." 851 35120971 CircZNF652 promotes the goblet cell metaplasia by targeting the miR-452-5p/JAK2 signaling pathway in allergic airway epithelia. mmu_circ_0003573 circZNF652 mmu_circ_ZNF652 ZNF652 Mus musculus allergic asthma MONDO:0004784 allergic asthma DOID:9415 bronchial and alveolar epithelia up-regulated "In OVA-induced mouse allergic airway inflammation, circZNF652/mmu_circ_0003573 is up-regulated predominantly in bronchial and alveolar epithelial cells, with high expression reported in CC10+ airway epithelial cells. Knockdown of circZNF652 attenuated goblet cell metaplasia in allergic airway inflammation." 852 35122957 Andrographolide suppresses osteoarthritis progression by regulating circ_Rapgef1/miR-383-3p/NLRP3 signaling axis. mmu_circ_Rapgef1 Rapgef1 Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 mouse primary chondrocytes up-regulated "circ_Rapgef1 expression is elevated in LPS-induced osteoarthritis-model mouse primary chondrocytes. Functional experiments in chondrocytes linked circ_Rapgef1 to proliferation, apoptosis and inflammatory responses." 853 35122957 Andrographolide suppresses osteoarthritis progression by regulating circ_Rapgef1/miR-383-3p/NLRP3 signaling axis. mmu_circ_Rapgef1 Rapgef1 Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 mouse primary chondrocytes down-regulated AD treatment reduces circ_Rapgef1 expression in LPS-induced osteoarthritis-model mouse primary chondrocytes. Functional experiments indicate that circ_Rapgef1 overexpression counteracts AD-mediated protective effects in chondrocytes. 854 35136049 Hsa_circ_0134111 promotes intervertebral disc degeneration via sponging miR-578. Hsa_circ_0134111 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 NP cells up-regulated "In primary cultured nucleus pulposus cells, IL-1¦Â and TNF-¦Á treatment increased circ_0134111 expression as measured by qRT-PCR. Functional experiments in NP cells showed that circ_0134111 overexpression promoted proliferation, pro-inflammatory cytokine secretion, and ECM degradation." 855 35154330 Identification of circRNA Expression Profiles in BMSCs from Glucocorticoid-Induced Osteoporosis Model. circARSB rno_circ_Arsb Arsb Rattus norvegicus glucocorticoid-induced osteoporosis MONDO:0000757 glucocorticoid-induced osteoporosis DOID:0060343 BMSCs up-regulated "circARSB was upregulated in primary rat BMSCs from the glucocorticoid-induced osteoporosis group compared with normal controls, based on RNA-seq and qRT-PCR validation. Knockdown experiments suggested circARSB negatively regulates BMSC osteogenic differentiation." 856 35154330 Identification of circRNA Expression Profiles in BMSCs from Glucocorticoid-Induced Osteoporosis Model. circAKT3 rno_circ_Akt3 Akt3 Rattus norvegicus glucocorticoid-induced osteoporosis MONDO:0000757 glucocorticoid-induced osteoporosis DOID:0060343 BMSCs up-regulated "circAKT3 was upregulated in primary rat BMSCs from the glucocorticoid-induced osteoporosis group compared with normal controls, based on RNA-seq and qRT-PCR validation." 857 35154330 Identification of circRNA Expression Profiles in BMSCs from Glucocorticoid-Induced Osteoporosis Model. circTRPM7 rno_circ_Trpm7 Trpm7 Rattus norvegicus glucocorticoid-induced osteoporosis MONDO:0000757 glucocorticoid-induced osteoporosis DOID:0060343 BMSCs down-regulated "circTRPM7 was downregulated in primary rat BMSCs from the glucocorticoid-induced osteoporosis group compared with normal controls, based on RNA-seq and qRT-PCR validation." 858 35154330 Identification of circRNA Expression Profiles in BMSCs from Glucocorticoid-Induced Osteoporosis Model. circPTEN rno_circ_Pten Pten Rattus norvegicus glucocorticoid-induced osteoporosis MONDO:0000757 glucocorticoid-induced osteoporosis DOID:0060343 BMSCs down-regulated "circPTEN was downregulated in primary rat BMSCs from the glucocorticoid-induced osteoporosis group compared with normal controls, based on RNA-seq and qRT-PCR validation. Knockdown experiments suggested circPTEN positively regulates BMSC osteogenic differentiation." 859 35172608 circPlekha7 suppresses renal fibrosis via targeting miR-493-3p/KLF4. circPlekha7 mmu_circ_Plekha7 Plekha7 Mus musculus renal fibrosis MONDO:0000494 renal fibrosis DOID:0050855 primary cultured renal tubular epithelial cells down-regulated circPlekha7 is reduced in TGF-¦Â1-treated renal tubular epithelial cells under an in vitro fibrosis-inducing condition. Overexpression of circPlekha7 suppressed EMT and fibrogenesis in this renal fibrosis model. 860 35174214 Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts. hsa_circ_0001055 Homo sapiens keloid MONDO:0005348 keloid keloid dermal fibroblasts (KDFs) up-regulated "hsa_circ_0001055 was significantly upregulated in keloid dermal fibroblasts compared with normal dermal fibroblasts, supported by qRT-PCR validation after primary fibroblast culture." GSE184097 861 35174214 Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts. hsa_circ_0006867 hsa_circ_LRBA LRBA Homo sapiens keloid MONDO:0005348 keloid keloid dermal fibroblasts (KDFs) up-regulated "hsa_circ_0006867 was significantly increased in keloid dermal fibroblasts compared with normal dermal fibroblasts. Silencing hsa_circ_0006867 suppressed proliferation, migration, and invasion of keloid fibroblasts in vitro." GSE184097 862 35174214 Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts. hsa_circ_0073244 Homo sapiens keloid MONDO:0005348 keloid keloid dermal fibroblasts (KDFs) up-regulated "hsa_circ_0073244 was significantly upregulated in keloid dermal fibroblasts compared with normal dermal fibroblasts, supported by qRT-PCR validation after primary fibroblast culture." GSE184097 863 35174214 Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts. hsa_circ_0004662 hsa_circRNA_004662 hsa_circ_SOD2 SOD2 Homo sapiens keloid MONDO:0005348 keloid keloid dermal fibroblasts (KDFs) down-regulated "hsa_circ_0004662 was significantly downregulated in keloid dermal fibroblasts compared with normal dermal fibroblasts, supported by qRT-PCR validation after primary fibroblast culture." GSE184097 864 35174214 Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts. hsa_circ_0000479 hsa_circRNA_000479 hsa_circ_EPSTI1 EPSTI1 Homo sapiens keloid MONDO:0005348 keloid keloid dermal fibroblasts (KDFs) down-regulated "hsa_circ_0000479 was significantly downregulated in keloid dermal fibroblasts compared with normal dermal fibroblasts, supported by qRT-PCR validation after primary fibroblast culture." GSE184097 865 35182060 CircRNA-011235 Counteracts The Deleterious Effect of Irradiation Treatment on Bone Mesenchymal Stem Cells by Regulating The miR-741-3p/CDK6 Pathway. circRNA-011235 Mus musculus irradiation-induced BMSCs injury MONDO:0033938 acute radiation syndrome bone mesenchymal stem cells (BMSCs) up-regulated "In mouse bone mesenchymal stem cells isolated from femurs and tibias and identified by flow sorting, circ-011235 was increased after irradiation compared with 0 Gy control in a dose-dependent manner. Functional experiments in irradiation-treated BMSCs indicated that circ-011235 overexpression promoted proliferation and cell cycle progression through the miR-741-3p/CDK6 pathway." 866 35184419 Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma. circRNA_101093 / cir93 hsa_circ_NUP107 NUP107 Homo sapiens lung adenocarcinoma MONDO:0005061 lung adenocarcinoma DOID:3910 EpCAM (+) cells up-regulated circRNA_101093 (cir93) is higher in sorted EpCAM-positive tumor epithelial cells than in EpCAM-negative cells from primary LUAD tumors. The study further links tumor-cell exosomal cir93 to maintenance of intracellular cir93 and ferroptosis desensitization in LUAD cells. 867 35184658 The circular RNA circ_0030018/miR-136/migration and invasion enhancer 1 (MIEN1) axis promotes the progression of polycystic ovary syndrome. hsa_circ_0030018 circ_0030018 / circ-POSTN hsa_circ_POSTN POSTN Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 ovarian GCs up-regulated "circ_0030018 is up-regulated in isolated ovarian GCs from patients with PCOS compared with healthy subjects, as measured by qPCR." GSE145296 868 35187630 Hsa_circ_0048674 facilitates hepatocellular carcinoma progression and natural killer cell exhaustion depending on the regulation of miR-223-3p/PDL1. hsa_circ_0048674 circUHRF1 hsa_circ_UHRF1 UHRF1 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 NK cells up-regulated Primary human NK cells were isolated and hsa_circ_0048674 expression was measured by qRT-PCR after co-culture with HCC cells versus culture alone. The study reports that hsa_circ_0048674 knockdown recovered HCC cell-induced impairment of IFN-¦Ã and TNF-¦Á concentrations in NK cells. 869 35189704 CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke. mmu_circ_0000231 CircOGDH mmu_circ_OGDH OGDH Mus musculus ischemic stroke MONDO:1060198 ischemic stroke neurons up-regulated "CircOGDH is preferentially localized in neurons of the ischemic penumbra in MCAO mice compared with contralateral tissue, with limited localization in microglia and astrocytes. Functional experiments indicate CircOGDH contributes to neuronal apoptosis and injury under ischemic conditions." 870 35189704 CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke. mmu_circ_0000231 CircOGDH mmu_circ_OGDH OGDH Mus musculus ischemic stroke MONDO:1060198 ischemic stroke primary cortical neurons up-regulated CircOGDH expression is higher in primary cortical neurons under ischemic conditions than under normoxic conditions. Knockdown of CircOGDH ameliorates neuronal apoptosis under ischemic conditions. 871 35189704 CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke. mmu_circ_0000231 CircOGDH mmu_circ_OGDH OGDH Mus musculus ischemic stroke MONDO:1060198 ischemic stroke primary cortical neurons up-regulated CircOGDH is significantly elevated in exosomes from primary cortical neurons under ischemic conditions. The study further indicates neuronal exosomal CircOGDH can regulate COL4A4 expression in recipient neurons. 872 35189958 circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-¦ÊB signaling pathway. hsa_circ_0000234 circCUL2 hsa_circ_CUL2 CUL2 Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 cancer-associated fibroblasts (CAFs) up-regulated "circCUL2 is up-regulated in primary PDAC cancer-associated fibroblasts compared with paired normal fibroblasts, supported by circRNA sequencing and qRT-PCR. Functional experiments indicate circCUL2 promotes an inflammatory CAF phenotype and PDAC progression via IL6-related signaling." GSE172096 873 35192424 Hsa_circ_0007059 promotes apoptosis and inflammation in cardiomyocytes during ischemia by targeting microRNA-378 and microRNA-383. hsa_circ_0007059 Homo sapiens myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 cardiomyocytes up-regulated "circ_0007059 expression was elevated in isolated mouse cardiomyocytes after H2O2 treatment compared with untreated controls. Functional experiments in cardiomyocytes linked circ_0007059 to H2O2-induced apoptosis, inflammation and oxidative stress." 874 35196925 Circ_0110251 overexpression alleviates IL-1¦Â-induced chondrocyte apoptosis and extracellular matrix degradation by regulating miR-3189-3p/SPRY1 axis in osteoarthritis. hsa_circ_0110251 circ_0110251 hsa_circ_COL11A1 COL11A1 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes down-regulated "circ_0110251 was down-regulated in IL-1b-induced primary chondrocytes compared with PBS-treated control chondrocytes, as measured by qRT-PCR. Functional experiments indicated that circ_0110251 overexpression protected chondrocytes from IL-1b-induced apoptosis and ECM-related injury." 875 35222790 Arterial Pulsatility Augments Microcirculatory Perfusion and Maintains the Endothelial Integrity during Extracorporeal Membrane Oxygenation via hsa_circ_0007367 Upregulation in a Canine Model with Cardiac Arrest. hsa_circ_0007367 circUBAP2 hsa_circ_UBAP2 UBAP2 Homo sapiens cardiac arrest MONDO:0000745 cardiac arrest DOID:0060319 pulmonary vascular endothelial cells (PMVECs) up-regulated "In isolated PMVEC primary cultures, hsa_circ_0007367/circUBAP2 was upregulated after pulsatile flow compared with nonpulsatile flow, measured by qRT-PCR. Functional experiments in PMVECs showed hsa_circ_0007367 was required for pulsatile-flow effects on tight junction markers and endothelial inflammation." 876 35225027 Evaluating the Effect of Circ-Sirt1 on the Expression of SIRT1 and Its Role in Pathology of Pulmonary Hypertension. circ-Sirt1 rno_circ_Sirt1 Sirt1 Rattus norvegicus pulmonary arterial hypertension MONDO:0015924 pulmonary arterial hypertension pulmonary artery smooth muscle cells (PASMC) down-regulated Primary rat pulmonary artery smooth muscle cells were isolated and used to show reduced circ-Sirt1 expression in response to hypoxia. Functional experiments indicated that circ-Sirt1 overexpression inhibited PASMC proliferation and migration. 877 35233964 circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity. hsa_circRNA_400564 hsa_circ_REEP3 REEP3 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 invasive CRC cells up-regulated "circREEP3 was among circRNAs up-regulated in invasive CRC primary sample cells compared with noninvasive tumor cells, with upregulation validated by qRT-PCR. Functional screening indicated circREEP3 knockdown inhibited CRC proliferation and invasion." GSE196203 878 35264957 Hsa_Circ_0098181 Suppresses Hepatocellular Carcinoma by Sponging miR-18a-3p and Targeting PPARA. hsa_circ_0098181 hsa_circ_SOX5 SOX5 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 hepatocytes down-regulated "FISH showed hsa_circ_0098181 enrichment in paratumor tissue compared with HCC tissue and dominant cytoplasmic localization in hepatocytes, supporting reduced expression in the tumor context." 879 35266112 rtcisE2F promotes the self-renewal and metastasis of liver tumor-initiating cells via N6-methyladenosine-dependent E2F3/E2F6 mRNA stability. rtcisE2F CYP2C18; CYP2C19 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 CD133 + liver TICs up-regulated rtcisE2F is highly expressed in CD133+ liver tumor-initiating cells compared with CD133- liver non-TICs. Functional assays in liver TIC-related systems showed that rtcisE2F supports TIC self-renewal and metastatic activity. 880 35275449 Knockdown of circular RNA hsa_circ_0003307 inhibits synovial inflammation in ankylosing spondylitis by regulating the PI3K/AKT pathway. hsa_circ_0003307 Homo sapiens ankylosing spondylitis MONDO:0005306 ankylosing spondylitis DOID:7147 fibroblast-like synoviocytes (FLS); AS-FLS up-regulated hsa_circ_0003307/circRNA_0003307 was detected by qRT-PCR in primary fibroblast-like synoviocytes isolated from synovial tissues of ankylosing spondylitis patients and was described as highly expressed in AS-FLS. Knockdown of circRNA_0003307 reduced inflammatory responses in AS-FLS through regulation of the PI3K/AKT pathway. 881 35278480 Circ_0002945 functions as a competing endogenous RNA to promote A¦Â25-35-induced endoplasmic reticulum stress and apoptosis in SK-N-SH cells and human primary neurons. hsa_circ_0002945 circ_0002945 hsa_circ_AXL AXL Homo sapiens Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 human primary neurons (HPNs) up-regulated circ_0002945 was up-regulated in human primary neurons after A¦Â 25-35 stimulation. Knockdown experiments in HPNs supported a role for circ_0002945 in A¦Â 25-35-induced apoptosis and endoplasmic reticulum stress. 882 35286916 Hsa_circ_0087352 promotes the inflammatory response of macrophages in abdominal aortic aneurysm by adsorbing hsa-miR-149-5p. hsa_circ_0087352 hsa_circ_UBQLN1 UBQLN1 Homo sapiens abdominal aortic aneurysm MONDO:0005350 abdominal aortic aneurysm DOID:7693 CD68 (macrophage marker) unknown FISH combined with CD68 immunostaining showed co-expression of hsa-circ-0087352 with macrophages in AAA patient tissue. The study further reports that hsa_circ_0087352 promotes inflammatory responses in macrophages. 883 35300071 Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis. rno_circ_RHOT1 RHOT1 Rattus norvegicus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes down-regulated "Primary rat chondrocytes were isolated and circRHOT1 expression was measured by qPCR, showing shRNA-mediated depletion in chondrocytes. In these chondrocytes, circRHOT1 depletion reduced viability and proliferation and induced apoptosis." 884 35303684 Circular RNA circRNF169 functions as a miR-30c-5p sponge to promote cellular senescence. mmu_circ_0001605 mmu_circ_RNF169 RNF169 Mus musculus cellular senescence others others mouse embryonic fibroblasts (MEFs) up-regulated "circRNF169/mmu_circ_0001605 is up-regulated in senescent primary mouse embryonic fibroblasts compared with young MEFs, verified by qRT-PCR after prior RNA-seq identification. Functional assays in MEFs showed that circRNF169 promotes cellular senescence and suppresses proliferation through miR-30c-5p sponging." 885 35306484 Circular RNA circ_0001006 aggravates cardiac hypertrophy via miR-214-3p/PAK6 axis. hsa_circ_0001006 Homo sapiens cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocytes up-regulated "circ_0001006 was up-regulated in primary cardiomyocytes after Ang II-induced hypertrophic treatment. Functional experiments in cardiomyocytes showed that circ_0001006 gain of function induced hypertrophy, while knockdown reduced Ang II-induced hypertrophy." 886 35307784 CircOAS3 Regulates Keratinocyte Proliferation and Psoriatic Inflammation by Interacting with Hsc70 via the JNK/STAT3/NF-¦ÊB Signaling Pathway. hsa_circ_0028434 hsa_circ_OAS3 OAS3 Homo sapiens psoriasis MONDO:0005083 psoriasis DOID:8893 keratinocytes up-regulated "circOAS3 expression was increased in M5-stimulated keratinocytes, including primary NHEKs, using qRT-PCR after primary keratinocyte isolation and culture." 887 35358709 "Circular RNA circ_0130438 suppresses TNF-¦Á-induced proliferation, migration, invasion and inflammation in human fibroblast-like MH7A synoviocytes by regulating miR-130a-3p/KLF9 axis." hsa_circ_0130438 hsa_circ_KPNA5 KPNA5 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs down-regulated "circ_0130438 is down-regulated in fibroblast-like synoviocytes isolated from rheumatoid arthritis synovial tissues compared with normal FLSs, based on primary cell isolation followed by qRT-PCR." 888 35359572 Hsa_circ_0031608: A Potential Modulator of VSMC Phenotype in the Rupture of Intracranial Aneurysms. hsa_circ_0031608 hsa_circ_SNX6 SNX6 Homo sapiens Intracranial aneurysm MONDO:0005291 brain aneurysm DOID:10941 VSMCs up-regulated "hsa_circ_0031608 was significantly increased in TNF-¦Á-induced phenotypically transformed VSMCs, supporting up-regulation in inflammatory/phenotypically modulated vascular smooth muscle cells relevant to intracranial aneurysm rupture. Overexpression of hsa_circ_0031608 promoted VSMC phenotypic transformation, migration, and proliferation." 889 35361779 Circular RNA circStag1 promotes bone regeneration by interacting with HuR. hsa_circ_0003626 hsa_circ_STAG1 STAG1 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 bone marrow mesenchymal stem cells (BMSCs) down-regulated "circStag1 was downregulated in osteoporotic BMSCs from OVX rats compared with sham controls, supported by circRNA RNA-seq followed by qPCR validation. Functional assays in BMSCs showed that circStag1 promoted osteogenic differentiation via HuR/Wnt signaling." 890 35361779 Circular RNA circStag1 promotes bone regeneration by interacting with HuR. circStag1 rno_circ_Stag1 Stag1 Rattus norvegicus osteoporosis MONDO:0005298 osteoporosis DOID:11476 bone marrow mesenchymal stem cells (BMSCs) down-regulated "circStag1 was downregulated in osteoporotic BMSCs from OVX rats compared with sham controls, supported by circRNA RNA-seq followed by qPCR validation. Functional assays in BMSCs showed that circStag1 promoted osteogenic differentiation via HuR/Wnt signaling." 891 35366240 Circular RNA circGSE1 promotes angiogenesis in ageing mice by targeting the miR-323-5p/NRP1 axis. circGSE1 mmu_circ_GSE1 GSE1 Mus musculus ageing-related cardiovascular diseases others others old endothelial cells (OECs) down-regulated "circGSE1 is down-regulated in ageing mouse aortic endothelial cells compared with young endothelial cells, based on circRNA sequencing and qRT-PCR after primary endothelial cell isolation. In MAECs, circGSE1 promotes proliferation, migration and tube formation through the miR-323-5p/NRP1 axis." 892 35371308 Circular RNA circASPM promotes the progression of glioblastoma by acting as a competing endogenous RNA to regulate miR-130b-3p/E2F1 axis. hsa_circ_0015772 circASPM / circAPSM hsa_circ_ASPM ASPM Homo sapiens glioblastoma MONDO:0018177 glioblastoma DOID:3068 patient-derived GSCs up-regulated "circASPM was measured by qPCR in patient-derived glioma stem cells isolated from fresh GBM specimens and was higher in GSCs than in normal human astrocytes. Functional experiments in GSCs showed circASPM promoted proliferation, neurosphere formation, and tumorigenesis." 893 35378401 Peripheral blood circular RNA hsa_circ_0058493 as a potential novel biomarker for silicosis and idiopathic pulmonary fibrosis. hsa_circ_0003638 hsa_circ_NLK NLK Homo sapiens silicosis MONDO:0005960 silicosis DOID:10325 peripheral blood lymphocyte (PBL) up-regulated hsa_circ_0003638 was identified from PBL circRNA RNA-seq screening and reported as significantly highly expressed in silicosis cases compared with controls. 894 35378401 Peripheral blood circular RNA hsa_circ_0058493 as a potential novel biomarker for silicosis and idiopathic pulmonary fibrosis. hsa_circ_0058493 hsa_circ_RHBDD1 RHBDD1 Homo sapiens silicosis MONDO:0005960 silicosis DOID:10325 peripheral blood lymphocyte (PBL) up-regulated hsa_circ_0058493 was identified from PBL circRNA RNA-seq screening and reported as significantly highly expressed in silicosis cases compared with controls. 895 35387588 CircUBE2Q2 promotes differentiation of cattle muscle stem cells and is a potential regulatory molecule of skeletal muscle development. bta_circ_0002760 CircUBE2Q2 bta_circ_UBE2Q2 UBE2Q2 Bos taurus skeletal muscle development MONDO:0020120 skeletal muscle disorder cattle MuSCs up-regulated "CircUBE2Q2 was up-regulated in differentiated cattle MuSCs compared with proliferating MuSCs, supported by RNA-seq and RT-qPCR after primary MuSC isolation and culture. Functional assays in MuSCs showed effects on proliferation, apoptosis, and differentiation." GSE152398 896 35387588 CircUBE2Q2 promotes differentiation of cattle muscle stem cells and is a potential regulatory molecule of skeletal muscle development. bta_circ_0002760 CircUBE2Q2 bta_circ_UBE2Q2 UBE2Q2 Bos taurus skeletal muscle development MONDO:0020120 skeletal muscle disorder adipocytes (SVFs) derived from intramuscular fat up-regulated "CircUBE2Q2 was expressed at a higher level in adipocytes/SVFs derived from intramuscular fat than in MuSCs, measured by RT-qPCR." 897 35387588 CircUBE2Q2 promotes differentiation of cattle muscle stem cells and is a potential regulatory molecule of skeletal muscle development. bta_circ_0002760 CircUBE2Q2 bta_circ_UBE2Q2 UBE2Q2 Bos taurus skeletal muscle development MONDO:0020120 skeletal muscle disorder SVFs up-regulated "CircUBE2Q2 was up-regulated during adipogenic differentiation of SVFs and remained expressed until differentiation maturity, measured by RT-qPCR." 898 35390056 "Hsa_circ_0056686, derived from cancer-associated fibroblasts, promotes cell proliferation and suppresses apoptosis in uterine leiomyoma through inhibiting endoplasmic reticulum stress." hsa_circ_0056686 hsa_circ_KIF5C KIF5C Homo sapiens uterine leiomyoma MONDO:0007886 uterine corpus leiomyoma DOID:13223 cancer-associated fibroblasts (CAFs) up-regulated "Primary CAFs isolated from uterine leiomyoma tumor zones showed higher hsa_circ_0056686 expression than corresponding normal fibroblasts. CAF-derived hsa_circ_0056686 contributed to CAF-mediated proliferation, migration, ECM accumulation, and reduced apoptosis in ULM cells." 899 35390056 "Hsa_circ_0056686, derived from cancer-associated fibroblasts, promotes cell proliferation and suppresses apoptosis in uterine leiomyoma through inhibiting endoplasmic reticulum stress." hsa_circ_0056686 hsa_circ_KIF5C KIF5C Homo sapiens uterine leiomyoma MONDO:0007886 uterine corpus leiomyoma DOID:13223 leiomyoma smooth muscle cells (LSMCs) up-regulated "Primary leiomyoma smooth muscle cells treated with CAF-conditioned medium showed significantly increased hsa_circ_0056686 expression compared with paired NF-conditioned medium treatment. Functional assays linked CAF-derived hsa_circ_0056686 to LSMC proliferation, migration, ECM accumulation, and apoptosis regulation." 900 35391605 Circular RNA circ_0001445 alleviates the ox-LDL-induced endothelial injury in human primary aortic endothelial cells through regulating ABCG1 via acting as a sponge of miR-208b-5p. hsa_circ_0001445 circ_0001445 hsa_circ_SMARCA5 SMARCA5 Homo sapiens Coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 Human primary aortic endothelial cells; HAECs down-regulated "circ_0001445 was down-regulated in ox-LDL-treated human primary aortic endothelial cells used as an in vitro CAD model. Functional assays in HAECs showed that circ_0001445 overexpression weakened ox-LDL-induced endothelial injury by affecting proliferation, migration, inflammation, and ECM accumulation." 901 35396771 Exosomal circGSE1 promotes immune escape of hepatocellular carcinoma by inducing the expansion of regulatory T cells. hsa_circ_0000722 circGSE1 hsa_circ_GSE1 GSE1 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 T cells up-regulated "circGSE1 was up-regulated in sorted human T cells after treatment with HCC patient serum-derived or HCC cell-derived exosomes, as measured by qRT-PCR. FISH further showed cytoplasmic circGSE1 signals in T cells after exosome treatment." GSE100206; GSE100207 902 35400095 "circRNA Expression Pattern and circRNA-miRNA-mRNA Network in HCs, HSCs, and KCs of Murine Liver After Echinococcus multilocularis Infection." circDENND1B Mus musculus alveolar echinococcosis MONDO:0017282 alveolar echinococcosis DOID:12148 HCs up-regulated circDENND1B was up-regulated in isolated murine hepatocytes at 3 months after E. multilocularis infection. PRJNA732233 903 35400095 "circRNA Expression Pattern and circRNA-miRNA-mRNA Network in HCs, HSCs, and KCs of Murine Liver After Echinococcus multilocularis Infection." mmu_circ_0001679 mmu-circ-0001679 Mus musculus alveolar echinococcosis MONDO:0017282 alveolar echinococcosis DOID:12148 HC up-regulated mmu-circ-0001679 was increased in isolated murine hepatocytes at 3 months after E. multilocularis infection. PRJNA732233 904 35400095 "circRNA Expression Pattern and circRNA-miRNA-mRNA Network in HCs, HSCs, and KCs of Murine Liver After Echinococcus multilocularis Infection." mmu_circ_0001209 circ-0001209 Mus musculus alveolar echinococcosis MONDO:0017282 alveolar echinococcosis DOID:12148 HCs up-regulated circ-0001209 was reported as up-regulated at 3 months after infection in the hepatocyte-focused discussion of metabolic circRNAs. PRJNA732233 905 35400095 "circRNA Expression Pattern and circRNA-miRNA-mRNA Network in HCs, HSCs, and KCs of Murine Liver After Echinococcus multilocularis Infection." circPSD3 Mus musculus alveolar echinococcosis MONDO:0017282 alveolar echinococcosis DOID:12148 HCs down-regulated circPSD3 was down-regulated in isolated murine hepatocytes after E. multilocularis infection. PRJNA732233 906 35400095 "circRNA Expression Pattern and circRNA-miRNA-mRNA Network in HCs, HSCs, and KCs of Murine Liver After Echinococcus multilocularis Infection." circPSD3 Mus musculus alveolar echinococcosis MONDO:0017282 alveolar echinococcosis DOID:12148 HSCs down-regulated circPSD3 was down-regulated in isolated murine hepatic stellate cells after E. multilocularis infection. PRJNA732233 907 35400095 "circRNA Expression Pattern and circRNA-miRNA-mRNA Network in HCs, HSCs, and KCs of Murine Liver After Echinococcus multilocularis Infection." mmu_circ_0007007 mmu-circ-0007007 Mus musculus alveolar echinococcosis MONDO:0017282 alveolar echinococcosis DOID:12148 HSCs up-regulated mmu-circ-0007007 was continuously up-regulated in isolated murine hepatic stellate cells after E. multilocularis infection. PRJNA732233 908 35400095 "circRNA Expression Pattern and circRNA-miRNA-mRNA Network in HCs, HSCs, and KCs of Murine Liver After Echinococcus multilocularis Infection." mmu_circ_0013854 mmu-circ-0013854 Mus musculus alveolar echinococcosis MONDO:0017282 alveolar echinococcosis DOID:12148 HSCs up-regulated mmu-circ-0013854 was continuously up-regulated in isolated murine hepatic stellate cells after E. multilocularis infection. PRJNA732233 909 35400095 "circRNA Expression Pattern and circRNA-miRNA-mRNA Network in HCs, HSCs, and KCs of Murine Liver After Echinococcus multilocularis Infection." mmu_circ_0012341 mmu-circ-0012341 Mus musculus alveolar echinococcosis MONDO:0017282 alveolar echinococcosis DOID:12148 HSCs up-regulated mmu-circ-0012341 was continuously up-regulated in isolated murine hepatic stellate cells after E. multilocularis infection. PRJNA732233 910 35402068 The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis. circNlgn hsa_circ_Nlgn Nlgn Homo sapiens doxorubicin-induced cardiofibrosis MONDO:0023006 doxorubicin induced cardiomyopathy primary cardiomyocytes (PCMs) up-regulated "circNlgn was significantly upregulated in isolated primary cardiomyocytes from circNlgn-transgenic mouse hearts compared with litter-matched circNlgn-negative mouse hearts, as measured by real-time PCR." 911 35402073 CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7. hsa_circ_0080914 circHGF hsa_circ_HGF HGF Homo sapiens steroid-induced osteonecrosis of the femoral head MONDO:0012126 familial avascular necrosis of femoral head BMSCs up-regulated "circHGF / hsa_circ_0080914 was up-regulated in isolated BMSCs from steroid-induced ONFH patients compared with control BMSCs, with validation by RT-qPCR. In BMSCs, circHGF suppressed proliferation and osteogenic differentiation through the miR-25-3p/SMAD7 axis." 912 35416113 Inhibition of Circ-Snrk ameliorates apoptosis and inflammation in acute kidney injury by regulating the MAPK pathway. rno_circ_SNRK SNRK Rattus norvegicus acute kidney injury MONDO:0002492 acute kidney injury DOID:3021 renal tubular epithelial cells unknown FISH with E-cadherin as a renal tubular epithelial cell marker confirmed localization of circ-Snrk in renal tubular epithelial cells in the rat kidney. The cell-type-resolved evidence supports localization but does not establish a cell-specific differential expression direction. 913 35429518 Circular RNA Signatures of Human Healing and Nonhealing Wounds. hsa-CHST15_0003 hsa_circ_CHST15 CHST15 Homo sapiens venous ulcers MONDO:0004634 vein disorder DOID:866 human epidermal KCs unknown hsa-CHST15_0003 was detected in primary human epidermal keratinocytes and was reported as upregulated in VU tissue. Knockdown in keratinocytes affected migration- and cell cycle-related gene programs and altered keratinocyte migration and growth. GSE174661; GSE188939 914 35429518 Circular RNA Signatures of Human Healing and Nonhealing Wounds. hsa-TNFRSF21_0001 hsa_circ_TNFRSF21 TNFRSF21 Homo sapiens venous ulcers MONDO:0004634 vein disorder DOID:866 human epidermal KCs unknown "hsa-TNFRSF21_0001 was detected in primary human epidermal keratinocytes and was reported as upregulated in VU tissue. Knockdown in keratinocytes altered differentiation, adhesion, EMT and cell-cycle gene programs and promoted migration while delaying growth." GSE174661; GSE188939 915 35435123 CircRNA CTNNB1 (circCTNNB1) ameliorates cerebral ischemia/reperfusion injury by sponging miR-96-5p to up-regulate scavenger receptor class B type 1 (SRB1) expression. mmu_circ_CTNNB1 CTNNB1 Mus musculus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary mouse astrocytes (mAS) down-regulated "circCTNNB1 was down-regulated in primary mouse astrocytes after OGD/R treatment compared with control cells. Overexpression experiments in mAS cells indicated protective effects against apoptosis, oxidative stress and inflammatory responses induced by OGD/R." 916 35436629 CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis. circ608 Mus musculus nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 PHSCs down-regulated circ608 was down-regulated in PINK1-knockdown primary hepatic stellate cells compared with si-NC PHSCs in a circRNA sequencing analysis related to NASH-related liver fibrosis. 917 35436629 CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis. circ929 Mus musculus nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 PHSCs down-regulated circ929 was down-regulated in PINK1-knockdown primary hepatic stellate cells compared with si-NC PHSCs in a circRNA sequencing analysis related to NASH-related liver fibrosis. 918 35436629 CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis. circ5 Mus musculus nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 PHSCs down-regulated circ5 was down-regulated in PINK1-knockdown primary hepatic stellate cells compared with si-NC PHSCs in a circRNA sequencing analysis related to NASH-related liver fibrosis. 919 35436629 CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis. circ1125 Mus musculus nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 PHSCs down-regulated circ1125 was down-regulated in PINK1-knockdown primary hepatic stellate cells compared with si-NC PHSCs in a circRNA sequencing analysis related to NASH-related liver fibrosis. 920 35436629 CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis. circ1177 Mus musculus nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 PHSCs down-regulated circ1177 was down-regulated in PINK1-knockdown primary hepatic stellate cells compared with si-NC PHSCs in a circRNA sequencing analysis related to NASH-related liver fibrosis. 921 35436629 CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis. circ34 Mus musculus nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 PHSCs down-regulated circ34 was down-regulated in PINK1-knockdown primary hepatic stellate cells compared with si-NC PHSCs in a circRNA sequencing analysis related to NASH-related liver fibrosis. 922 35436629 CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis. circ846 Mus musculus nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 PHSCs down-regulated circ846 was down-regulated in PINK1-knockdown primary hepatic stellate cells compared with si-NC PHSCs in a circRNA sequencing analysis related to NASH-related liver fibrosis. 923 35436629 CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis. circ401 Mus musculus nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 PHSCs up-regulated circ401 was up-regulated in PINK1-knockdown primary hepatic stellate cells compared with si-NC PHSCs in a circRNA sequencing analysis related to NASH-related liver fibrosis. 924 35436629 CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis. circ1226 Mus musculus nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 PHSCs up-regulated circ1226 was up-regulated in PINK1-knockdown primary hepatic stellate cells compared with si-NC PHSCs in a circRNA sequencing analysis related to NASH-related liver fibrosis. 925 35439733 Circular RNA circ_0000423 regulates cartilage ECM synthesis via circ_0000423/miRNA-27b-3p/MMP-13 axis in osteoarthritis. hsa_circ_0000423 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocyte up-regulated Circ_0000423 is up-regulated in IL-1¦Â-induced primary chondrocytes compared with normal chondrocytes. Functional experiments in chondrocytes showed that Circ_0000423 affects MMP-13 and collagen II expression through miRNA-27b-3p. 926 35447224 Circular RNA circTLK1 regulates dopaminergic neuron injury during Parkinson's disease by targeting miR-26a-5p/DAPK1. circTLK1 mmu_circ_TLK1 TLK1 Mus musculus Parkinson's disease MONDO:0005180 Parkinson disease DOID:14330 primary mesencephalic neurons up-regulated "In mouse primary mesencephalic neurons, rotenone treatment elevated circTLK1 expression by RT-PCR. circTLK1 depletion reversed rotenone-induced decreases in viability and reduced apoptosis/cytotoxicity in these primary neurons." 927 35447889 Patterns of Differentially Expressed circRNAs in Human Thymocytes. hsa_circIKZF1_0001 hsa_circ_IKZF1 IKZF1 Homo sapiens others others others thymocytes up-regulated hsa_circIKZF1_0001 increases progressively across sorted human thymocyte differentiation stages based on RNA-seq of purified thymocyte populations. GSE178889 928 35447889 Patterns of Differentially Expressed circRNAs in Human Thymocytes. hsa_circHIPK3_0001 hsa_circ_HIPK3 HIPK3 Homo sapiens others others others thymocytes down-regulated hsa_circHIPK3_0001 decreases as sorted human thymocytes progress through differentiation stages based on RNA-seq. GSE178889 929 35447889 Patterns of Differentially Expressed circRNAs in Human Thymocytes. hsa_circLEF1_0001 hsa_circ_LEF1 LEF1 Homo sapiens others others others intermediate CD1A+ thymocytes up-regulated hsa_circLEF1_0001 is significantly up-regulated in sorted ST2 intermediate CD1A+ human thymocytes compared with ST1 and ST3 thymocyte stages. GSE178889 930 35447889 Patterns of Differentially Expressed circRNAs in Human Thymocytes. hsa_circ_0031584 ARHGAP5 R Homo sapiens others others others thymocytes down-regulated hsa_circ_0031584 is down-regulated from ST1 to ST3 in sorted human thymocyte differentiation stages. The authors predict it may participate in a circRNA-miRNA-mRNA network involving RAG2 and hsa-miR-609. GSE178889 931 35447889 Patterns of Differentially Expressed circRNAs in Human Thymocytes. hsa_circ_0019079 hsa_circ_KIF20B KIF20B Homo sapiens others others others thymocytes down-regulated hsa_circ_0019079 is down-regulated from ST1 to ST3 in sorted human thymocyte differentiation stages. The authors predict it may participate in a circRNA-miRNA-mRNA network involving RAG2 and hsa-miR-609. GSE178889 932 35447889 Patterns of Differentially Expressed circRNAs in Human Thymocytes. hsa_NEIL3_0001 hsa_circ_NEIL3 NEIL3 Homo sapiens others others others thymocytes dys-regulated "hsa_NEIL3_0001 was differentially expressed across all three pairwise comparisons among sorted human thymocyte differentiation stages, but the direction of change is not specified in the provided text." GSE178889 933 35458413 Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients. hsa-SATB1_AS1_0002 hsa_circ_SATB1_AS1 SATB1_AS1 Homo sapiens HIV-1 infection MONDO:0005109 HIV infectious disease DOID:526 activated CD4+ T (CD3+/CD4+/CD38+/HLA-DR+) lymphocytes up-regulated "In FACS-enriched activated CD4+ T lymphocytes from HIV-1/HCV coinfected patients, circSATB1-as was upregulated before ART compared with after ART suppression." SRP068424 934 35458413 Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients. hsa-ANKRD17_0008 hsa_circ_ANKRD17 ANKRD17 Homo sapiens HIV-1 infection MONDO:0005109 HIV infectious disease DOID:526 activated CD4+ T (CD3+/CD4+/CD38+/HLA-DR+) lymphocytes up-regulated "In FACS-enriched activated CD4+ T lymphocytes from HIV-1/HCV coinfected patients, circANKRD17 was detected in all viremic pre-ART patients and not detectable after ART suppression." SRP068424 935 35458413 Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients. hsa-ATXN1_0001 hsa_circ_ATXN1 ATXN1 Homo sapiens HIV-1 infection MONDO:0005109 HIV infectious disease DOID:526 activated CD4+ T (CD3+/CD4+/CD38+/HLA-DR+) lymphocytes up-regulated "In FACS-enriched activated CD4+ T lymphocytes from HIV-1/HCV coinfected patients, circATXN1 was detected in all viremic pre-ART patients and not detectable after ART suppression." SRP068424 936 35458413 Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients. hsa-FAM13B_0019 hsa_circ_FAM13B FAM13B Homo sapiens HIV-1 infection MONDO:0005109 HIV infectious disease DOID:526 activated CD4+ T (CD3+/CD4+/CD38+/HLA-DR+) lymphocytes up-regulated "In FACS-enriched activated CD4+ T lymphocytes from HIV-1/HCV coinfected patients, circFAM13B was detected in all viremic pre-ART patients and not detectable after ART suppression." SRP068424 937 35458413 Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients. hsa-FBXW7_0005 hsa_circ_FBXW7 FBXW7 Homo sapiens HIV-1 infection MONDO:0005109 HIV infectious disease DOID:526 activated CD4+ T (CD3+/CD4+/CD38+/HLA-DR+) lymphocytes up-regulated "In FACS-enriched activated CD4+ T lymphocytes from HIV-1/HCV coinfected patients, circFBXW7 was detected in all viremic pre-ART patients and not detectable after ART suppression." SRP068424 938 35458413 Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients. hsa-HIPK3_0001 hsa_circ_HIPK3 HIPK3 Homo sapiens HIV-1 infection MONDO:0005109 HIV infectious disease DOID:526 activated CD4+ T (CD3+/CD4+/CD38+/HLA-DR+) lymphocytes up-regulated "In FACS-enriched activated CD4+ T lymphocytes from HIV-1/HCV coinfected patients, circHIPK3 was detected in all viremic pre-ART patients and not detectable after ART suppression." SRP068424 939 35458413 Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients. hsa-PHC3_0020 hsa_circ_PHC3 PHC3 Homo sapiens HIV-1 infection MONDO:0005109 HIV infectious disease DOID:526 activated CD4+ T (CD3+/CD4+/CD38+/HLA-DR+) lymphocytes up-regulated "In FACS-enriched activated CD4+ T lymphocytes from HIV-1/HCV coinfected patients, circPHC3 was detected in all viremic pre-ART patients and not detectable after ART suppression." SRP068424 940 35458413 Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients. hsa-ZNF609_0001 hsa_circ_ZNF609 ZNF609 Homo sapiens HIV-1 infection MONDO:0005109 HIV infectious disease DOID:526 activated CD4+ T (CD3+/CD4+/CD38+/HLA-DR+) lymphocytes up-regulated "In FACS-enriched activated CD4+ T lymphocytes from HIV-1/HCV coinfected patients, circZNF609 was detected in all viremic pre-ART patients and not detectable after ART suppression." SRP068424 941 35479829 Circular RNA Fbxl5 Regulates Cardiomyocyte Apoptosis During Ischemia Reperfusion Injury via Sponging microRNA-146a. mmu_circ_0001346 mmu_circ_Fbxl5 Fbxl5 Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury neonatal mice ventricular myocytes (NMVMs) up-regulated circRNA Fbxl5 was significantly upregulated in primary neonatal mouse ventricular myocytes after anoxia/reoxygenation. Knockdown experiments in NMVMs showed that circRNA Fbxl5 promoted cardiomyocyte apoptosis via the miR-146a-MED1 axis. 942 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Ighv1-63 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated Ighv1-63 was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 943 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Ighv1-53 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated Ighv1-53 was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 944 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Ighv1-64 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated Ighv1-64 was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 945 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Ighv1-55 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated Ighv1-55 was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 946 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Ighv1-84 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated Ighv1-84 was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 947 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Ighv1-33 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated Ighv1-33 was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 948 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Spag5 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated Spag5 was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 949 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Ighv1-69 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated Ighv1-69 was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 950 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Ighv10-3 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated Ighv10-3 was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 951 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. 2010111I01Rik Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated 2010111I01Rik was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 952 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Lats1 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated Lats1 was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 953 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Rev1 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated Rev1 was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 954 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Stat6 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells up-regulated Stat6 was up-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 955 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Zcchc11 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells down-regulated Zcchc11 was down-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 956 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Klhdc2 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells down-regulated Klhdc2 was down-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 957 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Arhgap5 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells down-regulated Arhgap5 was down-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 958 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Acbd5 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells down-regulated Acbd5 was down-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 959 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Ppp1r12a Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells down-regulated Ppp1r12a was down-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 960 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Ubn2 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells down-regulated Ubn2 was down-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 961 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Ighv1-55 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells down-regulated Ighv1-55 was down-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 962 35480082 Coding and Noncoding RNA Expression Profiles of Spleen CD4+ T Lymphocytes in Mice with Echinococcosis. Iglv3 Mus musculus Cystic echinococcosis MONDO:0018408 cystic echinococcosis DOID:1495 spleen CD4+ T cells down-regulated Iglv3 was down-regulated in splenic CD4+ T cells from E. granulosus-infected mice compared with uninfected controls based on RNA-seq after CD4+ T cell isolation. 963 35482130 Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5. hsa_circ_0010729 Homo sapiens ischemic stroke MONDO:1060198 ischemic stroke human brain microvascular endothelial cells (HBMECs) up-regulated "In primary human brain microvascular endothelial cells used as an OGD/R ischemic injury model, hsa_circ_0010729 was up-regulated compared with control cells. Knockdown experiments linked hsa_circ_0010729 to OGD/R-induced changes in proliferation, apoptosis, inflammatory cytokines, and oxidative stress through the miR-665/ING5 axis." 964 35484432 hMSCs-derived exosome circCDK13 inhibits liver fibrosis by regulating the expression of MFGE8 through miR-17-5p/KAT2B. circCDK13 hsa_circ_CDK13 CDK13 Homo sapiens liver fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 TGF-¦Â-activated HSCs up-regulated "In primary human hepatic stellate cells activated with TGF-¦Â, hMSC-derived exosomal circCDK13 was detected and its level increased after Exo-circCDK13 treatment compared with control exosomes. The study further reported that Exo-circCDK13 inhibited activation and proliferation of HSCs through the miR-17-5p/KAT2B axis." 965 35493321 Identification of Functional CircRNA-miRNA-mRNA Regulatory Network in Dorsolateral Prefrontal Cortex Neurons of Patients With Cocaine Use Disorder. hsa_circ_0069982 circMTHFD2L hsa_circ_MTHFD2L MTHFD2L Homo sapiens cocaine use disorder MONDO:0005186 cocaine dependence DOID:9975 dlPFC neuronal nuclei down-regulated circMTHFD2L was down-regulated in human postmortem dlPFC neuronal nuclei from patients with cocaine use disorder compared with unaffected controls. GSE99349 966 35493321 Identification of Functional CircRNA-miRNA-mRNA Regulatory Network in Dorsolateral Prefrontal Cortex Neurons of Patients With Cocaine Use Disorder. circMALAT1-4 hsa_circ_MALAT1 MALAT1 Homo sapiens cocaine use disorder MONDO:0005186 cocaine dependence DOID:9975 dlPFC neuronal nuclei up-regulated circMALAT1-4 was up-regulated in human postmortem dlPFC neuronal nuclei from patients with cocaine use disorder compared with unaffected controls. GSE99349 967 35493321 Identification of Functional CircRNA-miRNA-mRNA Regulatory Network in Dorsolateral Prefrontal Cortex Neurons of Patients With Cocaine Use Disorder. circIL1RAPL1 hsa_circ_IL1RAPL1 IL1RAPL1 Homo sapiens cocaine use disorder MONDO:0005186 cocaine dependence DOID:9975 dlPFC neuronal nuclei up-regulated circIL1RAPL1 showed increased expression in human postmortem dlPFC neuronal nuclei from patients with cocaine use disorder compared with unaffected controls. GSE99349 968 35493321 Identification of Functional CircRNA-miRNA-mRNA Regulatory Network in Dorsolateral Prefrontal Cortex Neurons of Patients With Cocaine Use Disorder. hsa_circ_0034293 circTJP1 hsa_circ_TJP1 TJP1 Homo sapiens cocaine use disorder MONDO:0005186 cocaine dependence DOID:9975 dlPFC neuronal nuclei down-regulated circTJP1 was down-regulated in human postmortem dlPFC neuronal nuclei from patients with cocaine use disorder compared with unaffected controls. GSE99349 969 35493321 Identification of Functional CircRNA-miRNA-mRNA Regulatory Network in Dorsolateral Prefrontal Cortex Neurons of Patients With Cocaine Use Disorder. hsa_circ_0133534 circLUC7L2 hsa_circ_LUC7L2 LUC7L2 Homo sapiens cocaine use disorder MONDO:0005186 cocaine dependence DOID:9975 dlPFC neuronal nuclei down-regulated circLUC7L2 was down-regulated in human postmortem dlPFC neuronal nuclei from patients with cocaine use disorder compared with unaffected controls. GSE99349 970 35493321 Identification of Functional CircRNA-miRNA-mRNA Regulatory Network in Dorsolateral Prefrontal Cortex Neurons of Patients With Cocaine Use Disorder. hsa_circ_0005695 circSLC30A6 hsa_circ_SLC30A6 SLC30A6 Homo sapiens cocaine use disorder MONDO:0005186 cocaine dependence DOID:9975 dlPFC neuronal nuclei up-regulated circSLC30A6 was up-regulated in human postmortem dlPFC neuronal nuclei from patients with cocaine use disorder compared with unaffected controls. GSE99349 971 35493321 Identification of Functional CircRNA-miRNA-mRNA Regulatory Network in Dorsolateral Prefrontal Cortex Neurons of Patients With Cocaine Use Disorder. hsa_circ_0004317 circRASA1 hsa_circ_RASA1 RASA1 Homo sapiens cocaine use disorder MONDO:0005186 cocaine dependence DOID:9975 dlPFC neuronal nuclei down-regulated circRASA1 was down-regulated in human postmortem dlPFC neuronal nuclei from patients with cocaine use disorder compared with unaffected controls. GSE99349 972 35493321 Identification of Functional CircRNA-miRNA-mRNA Regulatory Network in Dorsolateral Prefrontal Cortex Neurons of Patients With Cocaine Use Disorder. hsa_circ_0008215 circMNAT1 hsa_circ_MNAT1 MNAT1 Homo sapiens cocaine use disorder MONDO:0005186 cocaine dependence DOID:9975 dlPFC neuronal nuclei down-regulated circMNAT1 was down-regulated in human postmortem dlPFC neuronal nuclei from patients with cocaine use disorder compared with unaffected controls. GSE99349 973 35523949 CircRTN4 aggravates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis. hsa_circ_0054595 circRTN4 hsa_circ_RTN4 RTN4 Homo sapiens lupus nephritis MONDO:0005556 lupus nephritis DOID:0080162 mesangial cells up-regulated "circRTN4 was detected by RNA FISH in kidney specimens and was higher in LN patients, with positive staining consistent with the mesangial area. Functional experiments indicated circRTN4 promoted mesangial cell proliferation and extracellular matrix-related FN expression." 974 35523949 CircRTN4 aggravates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis. hsa_circ_0054595 circRTN4 hsa_circ_RTN4 RTN4 Homo sapiens lupus nephritis MONDO:0005556 lupus nephritis DOID:0080162 peripheral blood mononuclear cells (PBMCs) up-regulated "circRTN4 was significantly enriched in PBMCs from LN patients compared with SLE patients without kidney damage, based on PBMC isolation followed by RT-qPCR and RNA FISH. The study further links peripheral blood circRTN4 to renal damage and mesangial cell dysfunction through exosome-mediated communication." 975 35538537 Hsa_circ_0000497 and hsa_circ_0000918 contributed to peritoneal metastasis of ovarian cancer via ascites. hsa_circ_0000497 hsa_circ_SLAIN1 SLAIN1 Homo sapiens ovarian cancer MONDO:0008170 ovarian cancer DOID:2394 ascites tumor cells up-regulated hsa_circ_0000497 was identified by circRNA RNA-seq analysis as up-regulated in ascites tumor cells from epithelial ovarian cancer patients compared with primary and metastatic lesions. These ASC tumor cells showed a mesenchymal phenotype. 976 35538537 Hsa_circ_0000497 and hsa_circ_0000918 contributed to peritoneal metastasis of ovarian cancer via ascites. hsa_circ_0000918 hsa_circ_GMIP GMIP Homo sapiens ovarian cancer MONDO:0008170 ovarian cancer DOID:2394 ascites tumor cells up-regulated hsa_circ_0000918 was identified by circRNA RNA-seq analysis and validated as significantly elevated in ascites tumor cells from epithelial ovarian cancer patients compared with primary and metastatic lesions. These ASC tumor cells showed a mesenchymal phenotype. 977 35571241 circPTP4A2-miR-330-5p-PDK2 Signaling Facilitates In Vivo Survival of HuMSCs on SF-SIS Scaffolds and Improves the Repair of Damaged Endometrium. circPTP4A2 hsa_circ_PTP4A2 PTP4A2 Homo sapiens intrauterine adhesions MONDO:0015299 Asherman syndrome HuMSCs up-regulated "circPTP4A2 was up-regulated in HuMSCs cultured on SF-SIS scaffolds compared with normal HuMSCs, based on circRNA RNA-seq and qRT-PCR validation. The study further linked circPTP4A2 in HuMSCs to stabilization of mitochondrial metabolism through miR-330-5p-PDK2 signaling." 978 35571247 circHtra1/miR-3960/GRB10 Axis Promotes Neuronal Loss and Immune Deficiency in Traumatic Brain Injury. hsa_circ_0020269 circHtra1 hsa_circ_Htra1 Htra1 Homo sapiens Traumatic brain injury MONDO:0858950 traumatic brain injury DOID:0081292 primary cultured neurons up-regulated "In primary cultured neurons, KA-induced excitotoxic injury increased circHtra1 expression, while IGF-1 and ADAR1 reduced its expression. Functional experiments in primary neurons indicated that circHtra1 inhibits proliferation and promotes neuronal death through the miR-3960/GRB10 axis." 979 35575762 CircRNA has_circ_0069313 induced OSCC immunity escape by miR-325-3p-Foxp3 axes in both OSCC cells and Treg cells. hsa_circ_0069313 Homo sapiens oral squamous cell carcinoma / OSCC MONDO:0004958 oral cavity squamous cell carcinoma DOID:0050866 Treg cells up-regulated "In purified human Treg cells, OSCC-derived exosome treatment or co-culture increased has_circ_0069313 levels measured by qRT-PCR. The study links exosomal has_circ_0069313 transfer to maintenance of Foxp3 levels and promotion of Treg function." 980 35579772 CircATIC Contributes to Multiple Myeloma Progression via miR-324-5p-Dependent Regulation of HGF. hsa_circ_0058058 circATIC hsa_circ_ATIC ATIC Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 BM-derived plasma cells up-regulated "circATIC is up-regulated in CD138-purified bone marrow-derived plasma cells from multiple myeloma patients compared with healthy donors, measured by qRT-PCR after magnetic-bead purification." 981 35591844 Circ-RHOJ.1 regulated myocardial cell proliferation and apoptosis via targeting the miR-124-3p/NRG-1 axis in myocardial ischemia/reperfusion injury. circ-RHOJ.1 rno_circ_RHOJ RHOJ Rattus norvegicus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury myocardial cells down-regulated "circ-RHOJ.1 was down-regulated in isolated rat myocardial cells after I/R injury compared with sham cells, as measured by qRT-PCR. In the same primary myocardial cell system, circ-RHOJ.1 overexpression promoted proliferation and inhibited apoptosis and inflammatory cytokine responses after I/R injury." 982 35592503 CircERBB2IP promotes post-infarction revascularization via the miR-145a-5p/Smad5 axis. mmu_circ_0000495 circERBB2IP mmu_circ_ERBB2IP ERBB2IP Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 endothelial cells; CMECs; cardiac microvascular endothelial cells up-regulated "circERBB2IP was mainly expressed in endothelial cells among isolated neonatal mouse cardiac cell types. In primary CMECs, circERBB2IP promoted proliferation, migration and tube formation through the miR-145a-5p/Smad5 axis." 983 35592503 CircERBB2IP promotes post-infarction revascularization via the miR-145a-5p/Smad5 axis. mmu_circ_0000495 circERBB2IP mmu_circ_ERBB2IP ERBB2IP Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 cardiomyocytes up-regulated circERBB2IP was mainly expressed in cardiomyocytes among isolated neonatal mouse cardiac cell types. The provided text does not report cardiomyocyte-specific functional validation for circERBB2IP. 984 35610079 "CircSLC8A1 targets miR-181a-5p/HIF1AN pathway to inhibit the growth, migration and extracellular matrix deposition of human keloid fibroblasts." hsa_circ_0000994 circSLC8A1 hsa_circ_SLC8A1 SLC8A1 Homo sapiens keloid MONDO:0005348 keloid HKFs down-regulated "circSLC8A1 was down-regulated in primary human keloid fibroblasts compared with human dermal fibroblasts. In HKFs, circSLC8A1 overexpression suppressed proliferation, migration and ECM deposition and promoted apoptosis." 985 35615580 Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1. hsa_circ_0018146 hsa_circ_ITGB1 ITGB1 Homo sapiens Acute myocardial infarction MONDO:0004781 acute myocardial infarction DOID:9408 human mdDCs down-regulated "In primary culture-derived human monocyte-derived dendritic cells, circITGB1 was detected in mdDC-derived EVs and was significantly reduced after LPS stimulation. Functional experiments showed that EV-circITGB1 regulated human mdDC maturation via the miR-342-3p/NFAM1 axis." 986 35642253 circRNA422 enhanced osteogenic differentiation of bone marrow mesenchymal stem cells during early osseointegration through the SP7/LRP5 axis. circRNA422 rno_circ_KLHL8 KLHL8 Rattus norvegicus early osseointegration MONDO:0000001 disease DOID:4 rat bone marrow mesenchymal stem cells (BMSCs) up-regulated "In primary rat BMSCs undergoing osteogenic differentiation, circRNA422 was up-regulated on SLA titanium surfaces compared with smooth titanium surfaces. The study linked circRNA422 to enhanced proliferation and osteogenic differentiation of BMSCs." 987 35642253 circRNA422 enhanced osteogenic differentiation of bone marrow mesenchymal stem cells during early osseointegration through the SP7/LRP5 axis. circRNA422 rno_circ_KLHL8 KLHL8 Rattus norvegicus early osseointegration MONDO:0000001 disease DOID:4 BMSCs up-regulated "In primary rat BMSCs, circRNA422 expression gradually increased during osteogenic differentiation. Functional assays showed that circRNA422 regulated BMSC osteogenic differentiation through SP7 and LRP5." 988 35646066 High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes. novel-circ-0006245 Rattus norvegicus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 primary cultured astrocytes down-regulated "novel-circ-0006245 was reported as downregulated in primary cultured rat astrocytes in the A¦Â-treated condition compared with untreated control astrocytes, based on circRNA RNA-seq." PRJNA807497 989 35646066 High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes. novel-circ-0006245 Rattus norvegicus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 primary cultured astrocytes down-regulated "novel-circ-0006245 was reported as downregulated in primary cultured rat senescent astrocytes compared with control astrocytes, based on circRNA RNA-seq." PRJNA807497 990 35646066 High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes. novel-circ-0006244 Rattus norvegicus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 primary cultured astrocytes down-regulated "novel-circ-0006244 was reported as downregulated in primary cultured rat astrocytes in the A¦Â-treated condition compared with untreated control astrocytes, based on circRNA RNA-seq." PRJNA807497 991 35646066 High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes. novel-circ-0006244 Rattus norvegicus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 primary cultured astrocytes down-regulated "novel-circ-0006244 was reported as downregulated in primary cultured rat senescent astrocytes compared with control astrocytes, based on circRNA RNA-seq." PRJNA807497 992 35646066 High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes. novel-circ-0004037 Rattus norvegicus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 primary cultured astrocytes down-regulated "novel-circ-0004037 was reported as downregulated in primary cultured rat astrocytes in the A¦Â-treated condition compared with untreated control astrocytes, based on circRNA RNA-seq." PRJNA807497 993 35646066 High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes. novel-circ-0004037 Rattus norvegicus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 primary cultured astrocytes down-regulated "novel-circ-0004037 was reported as downregulated in primary cultured rat senescent astrocytes compared with control astrocytes, based on circRNA RNA-seq." PRJNA807497 994 35646066 High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes. novel-circ-0002315 Rattus norvegicus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 primary cultured astrocytes down-regulated "novel-circ-0002315 was reported as downregulated in primary cultured rat astrocytes in the A¦Â-treated condition compared with untreated control astrocytes, based on circRNA RNA-seq." PRJNA807497 995 35646066 High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes. novel-circ-0002315 Rattus norvegicus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 primary cultured astrocytes down-regulated "novel-circ-0002315 was reported as downregulated in primary cultured rat senescent astrocytes compared with control astrocytes, based on circRNA RNA-seq." PRJNA807497 996 35668777 Circ-GTF2I/miR-590-5p Axis Aggravates Myocardial Ischemia-Reperfusion Injury by Regulating Kelch Repeat and BTB Domain-Containing Protein 7. circ-GTF2I rno_circ_GTF2I GTF2I Rattus norvegicus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury neonatal rat cardiomyocytes up-regulated circ-GTF2I was up-regulated in isolated neonatal rat cardiomyocytes after hypoxia/reoxygenation treatment compared with normal neonatal rat cardiomyocytes. Knockdown experiments in this cardiomyocyte injury model indicated effects on proliferation and apoptosis. 997 35678490 Circ_0062491 alleviates LPS-induced apoptosis and inflammation in periodontitis by regulating miR-498/SOCS6 axis. hsa_circ_0062491 hsa_circ_MIR650 MIR650 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 PDLCs down-regulated "In primary cultured human PDLCs used to model periodontitis-related inflammatory conditions, circ_0062491 was down-regulated after LPS treatment compared with untreated cells. Functional experiments indicated that circ_0062491 overexpression attenuated LPS-evoked apoptosis and inflammation in PDLCs." 998 35681442 Circ0001470 Acts as a miR-140-3p Sponge to Facilitate the Progression of Embryonic Development through Regulating PTGFR Expression. circ0001470 ssc_circ_GRN GRN Sus scrofa embryonic implantation and development MONDO:0000001 disease DOID:4 endometrial epithelial cells (EECs) unknown "Primary endometrial epithelial cells were isolated and used to detect circ0001470 by qRT-PCR/FISH, supporting that circ0001470 is expressed in EECs and preferentially localized in the cytoplasm. Functional assays in EECs showed effects on proliferation and apoptosis." 999 35686126 Circular RNA circNUP214 Modulates the T Helper 17 Cell Response in Patients With Rheumatoid Arthritis. hsa_circ_0089172 circNUP214 hsa_circ_NUP214 NUP214 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 human CD4+ T cells down-regulated "circNUP214 was detected in magnetic bead-purified human CD4+ T cells by qRT-PCR, and siRNA-mediated knockdown reduced its expression. In this CD4+ T cell system, circNUP214 knockdown decreased IL-23R, IL-17A expression and the percentage of Th17 cells." 1000 35689709 Circ_0005925 Promotes Granulosa Cell Growth by Targeting MiR-324-3p to Upregulate MAP2K6 in Polycystic Ovary Syndrome. hsa_circ_0005925 circ_0005925 hsa_circ_PILRB PILRB Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 GCs up-regulated "circ_0005925 was up-regulated in granulosa cells isolated from follicular fluid of PCOS patients compared with granulosa cells from normal controls, as measured by qRT-PCR." 1001 35692080 Circular RNA circ-RCCD promotes cardiomyocyte differentiation in mouse embryo development via recruiting YY1 to the promoter of MyD88. mmu_circ_0000804 Mus musculus Congenital heart disease MONDO:0005453 congenital heart disease DOID:1682 primary cardiomyocytes up-regulated circ_RCCD was detected by RT-qPCR after isolation of primary cardiomyocytes from mouse ventricular myocardium and was reported to be enriched. The study further reported that circ_RCCD promotes cardiomyocyte differentiation through regulation of MyD88. 1002 35700140 The circular RNA hsa_circ_0003091 regulates sepsis-induced lung injury by sponging the miR-149/Smad2 axis. mmu_circ_0015268 Mus musculus sepsis-induced ALI MONDO:0015796 acute lung injury lung endothelial cells up-regulated "mmu_circ_0015268 was elevated in sorted lung endothelial cells from LPS-induced ALI mice. The study links mmu_circ_0015268 to endothelial activation, inflammation, and apoptosis in sepsis-induced ALI." 1003 35700140 The circular RNA hsa_circ_0003091 regulates sepsis-induced lung injury by sponging the miR-149/Smad2 axis. mmu_circ_0015268 Mus musculus sepsis-induced ALI MONDO:0015796 acute lung injury primary murine pulmonary microvascular endothelial cells (PMVECs) up-regulated mmu_circ_0015268 was increased in LPS-treated primary murine pulmonary microvascular endothelial cells compared with untreated cells. Functional assays in PMVECs indicate that mmu_circ_0015268 promotes LPS-stimulated apoptosis and inflammation via the miR-149/Smad2 axis. 1004 35716032 CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR-30a-3p and promoting PON2. hsa_circ_000284 hsa_circ_HIPK3 HIPK3 Homo sapiens Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 HC_a chondrocytes down-regulated "In human primary HC_a chondrocytes, IL_1¦Â stimulation decreased circHIPK3 expression by RT-qPCR. Functional experiments in the same chondrocyte system showed circHIPK3 regulated ROS production and mitochondria-mediated apoptosis." 1005 35726320 Exosomal Circular RNA hsa_circ_0046060 of Umbilical Cord Mesenchymal Stromal Cell Ameliorates Glucose Metabolism and Insulin Resistance in Gestational Diabetes Mellitus via the miR-338-3p/G6PC2 Axis. hsa_circ_0046060 hsa_circ_RPTOR RPTOR Homo sapiens gestational diabetes mellitus MONDO:0005406 gestational diabetes DOID:11714 hUMSCs up-regulated "hsa_circ_0046060 was detected by RT-qPCR in isolated and cultured hUMSCs and hUMSC-derived exosomes, with higher expression in GDM-derived hUMSC-EXOs than controls. Functional experiments indicated that knocking down exosomal hsa_circ_0046060 ameliorated abnormal glucose metabolism and insulin resistance." 1006 35726320 Exosomal Circular RNA hsa_circ_0046060 of Umbilical Cord Mesenchymal Stromal Cell Ameliorates Glucose Metabolism and Insulin Resistance in Gestational Diabetes Mellitus via the miR-338-3p/G6PC2 Axis. mmu_circ_0002819 mmu_circ_RPTOR RPTOR Mus musculus gestational diabetes mellitus MONDO:0005406 gestational diabetes DOID:11714 mUMSCs up-regulated "mmu_circ_0002819 was detected by RT-qPCR in isolated mouse UMSCs and mUMSC-derived exosomes, and was up-regulated in GDM mouse-derived exosomes compared with controls. Silencing exosomal mmu_circ_0002819 improved glucose and insulin tolerance in GDM mice." 1007 35729156 circ_0003204 regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis. hsa_circ_0003204 hsa_circ_USP36 USP36 Homo sapiens bone defects MONDO:0002081 musculoskeletal system disorder DOID:17 human adipose-derived stem cells (hASCs) down-regulated circ_0003204 was significantly down-regulated in hASCs after osteogenic induction compared with control hASCs. Functional experiments showed circ_0003204 negatively regulated osteogenic differentiation of hASCs through the miR-370-3p/HDAC4 axis. 1008 35730627 Silencing of circular RNA_ZYG11B exerts a neuroprotective effect against retinal neurodegeneration. mmu_circ_0011029 mmu_circ_ZYG11B ZYG11B Mus musculus retinal neurodegeneration MONDO:0004580 retinal degeneration DOID:8466 isolated RGCs up-regulated "In primary isolated mouse retinal ganglion cells, circZYG11B expression was increased after hypoxic stress compared with untreated control cells. Functional assays in RGCs showed that circZYG11B silencing alleviated hypoxic stress-induced RGC injury." 1009 35730627 Silencing of circular RNA_ZYG11B exerts a neuroprotective effect against retinal neurodegeneration. mmu_circ_0011029 mmu_circ_ZYG11B ZYG11B Mus musculus retinal neurodegeneration MONDO:0004580 retinal degeneration DOID:8466 isolated RGCs up-regulated "In primary isolated mouse retinal ganglion cells, circZYG11B expression was increased after oxidative stress compared with untreated control cells. Functional assays in RGCs showed that circZYG11B silencing alleviated oxidative stress-induced RGC injury." 1010 35737129 Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs. hsa_circ_0104801 hsa_circ_AKAP13 AKAP13 Homo sapiens heart failure MONDO:0005252 heart failure human cardiomyocytes up-regulated "In primary human cardiomyocytes, ADAR2 reduction increased circAKAP13 expression as measured by qRT-PCR. The study links this mechanism to increased circAKAP13 formation in heart failure." 1011 35740877 Sus_circPAPPA2 Regulates Fat Deposition in Castrated Pigs through the miR-2366/GK Pathway. 9:118402663|118403734 ssc_circ_PAPPA2 PAPPA2 Sus scrofa castration-induced fat deposition MONDO:0000001 disease DOID:4 porcine preadipocytes up-regulated "In primary porcine preadipocytes undergoing induced differentiation, 100 nM testosterone increased sus_circPAPPA2 expression. The study further reported that sus_circPAPPA2 overexpression inhibited preadipocyte differentiation." 1012 35752700 Rheumatoid arthritis fibroblast-like synoviocytes maintain tumor-like biological characteristics through ciRS-7-dependent regulation of miR-7. ciRS-7 hsa_circ_CDR1as CDR1as Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLS up-regulated "ciRS-7 was measured by RT-qPCR in primary-cultured fibroblast-like synoviocytes and was up-regulated in RA-FLS compared with HC-FLSs. Functional experiments in RA-FLS indicated that miR-7 and ciRS-7 regulate proliferation, apoptosis, migration, and invasion." 1013 35754140 Circular RNA hsa_circ_0043688 serves as a competing endogenous RNA for microRNA-145-5p to promote the progression of Keloids via Fibroblast growth factor-2. hsa_circ_0043688 hsa_circ_FKBP10 FKBP10 Homo sapiens keloid MONDO:0005348 keloid keloid fibroblasts up-regulated "hsa_circ_0043688 is up-regulated in primary keloid fibroblasts compared with normal fibroblasts, based on RT-qPCR after primary fibroblast isolation. Functional assays in keloid fibroblasts showed that hsa_circ_0043688 knockdown reduced proliferation, invasion, migration and ECM production and increased apoptosis." 1014 35767605 Suppression of osteoclast multinucleation via a posttranscriptional regulation-based spatiotemporally selective delivery system. mmu_circ_0001757 mmu_circ_BBS9 BBS9 Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 pOCs up-regulated Mouse circBBS9/mmu_circ_0001757 was identified by RNA-seq and validated by RT-qPCR as up-regulated in mononucleated preosteoclasts during RANKL-induced osteoclast multinucleation. Functional experiments indicated that circBBS9 knockdown on day 3 suppressed osteoclast multinucleation and bone resorption-related genes. 1015 35767605 Suppression of osteoclast multinucleation via a posttranscriptional regulation-based spatiotemporally selective delivery system. hsa_circ_0134188 hsa_circ_BBS9 BBS9 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 PBMC-derived OCs up-regulated "Human hsa_circ_0134188/hsa_circBBS9 was increased in PBMC-derived osteoclasts as measured by qPCR, and bulk cancellous bone data linked it to osteoporosis samples. The paper further reports that knockdown of hsa_circ_0134188 alleviated osteoclast-related gene expression in human OCs." 1016 35767605 Suppression of osteoclast multinucleation via a posttranscriptional regulation-based spatiotemporally selective delivery system. mmu_circ_0001757 mmu_circ_BBS9 BBS9 Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 OSCAR+ cells deemed pOCs down-regulated "In OVX-induced osteoporosis mice, OSCAR+ preosteoclasts were FACS-sorted from bone marrow and RT-qPCR showed decreased circBBS9 after POCM-NPs@siRNAcircBBS9 treatment. This supports cell-type-resolved knockdown of circBBS9 in pOCs in vivo." 1017 35768408 CircRNA-3302 promotes endothelial-to-mesenchymal transition via sponging miR-135b-5p to enhance KIT expression in Kawasaki disease. Hsa-circ3302 Homo sapiens Kawasaki disease MONDO:0012727 Kawasaki disease DOID:13378 human umbilical vein endothelial cells (HUVECs) up-regulated "circ3302 was up-regulated in HUVEC endothelial cells treated with Kawasaki disease serum compared with healthy control serum, based on circRNA-seq and RT-qPCR. Functional experiments in HUVECs indicated that circ3302 promoted KD-associated EndMT via the miR-135b-5p/KIT axis." PRJNA790660 1018 35768408 CircRNA-3302 promotes endothelial-to-mesenchymal transition via sponging miR-135b-5p to enhance KIT expression in Kawasaki disease. Hsa-circ4571 Homo sapiens Kawasaki disease MONDO:0012727 Kawasaki disease DOID:13378 human umbilical vein endothelial cells (HUVECs) up-regulated circ4571 was among up-regulated circRNAs selected and validated by RT-qPCR in HUVEC endothelial cells treated with KD serum compared with healthy control serum. PRJNA790660 1019 35768408 CircRNA-3302 promotes endothelial-to-mesenchymal transition via sponging miR-135b-5p to enhance KIT expression in Kawasaki disease. Hsa-circ7632 Homo sapiens Kawasaki disease MONDO:0012727 Kawasaki disease DOID:13378 human umbilical vein endothelial cells (HUVECs) up-regulated circ7632 was among up-regulated circRNAs selected and validated by RT-qPCR in HUVEC endothelial cells treated with KD serum compared with healthy control serum. PRJNA790660 1020 35768408 CircRNA-3302 promotes endothelial-to-mesenchymal transition via sponging miR-135b-5p to enhance KIT expression in Kawasaki disease. Hsa-circ24609 Homo sapiens Kawasaki disease MONDO:0012727 Kawasaki disease DOID:13378 human umbilical vein endothelial cells (HUVECs) up-regulated circ24609 was among up-regulated circRNAs selected and validated by RT-qPCR in HUVEC endothelial cells treated with KD serum compared with healthy control serum. PRJNA790660 1021 35772682 Hsa_circ_0010729 regulates H2O2-induced myocardial injury by regulating miR-1184/RIPK1 axis. Hsa_circ_0010729 circ_0010729 Homo sapiens H2O2-induced myocardial injury MONDO:0005203 ischemia reperfusion injury human cardiac myocytes (HCMs) up-regulated circ_0010729 is up-regulated in primary human cardiac myocytes after H2O2 treatment compared with control. Knockdown of circ_0010729 reduced apoptosis and oxidative stress and promoted proliferation in H2O2-treated HCMs. 1022 35776289 circ-CCND1 regulates the CCND1/P53/P21 pathway through sponging miR-138-5p in valve interstitial cells to aggravate aortic valve calcification. ssc_circ_CCND1 CCND1 Sus scrofa Calcific aortic valve disease MONDO:0005463 aortic valve calcification porcine aortic valve interstitial cells (AVICs) dys-regulated "In isolated porcine aortic valve interstitial cells, circ-CCND1 was experimentally interfered or overexpressed and measured by RT-qPCR. Functional assays in AVICs showed that circ-CCND1 promoted calcification and osteogenic differentiation-associated changes." 1023 35791460 CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758-3p/KDM6A axis. hsa_circ_005660 hsa_circ_NFIX NFIX Homo sapiens Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human adipose_drived stem cells (hADSCs) dys-regulated "In primary human adipose-derived stem cells undergoing chondrogenesis, circNFIX increased during early and middle chondrogenic differentiation and decreased during late-stage degeneration. Functional experiments indicated that circNFIX inhibition attenuated hADSC chondrogenesis." PRJNA755468 1024 35791460 CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758-3p/KDM6A axis. hsa_circ_005660 hsa_circ_NFIX NFIX Homo sapiens Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes down-regulated "In primary human chondrocytes isolated from cartilage, circNFIX expression was lower in osteoarthritis samples than in normal controls. In PHCs, circNFIX perturbation altered markers of extracellular matrix metabolism and chondrocyte degeneration." 1025 35835384 Genome-wide identification m6A modified circRNAs revealed their key roles in skin ulceration syndrome disease development in Apostichopus japonicus. MRZV01001545.1:107964-126376+ Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 coelomocytes up-regulated "MRZV01001545.1:107964-126376+ was up-regulated with increased m6A level in coelomocytes from SUS-diseased Apostichopus japonicus compared with control, based on circRNA RNA-seq/MeRIP-seq analysis of isolated coelomocytes." 1026 35835384 Genome-wide identification m6A modified circRNAs revealed their key roles in skin ulceration syndrome disease development in Apostichopus japonicus. MRZV01001322.1:161535-168532- Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 coelomocytes up-regulated "MRZV01001322.1:161535-168532- was up-regulated with increased m6A level in coelomocytes from SUS-diseased Apostichopus japonicus compared with control, based on circRNA RNA-seq/MeRIP-seq analysis of isolated coelomocytes." 1027 35835384 Genome-wide identification m6A modified circRNAs revealed their key roles in skin ulceration syndrome disease development in Apostichopus japonicus. MRZV01000129.1:769508-769739 Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 coelomocytes up-regulated MRZV01000129.1:769508-769739 was part of the up-regulated circRNA/increased m6A network in coelomocytes from SUS-diseased Apostichopus japonicus compared with control. 1028 35835384 Genome-wide identification m6A modified circRNAs revealed their key roles in skin ulceration syndrome disease development in Apostichopus japonicus. MRZV01000895.1:48773-72891+ Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 coelomocytes down-regulated MRZV01000895.1:48773-72891+ was down-regulated with decreased m6A level in coelomocytes from SUS-resistant Apostichopus japonicus compared with control after Vibrio splendidus challenge. 1029 35865405 CircCTNNA1 is Upregulated in Mantle Cell Lymphoma and Predicts Poor Survival by Sponging miR-34a to Increase Cell Proliferation. circCTNNA1 hsa_circ_CTNNA1 CTNNA1 Homo sapiens mantle cell lymphoma MONDO:0018876 mantle cell lymphoma DOID:0050746 B lymphocytes up-regulated "circCTNNA1 was significantly increased in separated B lymphocyte samples from mantle cell lymphoma patients compared with healthy controls, as measured by RT-qPCR after CD19-based separation." 1030 35871061 UPF1/circRPPH1/ATF3 feedback loop promotes the malignant phenotype and stemness of GSCs. hsa_circ_0000512 hsa_circ_RPPH1 RPPH1 Homo sapiens glioblastoma MONDO:0018177 glioblastoma DOID:3068 Glioma stem cells up-regulated "circRPPH1 was reported to be up-regulated in glioma stem cells in glioblastoma, with GSCs isolated from fresh clinical GBM tissues and circRPPH1 detected by qPCR. Functional experiments in GSCs showed that circRPPH1 promoted proliferation, invasion, and self-renewal/stemness." 1031 35873481 RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis. hsa_circ_0000348 circ_0000348 hsa_circ_FAT3 FAT3 Homo sapiens ankylosing spondylitis MONDO:0005306 ankylosing spondylitis DOID:7147 bone marrow-derived mesenchymal stem cells (BMSCs) up-regulated "circ_0000348 was up-regulated in osteogenically differentiated BMSCs from patients with ankylosing spondylitis compared with BMSCs from healthy donors, based on circRNA sequencing and qRT-PCR validation." unclear 1032 35873481 RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis. hsa_circ_0001493 circ_0001493 hsa_circ_ERBB2IP ERBB2IP Homo sapiens ankylosing spondylitis MONDO:0005306 ankylosing spondylitis DOID:7147 bone marrow-derived mesenchymal stem cells (BMSCs) down-regulated circ_0001493 was down-regulated in osteogenically differentiated BMSCs from patients with ankylosing spondylitis compared with BMSCs from healthy donors. Knockdown experiments in BMSCs supported a pro-osteogenic role for circ_0001493. unclear 1033 35873481 RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis. hsa_circ_0070562 hsa_circ_TET2 TET2 Homo sapiens ankylosing spondylitis MONDO:0005306 ankylosing spondylitis DOID:7147 bone marrow-derived mesenchymal stem cells (BMSCs) up-regulated circ_0070562 was up-regulated in osteogenically differentiated BMSCs from patients with ankylosing spondylitis compared with BMSCs from healthy donors. Functional knockdown experiments indicated that circ_0070562 has pro-osteogenic effects in BMSCs. unclear 1034 35874804 Circ_0005918 Sponges miR-622 to Aggravate Intervertebral Disc Degeneration. hsa_circ_0005918 circ_0005918 Homo sapiens Intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 NP cells up-regulated circ_0005918 was upregulated in nucleus pulposus cells from the IDD group compared with controls. Functional assays in NP cells showed that circ_0005918 promoted cell growth and inflammatory cytokine secretion. 1035 35874804 Circ_0005918 Sponges miR-622 to Aggravate Intervertebral Disc Degeneration. hsa_circ_0005918 circ_0005918 Homo sapiens Intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 NP cells up-regulated "In primary cultured NP cells, IL-1¦Â and TNF-¦Á treatment induced circ_0005918 expression compared with control treatment. Functional assays in NP cells showed that circ_0005918 promoted cell growth and inflammatory cytokine secretion." 1036 35876480 Circ_0057452 sponges miR-7-5p to promote keloid progression through upregulating GAB1. hsa_circ_0057452 circ_0057452 hsa_circ_COL5A2 COL5A2 Homo sapiens keloid MONDO:0005348 keloid keloid fibroblasts (KFs) up-regulated "circ_0057452 was up-regulated in primary keloid fibroblasts compared with normal fibroblasts. Knockdown experiments in KFs showed effects on proliferation, apoptosis, migration, invasion, and collagen synthesis." 1037 35891711 Circ_0018168 inhibits the proliferation and osteogenic differentiation of fibroblasts in ankylosing spondylitis via regulating miR-330-3p/DKK1 axis. hsa_circ_0018168 circ_0018168 hsa_circ_PARD3 PARD3 Homo sapiens ankylosing spondylitis MONDO:0005306 ankylosing spondylitis DOID:7147 AS fibroblasts up-regulated "Primary AS fibroblasts isolated from hip capsule specimens were used for qRT-PCR-based circ_0018168 detection after overexpression vector transfection. Circ_0018168 overexpression inhibited proliferation, cell cycle progression and osteogenic differentiation in AS fibroblasts." 1038 35904110 "Knockdown of circ_0025908 inhibits proliferation, migration, invasion, and inflammation while stimulates apoptosis in fibroblast-like synoviocytes by regulating miR-650-dependent SCUBE2." hsa_circ_0025908 hsa_circ_PPHLN1 PPHLN1 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 fibroblast-like synoviocytes (FLS) up-regulated "circ_0025908 was up-regulated in isolated fibroblast-like synoviocytes from rheumatoid arthritis patients compared with FLS from normal controls. Knockdown experiments in FLS-RA linked circ_0025908 to proliferation, migration, invasion, inflammation and apoptosis regulation." 1039 35918573 "Circ_0088194 Regulates Proliferation, Migration, Apoptosis, and Inflammation by miR-30a-3p/ADAM10 Axis in Rheumatoid Arthritis Fibroblastic Synovial Cells." hsa_circ_0088194 circ_0088194 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-fibroblast-like synoviocytes (RA-FLSs) up-regulated "circ_0088194 was up-regulated in RA-FLSs compared with normal-FLSs, as measured by RT-qPCR. Functional assays in RA-FLSs indicated that circ_0088194 promoted proliferation, migration, and inflammation and inhibited apoptosis via the miR-30a-3p/ADAM10 axis." 1040 35930101 CircJag1 promotes apoptosis of ethylene thiourea-exposed anorectal malformations through sponging miR-137-3p by regulating Sox9 and suppressing Wnt/¦Â-catenin pathway during the hindgut development of rat embryos. novel_circ_011174 rno_circ_Jag1 Jag1 Rattus norvegicus anorectal malformations MONDO:0001046 imperforate anus DOID:10488 epithelial cells of the unfused parts up-regulated FISH-based spatial analysis showed stronger circJag1-positive epithelial-cell expression in ETU-induced ARM rat embryos than in normal embryos during hindgut development. The study links elevated circJag1 to epithelial apoptosis and reduced proliferation through the miR-137-3p/Sox9 and Wnt/¦Â-catenin pathway. 1041 35933226 Circ_0099630 Participates in SPRY1-Mediated Repression in Periodontitis. hsa_circ_0099630 hsa_circ_RMST RMST Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 inflamed PDLCs (iPDLCs) up-regulated circ_0099630 is up-regulated in primary cultured inflamed periodontal ligament cells from periodontitis patients compared with healthy periodontal ligament cells. Functional assays in iPDLCs showed circ_0099630 restrained proliferation and osteogenic differentiation through the miR-212-5p/SPRY1 axis. 1042 35945192 CircKPNB1 mediates a positive feedback loop and promotes the malignant phenotypes of GSCs via TNF-¦Á/NF-¦ÊB signaling. hsa_circ_0004796 hsa_circ_KPNB1 KPNB1 Homo sapiens glioblastoma MONDO:0018177 glioblastoma DOID:3068 Glioma stem cells (GSCs) unknown "circKPNB1 expression was detected in six patient-derived primary glioma stem cells from WHO grade IV glioma. Functional assays in these GSCs showed that circKPNB1 promoted malignant phenotypes including proliferation, invasion, neurosphere formation, and stemness." 1043 35945200 Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-¦ÊB signaling. hsa_circ_0008012 hsa_circ_NFKB1 NFKB1 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human chondrocytes up-regulated circNFKB1 is up-regulated in IL-1¦Â-stimulated primary human chondrocytes compared with untreated chondrocytes based on circRNA sequencing and qRT-PCR validation. Functional experiments in human chondrocytes indicate that circNFKB1 promotes ECM catabolism and sustains NF-¦ÊB signaling. GSE158875 1044 35947965 Circ_0061140 Facilitates Adenomyosis Progression by Upregulating LIN28B in vitro. hsa_circ_0061140 circ_0061140 hsa_circ_C20orf11 C20orf11 Homo sapiens adenomyosis MONDO:0010888 adenomyosis DOID:288 endometrial epithelial cells down-regulated "Primary endometrial epithelial cells were isolated and analyzed by qRT-PCR; si-circ_0061140 reduced circ_0061140 expression in these cells. Functional assays in endometrial epithelial cells showed that circ_0061140 knockdown suppressed proliferation, migration and invasion and promoted apoptosis." 1045 35953472 Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription. mmu_circ_0007131 circTmem241 mmu_circ_Tmem241 Tmem241 Mus musculus Citrobacter rodentium infection MONDO:0000001 disease DOID:4 CHILPs up-regulated circTmem241 is highly expressed in sorted CHILPs compared with other tested lymphocyte progenitors and immune cells. Knockdown or deficiency of circTmem241 in CHILP-based differentiation assays impaired ILC3 differentiation. 1046 35953472 Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription. mmu_circ_0007131 circTmem241 mmu_circ_Tmem241 Tmem241 Mus musculus Citrobacter rodentium infection MONDO:0000001 disease DOID:4 ILCPs up-regulated "circTmem241 is highly expressed in sorted ILCPs compared with other tested lymphocyte progenitors and immune cells. In ILCPs, circTmem241 promotes ILC3 commitment through the Nono-Ash1l-Elk3 axis." GSE201065 1047 35953472 Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription. mmu_circ_0007131 circTmem241 mmu_circ_Tmem241 Tmem241 Mus musculus Citrobacter rodentium infection MONDO:0000001 disease DOID:4 intestinal ILC3s up-regulated circTmem241 is highly expressed in sorted intestinal ILC3s compared with other tested lymphocyte progenitors and immune cells. circTmem241 deficiency reduced ILC3 numbers and IL-22 production during C. rodentium infection. 1048 35957556 Down-regulation of hsa-circ-0107593 promotes osteogenic differentiation of hADSCs via miR-20a-5p/SMAD6 signaling. hsa_circ_0107593 hsa-circ-0107593 Homo sapiens skull defect MONDO:0002081 musculoskeletal system disorder DOID:17 human adipose-derived stem cells (hADSCs) down-regulated hsa-circ-0107593 expression decreased during osteogenic differentiation of human adipose-derived stem cells as detected by RT-PCR. Knockdown of hsa-circ-0107593 promoted osteogenic differentiation of hADSCs via the miR-20a-5p/SMAD6 pathway. 1049 35963645 Targeting circRNA-MAP4K2 for the treatment of diabetes-induced retinal vascular dysfunction. hsa_circ_MAP4K2 MAP4K2 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 Human retinal vascular endothelial cells (HRVECs) up-regulated "cMAP4K2 expression was significantly induced in human retinal vascular endothelial cells after high-glucose exposure compared with normoglycemia or L-glucose control. In HRVECs, cMAP4K2 regulated endothelial angiogenic functions including proliferation, migration, and tube formation." 1050 35967789 CircRNA-mediated regulation of brown adipose tissue adipogenesis. mmu_circ_0000231 circOgdh mmu_circ_Ogdh Ogdh Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 brown adipocytes dys-regulated "In primary mouse brown adipocytes, circOgdh was detected by FISH mainly in the cytoplasm and showed dynamic expression during brown adipocyte differentiation, increasing early and decreasing by day 6. Functional experiments in brown adipocytes indicated that circOgdh promotes proliferation and lipolysis while reducing lipid deposition." 1051 35986280 Circular RNA circFIRRE drives osteosarcoma progression and metastasis through tumorigenic-angiogenic coupling. hsa_circ_0001944 circFIRRE hsa_circ_FIRRE FIRRE Homo sapiens osteosarcoma MONDO:0009807 osteosarcoma DOID:3347 primary endothelial cells up-regulated CD31+ magnetic bead-sorted primary endothelial cells from metastatic osteosarcoma showed significantly higher circFIRRE expression than endothelial cells from localized/non-metastatic osteosarcoma by RT-qPCR. Functional endothelial assays indicated that circFIRRE supports angiogenic activity. 1052 35996149 Circular RNA circWWC3 augments breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4. hsa_circ_0001910 circWWC3 hsa_circ_WWC3 WWC3 Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 breast cancer cells up-regulated "In patient breast cancer tissues, circWWC3 was detected by FISH, and circWWC3-high tissues showed high IL-4 and PD-L1 expression in breast cancer cells. The study links high circWWC3 expression with M2-like TAM polarization and PD-L1-associated immune escape." 1053 35997022 Reduced CircSMOC1 Level Promotes Metabolic Reprogramming via PTBP1 (Polypyrimidine Tract-Binding Protein) and miR-329-3p in Pulmonary Arterial Hypertension Rats. hsa_circ_0032358 Homo sapiens pulmonary arterial hypertension MONDO:0015924 pulmonary arterial hypertension PASMCs down-regulated "circSMOC1 was downregulated in primary cultured pulmonary artery smooth muscle cells isolated from PAH rat pulmonary arteries compared with controls, while endothelial cells did not show this downregulation. Functional experiments in PASMCs linked reduced circSMOC1 to proliferation, migration, and metabolic reprogramming." 1054 35997022 Reduced CircSMOC1 Level Promotes Metabolic Reprogramming via PTBP1 (Polypyrimidine Tract-Binding Protein) and miR-329-3p in Pulmonary Arterial Hypertension Rats. circSMOC1 rno_circ_SMOC1 SMOC1 Rattus norvegicus pulmonary arterial hypertension MONDO:0015924 pulmonary arterial hypertension PASMCs down-regulated "circSMOC1 was downregulated in primary cultured pulmonary artery smooth muscle cells isolated from PAH rat pulmonary arteries compared with controls, while endothelial cells did not show this downregulation. Functional experiments in PASMCs linked reduced circSMOC1 to proliferation, migration, and metabolic reprogramming." 1055 36003513 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. mmu-Hecw2_0009 mmu_circ_Hecw2 Hecw2 Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocytes up-regulated mmu-Hecw2_0009 was mainly expressed in isolated neonatal mouse cardiomyocytes compared with cardiac fibroblasts by qRT-PCR. 1056 36003513 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. mmu-Nfkb1_0001 mmu_circ_Nfkb1 Nfkb1 Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocytes up-regulated mmu-Nfkb1_0001 was mainly expressed in isolated neonatal mouse cardiomyocytes compared with cardiac fibroblasts by qRT-PCR. 1057 36003513 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. mmu-Cpeb3_0007 mmu_circ_Cpeb3 Cpeb3 Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocytes up-regulated mmu-Cpeb3_0007 was mainly expressed in isolated neonatal mouse cardiomyocytes compared with cardiac fibroblasts by qRT-PCR. 1058 36003513 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. mmu-Ryr2_0040 mmu_circ_Ryr2 Ryr2 Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocytes up-regulated mmu-Ryr2_0040 was mainly expressed in isolated neonatal mouse cardiomyocytes compared with cardiac fibroblasts by qRT-PCR. 1059 36003513 Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. mmu-Itgbl1_0002 mmu_circ_Itgbl1 Itgbl1 Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiac fibroblasts up-regulated mmu-Itgbl1_0002 was mainly expressed in isolated neonatal mouse cardiac fibroblasts compared with cardiomyocytes by qRT-PCR. 1060 36058431 Oxidant stress-sensitive circRNA Mdc1 controls cardiomyocyte chromosome stability and cell cycle re-entry during heart regeneration. circRNA_30491 mmu_circ_Mdc1 Mdc1 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 cardiomyocytes up-regulated "In primary mouse cardiomyocytes, circMdc1 expression was increased by H2O2-induced oxidative stress and reversed by NAC. Functional experiments in cardiomyocytes showed that circMdc1 inhibits cardiomyocyte proliferation and contributes to DNA damage and chromosomal instability through Mdc1 regulation." 1061 36064433 CircRIC8B regulates the lipid metabolism of chronic lymphocytic leukemia through miR199b-5p/LPL axis. circRIC8B hsa_circ_RIC8B RIC8B Homo sapiens chronic lymphocytic leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 CLL-B cells (CD19_+) up-regulated "CD19 MicroBead-isolated CLL-B cells from CLL patients showed significantly higher circRIC8B expression than CD19- cells. The study further links circRIC8B to CLL cell proliferation, lipid accumulation, and ezetimibe sensitivity." 1062 36068644 CircPRKCH modulates extracellular matrix formation and metabolism by regulating the miR-145/HGF axis in osteoarthritis. hsa_circ_0032131 circPRKCH hsa_circ_PRKCH PRKCH Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes up-regulated "In isolated primary human chondrocytes used to model osteoarthritis, IL-1¦Â treatment increased circPRKCH expression compared with untreated control chondrocytes. Functional experiments in these chondrocytes showed that circPRKCH knockdown inhibited IL-1¦Â-induced apoptosis and ECM degradation through the miR-145/HGF axis." 1063 36072601 The landscape of circular RNA in preterm birth. hsa-SLTM_0001 hsa_circ_SLTM SLTM Homo sapiens Preterm birth MONDO:0012511 preterm premature rupture of the membranes DOID:0111144 maternal monocytes up-regulated hsa-SLTM_0001 was up-regulated in maternal monocytes from preterm pregnancies compared with term pregnancies based on RNA-seq circRNA identification from public datasets. GSE96077 1064 36072601 The landscape of circular RNA in preterm birth. chr1:16891302|16893846 Homo sapiens Preterm birth MONDO:0012511 preterm premature rupture of the membranes DOID:0111144 maternal monocytes down-regulated chr1:16891302|16893846 was down-regulated in maternal monocytes from preterm pregnancies compared with term pregnancies based on RNA-seq circRNA identification from public datasets. GSE96077 1065 36072601 The landscape of circular RNA in preterm birth. hsa-LILRB1_0006 hsa_circ_LILRB1 LILRB1 Homo sapiens Preterm birth MONDO:0012511 preterm premature rupture of the membranes DOID:0111144 maternal monocytes dys-regulated hsa-LILRB1_0006 was identified among differentially expressed circRNAs in maternal monocytes from preterm versus term pregnancies and was significantly correlated with its host gene and immune inflammatory factors including IL1B and IL6. GSE96077 1066 36076572 Hypoxic ADSC-derived exosomes enhance wound healing in diabetic mice via delivery of circ-Snhg11 and induction of M2-like macrophage polarization. mmu_circ_0001100 circ-Snhg11 mmu_circ_Snhg11 Snhg11 Mus musculus diabetic wounds MONDO:0005015 diabetes mellitus DOID:9351 EPCs down-regulated "circ-Snhg11 expression was decreased in endothelial progenitor cells under high-glucose conditions, based on RT-qPCR after primary EPC culture. Overexpression of circ-Snhg11 partially restored EPC angiogenic differentiation and inhibited apoptosis and inflammatory factor secretion under HG conditions." 1067 36076572 Hypoxic ADSC-derived exosomes enhance wound healing in diabetic mice via delivery of circ-Snhg11 and induction of M2-like macrophage polarization. mmu_circ_0001100 circ-Snhg11 mmu_circ_Snhg11 Snhg11 Mus musculus diabetic wounds MONDO:0005015 diabetes mellitus DOID:9351 ADSCs up-regulated "circ-Snhg11 was significantly upregulated in hypoxic ADSC-derived exosomes compared with normoxic ADSC-derived exosomes, detected by high-throughput RNA sequencing and RT-qPCR validation. The authors linked hypoxic ADSC-exosomal circ-Snhg11 delivery to enhanced diabetic wound healing." 1068 36088391 PLGA-microspheres-carried circGMCL1 protects against Crohn's colitis through alleviating NLRP3 inflammasome-induced pyroptosis by promoting autophagy. hsa_circ_0055097 circGMCL1 hsa_circ_GMCL1 GMCL1 Homo sapiens Crohn's disease MONDO:0005011 Crohn disease DOID:8778 epithelial cells isolated from CD patients up-regulated "circGMCL1 was significantly higher in epithelial cells isolated from Crohn's disease patients than in epithelial cells isolated from normal controls, based on qRT-PCR analysis. The study links circGMCL1 to regulation of autophagy and NLRP3 inflammasome-mediated epithelial pyroptosis." 1069 36104951 circS100A11 enhances M2a macrophage activation and lung inflammation in children with asthma. hsa_circ_0014208 circS100A11 hsa_circ_S100A11 S100A11 Homo sapiens asthma MONDO:0004979 asthma DOID:2841 monocytes in human PBMCs up-regulated "circS100A11 was mainly expressed in monocytes among separated human PBMC components, compared with T cells and B cells. The same study reported circS100A11 was upregulated in children with asthma and promoted M2a macrophage activation." 1070 36110046 A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway. circ-ZNF609 rno_circ_ZNF609 ZNF609 Rattus norvegicus ischemic AKI MONDO:0002492 acute kidney injury DOID:3021 renal tubular epithelial cells (RTECs) up-regulated FISH co-localization in rat kidneys showed circ-ZNF609 was mainly located in renal tubular epithelial cells and low in non-epithelial cells after renal I/R injury. The study further linked circ-ZNF609 to RTEC apoptosis and autophagic flux impairment in ischemic AKI. 1071 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0026652 circ_0026652 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) down-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0026652 was decreased in complete response cases compared with non-response cases." 1072 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0068708 circ_0068708 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) down-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0068708 was decreased in complete response cases compared with non-response cases." 1073 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0088128 circ_0088128 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) down-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0088128 was decreased in complete response cases compared with non-response cases." 1074 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0001566 circ_0001566 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) down-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0001566 was decreased in complete response cases compared with non-response cases." 1075 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0031113 circ_0031113 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) up-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0031113 was increased in complete response cases compared with non-response cases." 1076 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0083587 circ_0083587 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) up-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0083587 was increased in complete response cases compared with non-response cases." 1077 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0005552 circ_0005552 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) up-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0005552 was increased in complete response cases compared with non-response cases." 1078 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0007171 circ_0007171 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) up-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0007171 was increased in complete response cases compared with non-response cases." 1079 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0026652 circ_0026652 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) down-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0026652 was decreased in complete response cases compared with non-complete response cases." 1080 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0068708 circ_0068708 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) down-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0068708 was decreased in complete response cases compared with non-complete response cases." 1081 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0088128 circ_0088128 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) down-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0088128 was decreased in complete response cases compared with non-complete response cases." 1082 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0031113 circ_0031113 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) up-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0031113 was increased in complete response cases compared with non-complete response cases." 1083 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0083587 circ_0083587 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) up-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0083587 was increased in complete response cases compared with non-complete response cases." 1084 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0005552 circ_0005552 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) up-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0005552 was increased in complete response cases compared with non-complete response cases." 1085 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0007171 circ_0007171 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) up-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0007171 was increased in complete response cases compared with non-complete response cases." 1086 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0026652 circ_0026652 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) down-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0026652 was decreased in objective response cases compared with non-objective response cases." 1087 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0001566 circ_0001566 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) down-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0001566 was decreased in objective response cases compared with non-objective response cases." 1088 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0031113 circ_0031113 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) up-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0031113 was increased in objective response cases compared with non-objective response cases." 1089 36129153 "Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/¦Â_catenin pathway." hsa_circ_0083587 circ_0083587 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cells (BMPCs) up-regulated "In isolated bone marrow plasma cells from patients with multiple myeloma, circ_0083587 was increased in objective response cases compared with non-objective response cases." 1090 36138395 circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p. hsa_circ_0086296 circ_0086296 hsa_circ_UHRF2 UHRF2 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 endothelial-related marker CD31 up-regulated circ_0086296 is up-regulated in atherosclerotic plaque tissues and FISH shows colocalization with the endothelial marker CD31 in human coronary plaque tissues and artery tissues. Functional experiments in HUVECs indicate that circ_0086296 promotes endothelial injury phenotypes through the miR-576-3p/IFIT1/STAT1 feedback loop. 1091 36138942 Transcriptome Sequencing Reveal That Rno-Rsf1_0012 Participates in Levodopa-Induced Dyskinesia in Parkinson's Disease Rats via Binding to Rno-mir-298-5p. rno-Rsf1_0012 rno_circ_Rsf1 Rsf1 Rattus norvegicus Levodopa-induced dyskinesia in Parkinson's disease MONDO:0005180 Parkinson disease DOID:14330 neurons unknown "FISH/immunofluorescence evidence indicated that rno-Rsf1_0012 was mainly localized in the cytoplasm of neurons in rat striatum. Bulk striatal assays showed increased rno-Rsf1_0012 in LID rats, but the neuron-specific differential expression direction was not directly quantified." 1092 36142402 Role of Circular RNAs in Pulmonary Fibrosis. hsa_circ_0058493 Homo sapiens silicosis MONDO:0005960 silicosis DOID:10325 peripheral blood lymphocyte up-regulated "hsa_circ_0058493 was highly expressed in peripheral blood lymphocytes from silicosis cases, based on whole-transcriptome RNA-seq and multi-stage validation." 1093 36142402 Role of Circular RNAs in Pulmonary Fibrosis. hsa_circ_0058493 Homo sapiens silicosis MONDO:0005960 silicosis DOID:10325 peripheral blood lymphocyte up-regulated "hsa_circ_0058493 was highly expressed in peripheral blood lymphocytes from IPF cases, based on whole-transcriptome RNA-seq and multi-stage validation." 1094 36163585 CircMERTK modulates the suppressive capacity of tumor-associated macrophage via targeting IL-10 in colorectal cancer. hsa_circ_0056121 circMERTK hsa_circ_MERTK Mertk Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 macrophages marker CD68 up-regulated ISH combined with CD68 immunofluorescence showed that circMERTK expression mainly overlapped with macrophages in CRC tissues and was higher in CRC tissues than matched normal tissues. The study further linked circMERTK in TAM-like cells to immunosuppressive activity through the circMERTK/miR-125a-3p/IL-10 axis. 1095 36167680 Circular RNA hsa_circ_0000915 promotes propranolol resistance of hemangioma stem cells in infantile haemangiomas. hsa_circ_0000915 hsa_circ_FKBP8 FKBP8 Homo sapiens infantile haemangiomas MONDO:0002407 capillary hemangioma DOID:2725 haemangioma derived stem cells (HemSCs) up-regulated "In primary HemSCs isolated from proliferating infantile haemangioma specimens, IL-6 treatment up-regulated Circ_0000915 expression by qRT-PCR. Functional experiments in HemSCs indicated Circ_0000915 reduced propranolol sensitivity via the miR-890/RNF187 pathway." 1096 36168302 CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRSF3 deubiquitination in epilepsy. rno_circ_Srrm4 Srrm4 Rattus norvegicus epilepsy MONDO:0005027 epilepsy DOID:1826 activated astrocytes up-regulated "In KA-induced epileptic rats, circSrrm4 fluorescence increased in chronic epilepsy and showed increased co-localization with the astrocyte marker GFAP, indicating elevated circSrrm4 expression in activated astrocytes." 1097 36169884 CircZNF367 suppresses osteogenic differentiation of human bone marrow mesenchymal stromal/stem cells via reducing HuR-mediated mRNA stability of LRP5. hsa_circ_0008842 circZNF367 hsa_circ_ZNF367 ZNF367 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 human bone marrow mesenchymal stromal/stem cells (hBMSCs) down-regulated "circZNF367 (hsa_circ_0008842) expression was gradually decreased in isolated human bone marrow mesenchymal stromal/stem cells during osteogenic differentiation, measured by qRT-PCR. Functional experiments in hBMSCs showed that circZNF367 suppressed migration, invasion and osteogenic differentiation." 1098 36181865 Role of circular RNA cdr1as in modulation of macrophage phenotype. mmu_circRNA_001946 mmu_circ_Cdr1 Cdr1 Mus musculus tissue inflammation MONDO:0021166 inflammatory disease pro-inflammatory macrophages down-regulated "In mouse bone marrow-derived macrophages, circ-Cdr1as was significantly downregulated in pro-inflammatory macrophages based on RT-qPCR validation of circRNA profiling data. Functional experiments indicate circ-Cdr1as participates in macrophage phenotypic switching toward an anti-inflammatory phenotype." 1099 36181865 Role of circular RNA cdr1as in modulation of macrophage phenotype. mmu_circRNA_001946 mmu_circ_Cdr1 Cdr1 Mus musculus tissue inflammation MONDO:0021166 inflammatory disease anti-inflammatory macrophages up-regulated "In mouse bone marrow-derived macrophages, circ-Cdr1as was significantly upregulated in anti-inflammatory macrophages based on RT-qPCR validation of circRNA profiling data. Functional experiments indicate circ-Cdr1as participates in macrophage phenotypic switching toward an anti-inflammatory phenotype." 1100 36185580 Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634. hsa_circ_0110634 circ-0110634 hsa_circ_TNFRSF1B TNFRSF1B Homo sapiens ankylosing spondylitis MONDO:0005306 ankylosing spondylitis DOID:7147 ASMSCs up-regulated "circ-0110634 is up-regulated in ankylosing spondylitis-derived mesenchymal stem cells compared with healthy donor mesenchymal stem cells, based on RT-qPCR after primary MSC isolation and culture. The study further links ASMSC-derived exosomal circ-0110634 transfer to inhibition of PBMC osteoclastogenesis." 1101 36194985 "Circ_0022383 alleviates IL-1¦Â-induced apoptosis, inflammation and extracellular matrix degeneration in osteoarthritis cell model by miR-3619-5p/SIRT1 axis." hsa_circ_0022383 circ_0022383 hsa_circ_FADS2 FADS2 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary chondrocytes down-regulated "circ_0022383 was decreased in IL-1¦Â-induced primary human chondrocytes compared with untreated chondrocytes in an in vitro osteoarthritis cell model. Overexpression experiments indicated that circ_0022383 attenuated IL-1¦Â-induced apoptosis, inflammation and ECM degradation in chondrocytes." 1102 36202171 CircNf1-mediated CXCL12 expression in the spinal cord contributes to morphine analgesic tolerance. rat_circ:chr10:66770890-66783965 rno_circ_Nf1 Nf1 Rattus norvegicus morphine tolerance MONDO:0005531 morphine dependence DOID:2560 neurons up-regulated "circNf1 was increased in spinal dorsal horn tissue after morphine treatment and was detected in the nucleus and cytoplasm of neurons by FISH/qRT-PCR evidence. Knockdown of spinal circNf1 attenuated morphine analgesic tolerance, but this functional assay was not neuron-specific." 1103 36213124 Characterization of circRNA-miRNA-mRNA networks regulating oxygen utilization in type II alveolar epithelial cells of Tibetan pigs. novel_circ_000898 Sus scrofa hypoxia-induced injury MONDO:0000001 disease DOID:4 ATII cells dys-regulated novel_circ_000898 was included in circRNA-miRNA-mRNA regulatory axes identified by whole-transcriptome sequencing of primary ATII cells cultured under hypoxic versus normoxic conditions. unclear 1104 36213124 Characterization of circRNA-miRNA-mRNA networks regulating oxygen utilization in type II alveolar epithelial cells of Tibetan pigs. novel_circ_004392 Sus scrofa hypoxia-induced injury MONDO:0000001 disease DOID:4 ATII cells dys-regulated novel_circ_004392 was identified as a notable circRNA in the circRNA-miRNA-mRNA network comparing Tibetan pig ATII cells under hypoxic and normoxic oxygen conditions. unclear 1105 36213124 Characterization of circRNA-miRNA-mRNA networks regulating oxygen utilization in type II alveolar epithelial cells of Tibetan pigs. novel_circ_003405 Sus scrofa hypoxia-induced injury MONDO:0000001 disease DOID:4 ATII cells dys-regulated novel_circ_003405 was identified as a central circRNA in the circRNA-miRNA-mRNA network comparing Landrace pig ATII cells under hypoxic and normoxic oxygen conditions. unclear 1106 36239357 "News from around the RNA world: new avenues in RNA biology, biotechnology and therapeutics from the 2022 SIBBM meeting." circ-Hdgfrp3 Hdgfrp3 Mus musculus amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 motoneurones unknown "Basescope-FISH was used to study circ-Hdgfrp3 localization in motoneurones. In ALS-linked FUS-mutant motoneurones, oxidative stress was associated with segregation of circ-Hdgfrp3 into cytoplasmic mutant FUS assemblies rather than a quantified expression change." 1107 36239525 circSMAD4 Promotes Experimental Colitis and Impairs Intestinal Barrier Functions by Targeting Janus Kinase 2 Through Sponging miR-135a-5p. hsa_circ_0006952 hsa_circ_SMAD4 SMAD4 Homo sapiens Crohn's disease MONDO:0005011 Crohn disease DOID:8778 isolated epithelial cells up-regulated "Primary epithelial cells isolated from Crohn's disease patients and normal controls were analyzed by qRT-PCR, showing the same up-regulation trend of circSMAD4 observed in colon tissues." 1108 36239525 circSMAD4 Promotes Experimental Colitis and Impairs Intestinal Barrier Functions by Targeting Janus Kinase 2 Through Sponging miR-135a-5p. circSMAD4 / mmu_circSMAD4 mmu_circ_SMAD4 SMAD4 Mus musculus colitis MONDO:0005292 colitis DOID:0060180 isolated epithelial cells down-regulated "In IL-10 KO experimental colitis mice, si-circSMAD4 treatment significantly reduced circSMAD4 expression in isolated epithelial cells. The same study reported improved tight junction protein expression and reduced epithelial apoptosis after si-circSMAD4 treatment." 1109 36239525 circSMAD4 Promotes Experimental Colitis and Impairs Intestinal Barrier Functions by Targeting Janus Kinase 2 Through Sponging miR-135a-5p. circSMAD4 / mmu_circSMAD4 mmu_circ_SMAD4 SMAD4 Mus musculus colitis MONDO:0005292 colitis DOID:0060180 CD4+T cells down-regulated "In IL-10 KO experimental colitis mice, CD4+ T cells purified from lamina propria mononuclear cells showed significantly reduced circSMAD4 expression after si-circSMAD4 treatment compared with controls. The treatment also altered CD4+ T cell differentiation." 1110 36244799 CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation. hsa_circ_0001599 hsa_circRNA_104101 / circ_0018429 hsa_circ_FKBP5 FKBP5 Homo sapiens pulpitis MONDO:0006937 pulpitis DOID:11121 hDPSCs down-regulated circFKBP5 was decreased in LPS-treated human dental pulp stem cells used to model the inflammatory condition of pulpitis. circFKBP5 overexpression attenuated LPS-induced apoptosis and inflammation and promoted osteogenic differentiation in hDPSCs. 1111 36252478 CircPalm2 knockdown alleviates LPS-evoked pulmonary microvascular endothelial cell apoptosis and inflammation via miR-450b-5p/ROCK1 axis. mmu_circ_0001212 circPalm2 / circ-Palm2 mmu_circ_Palm2 Palm2 Mus musculus sepsis-induced acute lung injury MONDO:0015796 acute lung injury Primary mice pulmonary microvascular endothelial cells (MPVECs) up-regulated "circPalm2 was up-regulated in primary mouse pulmonary microvascular endothelial cells after LPS treatment, an in vitro model of sepsis-induced acute lung injury. circPalm2 knockdown attenuated LPS-evoked apoptosis and inflammatory cytokine production in MPVECs." 1112 36254231 CircCRIM1 Ameliorates Endothelial Cell Angiogenesis in Aging through the miR-455-3p/Twist1/VEGFR2 Signaling Axis. mmu_circ_0007020 circCRIM1 mmu_circ_CRIM1 CRIM1 Mus musculus age-related vascular endothelial dysfunction others others mouse aortic endothelial cell (MAEC) down-regulated "circCRIM1/mmu_circ_0007020 was downregulated in old mouse aortic endothelial cells compared with young endothelial cells based on primary MAEC isolation followed by qRT-PCR. Functional experiments in MAECs showed that circCRIM1 promoted proliferation, migration, and tube formation related to angiogenesis." 1113 36257575 Spinal CircKcnk9 Regulates Chronic Visceral Hypersensitivity of Irritable Bowel Syndrome. circRNA_7685 / circKcnk9 rno_circ_Kcnk9 Kcnk9 Rattus norvegicus irritable bowel syndrome MONDO:0005052 irritable bowel syndrome DOID:9778 spinal neurons up-regulated "circKcnk9 was increased in spinal neurons of IBS-like rats, and FISH with cell-type markers supported neuron-specific expression in the spinal dorsal horn." 1114 36260529 "N6-methyladenosine modification in trophoblasts promotes circSETD2 expression, inhibits miR-181a-5p, and elevates MCL1 transcription to reduce apoptosis of trophoblasts." circSETD2 rno_circ_SETD2 SETD2 Rattus norvegicus Preeclampsia MONDO:0005081 preeclampsia DOID:10591 chorionic trophoblasts down-regulated "circSETD2 was down-regulated in isolated chorionic trophoblasts from PE rat models compared with normal pregnant rats, as measured by RT-qPCR. In vivo manipulation suggested circSETD2 affected chorionic trophoblast apoptosis." 1115 36265525 RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice. circRNA-0520 Mus musculus DSS-induced colitis MONDO:0005265 inflammatory bowel disease DOID:0050589 bone marrow-derived dendritic cells / BMDCs dys-regulated circRNA-0520 was identified in BMDCs from DSS-induced colitis mice and was implicated among differentially expressed circRNAs after melatonin treatment versus untreated DSS colitis. It was predicted to participate in a ceRNA network involving miRNA-709 and PI3K-Akt pathway-related genes. 1116 36265525 RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice. circRNA-2243 Mus musculus DSS-induced colitis MONDO:0005265 inflammatory bowel disease DOID:0050589 bone marrow-derived dendritic cells / BMDCs dys-regulated circRNA-2243 was identified in BMDCs from DSS-induced colitis mice and was implicated among differentially expressed circRNAs after melatonin treatment versus untreated DSS colitis. It was predicted to participate in a ceRNA network involving miRNA-709 and PI3K-Akt pathway-related genes. 1117 36265525 RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice. circRNA-0348 Mus musculus DSS-induced colitis MONDO:0005265 inflammatory bowel disease DOID:0050589 bone marrow-derived dendritic cells / BMDCs dys-regulated circRNA-0348 was identified in BMDCs from DSS-induced colitis mice in circRNA-miRNA and circRNA-miRNA-mRNA networks generated from differentially expressed RNAs after melatonin treatment versus untreated DSS colitis. 1118 36267809 circMTND5 Participates in Renal Mitochondrial Injury and Fibrosis by Sponging MIR6812 in Lupus Nephritis. circMTND5 hsa_circ_MTND5 MTND5 Homo sapiens lupus nephritis MONDO:0005556 lupus nephritis DOID:0080162 renal tubular epithelial cells down-regulated circMTND5 was localized mainly in the cytoplasm of renal tubular epithelial cells by FISH in human kidney biopsies and was decreased in lupus nephritis kidneys compared with normal kidneys. Functional experiments in HK-2 renal tubular epithelial cells supported a role for circMTND5 in mitochondrial injury and fibrosis through MIR6812. GSE108340; GSE108735 1119 36271413 Competing endogenous RNA networks related to prognosis in chronic lymphocytic leukemia: comprehensive analyses and construction of a novel risk score model. circ_0002078 Homo sapiens chronic lymphocytic leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 B cells up-regulated "circ_0002078 was up-regulated in CLL patient B-cell specimens compared with normal B cells, based on circRNA expression profiling after B-cell separation and Illumina sequencing." 1120 36271413 Competing endogenous RNA networks related to prognosis in chronic lymphocytic leukemia: comprehensive analyses and construction of a novel risk score model. circ_0007675 Homo sapiens chronic lymphocytic leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 B cells up-regulated "circ_0007675 was up-regulated in CLL patient B-cell specimens compared with normal B cells, supported by circRNA profiling from separated B cells and reported validation of increased expression." 1121 36293208 "Analyses of circRNA Expression throughout the Light-Dark Cycle Reveal a Strong Regulation of Cdr1as, Associated with Light Entrainment in the SCN." Cdr1as mmu_circ_Cdr1 Cdr1 Mus musculus others others others microglia up-regulated Cdr1as was highly expressed in MACS-isolated mouse microglia from hippocampus and frontal cortex and was significantly up-regulated during the light phase compared with the dark phase. GSE199791; GSE200314 1122 36302650 circEXOC5 promotes acute lung injury through the PTBP1/Skp2/Runx2 axis to activate autophagy. hsa_circ_0004399 circEXOC5 hsa_circ_EXOC5 EXOC5 Homo sapiens acute lung injury MONDO:0015796 acute lung injury lung macrophages up-regulated "circEXOC5 was reported as significantly up-regulated in lung macrophages from CLP-induced ALI mice compared with sham-operated mice, with qRT-PCR verification after macrophage isolation." 1123 36316334 Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair. circBNC2 mmu_circ_BNC2 BNC2 Mus musculus IRI-induced kidney fibrosis MONDO:0000494 renal fibrosis DOID:0050855 renal tubules / TECs down-regulated circBNC2 was identified by RNA-seq of isolated mouse renal tubules and was downregulated in renal tubular epithelial cells after severe IRI compared with sham controls. Functional experiments in TECs support a role for circBNC2 in limiting profibrotic maladaptive repair. GSE179620; GSE179506; GSE179505 1124 36325322 Progress in the application of body fluid and tissue level mRNAs-non-coding RNAs for the early diagnosis and prognostic evaluation of systemic lupus erythematosus. hsa_circ_0010957 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4+ T cells up-regulated hsa_circ_0010957 is up-regulated in CD4+ T cells from SLE patients compared with healthy persons and is linked to miR-125B/STAT3 signaling and IL-6-related inflammatory effects. 1125 36339585 Potential predictive and therapeutic applications of small extracellular vesicles-derived circPARD3B in osteoarthritis. hsa_circ_0008172 circPARD3B hsa_circ_PARD3B PARD3B Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 OA-FLS and HDMECs coculture down-regulated circPARD3B was down-regulated in an IL-1¦Â-stimulated coculture of OA-FLS and HDMECs compared with untreated control. Overexpression of circPARD3B reduced VEGF/MMP13 expression and angiogenic activity in this OA inflammatory coculture system. 1126 36360223 Deregulated Expression of Circular RNAs Is Associated with Immune Evasion and Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation. Hsa_circ_0012152 circRNF220 hsa_circ_RNF220 RNF220 Homo sapiens acute myeloid leukemia MONDO:0018874 acute myeloid leukemia DOID:9119 relapse blasts up-regulated Hsa_circ_0012152 / circRNF220 was up-regulated in CD34+ AML relapse blasts based on RNA-seq of magnetically enriched BM CD34+ cells. The paper links it to a predicted ceRNA interaction with miR-92a-1-5p and PVR in relapse blasts. 1127 36360223 Deregulated Expression of Circular RNAs Is Associated with Immune Evasion and Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation. hsa_circ_0002768 circMYLK hsa_circ_MYLK MYLK Homo sapiens acute myeloid leukemia MONDO:0018874 acute myeloid leukemia DOID:9119 relapse blasts down-regulated hsa_circ_0002768 / circMYLK was down-regulated in CD34+ AML relapse blasts based on RNA-seq of magnetically enriched BM CD34+ cells. The paper links circMYLK down-regulation to CIITA/HLA class II regulator expression in relapse blasts. 1128 36394649 "A circular RNA, circPTPN14, increases MYC transcription by interacting with FUBP1 and exacerbates renal fibrosis." mmu_circ_0000130 CircPTPN14 mmu_circ_PTPN14 PTPN14 Mus musculus renal fibrosis MONDO:0000494 renal fibrosis DOID:0050855 renal tubular epithelial cells (TECs) up-regulated circPTPN14 was localized by FISH with the proximal tubule marker LTL and was highly expressed in renal tubular epithelial cells in mouse kidney sections under physiological and fibrotic conditions. Functional experiments in TEC systems indicated that circPTPN14 promotes TGF¦Â1-induced fibrosis. GSE192791 1129 36397164 Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1. hsa_circ_0012077 circPTPRF hsa_circ_PTPRF PTPRF Homo sapiens Glioblastoma MONDO:0018177 glioblastoma DOID:3068 glioma stem cells (GSCs) up-regulated "circPTPRF / hsa_circ_0012077 is overexpressed in glioma stem cells compared with neural progenitor cells based on GEO circRNA expression analysis. Functional experiments in GSCs support roles in proliferation, invasion and neurosphere formation." GSE146463; GSE109569 1130 36402996 Uterine macrophages as treatment targets for therapy of premature rupture of membranes by modified ADSC-EVs through a circRNA/miRNA/NF-¦ÊB pathway. mmu_circ_0002047 cir2047 mmu_circ_B4galnt1 B4galnt1 Mus musculus premature rupture of membranes MONDO:0012511 preterm premature rupture of the membranes DOID:0111144 F4/80-positive cells up-regulated Cir2047/mmu_circ_0002047 was elevated in F4/80-positive macrophages after LPS-induced PROM modeling and was co-expressed with F4/80 in uterine macrophages by in situ hybridization and immunostaining. Functional experiments in F4/80-positive macrophages indicated that cir2047 maintains M1 polarization and MMP secretion through the miR-1931/TRAF6/NF-¦ÊB pathway. 1131 36409993 Inhibition of circ_0004381 improves cognitive function via miR-647/PSEN1 axis in an Alzheimer disease mouse model. circ_0004381 Mus musculus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 hippocampal neurons up-regulated "circ_0004381 was up-regulated in primary mouse hippocampal neurons after Ab1-42 treatment in an in vitro Alzheimer disease model, as measured by RT-qPCR. Knockdown of circ_0004381 attenuated Ab1-42-induced apoptosis, oxidative stress, and mitochondrial dysfunction in hippocampal neurons." 1132 36433954 circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. circCamsap1 mmu_circ_Camsap1 Camsap1 Mus musculus sarcoma MONDO:0005089 sarcoma DOID:1115 dsRED-labeled sarcoma cells up-regulated circCamsap1 was confirmed by RTqPCR in isolated dsRED-labeled sarcoma cells and was significantly up-regulated in malignant p53KOCcne1+ sarcoma cells compared with non-tumorigenic p53KO mesenchymal cells. 1133 36433954 circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. circRad23b mmu_circ_Rad23b Rad23b Mus musculus sarcoma MONDO:0005089 sarcoma DOID:1115 dsRED-labeled sarcoma cells up-regulated circRad23b was confirmed by RTqPCR in isolated dsRED-labeled sarcoma cells and was significantly up-regulated in malignant p53KOCcne1+ sarcoma cells compared with non-tumorigenic p53KO mesenchymal cells. 1134 36433954 circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. circBnc2 mmu_circ_Bnc2 Bnc2 Mus musculus sarcoma MONDO:0005089 sarcoma DOID:1115 dsRED-labeled sarcoma cells up-regulated circBnc2 was confirmed by RTqPCR in isolated dsRED-labeled sarcoma cells and was significantly up-regulated in malignant p53KOCcne1+ sarcoma cells compared with non-tumorigenic p53KO mesenchymal cells. 1135 36433954 circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. circRere mmu_circ_Rere Rere Mus musculus sarcoma MONDO:0005089 sarcoma DOID:1115 dsRED-labeled sarcoma cells up-regulated circRere was confirmed by RTqPCR in isolated dsRED-labeled sarcoma cells and was significantly up-regulated in malignant p53KOCcne1+ sarcoma cells compared with non-tumorigenic p53KO mesenchymal cells. 1136 36433954 circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. circAnkib1 mmu_circ_Ankib1 Ankib1 Mus musculus sarcoma MONDO:0005089 sarcoma DOID:1115 dsRED-labeled sarcoma cells up-regulated "circAnkib1 was confirmed by RTqPCR in isolated dsRED-labeled sarcoma cells and was significantly up-regulated in malignant p53KOCcne1+ sarcoma cells compared with non-tumorigenic p53KO mesenchymal cells. In sarcoma cells, circAnkib1 silencing increased interferon-related genes and pro-inflammatory cytokines, supporting a tumor-cell role in immune regulation." 1137 36433954 circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. circCsnk1g3 mmu_circ_Csnk1g3 Csnk1g3 Mus musculus sarcoma MONDO:0005089 sarcoma DOID:1115 dsRED-labeled sarcoma cells up-regulated "circCsnk1g3 was confirmed by RTqPCR in isolated dsRED-labeled sarcoma cells and was significantly up-regulated in malignant p53KOCcne1+ sarcoma cells compared with non-tumorigenic p53KO mesenchymal cells. In sarcoma cells, circCsnk1g3 silencing increased interferon-related genes and pro-inflammatory cytokines and reshaped immune infiltration." 1138 36435226 Myc-mediated circular RNA circMcph1/miR-370-3p/Irak2 axis is a progressive regulator in hepatic fibrosis. mmu_circ_0001663 circMcph1 mmu_circ_Mcph1 Mcph1 Mus musculus hepatic fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 primary KCs up-regulated "circMcph1 was up-regulated in primary Kupffer cells isolated from CCl4-induced hepatic fibrosis mice compared with vehicle controls, as measured by qRT-PCR." 1139 36435781 Circular RNA circLOC101928570 suppresses systemic lupus erythematosus progression by targeting the miR-150-5p/c-myb axis. circLOC101928570 hsa_circ_LOC101928570 LOC101928570 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4_+_T cells down-regulated circLOC101928570 was detected by qRT-PCR after MACS isolation and was downregulated in CD4+ T cells from SLE patients compared with healthy controls. 1140 36435781 Circular RNA circLOC101928570 suppresses systemic lupus erythematosus progression by targeting the miR-150-5p/c-myb axis. circLOC101928570 hsa_circ_LOC101928570 LOC101928570 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD8_+_T cells down-regulated circLOC101928570 was detected by qRT-PCR after MACS isolation and was downregulated in CD8+ T cells from SLE patients compared with healthy controls. 1141 36455645 CircRalgapa1 facilitates morphine tolerance via miR-873a-5p/A20 axis in mice. circRNA_014599 mmu_circ_Ralgapa1 Ralgapa1 Mus musculus morphine tolerance MONDO:0005531 morphine dependence DOID:2560 spinal dorsal horn neurons down-regulated "circRalgapa1 was localized mainly in spinal dorsal horn neurons by FISH combined with NeuN immunofluorescence. Its fluorescence intensity was reduced in the spinal dorsal horn after morphine tolerance, supporting decreased neuronal-associated circRalgapa1 in morphine-tolerant mice." 1142 36457055 Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-¦Â2 axis. circ_0001293 Mus musculus epilepsy MONDO:0005027 epilepsy DOID:1826 Astrocytes down-regulated "In primary mouse astrocytes, IL-1¦Â stimulation significantly inhibited circ_0001293 expression by RT-qPCR. Functional experiments linked circ_0001293 to alleviation of IL-1¦Â-induced astrocyte inflammation." 1143 36457055 Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-¦Â2 axis. circ_0001293 Mus musculus epilepsy MONDO:0005027 epilepsy DOID:1826 Astrocytes up-regulated "In IL-1¦Â-stimulated primary mouse astrocytes, HsTx2 treatment increased circ_0001293 expression by RT-qPCR. Knockdown experiments indicated that HsTx2 alleviated astrocyte inflammation by upregulating circ_0001293." 1144 36467610 Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome. circKcnk9 rno_circ_Kcnk9 Kcnk9 Rattus norvegicus irritable bowel syndrome MONDO:0005052 irritable bowel syndrome DOID:9778 neurons up-regulated "circKcnk9-positive cells were increased in the hippocampal CA1 region of IBS-like rats compared with controls, and circKcnk9 was largely colocalized with neurons rather than microglia or astrocytes. CA1 circKcnk9 manipulation affected LTP, visceral hypersensitivity, and anxiety in rats." 1145 36476974 CIRCKLHL2 KNOCKDOWN ALLEVIATES SEPSIS-INDUCED ACUTE LUNG INJURY BY REGULATING MIR-29B-3P MEDIATED ROCK1 EXPRESSION DOWN-REGULATION. mmu_circ_0001679 circKlhl2 mmu_circ_Klhl2 Klhl2 Mus musculus sepsis-induced acute lung injury MONDO:0015796 acute lung injury MPVECs up-regulated circKlhl2 was increased in LPS-treated primary murine pulmonary microvascular endothelial cells used to mimic sepsis-induced acute lung injury in vitro. Knockdown of circKlhl2 alleviated LPS-induced MPVEC dysfunction by modulating the miR-29b-3p/ROCK1 axis. 1146 36476986 Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p. 3:38470924|38472523 ssc_circ_CREBBP CREBBP Sus scrofa male reproductive diseases MONDO:0003150 male reproductive system disorder DOID:48 sperm down-regulated "circ-CREBBP expression was lower in sperm from low-motility boars than in sperm from high-motility boars, as measured by qPCR after sperm isolation. Functional experiments in sperm showed that circ-CREBBP knockdown decreased motility and increased apoptosis." GSE216966 1147 36483049 CircRNAs: Roles in regulating head and neck squamous cell carcinoma. hg19_circ_0005033 Homo sapiens laryngeal squamous cell carcinoma MONDO:0005595 laryngeal squamous cell carcinoma DOID:2876 CD133+ and CD44+ CSCs up-regulated Hg19_circ_0005033 was up-regulated in CD133+ CD44+ laryngeal cancer stem-like TDP cells compared with parental cells based on RNA sequencing. The review states that it may support stem cell properties through the miR4521/STAT5A axis. 1148 36506306 Non-coding RNAs in ossification of the posterior longitudinal ligament. hsa-circ-0092429 Homo sapiens ossification of the posterior longitudinal ligament MONDO:0011230 ossification of the posterior longitudinal ligament of the spine DOID:0060887 peripheral blood mononuclear cells (PBMCs) up-regulated "hsa-circ-0092429 was reported as the most upregulated circRNA in PBMCs from OPLL-related differential circRNA profiling, with RNA-seq results reconfirmed by RT-qPCR." 1149 36506306 Non-coding RNAs in ossification of the posterior longitudinal ligament. hsa-circ-0137606 Homo sapiens ossification of the posterior longitudinal ligament MONDO:0011230 ossification of the posterior longitudinal ligament of the spine DOID:0060887 peripheral blood mononuclear cells (PBMCs) down-regulated "hsa-circ-0137606 was reported as the most downregulated circRNA in PBMCs from OPLL-related differential circRNA profiling, with RNA-seq results reconfirmed by RT-qPCR." 1150 36506306 Non-coding RNAs in ossification of the posterior longitudinal ligament. hsa_circ_SKIL SKIL Homo sapiens ossification of the posterior longitudinal ligament MONDO:0011230 ossification of the posterior longitudinal ligament of the spine DOID:0060887 primary cervical posterior longitudinal ligament cells / primary posterior longitudinal ligament fibroblasts up-regulated circSKIL was significantly elevated in primary cervical posterior longitudinal ligament cells from OPLL patients. The article reports that circSKIL promoted proliferation and osteogenic differentiation of primary posterior longitudinal ligament fibroblasts through the JNK/STAT3 pathway. 1151 36512324 Extracellular Vesicle-Packaged circATP2B4 Mediates M2 Macrophage Polarization via miR-532-3p/SREBF1 Axis to Promote Epithelial Ovarian Cancer Metastasis. hsa_circ_0000173 hsa_circ_ATP2B4 ATP2B4 Homo sapiens ovarian cancer MONDO:0008170 ovarian cancer DOID:2394 macrophages up-regulated "EOC cell-derived EVs deliver circATP2B4 into macrophages, where circATP2B4 RNA abundance is increased and associated with M2 macrophage polarization." 1152 36514216 circ-BPTF serves as a miR-486-5p sponge to regulate CEMIP and promotes hypoxic pulmonary arterial smooth muscle cell proliferation in COPD. hsa_circ_0045462 hsa_circ_BPTF BPTF Homo sapiens chronic obstructive pulmonary disease MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 human pulmonary arterial smooth muscle cells (PASMCs) up-regulated circ-BPTF is up-regulated in primary human pulmonary arterial smooth muscle cells under hypoxia. Functional experiments in hPASMCs showed that circ-BPTF promotes proliferation through the miR-486-5p/CEMIP axis. 1153 36524862 "Circ_0047835 Combines with miR-144-3p to Promote the Proliferation, Invasion, Migration, and Fibrosis of TGF-¦Â1-Treated Human Tenon's Capsule Fibroblasts by Upregulating SP1." hsa_circ_0047835 hsa_circ_PMAIP1 PMAIP1 Homo sapiens glaucoma MONDO:0005041 glaucoma DOID:1686 Human Tenon's capsule fibroblasts (HTFs) up-regulated "circ_0047835 was up-regulated in TGF-¦Â1-treated human Tenon's capsule fibroblasts, an in vitro glaucoma-related fibrosis model, as measured by RT-qPCR. Knockdown experiments in these HTFs indicated roles in proliferation, invasion, migration, and fibrosis." 1154 36541023 Circular RNA CircSLC8A1 contributes to osteogenic differentiation in hBMSCs via CircSLC8A1/miR-144-3p/RUNX1 in periprosthetic osteolysis. hsa_circ_0000994 hsa_circ_SLC8A1 SLC8A1 Homo sapiens periprosthetic osteolysis MONDO:0005381 bone disorder DOID:0080001 human bone marrow mesenchymal stem cells (hBMSCs) down-regulated CircSLC8A1 was downregulated in Ti particle-treated hBMSCs used as an in vitro PPOL cell model. Functional assays in hBMSCs indicated that CircSLC8A1 promotes osteogenic differentiation and reduces apoptosis. 1155 36541023 Circular RNA CircSLC8A1 contributes to osteogenic differentiation in hBMSCs via CircSLC8A1/miR-144-3p/RUNX1 in periprosthetic osteolysis. hsa_circ_0000994 hsa_circ_SLC8A1 SLC8A1 Homo sapiens periprosthetic osteolysis MONDO:0005381 bone disorder DOID:0080001 hBMSCs up-regulated CircSLC8A1 increased progressively in hBMSCs during osteogenic differentiation. The authors propose that CircSLC8A1 may act as a regulatory molecule participating in osteogenic differentiation. 1156 36543889 Circ_0000284: A risk factor and potential biomarker for prehypertension and hypertension. hsa_circ_0000284 hsa_circ_HIPK3 HIPK3 Homo sapiens hypertension MONDO:0005044 hypertensive disorder DOID:10763 peripheral blood leukocytes up-regulated circ_0000284 was measured by qRT-PCR in isolated peripheral blood leukocyte layers and was up-regulated in prehypertensive subjects compared with normotensive controls. 1157 36543889 Circ_0000284: A risk factor and potential biomarker for prehypertension and hypertension. hsa_circ_0000284 hsa_circ_HIPK3 HIPK3 Homo sapiens hypertension MONDO:0005044 hypertensive disorder DOID:10763 peripheral blood leukocytes up-regulated circ_0000284 was measured by qRT-PCR in isolated peripheral blood leukocyte layers and was up-regulated in hypertensive subjects compared with normotensive controls. 1158 36551885 circRNAs May Be Involved in Dysfunction of Neutrophils of Type 2 Diabetic Mice through Regulation of Specific miRNAs. mmu_circRNA_29357 Mus musculus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 diabetic-derived neutrophils up-regulated mmu_circRNA_29357 was significantly increased in bone marrow-derived neutrophils from diabetic mice compared with non-diabetic mice after neutrophil isolation and qRT-PCR validation. GSE213297 1159 36578771 Genetic regulation of circular RNA expression in human aortic smooth muscle cells and vascular traits. hsa_circ_SLC4A7 SLC4A7 Homo sapiens high blood pressure MONDO:0005044 hypertensive disorder DOID:10763 human aortic smooth muscle cells down-regulated "circSLC4A7 expression was quantified in primary cultured human aortic smooth muscle cells, and its circQTL colocalized with a high blood pressure GWAS locus. The rs428239 risk allele was associated with lower circSLC4A7 expression in SMCs." GSE193817 1160 36585543 CircUBE3B High Expression Participates in Sevoflurane-Induced Human Hippocampal Neuron Injury via Targeting miR-326 and Regulating MYD88 Expression. hsa_circ_0028135 hsa_circ_UBE3B UBE3B Homo sapiens postoperative cognitive dysfunction / POCD MONDO:0002602 central nervous system disorder DOID:331 Human hippocampal neurons (HHNs) up-regulated circUBE3B expression was elevated in Sevo-treated human hippocampal neurons compared with control neurons. Functional experiments indicated that circUBE3B contributed to Sevo-induced HHN apoptosis and inflammation. 1161 36604982 CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post-translational modification. hsa_circ_0006381 CircZSWIM6 hsa_circ_ZSWIM6 ZSWIM6 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 ageing chondrocytes up-regulated CircZSWIM6 (hsa_circ_0006381) was identified by RNA-seq of primary human chondrocytes and validated by RT-qPCR as significantly increased in older/ageing chondrocytes. Functional experiments in chondrocytes showed that CircZSWIM6 regulates ECM and energy metabolism in osteoarthritis-related senescence. 1162 36608447 Circ_0001721 knockdown relieves IL-1¦Â-induced chondrocyte injury via regulating miR-373-3p/CXCR4 in osteoarthritis. hsa_circ_0001721 circ_0001721 hsa_circ_CDK14 CDK14 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated "circ_0001721 expression was increased in IL-1¦Â-induced human chondrocytes, an in vitro osteoarthritis cell model. Knockdown of circ_0001721 alleviated IL-1¦Â-induced chondrocyte injury involving proliferation, apoptosis, ECM degradation and inflammation." 1163 36613512 AML1-ETO-Related Fusion Circular RNAs Contribute to the Proliferation of Leukemia Cells. F-CircAE2 hsa_circ_RUNX1-RUNX1T1 RUNX1-RUNX1T1 Homo sapiens acute myeloid leukemia MONDO:0018874 acute myeloid leukemia DOID:9119 AML1-ETO-positive patient BMMNCs up-regulated F-CircAE2 was detected at higher levels in AML1-ETO-positive patient BMMNCs than in normal donor BMMNCs by PCR/qRT-PCR assays. Knockdown experiments in patient BMMNCs supported a role in maintaining primary leukemia cell growth and glycolysis. 1164 36625877 circFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p. hsa_circ_0092012 circFLNA hsa_circ_FLNA FLNA Homo sapiens sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 purified intestinal epithelial cells up-regulated circFLNA / hsa_circ_0092012 was up-regulated in purified intestinal epithelial cells from patients with abdominal sepsis compared with non-sepsis controls. Functional experiments indicated that circFLNA promoted apoptosis and inflammation through the miR-766-3p/Fas pathway. 1165 36625877 circFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p. hsa_circ_0001535 circFAM13B hsa_circ_FAM13B FAM13B Homo sapiens sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 purified intestinal epithelial cells up-regulated circFAM13B / hsa_circ_0001535 was up-regulated in purified intestinal epithelial cells from patients with abdominal sepsis compared with non-sepsis controls. 1166 36625877 circFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p. hsa_circ_0073244 circEDIL3 hsa_circ_EDIL3 EDIL3 Homo sapiens sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 purified intestinal epithelial cells up-regulated circEDIL3 / hsa_circ_0073244 was up-regulated in purified intestinal epithelial cells from patients with abdominal sepsis compared with non-sepsis controls. 1167 36625877 circFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p. hsa_circ_0003222 circLARP4 hsa_circ_LARP4 LARP4 Homo sapiens sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 purified intestinal epithelial cells up-regulated circLARP4 / hsa_circ_0003222 was up-regulated in purified intestinal epithelial cells from patients with abdominal sepsis compared with non-sepsis controls. 1168 36625877 circFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p. hsa_circ_0008732 circBNC2 hsa_circ_BNC2 BNC2 Homo sapiens sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 purified intestinal epithelial cells up-regulated circBNC2 / hsa_circ_0008732 was up-regulated in purified intestinal epithelial cells from patients with abdominal sepsis compared with non-sepsis controls. 1169 36637791 CircFhit Modulates GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a Rat Model of Neuropathic Pain. circFhit rno_circ_Fhit Fhit Rattus norvegicus neuropathic pain MONDO:0021667 neuralgia GABAergic neurons up-regulated "circFhit is up-regulated in inhibitory GABAergic neurons of the spinal dorsal horn following spared nerve injury in a rat neuropathic pain model, supported by RNA-FISH with neuronal and PAX2 marker co-localization. Functional experiments indicate that circFhit in GABAergic neurons reduces inhibitory synaptic transmission and enhances NK1R+ neuronal excitability." 1170 36642417 CircStrn3 targeting microRNA-9-5p is involved in the regulation of cartilage degeneration and subchondral bone remodelling in osteoarthritis. hsa_circ_STRN3 STRN3 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes down-regulated Primary chondrocytes isolated from OA mice and OA patients showed decreased circStrn3 expression compared with non-OA or sham controls by qRT-PCR. 1171 36642417 CircStrn3 targeting microRNA-9-5p is involved in the regulation of cartilage degeneration and subchondral bone remodelling in osteoarthritis. circStrn3 mmu_circ_Strn3 Strn3 Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 mechanically loaded chondrocytes down-regulated "Ribo-minus RNA-seq of primary chondrocytes exposed to mechanical loading identified circStrn3 as repressed, and qRT-PCR validation supported decreased circStrn3 in mechanically loaded chondrocytes." 1172 36681829 CircFBXW7 in patients with T-cell ALL: depletion sustains MYC and NOTCH activation and leukemia cell viability. circFBXW7 hsa_circ_FBXW7 FBXW7 Homo sapiens T-cell Acute Lymphoblastic Leukemia MONDO:0004963 T-cell acute lymphoblastic leukemia DOID:5603 T-cells; sorted human thymocyte populations down-regulated "circFBXW7 expression was quantified from RNA-seq in T-ALL patient cohorts and sorted normal human thymocyte populations, showing lower expression in T-ALL relative to the normal immature T-cell counterpart." GSE110636 1173 36709365 circRNA432 enhances the coelomocyte phagocytosis via regulating the miR-2008-ELMO1 axis in Vibrio splendidus-challenged Apostichopus japonicus. circ432 Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 coelomocytes up-regulated circ432 was identified by circRNA transcriptome sequencing in sea cucumber coelomocytes and was up-regulated in SUS-diseased sea cucumbers compared with healthy controls. PRJNA512578 1174 36709365 circRNA432 enhances the coelomocyte phagocytosis via regulating the miR-2008-ELMO1 axis in Vibrio splendidus-challenged Apostichopus japonicus. circ432 Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 coelomocytes up-regulated circ432 abundance was increased in sea cucumber coelomocytes after V. splendidus challenge and in primary coelomocytes after LPS stimulation. Functional knockdown experiments showed that circ432 positively regulates V. splendidus-induced coelomocyte phagocytosis. 1175 36716953 Circ-calm4 regulates hypoxia-induced pulmonary artery smooth muscle autophagy by binding Purb. mmu_circ_calm4 calmodulin 4 Mus musculus hypoxic pulmonary hypertension MONDO:0017157 pulmonary hypertension owing to lung disease and/or hypoxia pulmonary artery smooth muscle cells (PASMCs) up-regulated circ-calm4 is up-regulated under hypoxia in PASMCs and regulates hypoxia-induced PASMC autophagy. Knockdown of circ-calm4 inhibits autophagy in PASMCs induced by hypoxia. 1176 36717587 FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke. mmu_circ_Scmh1 Scmh1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke brain vascular ECs down-regulated circSCMH1 was decreased in flow-sorted brain vascular endothelial cells from the peri-infarct cortex of PT stroke mice compared with sham mice. 1177 36717587 FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke. mmu_circ_Scmh1 Scmh1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke brain vascular ECs up-regulated EV-circSCMH1 treatment increased or restored circSCMH1 levels in flow-sorted brain vascular endothelial cells from the peri-infarct cortex of PT stroke mice compared with untreated stroke controls. 1178 36728267 CircRNA_06354 might promote early-onset preeclampsia in humans via hsa-miR-92a-3p/vascular endothelial growth factor-A. circRNA_06354 hsa_circ_Metrnl Metrnl Homo sapiens early-onset preeclampsia MONDO:0005041 glaucoma DOID:1686 cytotrophoblast unknown "FISH analysis showed that circRNA_06354 was preferentially localized in cytotrophoblast in EOPE placentas, while control placentas showed distribution in syncytiotrophoblast. Functional assays in trophoblastic cells indicated effects on migration, invasion and tube formation." 1179 36732429 Extracellular Vesicles Derived from Bone Mesenchymal Stem Cells Carrying circ_0000075 Relieves Cerebral Ischemic Injury by Competitively Inhibiting miR-218-5p and Up-regulating E3 Ubiquitin Ligase SMURF2. circ_0000075 Homo sapiens cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury neurons down-regulated "In primary mouse neurons subjected to OGD/R, circ_0000075 expression was reduced by RT-qPCR, supporting neuron-resolved down-regulation in an in vitro cerebral ischemic injury model." 1180 36732429 Extracellular Vesicles Derived from Bone Mesenchymal Stem Cells Carrying circ_0000075 Relieves Cerebral Ischemic Injury by Competitively Inhibiting miR-218-5p and Up-regulating E3 Ubiquitin Ligase SMURF2. circ_0000075 Homo sapiens cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury neurons up-regulated "In primary mouse neurons after OGD/R, RVG-circ_0000075-EV treatment significantly increased circ_0000075 expression by RT-qPCR compared with control EV treatment. This treatment was associated with reduced neuronal apoptosis and damage." 1181 36735415 circ_0013613 Promotes the recovery of spinal cord injury by regulating mir-370-3p/caspase1 to regulate neuronal pyroptosis. circ_0013613 Mus musculus spinal cord injury MONDO:0043797 spinal cord injury primary spinal cord neurons up-regulated circ_0013613 is up-regulated in LPS-induced primary spinal cord neuronal cells compared with untreated controls. Knockdown of circ_0013613 alleviated LPS-induced inflammatory injury and pyroptosis-related changes in nerve cells. 1182 36758707 Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis. mmu_circ_0001182 circASPH mmu_circ_ASPH ASPH Mus musculus hepatic fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 primary hepatocytes up-regulated circASPH was up-regulated in hepatocyte-derived exosomes from hepatic fibrosis mice based on circRNA sequencing of isolated primary hepatocytes. 1183 36758707 Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis. mmu_circ_0001182 circASPH mmu_circ_ASPH ASPH Mus musculus hepatic fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 primary HSCs up-regulated "circASPH was up-regulated in primary hepatic stellate cells from CCl4-induced hepatic fibrosis mice, and FISH/IF showed colocalization of circASPH with the HSC activation marker ¦Á-SMA. Knockdown of circASPH reduced HSC activation and proliferation and promoted apoptosis through the miR-139-5p/Notch1 axis." 1184 36768295 circITGB1 Regulates Adipocyte Proliferation and Differentiation via the miR-23a/ARRB1 Pathway. circITGB1 oar_circ_ITGB1 ITGB1 Ovis aries others others others adipocytes up-regulated "In primary sheep adipocytes, circITGB1 expression reached its highest level at day six during adipocyte differentiation based on qPCR. Functional experiments in adipocytes showed that circITGB1 promoted proliferation and inhibited differentiation via the miR-23a/ARRB1 pathway." 1185 36775059 The circular RNA circHelz enhances cardiac fibrosis by facilitating the nuclear translocation of YAP1. mmu_circ_0000332 circHelz mmu_circ_Helz Helz Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 CFs up-regulated "circHelz is up-regulated in TGF-¦Â-treated primary mouse cardiac fibroblasts isolated from neonatal and adult mice. Functional experiments in CFs showed that circHelz promotes proliferation, migration, fibroblast-to-myofibroblast transition and fibrotic marker expression through YAP1." 1186 36778190 Circular RNA Involvement in Aging and Longevity. circNF1-419 Rattus norvegicus aging others others astrocytes unknown "circNF1-419 was identified in RNA-seq-based expression profiling of senescent astrocytes from rats, but the review does not specify the direction of its expression change." 1187 36780172 Circ_0115118 regulates endometrial functions through the miR-138-1-3p/WDFY2 axis in patients with PCOS_. hsa_circ_0115118 circ_0115118 hsa_circ_SAMHD1 SAMHD1 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 stromal cells up-regulated "circ_0115118 was significantly up-regulated in isolated endometrial stromal cells from patients with PCOS compared with controls, as measured by real-time PCR. Functional experiments in ESCs showed that circ_0115118 overexpression reduced proliferation, migration and invasion and affected decidualization." 1188 36780172 Circ_0115118 regulates endometrial functions through the miR-138-1-3p/WDFY2 axis in patients with PCOS_. hsa_circ_0115118 circ_0115118 hsa_circ_SAMHD1 SAMHD1 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 epithelial cells no change "circ_0115118 showed no significant expression difference in isolated endometrial epithelial cells from patients with PCOS compared with controls, as measured by real-time PCR." 1189 36793611 Emerging landscape of circFNDC3B and its role in human malignancies. circFNDC3B hsa_circ_FNDC3B FNDC3B Homo sapiens Abdominal aortic aneurysm MONDO:0005350 abdominal aortic aneurysm DOID:7693 primary VSMCs up-regulated "circFNDC3B expression was higher in isolated and cultured primary VSMCs from AAA patients, supporting cell-type-resolved up-regulation in vascular smooth muscle cells." 1190 36793611 Emerging landscape of circFNDC3B and its role in human malignancies. circFNDC3B hsa_circ_FNDC3B FNDC3B Homo sapiens Abdominal aortic aneurysm MONDO:0005350 abdominal aortic aneurysm DOID:7693 VSMCs up-regulated "In VSMCs, Ang-II treatment induced circFNDC3B expression in a dose-dependent manner in the context of AAA-related cell injury." 1191 36797769 Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-__B-IL-6 axis of tumor-associated macrophages. cSERPINE2 SERPINE2 Mus musculus breast cancer MONDO:0007254 breast cancer DOID:1612 BMDMs derived TAMs up-regulated "In primary murine BMDM-derived tumor-associated macrophages, tumor exosomal cSERPINE2 was increased after exposure to cSERPINE2-overexpressing EO771-derived conditioned medium or exosomes, supporting macrophage internalization of tumor exosomal cSERPINE2. The study further links macrophage-internalized cSERPINE2 to MALT1/NF-¦ÊB activation and IL-6 secretion." 1192 36803376 Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1. rno_circ_METTL9 METTL9 Rattus norvegicus traumatic brain injury MONDO:0858950 traumatic brain injury DOID:0081292 astrocytes up-regulated circMETTL9 is localized to rat cortical astrocytes by FISH and GFAP co-localization and is reported as differentially upregulated in rat cortical astrocytes following TBI. The study links astrocytic circMETTL9 to increased SND1 and pro-inflammatory chemokine signaling. 1193 36803376 Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1. rno_circ_METTL9 METTL9 Rattus norvegicus traumatic brain injury MONDO:0858950 traumatic brain injury DOID:0081292 cultured primary astrocytes up-regulated "In primary rat astrocyte culture, LPS treatment upregulated circMETTL9 expression measured by qPCR. circMETTL9 knockdown or overexpression altered astrocytic pro-inflammatory chemokine expression, supporting a role in inflammatory signaling." 1194 36806251 CircFNDC3B regulates osteoarthritis and oxidative stress by targeting miR-525-5p/HO-1 axis. hsa_circ_0001361 circFNDC3B hsa_circ_FNDC3B FNDC3B Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes (HCs) down-regulated "circFNDC3B was significantly down-regulated in IL-1¦Â-induced primary human chondrocytes compared with control chondrocytes. Functional experiments in human chondrocytes showed that circFNDC3B regulates proliferation, extracellular matrix metabolism, oxidative stress, and NF-¦ÊB pathway activity." PRJNA516555 1195 36827915 Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1. mmu_circ_0001468 mmu_circ_HIPK2 HIPK2 Mus musculus central nervous system inflammation MONDO:0005156 encephalomyelitis DOID:640 primary astrocytes up-regulated "In primary mouse astrocytes, LPS treatment increased circHIPK2 expression compared with untreated control cells. Knockdown of circHIPK2 suppressed inflammatory markers in LPS-treated primary astrocytes." 1196 36827915 Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1. mmu_circ_0001468 mmu_circ_HIPK2 HIPK2 Mus musculus central nervous system inflammation MONDO:0005156 encephalomyelitis DOID:640 primary astrocytes down-regulated "In LPS-treated active primary mouse astrocytes, rapamycin treatment decreased circHIPK2 expression compared with LPS alone. The authors link this decrease to suppression of astrocytic inflammation through the circHIPK2-SIGMAR1 axis." 1197 36834591 FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation. circCARHSP1 hsa_circ_CARHSP1 CARHSP1 Homo sapiens amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 human motor neurons (MNs) down-regulated circCARHSP1 was detected in human motor neurons and was downregulated in FUSP525L mutant motor neurons compared with FUSWT motor neurons. GSE94888 1198 36834591 FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation. circRHOBTB3 hsa_circ_RHOBTB3 RHOBTB3 Homo sapiens amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 human motor neurons (MNs) down-regulated circRHOBTB3 was detected in human motor neurons and was downregulated in FUSP525L mutant motor neurons compared with FUSWT motor neurons. GSE94888 1199 36834591 FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation. circCORO1C hsa_circ_CORO1C CORO1C Homo sapiens amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 human motor neurons (MNs) down-regulated circCORO1C was detected in human motor neurons and was downregulated in FUSP525L mutant motor neurons compared with FUSWT motor neurons. GSE94888 1200 36834591 FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation. circZNF124 hsa_circ_ZNF124 ZNF124 Homo sapiens amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 human motor neurons (MNs) down-regulated circZNF124 was detected in human motor neurons and was downregulated in FUSP525L mutant motor neurons compared with FUSWT motor neurons. GSE94888 1201 36834591 FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation. circSMARCA5 hsa_circ_SMARCA5 SMARCA5 Homo sapiens amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 human motor neurons (MNs) down-regulated circSMARCA5 was detected in human motor neurons and was downregulated in FUSP525L mutant motor neurons compared with FUSWT motor neurons. GSE94888 1202 36834591 FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation. circNAA35 hsa_circ_NAA35 NAA35 Homo sapiens amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 human motor neurons (MNs) down-regulated circNAA35 was detected in human motor neurons and was downregulated in FUSP525L mutant motor neurons compared with FUSWT motor neurons. GSE94888 1203 36834591 FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation. circPSME3 hsa_circ_PSME3 PSME3 Homo sapiens amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 human motor neurons (MNs) down-regulated circPSME3 was detected in human motor neurons and was downregulated in FUSP525L mutant motor neurons compared with FUSWT motor neurons. GSE94888 1204 36834591 FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation. circSLC8A1 hsa_circ_SLC8A1 SLC8A1 Homo sapiens amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 human motor neurons (MNs) down-regulated circSLC8A1 was detected in human motor neurons and was downregulated in FUSP525L mutant motor neurons compared with FUSWT motor neurons. GSE94888 1205 36834591 FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation. circDLC1 hsa_circ_DLC1 DLC1 Homo sapiens amyotrophic lateral sclerosis / ALS MONDO:0004976 amyotrophic lateral sclerosis DOID:332 human motor neurons (MNs) down-regulated "circDLC1 was detected in human motor neurons and was downregulated in FUSP525L mutant motor neurons compared with FUSWT motor neurons. Knockdown of circDLC1 in motor neurons reduced ENAH mRNA, supporting a circDLC1/miR-217 regulatory axis in this cell type." GSE94888 1206 36849569 mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs. mecirc8 / mcPGK1 hsa_circ_CYTB CYTB Homo sapiens liver cancer MONDO:0002691 liver cancer DOID:3571 liver TICs up-regulated "mcPGK1 is upregulated in liver tumor-initiating cells compared with non-TICs, supported by CD133+ cell sorting followed by circRNA sequencing and validation by real-time PCR, Northern blotting, FISH and RNAscope. Functional experiments show that mcPGK1 promotes liver TIC self-renewal and metabolic reprogramming from OXPHOS to glycolysis." GSE223661 1207 36861189 Crosstalk between m6A mRNAs and m6A circRNAs and the time-specific biogenesis of m6A circRNAs after OGD/R in primary neurons. chr11:26387228-26470948+ Mus musculus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary cerebral neurons down-regulated "In primary mouse cerebral neurons, m6A-modified circRNA chr11:26387228-26470948+ was control-specific and showed higher m6A level in untreated control neurons than in OGD/R-treated neurons." 1208 36861189 Crosstalk between m6A mRNAs and m6A circRNAs and the time-specific biogenesis of m6A circRNAs after OGD/R in primary neurons. chr17:29631671-29634768+ Mus musculus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary cerebral neurons up-regulated "In primary mouse cerebral neurons, m6A-modified circRNA chr17:29631671-29634768+ was specific to the OGD/R 1.5 h condition and showed higher m6A level than in control and OGD/R 3 h neurons." 1209 36861189 Crosstalk between m6A mRNAs and m6A circRNAs and the time-specific biogenesis of m6A circRNAs after OGD/R in primary neurons. chr7:97705589-97718381+ Mus musculus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary cerebral neurons up-regulated "In primary mouse cerebral neurons, m6A-modified circRNA chr7:97705589-97718381+ was specific to the OGD/R 3 h condition and showed higher m6A level than in control and OGD/R 1.5 h neurons." 1210 36865391 Studies on the role of non-coding RNAs in controlling the activity of T cells in asthma. hsa_circ_0005519 Homo sapiens asthma MONDO:0004979 asthma DOID:2841 CD4+ T cells of asthmatic patients dys-regulated "In CD4+ T cells from asthmatic patients, circRNA profiling found many differentially expressed circRNAs compared with healthy volunteers, including hsa_circ_0005519. hsa_circ_0005519 was reported to affect IL-13/IL-6 secretion through a hsa-let-7a-5p sponge mechanism in asthmatic T cell-mediated inflammation." 1211 36880874 The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons. mmu_circ_0000705 mmu_circ_App App Mus musculus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary cerebral neurons unknown "mmu_circ_0000705, encoded by App, was detected as an m1A-modified circRNA in primary mouse neurons analyzed under normal and OGD/R-treated conditions. The paper reports its m1A modification site and predicted translation-related features, but does not provide a directional expression change for this specific circRNA." PRJCA010978 1212 36880874 The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons. mmu_circ_0002207 mmu_circ_Foxo3 Foxo3 Mus musculus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury primary cerebral neurons unknown "mmu_circ_0002207, encoded by Foxo3, was detected as an m1A-modified circRNA in primary mouse neurons analyzed under normal and OGD/R-treated conditions. The paper reports its m1A modification site and predicted translation-related features, but does not provide a directional expression change for this specific circRNA." PRJCA010978 1213 36882410 CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes. hsa_circ_0131202 hsa_circ_TULP4 TULP4 Homo sapiens diabetic cardiomyopathy MONDO:0004994 cardiomyopathy DOID:0050700 cardiomyocytes down-regulated "DICAR, represented by mouse mm9_circ_008009 and conserved human hsa_circ_0131202, was downregulated in AGEs-treated mouse and human cardiomyocytes. Functional experiments in cardiomyocytes showed that DICAR overexpression inhibited, whereas DICAR knockdown enhanced, diabetic cardiomyocyte pyroptosis." 1214 36882410 CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes. mm9_circ_008009 mmu_circ_Tulp4 Tulp4 Mus musculus diabetic cardiomyopathy MONDO:0004994 cardiomyopathy DOID:0050700 cardiomyocytes down-regulated "DICAR, represented by mouse mm9_circ_008009 and conserved human hsa_circ_0131202, was downregulated in AGEs-treated mouse and human cardiomyocytes. Functional experiments in cardiomyocytes showed that DICAR overexpression inhibited, whereas DICAR knockdown enhanced, diabetic cardiomyocyte pyroptosis." 1215 36882410 CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes. hsa_circ_0131202 DICAR hsa_circ_TULP4 TULP4 Homo sapiens type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 peripheral blood mononuclear cells (PBMCs) down-regulated Human DICAR expression was lower in PBMCs from T2DM patients with or without cardiac dysfunction than in healthy controls. This PBMC evidence was based on isolated peripheral blood mononuclear cells from patient blood samples. 1216 36915149 Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-¦Â1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling. chr13:58960530-58962916 mmu_circ_Ntrk2 Ntrk2 Mus musculus pulmonary arterial hypertension MONDO:0015924 pulmonary arterial hypertension PASMCs up-regulated "circ-Ntrk2 was upregulated in hypoxia-treated primary mouse PASMCs compared with normoxic PASMCs, as measured by qPCR after PASMC isolation and culture. Functional experiments showed that circ-Ntrk2 promoted hypoxia-induced PASMC proliferation." 1217 36918335 "Circ_0008450 regulates keloid-derived fibroblast proliferation, migration, invasion and apoptosis with increased IGFBP5 through sponging miR-1224-5p." hsa_circ_0008450 circ_0008450 hsa_circ_CMTM3 CMTM3 Homo sapiens Keloid MONDO:0005348 keloid KD-derived fibroblasts up-regulated "circ_0008450 was up-regulated in primary cultured keloid-derived fibroblasts compared with normal fibroblasts. Functional experiments in keloid-derived fibroblasts showed that circ_0008450 promoted proliferation, migration and invasion and inhibited apoptosis." 1218 36922625 Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms. circMAN1A2 hsa_circ_MAN1A2 MAN1A2 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ bone marrow cells up-regulated circMAN1A2 was among the circRNAs upregulated in FACS-sorted/RNA-sequenced CD34+ bone marrow cells from MDS patients with U2AF1 mutations compared with MDS controls. 1219 36922625 Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms. circZNF609 hsa_circ_ZNF609 ZNF609 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ bone marrow cells up-regulated circZNF609 was upregulated in FACS-sorted/RNA-sequenced CD34+ bone marrow cells from MDS patients with U2AF1 mutations compared with U2AF1-wildtype MDS controls. 1220 36922625 Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms. circCSNK1G3 hsa_circ_CSNK1G3 CSNK1G3 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ bone marrow cells up-regulated circCSNK1G3 was upregulated in FACS-sorted/RNA-sequenced CD34+ bone marrow cells from MDS patients with U2AF1 mutations compared with U2AF1-wildtype MDS controls. 1221 36922625 Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms. circKATNAL2 hsa_circ_KATNAL2 KATNAL2 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ bone marrow cells up-regulated circKATNAL2 was among the circRNAs upregulated in FACS-sorted/RNA-sequenced CD34+ bone marrow cells from MDS patients with U2AF1 mutations compared with MDS controls. 1222 36922625 Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms. circTRIM58 hsa_circ_TRIM58 TRIM58 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ bone marrow cells up-regulated circTRIM58 was among the circRNAs upregulated in FACS-sorted/RNA-sequenced CD34+ bone marrow cells from MDS patients with U2AF1 mutations compared with MDS controls. 1223 36922625 Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms. circUBAP2 hsa_circ_UBAP2 UBAP2 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ bone marrow cells up-regulated circUBAP2 was among the circRNAs upregulated in FACS-sorted/RNA-sequenced CD34+ bone marrow cells from MDS patients with U2AF1 mutations compared with MDS controls. 1224 36922625 Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms. circPDHX hsa_circ_PDHX PDHX Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ bone marrow cells up-regulated circPDHX was among the circRNAs upregulated in FACS-sorted/RNA-sequenced CD34+ bone marrow cells from MDS patients with U2AF1 mutations compared with MDS controls. 1225 36923408 CircRNA_0075723 protects against pneumonia-induced sepsis through inhibiting macrophage pyroptosis by sponging miR-155-5p and regulating SHIP1 expression. hsa_circ_0075723 hsa_circ_NUP153 NUP153 Homo sapiens pneumonia-induced sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 CD14+ monocytes down-regulated "After magnetic sorting of CD14+ monocytes from peripheral blood, qRT-PCR showed that circ_0075723 was significantly downregulated in pneumonia-induced sepsis patients compared with pneumonia patients without sepsis and healthy controls. The study further linked circ_0075723 to inhibition of macrophage pyroptosis and inflammatory cytokine release." GSE218494 1226 36932387 Exosome-derived circCCAR1 promotes CD8_+_T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma. hsa_circ_0000240 circCCAR1 hsa_circ_CCAR1 CCAR1 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 CD8_+_T cells up-regulated "In primary activated human CD8+ T cells, HCC cell-derived exosomal circCCAR1 was taken up and increased circCCAR1 levels, promoting CD8+ T-cell dysfunction through PD1 protein stabilization." 1227 36935520 Circular RNA SLTM as a miR-421-competing endogenous RNA to mediate HMGB2 expression stimulates apoptosis and inflammation in arthritic chondrocytes. hsa_circ_0000605 circSLTM hsa_circ_SLTM SLTM Homo sapiens Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes up-regulated "In isolated primary human chondrocytes, IL-1¦Â treatment used to model OA increased circSLTM expression as measured by RT-qPCR. Functional experiments in these chondrocytes linked circSLTM to apoptosis and inflammation through the miR-421/HMGB2 axis." 1228 36965082 Exosome-Based Mitochondrial Delivery of circRNA mSCAR Alleviates Sepsis by Orchestrating Macrophage Activation. circRNA SCAR Mus musculus sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 monocytes down-regulated circRNA mSCAR was downregulated in monocytes isolated from septic mice compared with sham mice by qRT-PCR. The study further links circRNA mSCAR to macrophage polarization and inflammatory regulation in sepsis. 1229 36965082 Exosome-Based Mitochondrial Delivery of circRNA mSCAR Alleviates Sepsis by Orchestrating Macrophage Activation. hsa_circ_0008882 Homo sapiens sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 monocytes down-regulated The mouse homologue of hsa_circ_0008882 was downregulated in monocytes isolated from septic mice compared with sham mice by qRT-PCR. 1230 36965082 Exosome-Based Mitochondrial Delivery of circRNA mSCAR Alleviates Sepsis by Orchestrating Macrophage Activation. hsa_circ_0002363 Homo sapiens sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 monocytes down-regulated The mouse homologue of hsa_circ_0002363 was downregulated in monocytes isolated from septic mice compared with sham mice by qRT-PCR. 1231 36965082 Exosome-Based Mitochondrial Delivery of circRNA mSCAR Alleviates Sepsis by Orchestrating Macrophage Activation. hsa_circ_0089761 Homo sapiens sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 monocytes no change The mouse homologue of hsa_circ_0089761 showed no significant expression change in monocytes isolated from septic mice compared with sham mice by qRT-PCR. 1232 36982956 Circular RNA CircCDKN2B-AS_006 Promotes the Tumor-like Growth and Metastasis of Rheumatoid Arthritis Synovial Fibroblasts by Targeting the miR-1258/RUNX1 Axis. hsa_circCDKN2B_AS_006 hsa_circ_CDKN2B_AS_006 CDKN2B_AS_006 Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RASFs up-regulated "circCDKN2B_AS_006 was upregulated in primary rheumatoid arthritis synovial fibroblasts compared with normal synovial fibroblasts. Functional experiments in RASFs showed that circCDKN2B_AS_006 promoted proliferation, migration, and invasion." 1233 37008951 Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility. hsa_circ_0004872 hsa_circ_MAPK1 MAPK1 Homo sapiens peritoneal endometriosis-associated infertility MONDO:0005133 endometriosis DOID:289 cumulus cells up-regulated "hsa_circ_0004872 is up-regulated in isolated cumulus cells from patients with peritoneal endometriosis-associated infertility compared with ovarian endometriosis-associated infertility and tubal factor infertility controls. The authors constructed ceRNA networks and reported enriched apoptosis, PI3K-AKT, p53, JAK-STAT and TGF-¦Â signaling pathways among predicted target genes." HRA003694 1234 37008951 Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility. hsa_circ_0005205 hsa_circ_HIF1A HIF1A Homo sapiens peritoneal endometriosis-associated infertility MONDO:0005133 endometriosis DOID:289 cumulus cells up-regulated hsa_circ_0005205 is increased in isolated cumulus cells from patients with peritoneal endometriosis-associated infertility compared with tubal factor infertility controls. HRA003694 1235 37008951 Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility. hsa_circ_0003638 hsa_circ_NLK NLK Homo sapiens ovarian endometriosis MONDO:0006337 ovarian endometriosis DOID:11432 cumulus cells up-regulated "hsa_circ_0003638 is up-regulated by qRT-PCR in isolated cumulus cells from ovarian endometriosis-associated infertility compared with tubal factor infertility controls, although the authors note this was opposite to the RNA-seq result." HRA003694 1236 37008951 Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility. hsa_circ_0008927 hsa_circ_ATG7 ATG7 Homo sapiens peritoneal endometriosis-associated infertility MONDO:0005133 endometriosis DOID:289 cumulus cells up-regulated "hsa_circ_0008927 is marginally up-regulated in isolated cumulus cells from peritoneal endometriosis-associated infertility compared with tubal factor infertility controls, but not significantly different compared with ovarian endometriosis-associated infertility." HRA003694 1237 37012879 Cardioprotective effects of circ_0002612 in myocardial ischemia/reperfusion injury correlate with disruption of miR-30a-5p-dependent Ppargc1a inhibition. circ_0002612 Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury primary cardiomyocytes down-regulated circ_0002612 was decreased in primary mouse cardiomyocytes challenged with hypoxia/reoxygenation compared with control cardiomyocytes. Functional experiments indicated that circ_0002612 promoted cardiomyocyte viability and inhibited apoptosis through the miR-30a-5p/Ppargc1a axis. 1238 37014014 Hsa_circ_0008500 inhibits apoptosis of adipose-derived stem cells under high glucose through hsa-miR-1273h-5p/ELK1 axis. hsa_circ_0008500 Homo sapiens diabetic wounds MONDO:0005015 diabetes mellitus DOID:9351 adipose tissue-derived stem cells (ADSCs) down-regulated "In primary human ADSCs cultured under high glucose versus normal glucose, hsa_circ_0008500 expression was decreased by qRT-PCR. Functional assays in ADSCs showed that hsa_circ_0008500 reduced high-glucose-induced apoptosis through the hsa-miR-1273h-5p/ELK1 axis." 1239 37014258 "CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy." circEPS15 hsa_circ_EPS15 EPS15 Homo sapiens Parkinson's disease MONDO:0005180 Parkinson disease DOID:14330 primary neurons up-regulated "circEPS15 expression was higher in primary neurons than in other tested primary and cell-line cell types, based on RT-PCR analysis of primary cultures." 1240 37014258 "CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy." circEPS15 hsa_circ_EPS15 EPS15 Homo sapiens Parkinson's disease MONDO:0005180 Parkinson disease DOID:14330 neurons down-regulated circEPS15 was reduced in neurons after MPP+ stimulation in an in vitro Parkinson disease model using primary neuronal cultures. 1241 37014258 "CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy." circEPS15 hsa_circ_EPS15 EPS15 Homo sapiens Parkinson's disease MONDO:0005180 Parkinson disease DOID:14330 TH+ cells up-regulated "After AAV-mediated circEPS15 overexpression in the MPTP mouse model, circEPS15 signal was dominantly localized in TH+ dopaminergic neurons in the SNpc." 1242 37035757 circRNA_17725 Promotes Macrophage Polarization towards M2 by Targeting FAM46C to Alleviate Arthritis. circRNA_17725 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 CD14+ monocytes down-regulated circRNA_17725 was measured by real-time PCR after CD14+ magnetic bead sorting and was significantly reduced in CD14+ monocytes from RA patients compared with controls. 1243 37044033 Hsa_circ_0073453 modulates IL-8 secretion by GC-MSCs to promote gastric cancer progression by sponging miR-146a-5p. hsa_circ_0073453 circ_0073453 hsa_circ_RHOBTB3 RHOBTB3 Homo sapiens gastric cancer MONDO:0001056 gastric cancer DOID:10534 GC-MSCs up-regulated "circ_0073453 is upregulated in gastric cancer-associated mesenchymal stem cells compared with bone marrow-derived mesenchymal stem cells, supported by ceRNA array screening and qRT-PCR validation. In GC-MSCs, circ_0073453 regulates IL-8 secretion and contributes to GC cell migration, invasion, and resistance to CD8+ T cell killing." 1244 37046045 Exosomal circSPIRE1 mediates glycosylation of E-cadherin to suppress metastasis of renal cell carcinoma. hsa_circ_0000829 circSPIRE1 hsa_circ_SPIRE1 SPIRE1 Homo sapiens renal cell carcinoma MONDO:0005086 renal cell carcinoma DOID:4450 RCC cells unknown "Histological FISH with cell-type markers showed circSPIRE1 expression in RCC cells in renal cell carcinoma tissue, but the direction of cell-specific expression change was not specified." 1245 37046045 Exosomal circSPIRE1 mediates glycosylation of E-cadherin to suppress metastasis of renal cell carcinoma. hsa_circ_0000829 circSPIRE1 hsa_circ_SPIRE1 SPIRE1 Homo sapiens renal cell carcinoma MONDO:0005086 renal cell carcinoma DOID:4450 cancer-adjacent endothelial cells unknown "Histological FISH with CD34 labeling showed circSPIRE1 expression in cancer-adjacent endothelial cells, and endothelial circSPIRE1 levels were positively related to RCC-cell circSPIRE1 levels." 1246 37047838 Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice. mmu_circ_DNAH7 DNAH7 Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 epididymal SPZ up-regulated "circDNAH7 was up-regulated in spermatozoa from HFD mice compared with CTRL mice, validated by qRT-PCR after sperm collection." 1247 37047838 Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice. mmu_circ_PTPN11 PTPN11 Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 epididymal SPZ up-regulated "circPTPN11 was up-regulated in spermatozoa from HFD mice compared with CTRL mice, validated by qRT-PCR after sperm collection." 1248 37047838 Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice. mmu_circ_CPSF6 CPSF6 Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 epididymal SPZ up-regulated "circCPSF6 was up-regulated in spermatozoa from HFD mice compared with CTRL mice, validated by qRT-PCR after sperm collection." 1249 37047838 Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice. mmu_circ_ADAM10 ADAM10 Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 epididymal SPZ up-regulated circADAM10 was up-regulated only in spermatozoa from HFD mice compared with CTRL mice and was linked to enhanced endogenous sperm backsplicing. 1250 37047838 Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice. mmu_circ_RESP18 RESP18 Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 epididymal SPZ up-regulated "circRESP18 was up-regulated only in spermatozoa from HFD mice compared with CTRL mice, validated by qRT-PCR after sperm collection." 1251 37047838 Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice. mmu_circ_MAPT MAPT Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 epididymal SPZ up-regulated "circMAPT was up-regulated only in spermatozoa from HFD mice compared with CTRL mice, validated by qRT-PCR after sperm collection." 1252 37047838 Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice. mmu_circ_DNER DNER Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 epididymal SPZ up-regulated "circDNER was up-regulated only in spermatozoa from HFD mice compared with CTRL mice, validated by qRT-PCR after sperm collection." 1253 37047838 Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice. mmu_circ_MAGED1 MAGED1 Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 epididymal SPZ down-regulated "circMAGED1 was down-regulated in spermatozoa from HFD mice compared with CTRL mice, validated by qRT-PCR after sperm collection." 1254 37047838 Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice. mmu_circ_ATRN ATRN Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 epididymal SPZ down-regulated "circATRN was down-regulated in spermatozoa from HFD mice compared with CTRL mice, validated by qRT-PCR after sperm collection." 1255 37047838 Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice. mmu_circ_SMAD2 SMAD2 Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 epididymal SPZ down-regulated circSMAD2 was down-regulated in spermatozoa from HFD mice compared with CTRL mice. Recovery of circSMAD2 by CTRL epididymal luminal fluid was associated with improved HFD sperm motility. 1256 37047838 Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice. mmu_circ_INPP5B INPP5B Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 epididymal SPZ down-regulated "circINPP5B was down-regulated in spermatozoa from HFD mice compared with CTRL mice, validated by qRT-PCR after sperm collection." 1257 37047838 Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice. mmu_circ_PCSK6 PCSK6 Mus musculus obesity MONDO:0011122 obesity disorder DOID:9970 epididymal SPZ down-regulated "circPCSK6 was down-regulated in spermatozoa from HFD mice compared with CTRL mice, validated by qRT-PCR after sperm collection." 1258 37066229 Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease. hsa_circ_DNAJC6 DNAJC6 Homo sapiens Parkinson's disease MONDO:0005180 Parkinson disease DOID:14330 dopamine neurons down-regulated "Laser-capture RNA-seq detected circDNAJC6 as highly expressed in human dopamine neurons, and its expression was reduced in dopamine neurons from prodromal Parkinson¡¯s disease-associated Lewy body neuropathology compared with controls." GSE218203 1259 37097437 CircZfp609 contributes to cerebral infarction via sponging miR-145a-5p to regulate BACH1. mmu_circ_0001797 mmu_circ_Zfp609 Zfp609 Mus musculus cerebral infarction MONDO:0002679 cerebral infarction DOID:3526 primary mouse astrocytes up-regulated "circZfp609 was up-regulated in primary mouse astrocytes after OGD/R treatment compared with untreated control astrocytes. Knockdown experiments in these astrocytes linked circZfp609 to OGD/R-induced injury, including proliferation, apoptosis and inflammation-related outcomes." 1260 37100987 CircHIPK2 facilitates phenotypic switching of vascular smooth muscle cells in hypertension. hsa_circ_0001756 hsa_circ_HIPK2 HIPK2 Homo sapiens hypertension MONDO:0005044 hypertensive disorder DOID:10763 VSMCs up-regulated "circHIPK2 is up-regulated in vascular smooth muscle cells of hypertensive patients, with FISH-IF showing localization in ¦Á-SMA-positive VSMCs in thoracic aorta tissue. Functional studies indicate circHIPK2 promotes AngII-induced VSMC phenotypic switching via the miR-145-5p/ADAM17 axis." 1261 37144575 Downregulation of ciRNA-Kat6b in dorsal spinal horn is required for neuropathic pain by regulating Kcnk1 in miRNA-26a-dependent manner. mmu_circ_Kat6b Kat6b Mus musculus neuropathic pain MONDO:0021667 neuralgia spinal cord neurons up-regulated "ciRNA_Kat6b was mainly expressed in spinal cord neurons, supported by FISH with NeuN staining and qRT-PCR after isolation/culture of spinal neurons, astrocytes and microglia." 1262 37144575 Downregulation of ciRNA-Kat6b in dorsal spinal horn is required for neuropathic pain by regulating Kcnk1 in miRNA-26a-dependent manner. mmu_circ_Kat6b Kat6b Mus musculus neuropathic pain MONDO:0021667 neuralgia cultured spinal neurons down-regulated "In primary cultured spinal neurons, KCl treatment used to mimic sensitized neurons significantly decreased ciRNA_Kat6b expression." 1263 37153995 [Effect of circRASA2 targeting miR-543/TRAF6 axis on LPS-induced periodontal ligament cell proliferation and osteogenic differentiation]. hsa_circ_0067582 hsa_circ_RASA2 RASA2 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 periodontal ligament cells (PDLCs) up-regulated "circRASA2 is up-regulated in primary human PDLCs after LPS treatment, an in vitro periodontitis-related inflammatory model. Knockdown of circRASA2 promoted proliferation, migration and osteogenic differentiation of LPS-treated PDLCs through the miR-543/TRAF6 axis." 1264 37166618 CircRNA7632 down-regulation alleviates endothelial cell dysfunction in Kawasaki disease via regulating IL-33 expression. circ7632 Homo sapiens Kawasaki disease MONDO:0012727 Kawasaki disease DOID:13378 HUVECs up-regulated "circ7632 was up-regulated in primary HUVECs treated with Kawasaki disease serum compared with HC serum-treated endothelial cells. Functional experiments in HUVECs indicated that circ7632 silencing alleviated KD serum-induced EndoMT and migration, likely through regulating IL-33 expression." PRJNA884005; PRJNA793389 1265 37212178 Circular RNA hsa_circ_0084054 promotes the progression of periodontitis with diabetes via the miR-508-3p/PTEN axis. hsa_circ_0084054 hsa_circ_ADAM32 ADAM32 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 periodontal ligament cells up-regulated "In primary cultured periodontal ligament cells, hsa_circ_0084054 was increased after high-glucose plus P. gingivalis LPS treatment compared with control and LPS-treated cells. Functional experiments in PDLCs indicated that silencing hsa_circ_0084054 reduced inflammatory factors, oxidative stress markers, and apoptosis." 1266 37243831 EIF4A3-Induced Exosomal circLRRC8A Alleviates Granulosa Cells Senescence Via the miR-125a-3p/NFE2L1 axis. hsa_circ_0007311 hsa_circ_LRRC8A LRRC8A Homo sapiens Premature ovarian failure MONDO:0001119 premature menopause DOID:10787 granulosa cells (GCs); primary human GCs down-regulated "circLRRC8A was reduced in senescent granulosa cells, including primary human GCs derived from POF patients compared with primary human GCs from patients with normal ovarian reserve. The evidence was based on qRT-PCR detection in granulosa cell samples." GSE97193 1267 37246269 "Smoking-Induced M2-TAMs, via circEML4 in EVs, Promote the Progression of NSCLC through ALKBH5-Regulated m6A Modification of SOCS2 in NSCLC Cells." hsa_circ_0054243 hsa_circ_EML4 EML4 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 M2_TAMs up-regulated FISH with CD163 labeling showed increased circEML4-positive M2 tumor-associated macrophages in NSCLC tissues from smoking patients compared with non-smoking patients. The study links circEML4 in EVs from M2-TAMs to promotion of NSCLC progression through the SOCS2/JAK-STAT signaling axis. 1268 37264961 GC_MSC_derived circ_0024107 promotes gastric cancer cell lymphatic metastasis via fatty acid oxidation metabolic reprogramming mediated by the miR_5572/6855_5p/CPT1A axis. hsa_circ_0024107 hsa_circ_MMP1 MMP1 Homo sapiens gastric cancer MONDO:0001056 gastric cancer DOID:10534 gastric cancer tissue-derived mesenchymal stem cells (GC-MSCs) up-regulated "circ_0024107 / hsa_circ_0024107 was up-regulated in gastric cancer tissue-derived mesenchymal stem cells compared with bone marrow-derived MSCs, based on circRNA array screening and RT-qPCR verification after primary cell isolation/culture. Functional experiments linked GC-MSC-derived circ_0024107 to FAO metabolic reprogramming and promotion of gastric cancer cell migration, invasion and lymphatic metastasis." 1269 37298501 MITA Promotes Macrophage Proinflammatory Polarization and Its circRNA-Related Regulatory Mechanism in Recurrent Miscarriage. hsa_circ_0003241 hsa_circ_KIAA0391 KIAA0391 Homo sapiens recurrent miscarriage MONDO:0013727 "pregnancy loss, recurrent, susceptibility to, 1" decidual macrophages up-regulated "circKIAA0391 / Hsa_circ_0003241 is up-regulated in decidual macrophages from recurrent miscarriage patients compared with healthy controls, supported by circRNA high-throughput sequencing and qRT-PCR validation after CD14-positive cell sorting. Functional experiments in THP-1-derived macrophage cells showed that circKIAA0391 promotes apoptosis and proinflammatory polarization via the miR-512-5p/MITA axis." 1270 37306552 Hsa_circ_0023826 protects against glaucoma by regulating miR-188-3p/MDM4 axis. hsa_circ_0023826 hsa_circ_TENM4 TENM4 Homo sapiens glaucoma MONDO:0005041 glaucoma DOID:1686 retinal ganglion cells (RGCs) up-regulated "In primary isolated RGCs used for an in vitro glaucoma model, circ_0023826 expression was higher after NMDA treatment than after PBS treatment. Functional assays in RGCs indicated that circ_0023826 overexpression restored cell viability and attenuated apoptosis." 1271 37316908 Interaction between the expression of hsa_circRPRD1A and hsa_circHERPUD2 and classical coronary risk factors promotes the development of coronary artery disease. hsa_circRPRD1A hsa_circ_RPRD1A RPRD1A Homo sapiens coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 peripheral blood mononuclear cells down-regulated "hsa_circRPRD1A was significantly decreased in isolated PBMCs from coronary artery disease patients compared with controls, validated by qRT-PCR after RNA-seq-based identification." GSE205255 1272 37316908 Interaction between the expression of hsa_circRPRD1A and hsa_circHERPUD2 and classical coronary risk factors promotes the development of coronary artery disease. hsa_circHERPUD2 hsa_circ_HERPUD2 HERPUD2 Homo sapiens coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 peripheral blood mononuclear cells down-regulated "hsa_circHERPUD2 was significantly decreased in isolated PBMCs from coronary artery disease patients compared with controls, validated by qRT-PCR after RNA-seq-based identification." GSE205255 1273 37316908 Interaction between the expression of hsa_circRPRD1A and hsa_circHERPUD2 and classical coronary risk factors promotes the development of coronary artery disease. hsa_circLMBR1 hsa_circ_LMBR1 LMBR1 Homo sapiens coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 peripheral blood mononuclear cells no change hsa_circLMBR1 showed no significant expression difference in isolated PBMCs from coronary artery disease patients compared with controls in the qRT-PCR validation cohort. GSE205255 1274 37316908 Interaction between the expression of hsa_circRPRD1A and hsa_circHERPUD2 and classical coronary risk factors promotes the development of coronary artery disease. hsa_circDHTKD1 hsa_circ_DHTKD1 DHTKD1 Homo sapiens coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 peripheral blood mononuclear cells no change hsa_circDHTKD1 showed no significant expression difference in isolated PBMCs from coronary artery disease patients compared with controls in the qRT-PCR validation cohort. GSE205255 1275 37319356 Circular RNA circTRAPPC6B Enhances IL-6 and IL-1¦Â Expression and Repolarizes Mycobacteria Induced Macrophages from M2- to M1-Like Phenotype by Targeting miR-892c-3p. circTRAPPC6B hsa_circ_TRAPPC6B TRAPPC6B Homo sapiens tuberculosis MONDO:0018076 tuberculosis DOID:399 CD14 + monocytes down-regulated circTRAPPC6B expression was significantly reduced in CD14+ monocytes from tuberculosis patients compared with healthy controls. 1276 37319356 Circular RNA circTRAPPC6B Enhances IL-6 and IL-1¦Â Expression and Repolarizes Mycobacteria Induced Macrophages from M2- to M1-Like Phenotype by Targeting miR-892c-3p. circTRAPPC6B hsa_circ_TRAPPC6B TRAPPC6B Homo sapiens tuberculosis MONDO:0018076 tuberculosis DOID:399 M1-like macrophages up-regulated "In primary CD14+ monocyte-derived macrophages, circTRAPPC6B was higher in M1-like macrophages than in M2-like macrophages." 1277 37319356 Circular RNA circTRAPPC6B Enhances IL-6 and IL-1¦Â Expression and Repolarizes Mycobacteria Induced Macrophages from M2- to M1-Like Phenotype by Targeting miR-892c-3p. circTRAPPC6B hsa_circ_TRAPPC6B TRAPPC6B Homo sapiens tuberculosis MONDO:0018076 tuberculosis DOID:399 hMDMs down-regulated Mtb H37Rv infection significantly reduced circTRAPPC6B expression in human monocyte-derived macrophages compared with medium-treated controls. 1278 37336827 The quantification of circular RNA 0007841 during induction therapy helps estimate the response and survival benefits to bortezomib-based regimen in multiple myeloma. hsa_circ_0007841 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cell (BMPC) up-regulated circ_0007841 expression was measured by RT-qPCR in separated bone marrow plasma cells and was elevated in multiple myeloma patients compared with healthy controls. 1279 37336827 The quantification of circular RNA 0007841 during induction therapy helps estimate the response and survival benefits to bortezomib-based regimen in multiple myeloma. hsa_circ_0007841 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cell (BMPC) down-regulated "In separated bone marrow plasma cells from multiple myeloma patients, circ_0007841 expression decreased after bortezomib-based induction therapy compared with expression at diagnosis." 1280 37336827 The quantification of circular RNA 0007841 during induction therapy helps estimate the response and survival benefits to bortezomib-based regimen in multiple myeloma. hsa_circ_0007841 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 bone marrow plasma cell (BMPC) down-regulated "After bortezomib-based induction therapy, circ_0007841 expression in separated bone marrow plasma cells was lower in responding multiple myeloma patients than in non-responding patients." 1281 37343537 CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis. circARF3 mmu_circ_ARF3 ARF3 Mus musculus allergic rhinitis MONDO:0011786 allergic rhinitis DOID:4481 mice nasal epithelial cells (NEpCs) down-regulated circARF3 was significantly down-regulated in IL-4/IL-13-stimulated primary mouse nasal epithelial cells compared with control NEpCs. Functional experiments in NEpCs indicated that circARF3 overexpression alleviated IL-4/IL-13-induced apoptosis and inflammatory injury through the miR-205-5p/SIRT5 axis. 1282 37344798 CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension. rno_circ_Itgb5 Itgb5 Rattus norvegicus pulmonary arterial hypertension MONDO:0015924 pulmonary arterial hypertension pulmonary arterial smooth muscle cells (PASMCs) up-regulated "CircItgb5 was up-regulated in rat primary PASMCs after PDGF-BB treatment, based on high-throughput circRNA sequencing and RT-qPCR validation. FISH with ¦Á-SMA supported circItgb5 localization in PASMCs, and functional experiments showed that circItgb5 promoted PASMC proliferation and synthetic phenotype." CRA010798 1283 37347924 Loss of circIGF1R Suppresses Cardiomyocytes Proliferation by Sponging miR-362-5p. mmu_circ_0001582 mmu_circ_IGF1R IGF1R Mus musculus heart failure MONDO:0005252 heart failure CMs down-regulated circIGF1R was down-regulated in adult mouse cardiomyocytes compared with neonatal P1 cardiomyocytes based on qPCR after primary cell isolation. Knockdown experiments in primary cardiomyocytes supported a role in cardiomyocyte proliferation. 1284 37347924 Loss of circIGF1R Suppresses Cardiomyocytes Proliferation by Sponging miR-362-5p. mmu_circ_0001582 mmu_circ_IGF1R IGF1R Mus musculus heart failure MONDO:0005252 heart failure CFs down-regulated "circIGF1R was decreased in adult cardiac fibroblasts compared with earlier postnatal cardiac fibroblast samples, based on primary cell isolation and qPCR evidence." 1285 37352916 NSD2 promotes pressure overload-induced cardiac hypertrophy via activating circCmiss1/TfR1/ferroptosis signaling. mm9_circ_005252 mmu_circ_Cmss1 Cmss1 Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocytes up-regulated "In isolated mouse neonatal cardiomyocytes, Ang II treatment substantially upregulated circCmss1 as measured by real-time PCR. circCmss1 knockdown reduced Ang II-induced cardiomyocyte hypertrophy indicators." 1286 37360167 Prenatal alcohol exposure dysregulates spinal and circulating immune cell circular RNA expression in adult female rats with chronic sciatic neuropathy. circVopp1 rno_circ_Vopp1 Vopp1 Rattus norvegicus prenatal alcohol exposure MONDO:0000408 fetal alcohol spectrum disorder DOID:0050696 blood leukocytes down-regulated circVopp1 was validated by qRT-PCR as significantly down-regulated in isolated blood leukocytes from PAE rats compared with Sac control leukocytes. Linear Vopp1 mRNA was also down-regulated in PAE leukocytes. 1287 37370086 Circular RNA FEACR inhibits ferroptosis and alleviates myocardial ischemia/reperfusion injury by interacting with NAMPT. circRNA0008180 / FEACR mmu_circ_FBXW4 FBXW4 Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury cardiomyocytes isolated from I/R-induced mice down-regulated FEACR was downregulated in cardiomyocytes isolated from I/R-induced mouse hearts compared with sham mouse hearts. 1288 37370086 Circular RNA FEACR inhibits ferroptosis and alleviates myocardial ischemia/reperfusion injury by interacting with NAMPT. circRNA0008180 / FEACR mmu_circ_FBXW4 FBXW4 Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury H/R-treated cardiomyocytes down-regulated "FEACR/circRNA0008180 was significantly decreased in H/R-treated primary cardiomyocytes, an in vitro model used to mimic I/R injury." 1289 37400900 Downregulation of circ-Foxo3 in breast cancer stem-like cells. mmu_circ_FOXO3 FOXO3 Mus musculus breast cancer MONDO:0007254 breast cancer DOID:1612 breast cancer stem-like cells down-regulated Circ-Foxo3 was measured by RT-qPCR in spheroid-forming breast tumor cells enriched for cancer stem-like characteristics and was significantly down-regulated compared with 2D monolayer tumor cells. 1290 37407973 CircGNB1 facilitates the malignant phenotype of GSCs by regulating miR-515-5p/miR-582-3p-XPR1 axis. hsa_circ_0009362 circGNB1 hsa_circ_GNB1 GNB1 Homo sapiens glioma MONDO:0021042 glioma GSCs up-regulated "circGNB1 / hsa_circ_0009362 is up-regulated in glioma stem cells compared with neural progenitor cells, and qRT-PCR detected circGNB1 expression across patient-derived GSC cultures. Functional assays showed circGNB1 promotes GSC viability, proliferation, invasion and neurosphere formation." GSE146463 1291 37408496 Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1. hsa_circ_0000227 hsa_circ_ZEB1 ZEB1 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ BM cells up-regulated hsa_circ_0000227 is one of the ZEB1-derived circRNAs upregulated in CD34+ bone marrow cells from SF3B1-mutated MDS patients compared with MDS patients without detected mutation. PRJNA896500 1292 37408496 Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1. hsa_circ_0000228 hsa_circ_ZEB1 ZEB1 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ BM cells up-regulated hsa_circ_0000228 is the most highly expressed ZEB1-derived circRNA in CD34+ bone marrow cells from SF3B1-mutated MDS patients. PRJNA896500 1293 37408496 Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1. hsa_circ_0000230 hsa_circ_ZEB1 ZEB1 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ BM cells up-regulated hsa_circ_0000230 is one of the ZEB1-derived circRNAs upregulated in CD34+ bone marrow cells from SF3B1-mutated MDS patients compared with MDS patients without detected mutation. PRJNA896500 1294 37408496 Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1. hsa_circ_0002765 hsa_circ_ZEB1 ZEB1 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ BM cells up-regulated hsa_circ_0002765 is one of the ZEB1-derived circRNAs upregulated in CD34+ bone marrow cells from SF3B1-mutated MDS patients compared with MDS patients without detected mutation. PRJNA896500 1295 37408496 Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1. hsa_circ_0003519 hsa_circ_ZEB1 ZEB1 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ BM cells up-regulated hsa_circ_0003519 is upregulated in CD34+ bone marrow cells from SF3B1-mutated MDS patients compared with MDS patients without detected mutation. PRJNA896500 1296 37408496 Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1. hsa_circ_0003793 hsa_circ_ZEB1 ZEB1 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ BM cells up-regulated hsa_circ_0003793 is upregulated in CD34+ bone marrow cells from SF3B1-mutated MDS patients compared with MDS patients without detected mutation. PRJNA896500 1297 37408496 Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1. hsa_circ_0007045 hsa_circ_ZEB1 ZEB1 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ BM cells up-regulated hsa_circ_0007045 is one of the ZEB1-derived circRNAs upregulated in CD34+ bone marrow cells from SF3B1-mutated MDS patients compared with MDS patients without detected mutation. PRJNA896500 1298 37416515 Down-regulation of the Smad signaling by circZBTB46 via the Smad2-PDLIM5 axis to inhibit type I collagen expression. hsa_circ_0002805 hsa_circ_ZBTB46 ZBTB46 Homo sapiens abdominal aortic aneurysm MONDO:0005350 abdominal aortic aneurysm DOID:7693 human aortic VSMCs down-regulated circZBTB46 was detected in alpha-SMA-positive human aortic VSMCs by fluorescence in situ hybridization/alpha-SMA co-staining and was reduced after TGF-beta treatment. Functional experiments in VSMCs showed that circZBTB46 inhibits TGF-beta/Smad signaling and COL1A2 expression. 1299 37426524 RNA m6A-Regulated circ-ZNF609 Suppression Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating FTO. mmu_circ_Znf609 Znf609 Mus musculus DOX-induced cardiotoxicity MONDO:0004994 cardiomyopathy DOID:0050700 isolated adult mouse cardiomyocytes; cultured NRCMs up-regulated "circ-ZNF609 is significantly increased in isolated adult mouse cardiomyocytes from DOX-treated hearts and in DOX-treated primary neonatal rat cardiomyocytes, based on qRT-PCR after cell isolation. Knockdown experiments in cardiomyocytes showed effects on apoptosis, ROS accumulation, and mitochondrial iron overload." 1300 37426524 RNA m6A-Regulated circ-ZNF609 Suppression Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating FTO. rno_circ_Znf609 Znf609 Rattus norvegicus DOX-induced cardiotoxicity MONDO:0004994 cardiomyopathy DOID:0050700 isolated adult mouse cardiomyocytes; cultured NRCMs up-regulated "circ-ZNF609 is significantly increased in isolated adult mouse cardiomyocytes from DOX-treated hearts and in DOX-treated primary neonatal rat cardiomyocytes, based on qRT-PCR after cell isolation. Knockdown experiments in cardiomyocytes showed effects on apoptosis, ROS accumulation, and mitochondrial iron overload." 1301 37426524 RNA m6A-Regulated circ-ZNF609 Suppression Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating FTO. mmu_circ_Znf609 Znf609 Mus musculus DOX-induced cardiotoxicity MONDO:0004994 cardiomyopathy DOID:0050700 adult mouse cardiomyocytes up-regulated circ-ZNF609 is more abundant in isolated adult mouse cardiomyocytes than in isolated adult mouse cardiac fibroblasts. 1302 37426524 RNA m6A-Regulated circ-ZNF609 Suppression Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating FTO. mmu_circ_Znf609 Znf609 Mus musculus DOX-induced cardiotoxicity MONDO:0004994 cardiomyopathy DOID:0050700 isolated cardiac fibroblasts no change "In isolated cardiac fibroblasts, DOX treatment had no obvious effect on circ-ZNF609 expression, whereas cardiomyocytes showed increased expression." 1303 37443201 Circular RNA RSU1 promotes retinal vascular dysfunction by regulating miR-345-3p/TAZ. hsa_circ_0006577 hsa_circ_RSU1 RSU1 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 primary human retinal vascular endothelial cells (HRVECs) up-regulated "circRSU1/hsa_circ_0006577 is up-regulated in primary human retinal vascular endothelial cells under high-glucose conditions compared with baseline conditions. Functional experiments in HRVECs showed that circRSU1 promotes proliferation, migration, invasion and endothelial angiogenesis under high-glucose conditions." 1304 37444485 Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway. Hsa_circ_0006324 hsa_circ_DENND1B DENND1B Homo sapiens pituitary adenoma MONDO:0006373 pituitary gland adenoma DOID:3829 tumor-associated fibroblasts up-regulated "circDennd1b was elevated in exosomes derived from tumor-associated fibroblasts compared with normal fibroblast-derived exosomes in pituitary adenoma. TAF-derived exosomal circDennd1b promoted proliferation, migration, and invasion of PA cells via the miR-145-5p/ONECUT2 axis." 1305 37456162 Protective effects of hsa_circ_0072568 on interleukin_1¦Â_stimulated human chondrocytes are mediated via the miR_382_5p/TOP1 axis. hsa_circ_0072568 hsa_circ_PDE4D PDE4D Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes down-regulated "circ0072568 was decreased in IL-1¦Â-stimulated primary human chondrocytes, and overexpression of circ0072568 protected chondrocytes against IL-1¦Â-induced inflammation and ECM degradation." 1306 37467831 "N6-methyladenosine-modified circIRF2, identified by YTHDF2, suppresses liver fibrosis via facilitating FOXO3 nuclear translocation." mmu_circ_0001674 mmu_circ_IRF2 IRF2 Mus musculus liver fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 primary HSCs down-regulated circIRF2 was identified from circRNA profiling of primary mouse HSCs and was significantly down-regulated in primary HSCs isolated from CCl4- and TAA-induced liver fibrosis mice. Functional data in primary HSCs support an anti-fibrotic role for circIRF2. 1307 37467831 "N6-methyladenosine-modified circIRF2, identified by YTHDF2, suppresses liver fibrosis via facilitating FOXO3 nuclear translocation." mmu_circ_0001674 mmu_circ_IRF2 IRF2 Mus musculus liver fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 primary HSCs up-regulated circIRF2 expression in primary mouse HSCs was restored during the liver fibrosis resolution stage after cessation of CCl4 injury. Knockdown of circIRF2 impaired fibrosis resolution and maintained HSC activation. 1308 37474578 circSLC4A7 accelerates stemness and progression of gastric cancer by interacting with HSP90 to activate NOTCH1 signaling pathway. hsa_circ_0064618 hsa_circ_SLC4A7 SLC4A7 Homo sapiens gastric cancer MONDO:0001056 gastric cancer DOID:10534 CD44 positive GC cells up-regulated "circ0064618/circSLC4A7 is up-regulated in CD44-positive gastric cancer cells compared with CD44-negative cells after FACS separation and qRT-PCR measurement. The study further reports that circSLC4A7 increases CSC-like properties and promotes gastric cancer cell proliferation, migration, and invasion." 1309 37477923 Spatial Profiling of Circular RNAs in Cancer Reveals High Expression in Muscle and Stromal Cells. circSLC8A1 hsa_circ_SLC8A1 SLC8A1 Homo sapiens colon adenocarcinoma MONDO:0002271 colon adenocarcinoma DOID:234 muscle cells up-regulated "circSLC8A1 is highly enriched in muscle cells in colon adenocarcinoma and adjacent normal tissue, while epithelial and cancer cells are negative by single-molecule in situ hybridization." 1310 37477923 Spatial Profiling of Circular RNAs in Cancer Reveals High Expression in Muscle and Stromal Cells. circZNF91 hsa_circ_ZNF91 ZNF91 Homo sapiens colon adenocarcinoma MONDO:0002271 colon adenocarcinoma DOID:234 cancer cells up-regulated "circZNF91 is enriched in cancer cells in colon adenocarcinoma relative to most muscle and stromal cells, as shown by single-molecule in situ hybridization." 1311 37477923 Spatial Profiling of Circular RNAs in Cancer Reveals High Expression in Muscle and Stromal Cells. circITGA7 hsa_circ_ITGA7 ITGA7 Homo sapiens colon cancer MONDO:0021063 malignant colon neoplasm DOID:219 muscle cells up-regulated "circITGA7 is specifically detectable in muscle cells in colon cancer spatial analyses, consistent with the NanoString spatial profiling data." 1312 37477923 Spatial Profiling of Circular RNAs in Cancer Reveals High Expression in Muscle and Stromal Cells. ciRS-7 / CDR1as hsa_circ_CDR1 CDR1 Homo sapiens colon cancer MONDO:0021063 malignant colon neoplasm DOID:219 CD45-negative fractions up-regulated "ciRS-7 is abundant in colon tumor stroma and is more abundant in CD45-negative stromal fractions, which the authors state mostly include CAFs, than in CD45-positive fractions." 1313 37477923 Spatial Profiling of Circular RNAs in Cancer Reveals High Expression in Muscle and Stromal Cells. circCAMSAP1 hsa_circ_CAMSAP1 CAMSAP1 Homo sapiens colon cancer MONDO:0021063 malignant colon neoplasm DOID:219 cancer cells up-regulated circCAMSAP1 is more abundant in laser-capture microdissected colon cancer cells than in normal epithelial cells from adjacent tissue. GSE233800 1314 37477923 Spatial Profiling of Circular RNAs in Cancer Reveals High Expression in Muscle and Stromal Cells. circXPO1 hsa_circ_XPO1 XPO1 Homo sapiens colon cancer MONDO:0021063 malignant colon neoplasm DOID:219 cancer cells up-regulated circXPO1 is more abundant in laser-capture microdissected colon cancer cells than in normal epithelial cells from adjacent tissue. GSE233800 1315 37491377 Circular RNA encoded MET variant promotes glioblastoma tumorigenesis. hsa_circ_0082002 circMET hsa_circ_MET MET Homo sapiens glioblastoma MONDO:0018177 glioblastoma DOID:3068 patient-derived GSCs up-regulated circMET is up-regulated in patient-derived glioma stem cells compared with control neural stem cells and normal human astrocytes. Functional assays in GSCs support roles in proliferation and stem-like growth. PRJNA973050 1316 37491377 Circular RNA encoded MET variant promotes glioblastoma tumorigenesis. hsa_circ_0082002 circMET hsa_circ_MET MET Homo sapiens glioblastoma MONDO:0018177 glioblastoma DOID:3068 CD133-positive cells up-regulated FACS-sorted CD133-positive cells from clinical glioma surgical samples showed up-regulated circMET compared with CD133-negative cells. Functional assays in GSCs support roles in proliferation and stemness. 1317 37495592 Cancer-associated fibroblasts facilitate breast cancer progression through exosomal circTBPL1-mediated intercellular communication. hsa_circ_0077892 circTBPL1 hsa_circ_TBPL1 TBPL1 Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 cancer-associated fibroblasts (CAFs) up-regulated "circTBPL1 was enriched in exosomes derived from patient-derived breast cancer CAFs compared with paired normal fibroblasts, and elevated circTBPL1 was also confirmed in the corresponding CAFs. CAF-derived exosomal circTBPL1 was reported to mediate intercellular communication with breast cancer cells and promote malignant progression." 1318 37507642 circSNTB2 and CUL4A Induces Dysfunction of Nucleus Pulposus Cells by Competitively Binding miR-665. hsa_circ_0040039 hsa_circRNA_101852 hsa_circ_SNTB2 SNTB2 Homo sapiens lumbar disc herniation MONDO:0044339 lumbar disk degenerative disorder NP cells up-regulated "In isolated and cultured human NP cells, TNF-¦Á treatment used to simulate the LDH microenvironment increased circSNTB2 expression by RT-qPCR. Functional assays in NP cells showed that circSNTB2 knockdown promoted proliferation and inhibited apoptosis." 1319 37515578 CircRIMS promotes cerebral ischemia-reperfusion injury through increasing apoptosis and targeting the miR-96-5p/JAK/STAT1 axis. circ -014781 Mus musculus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury Primary astrocytes up-regulated circRIMS was up-regulated in primary mouse astrocytes after OGD/RX treatment compared with normal control astrocytes. Knockdown experiments in OGD/RX-treated astrocytes indicated involvement in apoptosis and inflammatory factor secretion. 1320 37520722 circIFNGR2 regulating ankylosing spondylitis-associated inflammation through macrophage polarization. hsa_circ_0002660 circIFNGR2 hsa_circ_IFNGR2 IFNGR2 Homo sapiens ankylosing spondylitis MONDO:0005306 ankylosing spondylitis DOID:7147 peripheral blood CD14+ cells up-regulated "circIFNGR2 was enriched in sorted peripheral blood CD14+ cells compared with CD14_ cells of PBMCs in the context of ankylosing spondylitis. Functional assays in macrophage models showed roles in proliferation, M1/M2 polarization, and inflammatory cytokine regulation." 1321 37536029 Uncovering the expression of circPVT1 in the extracellular vesicles of acute myeloid leukemia patients. hsa_circ_0001821 circPVT1 hsa_circ_PVT1 PVT1 Homo sapiens acute myeloid leukemia MONDO:0018874 acute myeloid leukemia DOID:9119 primary blast cells up-regulated "circPVT1 is overexpressed in AML primary blast/leukemic cells compared with normal CD34+ bone marrow cells, based on qRT-PCR analysis of isolated primary bone marrow mononuclear cells." 1322 37537636 Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China. hsa_circ_0020555 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 human-luteinized granulosa (hGL) cells down-regulated "hsa-circ-0020555 was downregulated in human-luteinized granulosa cells from PCOS compared with control, validated by real-time PCR." GSE145296 1323 37537636 Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China. hsa_circ_0027651 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 human-luteinized granulosa (hGL) cells down-regulated "hsa-circ-0027651 was downregulated in human-luteinized granulosa cells from PCOS compared with control, validated by real-time PCR." GSE145296 1324 37537636 Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China. hsa_circ_0086809 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 human-luteinized granulosa (hGL) cells down-regulated "hsa-circ-0086809 was downregulated in human-luteinized granulosa cells from PCOS compared with control, validated by real-time PCR." GSE145296 1325 37537636 Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China. hsa_circ_0118448 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 human-luteinized granulosa (hGL) cells down-regulated "hsa-circ-0118448 was downregulated in human-luteinized granulosa cells from PCOS compared with control, validated by real-time PCR." GSE145296 1326 37537733 CircGNB1 drives osteoarthritis pathogenesis by inducing oxidative stress in chondrocytes. hsa_circ_0008702 hsa_circ_GNB1 GNB1 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human articular chondrocytes (HCs) up-regulated "In primary human articular chondrocytes from OA patients, circGNB1 is up-regulated after inflammatory cytokine or oxidative stress treatment compared with untreated controls. Functional experiments in HCs indicate that circGNB1 promotes oxidative stress and OA phenotypes." 1327 37537733 CircGNB1 drives osteoarthritis pathogenesis by inducing oxidative stress in chondrocytes. hsa_circ_0008702 hsa_circ_GNB1 GNB1 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 HCs up-regulated "In human chondrocytes from OA patients, circGNB1 expression is higher in more severe medial condyle OA than in lateral condyle samples and increases with age. The study links this chondrocyte circGNB1 increase to age-related OA and oxidative stress." 1328 37542851 CDR1as promotes arrhythmias in myocardial infarction via targeting the NAMPT-NAD+ pathway. CDR1as Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 neonatal mouse cardiomyocytes up-regulated "CDR1as was up-regulated in primary neonatal mouse cardiomyocytes after hypoxic treatment, as measured by qRT-PCR. Functional experiments in hypoxic cardiomyocytes linked CDR1as to mitochondrial dysfunction, NAD+ depletion, and ion-channel dysregulation." 1329 37587471 Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors. USP32 hsa_circ_USP32 USP32 Homo sapiens gastroenteropancreatic neuroendocrine tumors MONDO:0024503 digestive system neuroendocrine neoplasm tumor-educated platelets (TEPs) down-regulated USP32-associated circRNA was significantly down-regulated in isolated tumor-educated platelets from GEP-NET patients compared with platelets from control subjects. 1330 37587471 Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors. EXOC5 hsa_circ_EXOC5 EXOC5 Homo sapiens gastroenteropancreatic neuroendocrine tumors MONDO:0024503 digestive system neuroendocrine neoplasm tumor-educated platelets (TEPs) down-regulated EXOC5-associated circRNA was significantly down-regulated in isolated tumor-educated platelets from GEP-NET patients compared with platelets from control subjects. 1331 37587471 Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors. IQGAP2 hsa_circ_IQGAP2 IQGAP2 Homo sapiens gastroenteropancreatic neuroendocrine tumors MONDO:0024503 digestive system neuroendocrine neoplasm tumor-educated platelets (TEPs) down-regulated IQGAP2-associated circRNA was significantly down-regulated in isolated tumor-educated platelets from GEP-NET patients compared with platelets from control subjects. 1332 37587471 Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors. DAAM1 hsa_circ_DAAM1 DAAM1 Homo sapiens gastroenteropancreatic neuroendocrine tumors MONDO:0024503 digestive system neuroendocrine neoplasm tumor-educated platelets (TEPs) down-regulated DAAM1-associated circRNA was significantly down-regulated in isolated tumor-educated platelets from GEP-NET patients compared with platelets from control subjects. 1333 37587471 Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors. TMCO3 hsa_circ_TMCO3 TMCO3 Homo sapiens gastroenteropancreatic neuroendocrine tumors MONDO:0024503 digestive system neuroendocrine neoplasm tumor-educated platelets (TEPs) down-regulated TMCO3-associated circRNA was significantly down-regulated in isolated tumor-educated platelets from GEP-NET patients compared with platelets from control subjects. 1334 37593150 Cfa-circ002203 was upregulated in rapidly paced atria of dogs and involved in the mechanisms of atrial fibrosis. cfa-circ002203 Canis lupus familiaris atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 atrial fibroblasts up-regulated "cfa-circ002203 was significantly up-regulated in primary canine atrial fibroblasts after Ang II-induced fibrotic stimulation. Functional experiments in these fibroblasts linked cfa-circ002203 to inflammation, fibrosis, proliferation, migration, and apoptosis regulation." 1335 37624989 CircASPH Enhances Exosomal STING to Facilitate M2 Macrophage Polarization in Colorectal Cancer. hsa_circ_0084615 hsa_circRNA_104634 hsa_circ_ASPH ASPH Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 primary IECs up-regulated "hsa_circRNA_104634/circASPH was significantly up-regulated in primary intestinal epithelial cells isolated from colorectal cancer tissues compared with primary IECs from normal colon tissues, as measured by RT-qPCR." 1336 37625563 CircSOD2 polarizes macrophages towards the M1 phenotype to alleviate cisplatin resistance in gastric cancer cells by targeting the miR-1296/STAT1 axis. hsa_circ_0004662 circSOD2 hsa_circ_SOD2 SOD2 Homo sapiens gastric cancer MONDO:0001056 gastric cancer DOID:10534 M1 macrophages up-regulated "circSOD2 is up-regulated in M1 macrophages compared with M2 macrophages, including macrophages derived from gastric cancer patient monocytes and measured by PCR/qRT-PCR. Functional assays indicate that circSOD2 promotes M1 polarization and macrophage-mediated reduction of cisplatin resistance in gastric cancer cells." 1337 37632638 Exosomes from circRNA-Ptpn4 can modify ADSC treatment and repair nerve damage caused by cerebral infarction by shifting microglial M1/M2 polarization. mmu_circ_Ptpn4 Ptpn4 Mus musculus cerebral infarction MONDO:0002679 cerebral infarction DOID:3526 adipose-derived stem cells up-regulated circ-Ptpn4 was up-regulated in exosomes derived from hypoxia-pretreated ADSCs compared with normoxic ADSC exosomes. Exosomal circ-Ptpn4 from ADSCs was linked to modulation of microglia/macrophage M1-to-M2 polarization in cerebral infarction models. 1338 37653038 CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90¦Â complex. mmu_circ_0001477 circFam190a mmu_circ_Fam190a Fam190a Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 osteoclasts up-regulated circFam190a was identified by circRNA-seq of primary mouse BMM-derived osteoclast differentiation stages and validated by qPCR as up-regulated in mature osteoclasts. Functional assays showed circFam190a promotes osteoclast differentiation and bone resorption. CRA009230 1339 37653038 CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90¦Â complex. mmu_circ_0001477 circFam190a mmu_circ_Fam190a Fam190a Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 BMMs up-regulated "circFam190a expression was significantly elevated in BMMs isolated from OVX mice compared with sham mice, based on qRT-PCR after primary cell isolation." 1340 37653038 CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90¦Â complex. hsa_circ_0127310 circFAM190A hsa_circ_FAM190A FAM190A Homo sapiens postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis PBMCs up-regulated "Human circFAM190A/hsa_circ_0127310 was measured in freshly isolated PBMCs, and its expression was significantly up-regulated in postmenopausal osteoporosis patients." 1341 37673874 "Exosomal circEZH2_005, an intestinal injury biomarker, alleviates intestinal ischemia/reperfusion injury by mediating Gprc5a signaling." circEZH2_005 mmu_circ_Ezh2 Ezh2 Mus musculus intestinal ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury intestinal Lgr5+ crypt stem cells up-regulated "circEZH2_005 is enriched in Lgr5+ intestinal crypt stem cells compared with Lgr5- cells, supported by FACS-based qRT-PCR and FISH colocalization with Lgr5 in mouse intestinal tissue. Functional experiments indicate circEZH2_005 supports intestinal crypt stem cell proliferation during hypoxia/reoxygenation or ischemia/reperfusion injury." 1342 37673874 "Exosomal circEZH2_005, an intestinal injury biomarker, alleviates intestinal ischemia/reperfusion injury by mediating Gprc5a signaling." circEZH2_005 mmu_circ_Ezh2 Ezh2 Mus musculus intestinal ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury intestinal Lgr5+ crypt stem cells down-regulated "In Lgr5+ intestinal crypt stem cells, circEZH2_005 is significantly reduced after intestinal ischemia/reperfusion treatment. Functional experiments indicate circEZH2_005 supports crypt stem cell proliferation during injury through hnRNPA1 and Gprc5a signaling." 1343 37679886 METTL3-mediated m6 A modification of circPRKAR1B promotes Crohn's colitis by inducing pyroptosis via autophagy inhibition. hsa_circ_0008039 circPRKAR1B hsa_circ_PRKAR1B PRKAR1B Homo sapiens Crohn's disease MONDO:0005011 Crohn disease DOID:8778 isolated epithelial cells up-regulated circPRKAR1B was significantly up-regulated in isolated epithelial cells from Crohn's disease patients compared with normal controls. The study links circPRKAR1B to autophagy impairment and NLRP3 inflammasome-mediated pyroptosis in colonic epithelial cells. 1344 37680984 The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms. hsa_circ_0003641 hsa_circ_ATM ATM Homo sapiens abdominal aortic aneurysm MONDO:0005350 abdominal aortic aneurysm DOID:7693 AAA patient-derived AoSMCs up-regulated "cATM is higher in primary aortic smooth muscle cells derived from AAA patients than in control AoSMCs, as measured by qRT-PCR after primary cell isolation/culture. Functional experiments in AoSMCs linked cATM modulation to apoptosis and proliferation." 1345 37680984 The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms. hsa_circ_0003641 hsa_circ_ATM ATM Homo sapiens abdominal aortic aneurysm MONDO:0005350 abdominal aortic aneurysm DOID:7693 commercially available primary AoSMCs up-regulated "cATM is increased in primary human aortic smooth muscle cells after angiotensin II stimulation, an in vitro AAA-mimicking treatment, as measured by qRT-PCR." 1346 37688444 Circ_0002295 facilitated myocardial fibrosis progression through the miR-1287/CXCR2 axis. circ_0002295 rno_circ_PTPRG PTPRG Rattus norvegicus myocardial fibrosis MONDO:0004994 cardiomyopathy DOID:0050700 cardiac fibroblasts up-regulated "circ_0002295 was up-regulated in Ang II-induced fibrotic primary cardiac fibroblasts compared with untreated control cells. Knockdown experiments in cardiac myofibroblasts showed effects on cell viability, migration and fibrosis marker expression." 1347 37691924 "Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine." circNUP205 (40).1 ssc_circ_NUP205 NUP205 Sus scrofa Porcine reproductive and respiratory syndrome MONDO:0025494 porcine reproductive and respiratory syndrome porcine alveolar macrophages up-regulated "circNUP205 (40).1 was detected in isolated porcine alveolar macrophages by circRNA sequencing and was up-regulated in PRRSV-infected PAMs, in association with CTLA4 within the ceRNA network." PRJNA982972 1348 37691924 "Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine." circNPL(L3).1 ssc_circ_NPL NPL Sus scrofa Porcine reproductive and respiratory syndrome MONDO:0025494 porcine reproductive and respiratory syndrome porcine alveolar macrophages down-regulated circNPL(L3).1 was down-regulated in isolated porcine alveolar macrophages from PRRSV-infected pigs and its expression was validated by RT-qPCR. PRJNA982972 1349 37691924 "Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine." circSPECC1 (2).1 ssc_circ_SPECC1 SPECC1 Sus scrofa Porcine reproductive and respiratory syndrome MONDO:0025494 porcine reproductive and respiratory syndrome PAMs dys-regulated circSPECC1 (2).1 was identified as a differentially expressed circRNA in isolated PAMs after PRRSV infection and was selected for RT-qPCR validation. PRJNA982972 1350 37691924 "Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine." "circSFMBT2 (2,3,4).1" ssc_circ_SFMBT2 SFMBT2 Sus scrofa Porcine reproductive and respiratory syndrome MONDO:0025494 porcine reproductive and respiratory syndrome PAMs dys-regulated "circSFMBT2 (2,3,4).1 was identified as a differentially expressed circRNA in isolated PAMs after PRRSV infection and was selected for RT-qPCR validation." PRJNA982972 1351 37692283 CircMAPK9 promotes adipogenesis through modulating hsa-miR-1322/FTO axis in obesity. hsa_circ_0001566 hsa_circ_MAPK9 MAPK9 Homo sapiens obesity MONDO:0011122 obesity disorder DOID:9970 primary preadipocytes up-regulated "In primary preadipocytes isolated from VATs and induced toward mature adipocytes, circMAPK9 expression increased during adipogenic differentiation. Functional manipulation in adipocytes showed circMAPK9 promoted adipogenic marker expression, triglyceride accumulation, and lipid droplet formation." 1352 37709179 CircRNA254 functions as the miR-375 sponge to inhibit coelomocyte apoptosis via targeting BAG2 in V. splendidus-challenged Apostichopus japonicus. circRNA254 / circ254 AjMEGF6 Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 coelomocytes down-regulated "circ254 was down-regulated in coelomocytes of V. splendidus-infected A. japonicus, a model of skin ulceration syndrome, as measured by qRT-PCR. Functional experiments in coelomocytes showed that circ254 suppresses pathogen-mediated coelomocyte apoptosis through the miR-375-AjBAG2 axis." 1353 37709179 CircRNA254 functions as the miR-375 sponge to inhibit coelomocyte apoptosis via targeting BAG2 in V. splendidus-challenged Apostichopus japonicus. circRNA254 / circ254 AjMEGF6 Apostichopus japonicus skin ulceration syndrome MONDO:0000001 disease DOID:4 primary coelomocytes down-regulated "circ254 was down-regulated in LPS-exposed primary coelomocytes compared with untreated controls. In primary coelomocytes, circ254 silencing promoted apoptosis and this effect was reversed by miR-375 inhibitors." 1354 37716232 Dietary Morus alba L. leaf supplementation improves hepatic lipid accumulation of laying hens via downregulating CircACACA. novel_circ_0000429 gga_circ_ACACA ACACA Gallus gallus Fatty liver hemorrhagic syndrome MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 primary hepatocytes up-regulated "In isolated primary chick hepatocytes used as an FFA-induced steatosis model, circACACA was experimentally overexpressed and verified by qPCR. circACACA overexpression reversed the lipid-lowering effect of mulberry leaf extract in hepatocytes." 1355 37723137 Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease. hsa_circ_DNAJC6 DNAJC6 Homo sapiens Parkinson's disease MONDO:0005180 Parkinson disease DOID:14330 dopamine neurons down-regulated "Laser-capture RNA-seq of human postmortem brain neurons detected circDNAJC6 as highly expressed in dopamine neurons. In dopamine neurons from prodromal Parkinson¡¯s disease-associated Lewy body neuropathology cases, circDNAJC6 expression was reduced/altered compared with controls." GSE218203 1356 37723588 CircRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCs. hsa_circ_0028912 hsa_circ_RNF10 RNF10 Homo sapiens glioblastoma MONDO:0018177 glioblastoma DOID:3068 GSCs up-regulated "circRNF10 was detected by qPCR in patient-derived glioma stem cells, with higher expression in SYNS03 and SYNS08 than in SYNS05 and SYNS06. Functional assays in GSCs supported roles in proliferation, stemness maintenance, and ferroptosis-related iron metabolism." 1357 37769807 Circ_0114581 promotes osteogenic differentiation of BMSCs via the MiR-155-5p/HNRNPA3 axis. hsa_circ_0114581 hsa_circDPYD_041 hsa_circ_DPYD DPYD Homo sapiens Osteoporosis MONDO:0005298 osteoporosis DOID:11476 BMSCs up-regulated "In human BMSCs undergoing osteogenic induction, hsa_circ_0114581 expression increased with osteogenic differentiation. Functional experiments in BMSCs indicated that hsa_circ_0114581 promoted osteogenesis through the miR-155-5p/HNRNPA3 axis." 1358 37794449 Exosome-derived circ_0001785 delays atherogenesis through the ceRNA network mechanism of miR-513a-5p/TGFBR3. hsa_circ_0001785 circ_0001785 hsa_circ_ELP3 ELP3 Homo sapiens coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 leukocytes down-regulated "circ_0001785 expression was significantly lower in leukocytes isolated from patients with coronary artery disease than in leukocytes from healthy controls, based on qRT-PCR." 1359 37802826 [Cangxi Tongbi Capsules promote chondrocyte autophagy by regulating circRNA£ß0008365/miR-1271/p38 MAPK pathway to inhibit development of knee osteoarthritis]. hsa_circ_0008365 Homo sapiens knee osteoarthritis MONDO:0005416 "osteoarthritis, knee" Èí¹Çϸ°û down-regulated "In primary chondrocytes, IL-1¦Â treatment down-regulated circRNA_0008365 as measured by qRT-PCR. The study linked reduced circRNA_0008365 with lower autophagy, increased apoptosis, and accelerated extracellular matrix catabolism in the KOA cell model." 1360 37817544 Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA. circ-pik3r1 mmu_circ_pik3r1 pik3r1 Mus musculus temporomandibular joint osteoarthritis / TMJOA MONDO:0005473 temporomandibular joint disorder primary mouse condylar chondrocytes (mCCs) down-regulated circ-pik3r1 was downregulated in primary mouse condylar chondrocytes after IFN¦Ã and TNF¦Á treatment in the TMJOA-related inflammatory model. 1361 37817544 Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA. circ-serpine2 mmu_circ_serpine2 serpine2 Mus musculus temporomandibular joint osteoarthritis / TMJOA MONDO:0005473 temporomandibular joint disorder primary mouse condylar chondrocytes (mCCs) down-regulated circ-serpine2 was downregulated in primary mouse condylar chondrocytes after IFN¦Ã and TNF¦Á treatment in the TMJOA-related inflammatory model. 1362 37817544 Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA. circ-slain2 mmu_circ_slain2 slain2 Mus musculus temporomandibular joint osteoarthritis / TMJOA MONDO:0005473 temporomandibular joint disorder mouse condylar chondrocytes (mCCs) down-regulated "circ-slain2 was cytoplasmic and downregulated in mouse condylar chondrocytes after IFN¦Ã and TNF¦Á treatment. In mCCs, elevated circ-slain2 showed anti-inflammatory effects and suppressed IFN¦Ã/TNF¦Á-induced ER stress." 1363 37819813 Targeting circular RNA-Glra2 alleviates retinal neurodegeneration induced by ocular hypertension. mmu_circ_0016226 cGlra2 mmu_circ_Glra2 Glra2 Mus musculus glaucoma MONDO:0005041 glaucoma DOID:1686 RGCs down-regulated "In primary mouse retinal ganglion cells, cGlra2 expression was detected by qRT-PCR and was markedly reduced after cGlra2 siRNA transfection. Functional assays in RGCs showed that cGlra2 silencing protected against oxidative stress- and hydrostatic stress-induced injury." 1364 37831180 Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis. hsa_circ_0058476 Homo sapiens MSC senescence others others MSCs up-regulated "hsa_circ_0058476 was significantly increased in late-passage primary cultured MSCs compared with early-passage MSCs, supported by RNA-seq and RT-qPCR validation." GSE178514 1365 37831180 Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis. hsa_circ_0019233 Homo sapiens MSC senescence others others MSCs up-regulated "hsa_circ_0019233 was significantly increased in late-passage primary cultured MSCs compared with early-passage MSCs, supported by RNA-seq and RT-qPCR validation." GSE178514 1366 37831180 Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis. hsa_circ_0005773 circSERPINE2 hsa_circ_SERPINE2 SERPINE2 Homo sapiens MSC senescence others others MSCs up-regulated hsa_circ_0005773 / circSERPINE2 accumulated in senescent late-passage primary cultured MSCs compared with early-passage MSCs. Functional experiments in MSCs showed that circSERPINE2 promoted senescence and impaired proliferative potential through the YBX3/PCNA/p21 axis. GSE178514 1367 37831180 Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis. circSerpine2 mmu_circ_Serpine2 Serpine2 Mus musculus aging-related osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 synovial Sca-1+ MSCs up-regulated Mouse circSerpine2 accumulated with aging-related OA in joints and was enriched in synovial Sca-1+ MSCs based on Base Scope detection with Sca-1 immunofluorescence. Intra-articular si-circSerpine2 reduced p21-positive Sca-1+ MSCs and alleviated OA-associated joint degeneration. 1368 37845343 Hesperetin derivative 2a inhibits lipopolysaccharide-induced acute liver injury in mice via downregulation of circDcbld2. mmu_circ_0000693 circDcbld2 mmu_circ_Dcbld2 Dcbld2 Mus musculus acute liver injury MONDO:0005154 liver disorder DOID:409 mouse primary macrophages dys-regulated circDcbld2 showed abnormal expression in inflammatory mouse primary macrophages based on circRNA sequencing after LPS treatment. 1369 37852428 Hypoxia-induced circ-CDYL-EEF1A2 transcriptional complex drives lung metastasis of cancer stem cells from hepatocellular carcinoma. hsa_circ_0008285 hsa_circ_CDYL CDYL Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 ICAM-1 + CCSCs up-regulated "In HCC patient peripheral blood CTCs, circ-CDYL was higher in ICAM-1+ circulating cancer stem cells than in ICAM-1_ CTCs, as measured by digital PCR after CTC enrichment." 1370 37852428 Hypoxia-induced circ-CDYL-EEF1A2 transcriptional complex drives lung metastasis of cancer stem cells from hepatocellular carcinoma. hsa_circ_0008285 hsa_circ_CDYL CDYL Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 liver CSCs up-regulated "In HCC primary tissue-derived CSC-enriched spheres, circ-CDYL expression was higher in liver CSCs than in non-CSCs by qRT-PCR." 1371 37852428 Hypoxia-induced circ-CDYL-EEF1A2 transcriptional complex drives lung metastasis of cancer stem cells from hepatocellular carcinoma. hsa_circ_0008285 hsa_circ_CDYL CDYL Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 HCC primary cells up-regulated "In HCC primary cells, hypoxia increased circ-CDYL expression compared with normoxia, along with increased HIF1¦Á, EIF4A3 and ICAM-1." 1372 37865306 "A novel circular RNA, circSQSTM1, protects the endothelial function in atherosclerosis." hsa_circRNA_075320 hsa_circ_SQSTM1 SQSTM1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 endothelial cells (ECs) up-regulated "circSQSTM1 was increased after atorvastatin treatment in HUVEC endothelial cells, with circRNA expression initially screened by microarray and verified using quantitative PCR. Functional experiments in HUVECs showed circSQSTM1 reduced inflammatory markers and monocyte adhesion, inhibited ROS production, and promoted autophagy." 1373 37869777 Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke. circPTP4A2 mmu_circ_PTP4A2 PTP4A2 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke primary mouse microglia up-regulated "circPTP4A2 expression was significantly increased in primary mouse microglia after OGD/R treatment, an in vitro ischemic condition model. The study links circPTP4A2 to STAT3-dependent microglial polarization and neuroinflammation." 1374 37882757 hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p/Rab5b axis. hsa_circ_BECN1 hsa_circ_BECN1 BECN1 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 ovarian granulosa cells up-regulated "circ_BECN1 is up-regulated in isolated ovarian granulosa cells from PCOS patients compared with granulosa cells from non-PCOS patients, as measured by RT-qPCR after collection from follicular fluid." 1375 37897547 Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia-reperfusion injury. mmu_circ_0000144 circRNA_0191 mmu_circ_Utrn Utrn Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 adult mouse cardiomyocytes up-regulated circUtrn is significantly up-regulated in isolated adult mouse cardiomyocytes after swim exercise training. RNA-seq profiling and RT-qPCR validation support this cardiomyocyte-specific expression change. PRJNA801905 1376 37897547 Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia-reperfusion injury. mmu_circ_0000144 circRNA_0191 mmu_circ_Utrn Utrn Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 isolated cardiac mouse fibroblasts no change "circUtrn showed no expression change in isolated cardiac mouse fibroblasts from swim-exercised mice compared with controls, supporting specificity for cardiomyocytes in the exercise model." 1377 37903473 YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes Keratinocyte Inflammation Induced by Cutibacterium acnes Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis. hsa_circ_0102678 hsa_circ_CRIM1 CRIM1 Homo sapiens acne MONDO:0011438 acne DOID:6543 human primary keratinocytes unknown "hsa_circ_0102678 was detected in primary human keratinocytes and was predominantly localized in the cytoplasm. In this primary keratinocyte acne-related model, hsa_circ_0102678 promoted C. acnes biofilm-induced inflammatory responses through the miR-146a/TRAF6 and IRAK1 axis." 1378 37939881 CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis. hsa_circ_0003594 circHDAC9 hsa_circ_HDAC9 HDAC9 Homo sapiens myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury Primary human cardiac myocytes (HCMs) up-regulated "circHDAC9 is up-regulated in primary human cardiac myocytes after hypoxia/reoxygenation treatment, an in vitro model related to myocardial ischemia-reperfusion injury. Knockdown of circHDAC9 inhibited apoptosis and inflammation in H/R-induced HCMs via the miR-671-5p/SOX4 axis." 1379 37947656 circRNA-miRNA-mRNA Deregulated Network in Ischemic Heart Failure Patients. hsa_circ_0000799 circBPTF hsa_circ_BPTF BPTF Homo sapiens ischemic heart failure MONDO:0005053 ischemic disease DOID:326 HUVEC endothelial cells up-regulated "circBPTF expression is induced in HUVEC endothelial cells under hypoxia compared with normoxic conditions. In HUVEC, circBPTF silencing decreased cell number and altered cell-cycle profiles with increased sub-G1 cells." 1380 37950151 Circular RNA ZNF800 (hsa_circ_0082096) regulates cancer stem cell properties and tumor growth in colorectal cancer. hsa_circ_0082096 hsa_circ_ZNF800 ZNF800 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 LGR5high/SOX9high cell population unknown Dual RNA-FISH/immunofluorescence showed circZNF800 co-resided with LGR5high/SOX9high intestinal stem cell-associated cells in non-pathological colorectal tissues from colorectal cancer patients. 1381 37950151 Circular RNA ZNF800 (hsa_circ_0082096) regulates cancer stem cell properties and tumor growth in colorectal cancer. hsa_circ_0082096 hsa_circ_ZNF800 ZNF800 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 tumor cell population unknown Dual RNA-FISH/immunofluorescence showed circZNF800 co-localized with Ki-67 in a proliferative tumor cell population in colorectal cancer tissue. 1382 37954137 N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes. hsa_circ_CDYL CDYL Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 EpCAM+ HCC cells up-regulated "Circ-CDYL expression was higher in flow cytometry-sorted EpCAM+ HCC cells than in EpCAM_ HCC cells, supporting enrichment in a stem-like/tumor-initiating HCC cell state." 1383 37963200 "CircMMP2(6,7) Cooperates with ¦Â-Catenin and PRMT5 to Disrupt Bone Homeostasis and Promote Breast Cancer Bone Metastasis." hsa_circ_0039408 "circMMP2(6,7)" hsa_circ_MMP2 MMP2 Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 breast cancer cells up-regulated "RNAscope ISH combined with H&E staining showed circMMP2(6,7) expression localized to breast cancer cells and was hardly detected in stromal or tumor-infiltrating immune cells in breast cancer tissues." 1384 37963200 "CircMMP2(6,7) Cooperates with ¦Â-Catenin and PRMT5 to Disrupt Bone Homeostasis and Promote Breast Cancer Bone Metastasis." hsa_circ_0039408 "circMMP2(6,7)" hsa_circ_MMP2 MMP2 Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 breast cancer cells up-regulated "RNAscope ISH showed circMMP2(6,7) signals were higher in primary breast cancer tissues with bone metastasis and highest in bone metastatic breast cancer tissues, and H&E-supported localization indicated expression mainly in breast cancer cells." 1385 37968534 Circular RNA hsa_circ_0000175 Serves as a Potential Biomarker for Rheumatoid Arthritis via miR-31-5p/GSDME Axis. hsa_circ_0000175 hsa_circ_ELK4 ELK4 Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 PBMCs up-regulated circ_0000175 was increased in PBMCs from RA patients compared with healthy controls based on RT-qPCR after PBMC separation. 1386 37968534 Circular RNA hsa_circ_0000175 Serves as a Potential Biomarker for Rheumatoid Arthritis via miR-31-5p/GSDME Axis. hsa_circ_0000175 hsa_circ_ELK4 ELK4 Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 FLSs up-regulated "In primary cultured RA-FLSs, LPS/ATP treatment increased circ_0000175 expression compared with untreated controls. circ_0000175 silencing reduced inflammatory cytokine secretion and pyroptosis in LPS/ATP-stimulated FLSs via the miR-31-5p/GSDME axis." 1387 37981258 Circ-Plod2 destabilizes Mpo mRNA by binding to IGF2BP2 to promote osteogenic differentiation of bone marrow mesenchymal stem cells. circRNA307 rno_circ_Plod2 Plod2 Rattus norvegicus postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis bone marrowderived mesenchymal stem cells (BMSCs) down-regulated "circ-Plod2 was down-regulated in BMSCs isolated from OVX rats compared with Sham control BMSCs, based on circRNA sequencing and verification. The study further showed that circ-Plod2 promotes osteogenic differentiation of BMSCs through an IGF2BP2-Mpo mechanism." 1388 37989109 Identification of Cuproptosis-Related circRNA-miRNA-mRNA Network in Laser-Induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-Related Macular Degeneration. circRNA3411 hsa_circ_NPEPPS NPEPPS Homo sapiens neovascular age-related macular degeneration MONDO:0005417 wet macular degeneration DOID:10873 peripheral blood mononuclear cells (PBMCs) up-regulated "In isolated human PBMCs, circNPEPPS was significantly up-regulated in patients with nAMD compared with controls by RT-qPCR." 1389 37989109 Identification of Cuproptosis-Related circRNA-miRNA-mRNA Network in Laser-Induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-Related Macular Degeneration. circTKT hsa_circ_TKT TKT Homo sapiens neovascular age-related macular degeneration MONDO:0005417 wet macular degeneration DOID:10873 peripheral blood mononuclear cells (PBMCs) down-regulated "In isolated human PBMCs, circTKT was significantly down-regulated in patients with nAMD compared with controls by RT-qPCR." 1390 37989109 Identification of Cuproptosis-Related circRNA-miRNA-mRNA Network in Laser-Induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-Related Macular Degeneration. circRNA8595 hsa_circ_ZNF644 ZNF644 Homo sapiens neovascular age-related macular degeneration MONDO:0005417 wet macular degeneration DOID:10873 peripheral blood mononuclear cells (PBMCs) down-regulated "In isolated human PBMCs, circZNF644 was significantly down-regulated in patients with nAMD compared with controls by RT-qPCR." 1391 37989109 Identification of Cuproptosis-Related circRNA-miRNA-mRNA Network in Laser-Induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-Related Macular Degeneration. circRNA6572 hsa_circ_MAMIL1 MAMIL1 Homo sapiens neovascular age-related macular degeneration MONDO:0005417 wet macular degeneration DOID:10873 peripheral blood mononuclear cells (PBMCs) down-regulated "In isolated human PBMCs, circMAMIL1 was reported as significantly down-regulated in patients with nAMD compared with controls by RT-qPCR." 1392 37993257 The upregulation of circFoxp1 influences keloid by promoting cell proliferation. hsa_circ_0001320 hsa_circ_FOXP1 FOXP1 Homo sapiens keloid MONDO:0005348 keloid HSFs / primary human dermal fibroblasts up-regulated "In primary human dermal fibroblast culture, circFoxp1 was experimentally upregulated by OE-circFoxp1 lentivirus compared with OE-NC control and confirmed by qRT-PCR. Functional assays in HSFs linked circFoxp1 upregulation to increased proliferation, migration, invasion, ECM-related fibrosis, inflammatory response, and reduced apoptosis." 1393 38008051 Thiram exposure induces tibial dyschondroplasia in broilers via the regulation effect of circ_003084/miR-130c-5p/BMPR1A crosstalk on chondrocyte proliferation and differentiation. circ_003084 gga_circ_RABGEF1 RABGEF1 Gallus gallus tibial dyschondroplasia MONDO:1012275 "tibial dyschondroplasia, chicken" TD chondrocytes up-regulated "Primary poultry chondrocytes were isolated from control and thiram-induced TD broilers, and qRT-PCR was used to detect circ_003084 in cells. circ_003084 was increased in cells under thiram exposure and was functionally linked to reduced proliferation and differentiation of TD chondrocytes." CRA005551 1394 38012734 Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer. hsa_circ_0053442 circBIRC6 hsa_circ_BIRC6 BIRC6 Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 cancer-associated fibroblasts (CAFs) up-regulated "In PDAC patient-derived isolated cells, circBIRC6 was elevated in CAFs compared with paired tumor cells, supporting CAFs as a major source of circBIRC6." 1395 38012734 Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer. hsa_circ_0053442 circBIRC6 hsa_circ_BIRC6 BIRC6 Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 CAFs up-regulated "In primary CAFs isolated from PDAC patients, circBIRC6 was higher in oxaliplatin-resistant patients than in oxaliplatin-sensitive patients." 1396 38012734 Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer. hsa_circ_0053442 circBIRC6 hsa_circ_BIRC6 BIRC6 Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 CAF-derived EVs up-regulated "circBIRC6 was enriched in EVs secreted by patient-derived CAFs, supporting CAF-derived extracellular vesicles as a carrier of circBIRC6 in PDAC." 1397 38012808 N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease. circRIMS2 mmu_circ_RIMS2 RIMS2 Mus musculus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 A¦Â-treated primary cortical mouse neurons up-regulated "circRIMS2 was up-regulated in A¦Â-treated primary cortical mouse neurons compared with scramble-treated primary cortical mouse neurons, supporting abnormal activation of the circRIMS2/miR-3968 pathway in an AD-related neuronal model." 1398 38016613 CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis. hsa_circ_0005505 circIRAK3 hsa_circ_IRAK3 IRAK3 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 IL-1¦Â treated chondrocytes up-regulated "circIRAK3 was increased in IL-1¦Â-treated primary human chondrocytes, a cellular inflammatory degeneration model relevant to osteoarthritis. Functional experiments in PHCs showed that circIRAK3 knockdown promoted apoptosis, reduced proliferation, and increased proinflammatory cytokine expression." 1399 38016613 CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis. hsa_circ_0060927 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 IL-1¦Â treated chondrocytes up-regulated hsa_circ_0060927 was significantly increased in IL-1¦Â-treated primary human chondrocytes. The authors did not detect obvious chondrocyte-related mRNA changes after hsa_circ_0060927 knockdown. 1400 38016613 CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis. hsa_circ_0005505 circIRAK3 hsa_circ_IRAK3 IRAK3 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 hBMSCs up-regulated "circIRAK3 increased during primary hBMSC chondrogenesis, with expression rising from day 0 to day 21 and again from day 28 to day 35. Knockdown of circIRAK3 in hBMSCs inhibited chondrogenesis and increased proinflammatory cytokine expression during differentiation." 1401 38021072 Novel_circ_003686 regulates the osteogenic differentiation of MSCs in patients with myeloma bone disease through miR-142-5p/IGF1 axis. circ_003686 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 MBD-BMSC down-regulated "circ_003686 was lower in primary BMSCs isolated from patients with multiple myeloma bone disease than in BMSCs from normal participants, as measured by RT-PCR." 1402 38021072 Novel_circ_003686 regulates the osteogenic differentiation of MSCs in patients with myeloma bone disease through miR-142-5p/IGF1 axis. circ_003686 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 MBD-BMSC up-regulated "circ_003686 expression increased after osteogenic induction in primary BMSC cultures from MBD patients, based on RT-PCR. Functional experiments in MBD-BMSCs supported a role for circ_003686 in promoting osteogenic differentiation." 1403 38029383 Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion. circFKBP5 hsa_circ_FKBP5 FKBP5 Homo sapiens KMT2A::AFF1 B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemia cells up-regulated circFKBP5 is up-regulated in KMT2A::AFF1 ALL leukemia cells compared with healthy CD34+ hematopoietic stem cells and B cells. Its silencing increased apoptosis and reduced proliferation in KMT2A::AFF1 ALL in vitro models. GSE213990 1404 38029383 Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion. circKLHL2 hsa_circ_KLHL2 KLHL2 Homo sapiens KMT2A::AFF1 B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemia cells up-regulated circKLHL2 is up-regulated in KMT2A::AFF1 ALL leukemia cells compared with healthy CD34+ hematopoietic stem cells and B cells. Its silencing increased apoptosis and reduced proliferation in KMT2A::AFF1 ALL in vitro models. GSE213990 1405 38029383 Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion. circNR3C1 hsa_circ_NR3C1 NR3C1 Homo sapiens KMT2A::AFF1 B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemia cells up-regulated circNR3C1 is up-regulated in KMT2A::AFF1 ALL leukemia cells compared with healthy CD34+ hematopoietic stem cells and B cells. Its silencing increased apoptosis and reduced proliferation in KMT2A::AFF1 ALL in vitro models. GSE213990 1406 38029383 Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion. circPAN3 hsa_circ_PAN3 PAN3 Homo sapiens KMT2A::AFF1 B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemia cells up-regulated circPAN3 is among the up-regulated circRNAs in KMT2A::AFF1 ALL malignant cells compared with healthy CD34+ hematopoietic stem cells and B cells. Its silencing increased apoptosis and reduced proliferation in KMT2A::AFF1 ALL in vitro models. GSE213990 1407 38029383 Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion. circHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens KMT2A::AFF1 B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemia cells up-regulated circHIPK3 is up-regulated in KMT2A::AFF1 ALL leukemia cells compared with healthy CD34+ hematopoietic stem cells and B cells. GSE213990 1408 38029383 Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion. circZNF609 hsa_circ_ZNF609 ZNF609 Homo sapiens KMT2A::AFF1 B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemia cells up-regulated circZNF609 is up-regulated in KMT2A::AFF1 ALL leukemia cells compared with healthy CD34+ hematopoietic stem cells and B cells. GSE213990 1409 38029383 Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion. circFLT3 hsa_circ_FLT3 FLT3 Homo sapiens KMT2A::AFF1 B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemia cells up-regulated circFLT3 is highly expressed/up-regulated in KMT2A::AFF1 ALL leukemia cells and is almost or completely absent in healthy control cell populations. GSE213990 1410 38029383 Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion. circPROM1 hsa_circ_PROM1 PROM1 Homo sapiens KMT2A::AFF1 B-cell precursor acute lymphoblastic leukemia MONDO:0020511 precursor B-cell acute lymphoblastic leukemia DOID:0080638 leukemia cells up-regulated circPROM1 is highly expressed/up-regulated in KMT2A::AFF1 ALL leukemia cells and is almost or completely absent in healthy control cell populations. GSE213990 1411 38035043 Circ_ST6GAL1-mediated competing endogenous RNA network regulates TGF-¦Â1-stimulated matrix Metalloproteinase-13 expression via Runx2 acetylation in osteoblasts. circ_ST6GAL1 rno_circ_ST6GAL1 ST6GAL1 Rattus norvegicus bone and bone-related disorders MONDO:0005381 bone disorder DOID:0080001 rat primary osteoblasts up-regulated "circ_ST6GAL1 expression was significantly increased in rat primary osteoblasts after TGF-¦Â1 treatment compared with control, measured by qPCR after primary osteoblast isolation." 1412 38041128 Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a/VGF axis. mmu_circ_0001261 Mus musculus pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 DRG cells up-regulated "In isolated murine DRG cells treated with exosomes from Gli1- or hsa-circ-0011536-overexpressing PDAC cells, the homologous circRNA mmu-circ-0001261/mmu-cic-0001261 was elevated. Functional experiments in DRG cells linked this circRNA to regulation of the miR-451a/VGF axis and neurite extension." 1413 38042362 Circular RNA circ-3626 promotes bone formation by modulating the miR-338-3p/Runx2 axis. hsa_circ_0003626 circ-3626 hsa_circ_STAG1 STAG1 Homo sapiens senile osteoporosis MONDO:0005298 osteoporosis DOID:11476 hBMSCs up-regulated "circ-3626 was up-regulated in hBMSCs during osteogenic differentiation compared with non-induced hBMSCs, based on circRNA sequencing and qPCR validation. Functional assays in hBMSCs indicated that circ-3626 promotes osteogenic differentiation through the miR-338-3p/Runx2 axis." 1414 38042362 Circular RNA circ-3626 promotes bone formation by modulating the miR-338-3p/Runx2 axis. circ-3626 STAG1 Mus musculus senile osteoporosis MONDO:0005298 osteoporosis DOID:11476 BMSCs down-regulated "circ-3626 was down-regulated in isolated BMSCs from aged mice with low bone density compared with control mice, based on BMSC isolation and qPCR measurement. The study further showed that circ-3626 promotes osteogenic capability of BMSCs." 1415 38045055 ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17. circCDK17 hsa_circ_CDK17 CDK17 Homo sapiens Pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 PASMCs down-regulated "In PASMCs under hypoxic conditions, whole transcriptome sequencing and qPCR-based validation identified circCDK17 as an ADAR1-regulated circRNA, with ADAR1 overexpression inhibiting circCDK17 expression. Functional assays showed that circCDK17 overexpression attenuated hypoxia-induced PASMC proliferation and cell cycle progression." 1416 38046397 Circular RNA circSMAD4 regulates cardiac fibrosis by targeting miR-671-5p and FGFR2 in cardiac fibroblasts. circSmad4 mmu_circ_Smad4 Smad4 Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 cardiac fibroblasts up-regulated circSmad4/circSMAD4 was up-regulated in Langendorff-isolated mouse cardiac fibroblasts after TAC-induced cardiac fibrosis compared with sham controls. The study links circSmad4 to cardiac fibroblast activation and cardiac fibrosis. GSE240332 1417 38046397 Circular RNA circSMAD4 regulates cardiac fibrosis by targeting miR-671-5p and FGFR2 in cardiac fibroblasts. circSMAD4 hsa_circ_SMAD4 SMAD4 Homo sapiens cardiac fibrosis MONDO:0005267 heart disorder DOID:114 primarily cultured human cardiac fibroblasts up-regulated circSMAD4 was increased in TGF-¦Â1-treated primarily cultured human cardiac fibroblasts. Functional assays in these fibroblasts showed circSMAD4 promotes myofibroblast activation and fibrosis-related phenotypes. 1418 38046397 Circular RNA circSMAD4 regulates cardiac fibrosis by targeting miR-671-5p and FGFR2 in cardiac fibroblasts. circBNC2 hsa_circ_BNC2 BNC2 Homo sapiens cardiac fibrosis MONDO:0005267 heart disorder DOID:114 human cardiac fibroblasts up-regulated circBNC2 was increased in TGF-¦Â1-treated human cardiac fibroblasts. Knockdown experiments did not support a role for circBNC2 in TGF-¦Â1-induced myofibroblast differentiation. 1419 38046397 Circular RNA circSMAD4 regulates cardiac fibrosis by targeting miR-671-5p and FGFR2 in cardiac fibroblasts. circNAV1 hsa_circ_NAV1 NAV1 Homo sapiens cardiac fibrosis MONDO:0005267 heart disorder DOID:114 human cardiac fibroblasts down-regulated circNAV1 was decreased in TGF-¦Â1-treated human cardiac fibroblasts. The authors ruled out circNAV1 for further mechanistic analysis because its direction was opposite to the in vivo TAC screening result. 1420 38046397 Circular RNA circSMAD4 regulates cardiac fibrosis by targeting miR-671-5p and FGFR2 in cardiac fibroblasts. circSmad4 mmu_circ_Smad4 Smad4 Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 cardiac fibroblasts up-regulated circSmad4 showed cardiac fibroblast-specific expression compared with cardiomyocytes in mouse heart-related experiments. This cell-type specificity supports the authors¡¯ focus on cardiac fibroblast-specific circRNAs in cardiac fibrosis. 1421 38053070 Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer? hsa_circ_0134036 hsa_circ_TAX1BP1 TAX1BP1 Homo sapiens Hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 CD133 positive (CD133_+) HCC cells up-regulated hsa_circ_0134036 was up-regulated in exosomes from sorted CD133+ liver cancer stem-like HCC cells compared with CD133- HCC cells. 1422 38053070 Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer? hsa_circ_0004907 circ-ZEB1 hsa_circ_ZEB1 ZEB1 Homo sapiens Hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 CD133 positive (CD133_+) HCC cells up-regulated circ-ZEB1 / hsa_circ_0004907 was up-regulated in exosomes from sorted CD133+ liver cancer stem-like HCC cells compared with CD133- HCC cells. The paper reports that circ-ZEB1 is associated with liver cancer stemness and EMT-related malignant transmission. 1423 38053070 Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer? hsa_circ_0001359 hsa_circ_PHC3 PHC3 Homo sapiens Hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 CD133 positive (CD133_+) HCC cells up-regulated hsa_circ_0001359 was up-regulated in exosomes from sorted CD133+ liver cancer stem-like HCC cells compared with CD133- HCC cells. 1424 38053070 Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer? hsa_circ_0069152 circ-AFAP1 hsa_circ_AFAP1 AFAP1 Homo sapiens Hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 CD133 positive (CD133_+) HCC cells up-regulated "circ-AFAP1 / hsa_circ_0069152 was up-regulated in exosomes from sorted CD133+ liver cancer stem-like HCC cells compared with CD133- HCC cells, and was also increased in CSV-positive and CD90-positive stem cells by real-time PCR. The study links circ-AFAP1 to liver cancer stemness, EMT, and CSC-to-non-CSC crosstalk." 1425 38053070 Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer? hsa_circ_0001495 hsa_circ_CCNB1 CCNB1 Homo sapiens Hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 CD133 positive (CD133_+) HCC cells up-regulated hsa_circ_0001495 was up-regulated in exosomes from sorted CD133+ liver cancer stem-like HCC cells compared with CD133- HCC cells. 1426 38070814 Functionally conserved PPARG exonic circRNAs enhance intramuscular fat deposition by regulating PPARG and HSL. circPPARG1 bbu_circ_PPARG PPARG Bubalus bubalis intramuscular fat deposition MONDO:0000001 disease DOID:4 buffalo intramuscular preadipocytes up-regulated circPPARG1 was up-regulated during adipogenic differentiation of primary buffalo intramuscular preadipocytes. Functional assays in the same cell type showed that circPPARGs enhanced adipogenesis and inhibited proliferation. 1427 38070814 Functionally conserved PPARG exonic circRNAs enhance intramuscular fat deposition by regulating PPARG and HSL. circPPARG2 bbu_circ_PPARG PPARG Bubalus bubalis intramuscular fat deposition MONDO:0000001 disease DOID:4 buffalo intramuscular preadipocytes up-regulated circPPARG2 was up-regulated during adipogenic differentiation of primary buffalo intramuscular preadipocytes. Functional assays in the same cell type showed that circPPARGs enhanced adipogenesis and inhibited proliferation. 1428 38070814 Functionally conserved PPARG exonic circRNAs enhance intramuscular fat deposition by regulating PPARG and HSL. circPPARG10 bbu_circ_PPARG PPARG Bubalus bubalis intramuscular fat deposition MONDO:0000001 disease DOID:4 buffalo intramuscular preadipocytes up-regulated circPPARG10 was up-regulated during adipogenic differentiation of primary buffalo intramuscular preadipocytes. Functional assays in the same cell type showed that circPPARGs enhanced adipogenesis and inhibited proliferation. 1429 38090284 CircRNA ARHGAP10 promotes osteogenic differentiation through the miR-335-3p/RUNX2 pathway in aortic valve calcification. hsa_circ_0008975 hsa_circ_ARHGAP10 ARHGAP10 Homo sapiens Calcific aortic valve disease MONDO:0005463 aortic valve calcification VICs up-regulated "In primary human valve interstitial cells, circARHGAP10 was enriched relative to vascular endothelial cells and control cell lines, supporting VIC-associated expression in the CAVD study context." 1430 38090284 CircRNA ARHGAP10 promotes osteogenic differentiation through the miR-335-3p/RUNX2 pathway in aortic valve calcification. hsa_circ_0007265 hsa_circ_ARHGAP10 ARHGAP10 Homo sapiens Calcific aortic valve disease MONDO:0005463 aortic valve calcification VICs up-regulated "In primary human valve interstitial cells cultured in osteogenic medium, circARHGAP10 expression increased steadily during osteogenic differentiation. Functional assays showed that circARHGAP10 promoted osteogenic differentiation through the miR-335-3p/RUNX2 pathway." 1431 38102848 Macrophages enhance cisplatin resistance in gastric cancer through the transfer of circTEX2. hsa_circ_0006479 hsa_circ_TEX2 TEX2 Homo sapiens gastric cancer MONDO:0001056 gastric cancer DOID:10534 human monocyte_derived M2 macrophages up-regulated circTEX2 was higher in human monocyte-derived M2 macrophages than in M1 macrophages generated from PBMCs of gastric cancer patients. M2 macrophage-derived exosomal circTEX2 promoted cisplatin resistance in gastric cancer cells. 1432 38105623 Circular RNA-circLRP6 protects cardiomyocyte from hypoxia-induced apoptosis by facilitating hnRNPM-mediated expression of FGF-9. circLRP6 2-2 rno_circ_LRP6 LRP6 Rattus norvegicus coronary heart disease MONDO:0005010 coronary artery disorder DOID:3393 primary cardiomyocytes up-regulated "circLRP6 2-2 was detected by qPCR in primary neonatal rat cardiomyocytes and cardiac fibroblasts, with higher abundance in cardiomyocytes than fibroblasts. The study links circLRP6 2-2 to cardiomyocyte protection in coronary heart disease-related ischemic injury." 1433 38125753 "Circular RNAs in intracranial aneurysms: Emerging roles in pathogenesis, diagnosis and therapeutic intervention." hsa_circ_0135895 circ_0135895 Homo sapiens multiple intracranial aneurysms MONDO:0005291 brain aneurysm DOID:10941 human peripheral blood mononuclear cells (PBMCs) up-regulated circ_0135895 was reported as up-regulated in human PBMCs in multiple intracranial aneurysms compared with controls based on circRNA sequencing. 1434 38125753 "Circular RNAs in intracranial aneurysms: Emerging roles in pathogenesis, diagnosis and therapeutic intervention." hsa_circ_0000682 circ_0000682 Homo sapiens multiple intracranial aneurysms MONDO:0005291 brain aneurysm DOID:10941 human peripheral blood mononuclear cells (PBMCs) down-regulated circ_0000682 was reported as down-regulated in human PBMCs in multiple intracranial aneurysms compared with controls based on circRNA sequencing. 1435 38125753 "Circular RNAs in intracranial aneurysms: Emerging roles in pathogenesis, diagnosis and therapeutic intervention." hsa_circ_0000690 circ_0000690 Homo sapiens multiple intracranial aneurysms MONDO:0005291 brain aneurysm DOID:10941 human peripheral blood mononuclear cells (PBMCs) down-regulated circ_0000690 was reported as down-regulated in human PBMCs in multiple intracranial aneurysms compared with controls based on circRNA sequencing. 1436 38129937 Circ_0008410 contributes to fibroblast-like synoviocytes dysfunction by regulating miR-149-5p/HIPK2 axis. hsa_circ_0008410 circ_0008410 hsa_circ_PGS1 PGS1 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RASFs up-regulated "circ_0008410 was up-regulated in rheumatoid arthritis fibroblast-like synoviocytes compared with normal fibroblast-like synoviocytes, based on qRT-PCR after primary cell isolation. Functional experiments in RASFs showed that circ_0008410 promoted proliferation, migration, invasion, and inflammation while inhibiting apoptosis." 1437 38141413 Hsa_circ_0105040 promotes Cutbacterium acnes biofilm induced inflammation via sponge miR-146a in human keratinocyte. hsa_circ_0105040 hsa_circ_FLNA FLNA Homo sapiens acne MONDO:0011438 acne DOID:6543 human primary keratinocytes unknown hsa_circ_0105040 was detected in human primary keratinocytes and shown by nuclear/cytoplasmic fractionation and FISH to be predominantly cytoplasmic. Functional experiments in human primary keratinocytes indicated that hsa_circ_0105040 promoted C. acnes biofilm-induced inflammatory responses. 1438 38154610 Citronellal can alleviate vascular endothelial dysfunction by reducing ectopic miR-133a expression. circRNA_102979 hsa_circ_RBCK1 RBCK1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 vascular endothelium up-regulated FISH localization in mouse common carotid artery showed that citronellal increased circRNA_102979 expression in vascular endothelium in a dose-dependent manner. 1439 38154610 Citronellal can alleviate vascular endothelial dysfunction by reducing ectopic miR-133a expression. circRNA_102979 hsa_circ_RBCK1 RBCK1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 vascular endothelium no change The study reported no significant difference in circRNA_102979 expression in vascular endothelium between high-fat diet and normal groups. 1440 38163571 Identification of circular RNA-Dcaf6 as a therapeutic target for optic nerve crush-induced RGC degeneration. mmu_circ_0008388 cDcaf6 mmu_circ_Dcaf6 Dcaf6 Mus musculus retinal neurodegeneration MONDO:0004580 retinal degeneration DOID:8466 primary RGCs up-regulated "In primary mouse retinal ganglion cells, H2O2-induced oxidative stress increased cDcaf6 expression by qRT-PCR. cDcaf6 silencing protected RGCs against oxidative stress-induced reduction of viability and apoptosis." 1441 38169845 Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis. mmu_circ_MEMO1 MEMO1 Mus musculus Obesity MONDO:0011122 obesity disorder DOID:9970 SPZ up-regulated Mmu circ-MEMO1 was among the selected spermatic circRNAs significantly up-regulated in HFD mouse spermatozoa compared with CTRL spermatozoa. 1442 38169845 Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis. mmu_circ_DNAH7 DNAH7 Mus musculus Obesity MONDO:0011122 obesity disorder DOID:9970 SPZ up-regulated Mmu circ-DNAH7 was among the selected spermatic circRNAs significantly up-regulated in HFD mouse spermatozoa compared with CTRL spermatozoa. 1443 38169845 Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis. mmu_circ_MAPT MAPT Mus musculus Obesity MONDO:0011122 obesity disorder DOID:9970 SPZ up-regulated Mmu circ-MAPT was among the selected spermatic circRNAs significantly up-regulated in HFD mouse spermatozoa compared with CTRL spermatozoa. 1444 38169845 Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis. mmu_circ_DNER DNER Mus musculus Obesity MONDO:0011122 obesity disorder DOID:9970 SPZ up-regulated Mmu circ-DNER was among the selected spermatic circRNAs significantly up-regulated in HFD mouse spermatozoa compared with CTRL spermatozoa. 1445 38169845 Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis. mmu_circ_CPSF6 CPSF6 Mus musculus Obesity MONDO:0011122 obesity disorder DOID:9970 SPZ up-regulated Mmu circ-CPSF6 was among the selected spermatic circRNAs significantly up-regulated in HFD mouse spermatozoa compared with CTRL spermatozoa. 1446 38169845 Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis. mmu_circ_PTPN11 PTPN11 Mus musculus Obesity MONDO:0011122 obesity disorder DOID:9970 SPZ up-regulated Mmu circ-PTPN11 was among the selected spermatic circRNAs significantly up-regulated in HFD mouse spermatozoa compared with CTRL spermatozoa. 1447 38169845 Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis. mmu_circ_ADAM10 ADAM10 Mus musculus Obesity MONDO:0011122 obesity disorder DOID:9970 SPZ up-regulated Mmu circ-ADAM10 was among the selected spermatic circRNAs significantly up-regulated in HFD mouse spermatozoa compared with CTRL spermatozoa. 1448 38169845 Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis. mmu_circ_RESP18 RESP18 Mus musculus Obesity MONDO:0011122 obesity disorder DOID:9970 SPZ up-regulated Mmu circ-RESP18 was among the selected spermatic circRNAs significantly up-regulated in HFD mouse spermatozoa compared with CTRL spermatozoa. 1449 38169845 Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis. mmu_circ_TULP4 TULP4 Mus musculus Obesity MONDO:0011122 obesity disorder DOID:9970 SPZ up-regulated Mmu circ-TULP4 was among the selected spermatic circRNAs significantly up-regulated in HFD mouse spermatozoa compared with CTRL spermatozoa. 1450 38172650 Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis. circPan3 rno_circ_Pan3 Pan3 Rattus norvegicus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocytes down-regulated circPan3 was downregulated in primary rat cardiomyocytes after ISO treatment used to induce cardiomyocyte hypertrophy. Functional experiments showed circPan3 protected cardiomyocytes from hypertrophy through the miR-320-3p/HSP20 pathway. 1451 38190869 circTldc1 increases Tldc1 expression by targeting miR-485-5p to promote fibroblast-like synoviocytes proliferation in collagen-induced arthritis. circTldc1 rno_circ_Tldc1 Tldc1 Rattus norvegicus rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 fibroblast-like synoviocytes (FLSs) up-regulated "circTldc1 was up-regulated in primary fibroblast-like synoviocytes from collagen-induced arthritis rats compared with control rat FLSs, based on circRNA sequencing and validation experiments. Functional experiments in FLSs showed that circTldc1 promoted FLS proliferation and inflammatory responses." 1452 38190869 circTldc1 increases Tldc1 expression by targeting miR-485-5p to promote fibroblast-like synoviocytes proliferation in collagen-induced arthritis. circHerpud2 rno_circ_Herpud2 Herpud2 Rattus norvegicus rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 fibroblast-like synoviocytes (FLSs) down-regulated "circHerpud2 was down-regulated in primary fibroblast-like synoviocytes from collagen-induced arthritis rats compared with control rat FLSs, with expression changes identified by circRNA sequencing and validated in FLSs." 1453 38192493 Expression Analysis of circRNAs in Human Adipogenesis. hsa_circ_0001600 hsa_circFKBP5_002 hsa_circ_FKBP5 FKBP5 Homo sapiens obesity MONDO:0011122 obesity disorder DOID:9970 adipocytes up-regulated hsa_circ_0001600 was validated by qPCR as up-regulated in human adipocytes compared with hADSCs after primary hADSC isolation and adipogenic differentiation. 1454 38192493 Expression Analysis of circRNAs in Human Adipogenesis. hsa_circ_0001974 hsa_circTKT_008 hsa_circ_TKT TKT Homo sapiens obesity MONDO:0011122 obesity disorder DOID:9970 adipocytes up-regulated hsa_circ_0001974 was validated by qPCR as up-regulated in human adipocytes compared with hADSCs after primary hADSC isolation and adipogenic differentiation. 1455 38193111 Circular RNA MAP2K2-modified immunosuppressive dendritic cells for preventing alloimmune rejection in organ transplantation. circMAP2K2 mmu_circ_MAP2K2 MAP2K2 Mus musculus alloimmune rejection MONDO:1010185 transplant rejection mature DCs up-regulated "In mouse bone marrow-derived dendritic cells, circMAP2K2 expression increases with DC maturation and is up-regulated in mature DCs compared with immature DCs. Knockdown of circMAP2K2 generates immunosuppressive DCs and attenuates alloimmune rejection in a mouse heart transplantation model." 1456 38203852 Specific Circular RNA Signature of Endothelial Cells: Potential Implications in Vascular Pathophysiology. circCARD6 hsa_circ_CARD6 CARD6 Homo sapiens others others others endothelial cells up-regulated "circCARD6 was identified as part of a four-circRNA signature common to multiple endothelial cell types and absent from non-endothelial controls, with RT-qPCR validation reported for selected circRNAs." SRR3192390; SRR3192391; SRR1959051; SRR1959052; SRR9163311; SRR9163312; SRR9163313; SRR9163314 1457 38203852 Specific Circular RNA Signature of Endothelial Cells: Potential Implications in Vascular Pathophysiology. circPLXNA2 hsa_circ_PLXNA2 PLXNA2 Homo sapiens others others others endothelial cells up-regulated "circPLXNA2 was identified as part of a four-circRNA signature common to multiple endothelial cell types and absent from non-endothelial controls, with RT-qPCR validation reported for selected circRNAs." SRR3192390; SRR3192391; SRR1959051; SRR1959052; SRR9163311; SRR9163312; SRR9163313; SRR9163314 1458 38203852 Specific Circular RNA Signature of Endothelial Cells: Potential Implications in Vascular Pathophysiology. circCASC15 hsa_circ_CASC15 CASC15 Homo sapiens others others others endothelial cells up-regulated "circCASC15 was identified as part of a four-circRNA signature common to multiple endothelial cell types and absent from non-endothelial controls, with RT-qPCR validation reported for selected circRNAs." SRR3192390; SRR3192391; SRR1959051; SRR1959052; SRR9163311; SRR9163312; SRR9163313; SRR9163314 1459 38203852 Specific Circular RNA Signature of Endothelial Cells: Potential Implications in Vascular Pathophysiology. circEPHB4 hsa_circ_EPHB4 EPHB4 Homo sapiens others others others endothelial cells up-regulated "circEPHB4 was identified as part of a four-circRNA signature common to multiple endothelial cell types and absent from non-endothelial controls, with RT-qPCR validation reported for selected circRNAs." SRR3192390; SRR3192391; SRR1959051; SRR1959052; SRR9163311; SRR9163312; SRR9163313; SRR9163314 1460 38203852 Specific Circular RNA Signature of Endothelial Cells: Potential Implications in Vascular Pathophysiology. hsa_circ_ZMYND8 ZMYND8 Homo sapiens others others others HUVECs up-regulated circZMYND8_A was detected specifically in HUVECs compared with other endothelial cells and was among the top 40% most expressed circRNAs in HUVECs. SRR1959051; SRR1959052 1461 38203852 Specific Circular RNA Signature of Endothelial Cells: Potential Implications in Vascular Pathophysiology. circPROX1 hsa_circ_PROX1 PROX1 Homo sapiens others others others HDLECs up-regulated "circPROX1 was identified in HDLECs as part of the HDLEC cell-type-specific circRNA set, while other endothelial cells did not express a circular isoform from PROX1." 1462 38203852 Specific Circular RNA Signature of Endothelial Cells: Potential Implications in Vascular Pathophysiology. circBMPR2 hsa_circ_BMPR2 BMPR2 Homo sapiens others others others HDLECs up-regulated circBMPR2 was reported in the HDLEC cell-type-specific circRNA gene set associated with endothelial cell differentiation pathway enrichment. 1463 38203852 Specific Circular RNA Signature of Endothelial Cells: Potential Implications in Vascular Pathophysiology. circSERPINE1 hsa_circ_SERPINE1 SERPINE1 Homo sapiens others others others HCAECs up-regulated circSERPINE1 was specifically detected in HCAECs among endothelial cells and was the fourth most highly expressed circRNA in HCAECs. SRR9163311; SRR9163312; SRR9163313; SRR9163314 1464 38205329 Circular RNAs: Potential biomarkers and therapeutic targets for autoimmune diseases. hsa_circ_0012919 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4+ T cells up-regulated hsa_circ_0012919 is up-regulated in CD4+ T cells from SLE patients compared with healthy control subjects. The review reports that hsa_circ_0012919 downregulation increased DNMT1 expression and that hsa_circ_0012919 regulates MDA5 via miR-125a-3p. 1465 38216551 Mutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death. circATXN7 hsa_circ_ATXN7 ATXN7 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 tumor-specific CTLs up-regulated circATXN7 expression is increased in tumor-specific CTLs from KRAS-mutant CRC compared with KRAS-wild-type CRC. Functional assays in tumor-specific CTLs link circATXN7 to increased AICD sensitivity. 1466 38216551 Mutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death. circATXN7 hsa_circ_ATXN7 ATXN7 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 CD8 cells up-regulated "circATXN7 is mainly detected in CD8+ tumor-specific CTLs among CRC tumor-infiltrating cell types, supported by sorted-cell RT-PCR/qRT-PCR and FISH co-localization with tumor-specific CTL markers." 1467 38216551 Mutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death. circATXN7 hsa_circ_ATXN7 ATXN7 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 tumor-specific CTLs up-regulated "In CRC samples, circATXN7 is mainly expressed in tumor-specific CTLs, and higher circATXN7 expression in pre-treatment biopsy samples is associated with poorer response to immune checkpoint inhibitors." 1468 38216964 "Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28." hsa_circ_0067557 circ_0067557 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 cancer-associated fibroblasts up-regulated circ_0067557 is up-regulated in exosomes derived from cancer-associated fibroblasts compared with normal fibroblasts in colorectal cancer. Functional experiments support that CAF-derived exosomal circ_0067557 promotes malignant phenotypes and chemoresistance of CRC cells. 1469 38219870 "The circUbqln1, regulated by XBP1s, interplays with 14-3-3¦Æ to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism." novel_circ_0000710 mmu_circ_Ubqln1 Ubqln1 Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary chondrocytes up-regulated "circUbqln1 was increased in the nucleus of primary chondrocytes from XBP1-specific knockout mice compared with control chondrocytes. Functional experiments in chondrocytes showed effects on proliferation, apoptosis, cartilage anabolism/catabolism, and PRODH-related proline metabolism." 1470 38219870 "The circUbqln1, regulated by XBP1s, interplays with 14-3-3¦Æ to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism." circUbqln1 mmu_circ_Ubqln1 Ubqln1 Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary chondrocytes up-regulated "circUbqln1 was upregulated in primary chondrocytes under IL-1¦Â-associated inflammatory conditions. The study links circUbqln1 to chondrocyte apoptosis, proliferation, and PRODH/proline metabolism." 1471 38226164 circGlis3 promotes ¦Â-cell dysfunction by binding to heterogeneous nuclear ribonucleoprotein F and encoding Glis3-348aa protein. mmu_circ_0000943 circGlis3 mmu_circ_Glis3 Glis3 Mus musculus type 2 diabetes mellitus MONDO:0005148 type 2 diabetes mellitus DOID:9352 ¦Â cells up-regulated "circGlis3 is up-regulated in lipotoxic ¦Â cells and associated with diabetic mouse islets. Functional experiments in ¦Â-cell systems indicate that circGlis3 overexpression impairs ¦Â-cell viability, proliferation and insulin secretion and increases apoptosis." 1472 38235556 Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice. CDR1as Mus musculus asthma MONDO:0004979 asthma DOID:2841 endothelial cells down-regulated "In an asthma-induced atherosclerosis mouse model, FISH/immunofluorescence-based cell-type analysis showed that CDR1as expression in endothelial cells was significantly reduced after CDR1as knockdown compared with asthma-scramble controls. This was associated with reduced ICAM-1 and VCAM-1 expression and alleviation of asthma-induced atherosclerosis." 1473 38243118 Circular RNA cVIM promotes hepatic stellate cell activation in liver fibrosis via miR-122-5p/miR-9-5p-mediated TGF-¦Â signaling cascade. mmu_circRNA_32994 mmu_circ_Vim Vim Mus musculus liver fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 primary HSCs up-regulated "cVIM/mmu_circRNA_32994 is up-regulated in primary hepatic stellate cells isolated from CCl4-induced fibrotic mouse livers. Functional experiments in primary HSCs support that cVIM promotes HSC proliferation, activation and collagen-associated fibrotic responses through the miR-122-5p/miR-9-5p-mediated TGF-¦Â pathway." 1474 38243118 Circular RNA cVIM promotes hepatic stellate cell activation in liver fibrosis via miR-122-5p/miR-9-5p-mediated TGF-¦Â signaling cascade. mmu_circRNA_32994 mmu_circ_Vim Vim Mus musculus liver fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 isolated primary hepatocytes up-regulated "cVIM is increased in isolated primary hepatocytes from CCl4-induced fibrotic mouse livers. Functional experiments in primary hepatocytes indicate that loss of cVIM affects hepatocyte proliferation, collagen expression and the TGF-¦Â/Smads pathway." 1475 38244519 Downregulation of circular RNA ETS1 promotes SLE activity and inhibits Treg cell differentiation through miR-1205/FoxP3 molecular axis. circETS1 hsa_circ_ETS1 ETS1 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4 + T cells down-regulated circETS1 was significantly down-regulated in CD4+ T cells from SLE patients compared with normal controls based on magnetic bead isolation followed by qRT-PCR. Functional experiments in CD4+ T cells showed that circETS1 overexpression promoted differentiation toward Treg cells through the miR-1205/FoxP3 axis. 1476 38260249 Regulation of neuronal circHomer1 biogenesis by PKA/CREB/ERK-mediated pathways and effects of glutamate and dopamine receptor blockade. circHomer1 mmu_circ_Homer1 Homer1 Mus musculus schizophrenia MONDO:0005090 schizophrenia DOID:5419 mouse primary cortical neurons up-regulated "In mouse primary cortical neurons, neuronal activity induced by Bic/4-AP increased circHomer1 expression measured by qRT-PCR. This cell-type-specific evidence is discussed in the context of schizophrenia-related neuronal signaling." 1477 38260249 Regulation of neuronal circHomer1 biogenesis by PKA/CREB/ERK-mediated pathways and effects of glutamate and dopamine receptor blockade. circHomer1 mmu_circ_Homer1 Homer1 Mus musculus schizophrenia MONDO:0005090 schizophrenia DOID:5419 mouse cortical neurons down-regulated "In mouse cortical neurons, NMDA receptor blockade with MK801 reduced circHomer1 expression measured by qRT-PCR. This neuronal regulation is presented in the context of schizophrenia-relevant glutamatergic signaling." 1478 38260249 Regulation of neuronal circHomer1 biogenesis by PKA/CREB/ERK-mediated pathways and effects of glutamate and dopamine receptor blockade. circHomer1 mmu_circ_Homer1 Homer1 Mus musculus bipolar disorder MONDO:0004985 bipolar disorder DOID:3312 mouse primary cortical neurons up-regulated "In mouse primary cortical neurons, neuronal activity induced by Bic/4-AP increased circHomer1 expression measured by qRT-PCR. This cell-type-specific evidence is discussed in the context of bipolar disorder-related neuronal signaling." 1479 38260249 Regulation of neuronal circHomer1 biogenesis by PKA/CREB/ERK-mediated pathways and effects of glutamate and dopamine receptor blockade. circHomer1 mmu_circ_Homer1 Homer1 Mus musculus bipolar disorder MONDO:0004985 bipolar disorder DOID:3312 mouse cortical neurons down-regulated "In mouse cortical neurons, NMDA receptor blockade with MK801 reduced circHomer1 expression measured by qRT-PCR. This neuronal regulation is presented in the context of bipolar disorder-relevant glutamatergic signaling." 1480 38279054 Circular RNA-Mediated Regulation of Oral Tissue-Derived Stem Cell Differentiation: Implications for Oral Medicine and Orthodontic Applications. hsa_circ_0087960 hsa_circ_LPAR1 LPAR1 Homo sapiens periodontal tissue regeneration MONDO:0002635 periodontal disorder DOID:3388 PDLSCs up-regulated "hsa_circ_0087960, also described as circRNA LPAR1, was increasingly expressed in PDLSCs after osteogenic induction and was confirmed by RT-qPCR." 1481 38279054 Circular RNA-Mediated Regulation of Oral Tissue-Derived Stem Cell Differentiation: Implications for Oral Medicine and Orthodontic Applications. circRNA1818 Homo sapiens orthodontic tooth movement MONDO:0000001 disease DOID:4 PDLSCs down-regulated "circRNA1818 was one of the downregulated circRNAs in PDLSCs exposed to mechanical forces, with RNA sequencing evidence and RT-qPCR validation." 1482 38279054 Circular RNA-Mediated Regulation of Oral Tissue-Derived Stem Cell Differentiation: Implications for Oral Medicine and Orthodontic Applications. circRNA1358 Homo sapiens orthodontic tooth movement MONDO:0000001 disease DOID:4 PDLSCs down-regulated "circRNA1358 was one of the downregulated circRNAs in PDLSCs exposed to mechanical forces, with RNA sequencing evidence and RT-qPCR validation." 1483 38282307 Circular RNA expression profile and functional analysis of circUvrag in light-induced photoreceptor degeneration. rno_circ_Uvrag Uvrag Rattus norvegicus light-induced photoreceptor degeneration MONDO:0004580 retinal degeneration DOID:8466 photoreceptor cells up-regulated "In rat light-induced photoreceptor degeneration, FISH showed circUvrag increased and enriched in the damaged ONL and localized mainly in the cytoplasm of photoreceptor cells. CircUvrag knockdown reduced photoreceptor apoptosis after light exposure." 1484 38287405 Circ-phkb promotes cell apoptosis and inflammation in LPS-induced alveolar macrophages via the TLR4/MyD88/NF-kB/CCL2 axis. rno_circ_Phkb Phkb Rattus norvegicus acute lung injury MONDO:0015796 acute lung injury alveolar macrophages up-regulated "circ-Phkb was up-regulated in alveolar macrophages isolated from LPS-induced ALI rats, verified by qRT-PCR. Functional experiments in rat alveolar macrophage NR8383 cells indicated that circ-Phkb promotes apoptosis and inflammatory factor release through the TLR4/MyD88/NF-kB/CCL2 axis." GSE226036 1485 38300888 Elevated expression of hsa_circ_0000479 in neutrophils correlates with features of systemic lupus erythematosus. hsa_circ_0000479 circEPSTI1 hsa_circ_EPSTI1 EPSTI1 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 neutrophils up-regulated "hsa_circ_0000479 is up-regulated in isolated peripheral blood neutrophils from SLE patients compared with healthy controls, based on qPCR after neutrophil isolation." 1486 38300888 Elevated expression of hsa_circ_0000479 in neutrophils correlates with features of systemic lupus erythematosus. hsa_circ_0000479 circEPSTI1 hsa_circ_EPSTI1 EPSTI1 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 neutrophils up-regulated "In SLE patients, hsa_circ_0000479 is expressed at higher levels in isolated peripheral blood neutrophils than in PBMCs, based on qPCR after cell isolation." 1487 38321980 Circ_0036490 and DKK1 competitively bind miR-29a to promote lipopolysaccharides-induced human gingival fibroblasts injury. hsa_circ_0036490 hsa_circ_MORF4L1 MORF4L1 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 HGFs up-regulated circ_0036490 was up-regulated in LPS-treated primary human gingival fibroblasts compared with untreated control HGFs. Functional experiments in HGFs indicated that circ_0036490 reversed miR-29a-mediated protection and promoted LPS-induced cell injury. 1488 38323094 A Novel Circular RNA circITGa9 Predominantly Generated in Human Heart Disease Induces Cardiac Remodeling and Fibrosis. hsa_circ_0030600 hsa_circ_ITGA9 ITGA9 Homo sapiens cardiac fibrosis MONDO:0005267 heart disorder DOID:114 cardiac fibroblasts up-regulated "FISH combined with immunofluorescence showed colocalization of delivered circITGa9 with cardiac fibroblasts. In primary isolated cardiac fibroblast cells, circITGa9 overexpression increased adhesion and migration and was associated with myofibroblast activation morphology." 1489 38348636 Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy. circ_lrrc49 mmu_circ_Lrrc49 Lrrc49 Mus musculus orofacial neuropathic pain MONDO:0021667 neuralgia neurons down-regulated circ_lrrc49 was downregulated in trigeminal ganglion after CCI-ION and RNA-FISH/IF showed its predominant localization in MAP2-positive neurons rather than GS-positive satellite glial cells. The study links reduced neuronal circ_lrrc49 in TG to impaired autophagy and orofacial neuropathic pain. PRJNA971771 1490 38388473 Fibroblast-like synoviocytes-derived exosomal circFTO deteriorates rheumatoid arthritis by enhancing N6-methyladenosine modification of SOX9 in chondrocytes. hsa_circ_0069492 Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs up-regulated "hsa_circ_0069492 was increased in exosomes derived from primary RA-FLSs compared with exosomes from healthy FLSs, based on RNA-seq and qRT-PCR validation." 1491 38388473 Fibroblast-like synoviocytes-derived exosomal circFTO deteriorates rheumatoid arthritis by enhancing N6-methyladenosine modification of SOX9 in chondrocytes. hsa_circ_0005941 circFTO hsa_circ_FTO FTO Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs up-regulated circFTO/hsa_circ_0005941 was increased in RA-FLSs and RA-FLS-derived exosomes compared with healthy FLSs/H-FLS-derived exosomes. The study further supports that RA-FLS-derived exosomal circFTO mediates effects on chondrocytes. 1492 38388473 Fibroblast-like synoviocytes-derived exosomal circFTO deteriorates rheumatoid arthritis by enhancing N6-methyladenosine modification of SOX9 in chondrocytes. hsa_circ_0001900 Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs down-regulated "hsa_circ_0001900 was decreased in exosomes derived from primary RA-FLSs compared with exosomes from healthy FLSs, based on RNA-seq and qRT-PCR validation." 1493 38388473 Fibroblast-like synoviocytes-derived exosomal circFTO deteriorates rheumatoid arthritis by enhancing N6-methyladenosine modification of SOX9 in chondrocytes. hsa_circ_0005941 circFTO hsa_circ_FTO FTO Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 chondrocytes up-regulated "Primary chondrocytes exposed to RA-FLS-derived exosomes showed increased circFTO levels. Exosomal circFTO inhibited chondrocyte proliferation and migration, promoted apoptosis, and altered chondrocyte metabolic balance through SOX9-related mechanisms." 1494 38412676 Hsa_circ_0036872 has an important promotional effect in enhancing osteogenesis of dental pulp stem cells by regulating the miR-143-3p/IGF2 axis. hsa_circ_0036872 hsa_circ_FURIN FURIN Homo sapiens others others others human dental pulp stem cells up-regulated "In isolated primary hDPSCs cultured under osteogenic induction, hsa_circ_0036872 was up-regulated compared with growth medium controls based on NGS and qRT-PCR. Functional experiments showed that hsa_circ_0036872 promoted osteogenic differentiation of hDPSCs through the miR-143-3p/IGF2 axis." 1495 38417635 mm9_circ_014683 regulates microglia polarization through canonical NF¦ÊB signaling pathway in diabetic retinopathy. mmu_circ_0000381 mm9_circ_014863 / mmu_circ_014863 mmu_circ_2700097O09Rik 2700097O09Rik Mus musculus diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 retinal microglia up-regulated "mm9_circ_014683 was up-regulated in isolated retinal microglia from diabetic retinopathy mice compared with control mice, supported by PCR and FISH assays. Inhibition of mm9_circ_014683 altered retinal microglial polarization in diabetic mice." SUB13453207 1496 38424136 circFAM193B interaction with PRMT6 regulates AML leukemia stem cells chemoresistance through altering the oxidative metabolism and lipid peroxidation. hsa_circ_0002972 circFAM193B hsa_circ_FAM193B FAM193B Homo sapiens acute myeloid leukemia MONDO:0018874 acute myeloid leukemia DOID:9119 CD34+CD38-LSCs down-regulated "Flow-sorted primary AML CD34+CD38- LSCs showed significantly lower circFAM193B expression than paired CD34+CD38+ leukemia cells, with validation by RT-qPCR. Functional experiments in sorted LSCs indicated that circFAM193B affects LSC chemoresistance, self-renewal/maintenance, metabolism and lipid peroxidation." 1497 38428311 Exosomal hsa_circ_0093884 derived from endothelial progenitor cells promotes therapeutic neovascularization via miR-145/SIRT1 pathway. hsa_circ_0093884 hsa_circ_SIRT1 SIRT1 Homo sapiens ischemic diseases MONDO:0005053 ischemic disease DOID:326 endothelial progenitor cells up-regulated hsa_circ_0093884 was detected in primary human endothelial progenitor cells and was most abundant/enriched in EPC-derived exosomes by RT-PCR/RT-qPCR. Functional experiments showed EPC-exosomal hsa_circ_0093884 promoted neovascularization through the miR-145/SIRT1 pathway. 1498 38434522 "Exploring the molecular biomarker utility of circCCT3 in multiple myeloma: A favorable prognostic indicator, particularly for R-ISS II patients." circCCT3 hsa_circ_CCT3 CCT3 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 CD138+ plasma cells up-regulated circCCT3 was quantified by nested real-time qPCR after CD138+ magnetic-bead enrichment of bone marrow plasma cells. Its intracellular expression was higher in CD138+ plasma cells from MM patients than from SMM patients. 1499 38438090 CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer. hsa_circ_0053441 hsa_circ_BIRC6 BIRC6 Homo sapiens gastric cancer MONDO:0001056 gastric cancer DOID:10534 cancer cells up-regulated "RNAscope analysis of gastric cancer tissue microarrays showed cytoplasmic circBIRC6 signal in cancer cells, with circBIRC6 considerably upregulated in gastric cancer tissues compared with benign gastric mucosa tissues." 1500 38449057 "Tetramethylpyrazine alleviates hypoxia-induced proliferation, migration, and inflammatory response of fibroblast-like synoviocytes via inhibiting the HIF-1¦Á- circCDC42BPB pathway." hsa_circ_0005178 circCDC42BPB hsa_circ_CDC42BPB CDC42BPB Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs up-regulated "In primary cultured RA-FLSs, circCDC42BPB was increased under hypoxic conditions based on RT-qPCR evidence." 1501 38449057 "Tetramethylpyrazine alleviates hypoxia-induced proliferation, migration, and inflammatory response of fibroblast-like synoviocytes via inhibiting the HIF-1¦Á- circCDC42BPB pathway." hsa_circ_0005178 circCDC42BPB hsa_circ_CDC42BPB CDC42BPB Homo sapiens Rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs down-regulated "In primary cultured hypoxic RA-FLSs, TMP treatment reduced circCDC42BPB expression measured by RT-qPCR. circCDC42BPB overexpression partly reversed TMP-mediated suppression of RA-FLS proliferation, migration, and inflammatory response." 1502 38458026 Circ_0001495 influences the development of endometriosis through the miRNA-34c-5p/E2F3 axis. hsa_circ_0001495 hsa_circ_CCNB1 CCNB1 Homo sapiens endometriosis MONDO:0005133 endometriosis DOID:289 ectopic endometrial stromal cells (EESCs) up-regulated "circ_0001495 was upregulated in primary ectopic endometrial stromal cells compared with normal endometrial stromal cells in endometriosis. Knockdown experiments in EESCs indicated roles in proliferation, migration, invasion, and apoptosis through the miR-34c-5p/E2F3 axis." 1503 38458967 Brucine alleviates fibroblast-like synoviocytes dysfunction and inflammation by regulating YY1 during rheumatoid arthritis. hsa_circ_0139658 circ_0139658 hsa_circ_LAMP2 LAMP2 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs up-regulated "Primary RA-FLSs isolated from rheumatoid arthritis patient synovial tissues showed higher circ_0139658 expression than normal FLSs by qRT-PCR. Functional experiments in RA-FLSs indicated that circ_0139658 silencing impaired proliferation, migration, invasion and inflammation." 1504 38458967 Brucine alleviates fibroblast-like synoviocytes dysfunction and inflammation by regulating YY1 during rheumatoid arthritis. hsa_circ_0139658 circ_0139658 hsa_circ_LAMP2 LAMP2 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs down-regulated "In isolated and cultured RA-FLSs, Brucine treatment decreased hsa_circ_0139658 expression by qRT-PCR. Circ_0139658 overexpression reversed the protective effects of Brucine on RA-FLS dysfunction and inflammation." 1505 38459511 circNOX4 activates an inflammatory fibroblast niche to promote tumor growth and metastasis in NSCLC via FAP/IL-6 axis. hsa_circ_0023988 hsa_circ_NOX4 NOX4 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 CAFs up-regulated "circNOX4 is up-regulated in primary CAFs compared with matched normal fibroblasts from human NSCLC samples. Functional experiments in fibroblasts support that circNOX4 promotes fibroblast activation and CAF-mediated NSCLC migration, invasion, tumor growth, and metastasis through the FAP/IL-6 axis." GSE244065 1506 38461272 Bladder-cancer-derived exosomal circRNA_0013936 promotes suppressive immunity by up-regulating fatty acid transporter protein 2 and down-regulating receptor-interacting protein kinase 3 in PMN-MDSCs. hsa_circ_0013936 Homo sapiens bladder cancer MONDO:0004986 urinary bladder carcinoma DOID:4007 PMN-MDSCs unknown "BCa-derived exosomal hsa_circ_0013936 was functionally detected in isolated PMN-MDSCs, where it associated with miR-320a and miR-301b-3p and regulated FATP2/RIPK3 pathways. The study supports an immunosuppressive role for circRNA_0013936 in PMN-MDSCs treated with bladder-cancer-derived exosomes." 1507 38467376 Phytic acid promotes high glucose-mediated bone marrow mesenchymal stem cells osteogenesis via modulating circEIF4B that sponges miR-186-5p and complexes with IGF2BP3. hsa_circ_0026506 circEIF4B hsa_circ_EIF4B EIF4B Homo sapiens diabetes-related hyperglycemia MONDO:0005015 diabetes mellitus DOID:9351 BMSCs up-regulated "In primary human jawbone-derived BMSCs under high-glucose culture, PA treatment increased circEIF4B expression compared with high glucose alone. Functional experiments indicated circEIF4B promoted osteogenic differentiation of BMSCs in the high-glucose microenvironment." 1508 38467376 Phytic acid promotes high glucose-mediated bone marrow mesenchymal stem cells osteogenesis via modulating circEIF4B that sponges miR-186-5p and complexes with IGF2BP3. hsa_circ_0026506 circEIF4B hsa_circ_EIF4B EIF4B Homo sapiens diabetes-related hyperglycemia MONDO:0005015 diabetes mellitus DOID:9351 BMSCs down-regulated "In primary human jawbone-derived BMSCs, circEIF4B expression was reduced under high-glucose culture compared with control conditions. The study links circEIF4B to osteogenic differentiation of BMSCs under diabetes-related high-glucose conditions." 1509 38470367 CircFOXO3 mediates hypoxia-induced autophagy of endometrial stromal cells in endometriosis. hsa_circ_0006404 hsa_circ_FOXO3 FOXO3 Homo sapiens endometriosis MONDO:0005133 endometriosis DOID:289 Primary human endometrial stromal cells (ESCs) down-regulated "In primary human endometrial stromal cells, hypoxia decreased circFOXO3 expression in a time-dependent manner by qRT-PCR-based analysis. The study links this decrease to hypoxia-associated autophagy in the context of endometriosis." 1510 38478029 CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice. mmu_circ_0008480 mmu_circ_AKT3 AKT3 Mus musculus postoperative cognitive dysfunction / POCD MONDO:0002602 central nervous system disorder DOID:331 hippocampal neurons down-regulated FISH evidence showed that circAKT3 is localized in hippocampal neuronal cytoplasm and is decreased in neurons of the hippocampal CA3 region in POCD mice. In vivo neuronal overexpression of circAKT3 reduced hippocampal neuronal apoptosis and alleviated POCD-related cognitive impairment. 1511 38497483 CircALMS1 Alleviates Pulmonary Microvascular Endothelial Cell Dysfunction in Pulmonary Hypertension. hsa_circ_ALMS1 ALMS1 Homo sapiens pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 pulmonary microvascular endothelial cells (PMECs) down-regulated "circALMS1 is reduced in human pulmonary microvascular endothelial cells under hypoxia compared with normoxia, supported by whole transcriptome sequencing and qRT-PCR. FISH co-localization with CD31 further supports circALMS1 expression in endothelial cells in PH lung tissue." 1512 38505381 Circular RNA hsa_circ_0051246 acts as a microRNA-375 sponge to promote the progression of gastric cancer stem cells via YAP1. hsa_circ_0051246 circ_0051246 Homo sapiens gastric cancer MONDO:0001056 gastric cancer DOID:10534 SGC-7901 CSCs (CD44+ EpCAM+ cells) up-regulated "circ_0051246 was overexpressed in sorted CD44+ EpCAM+ SGC-7901 gastric cancer stem cells compared with SGC-7901 cells, based on cell sorting followed by qRT-PCR. Functional experiments in these CSCs showed that circ_0051246 promoted proliferation, self-renewal, migration and invasion and inhibited apoptosis." 1513 38509870 Hypoxic Exosomal circPLEKHM1-Mediated Crosstalk between Tumor Cells and Macrophages Drives Lung Cancer Metastasis. circPLEKHM1 hsa_circ_PLEKHM1 PLEKHM1 Homo sapiens lung cancer MONDO:0008903 lung cancer DOID:1324 tumor_infiltrated M2 macrophages up-regulated circPLEKHM1 expression was higher in tumor-infiltrated M2 macrophages than in M1 macrophages isolated from lung cancer metastases in a mouse model. The study links this circPLEKHM1/PABPC1/eIF4G complex to OSMR translation and M2 macrophage polarization during lung cancer metastasis. 1514 38520084 Circular RNA Gtdc1 Protects Against Offspring Osteoarthritis Induced by Prenatal Prednisone Exposure by Regulating SRSF1-Fn1 Signaling. rno_circ_Gtdc1 Gtdc1 Rattus norvegicus PPE-induced chondrodysplasia MONDO:0022723 chondrodysplasia fetal rat primary chondrocytes down-regulated "In primary fetal rat chondrocytes, prednisolone treatment reduced circGtdc1 expression in a concentration-dependent manner by RT-qPCR. circGtdc1 overexpression reversed prednisolone-induced inhibition of chondrocyte proliferation and matrix synthesis." 1515 38533181 Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization. hsa_circ_0007909 circATXN1 hsa_circ_ATXN1 ATXN1 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 aging human nucleus pulposus cells (hNPCs) up-regulated "circATXN1 was increased in aging primary human nucleus pulposus cells compared with young hNPCs, supported by circRNA RNA-seq and RT-qPCR validation. Functional experiments in hNPCs showed that circATXN1 promotes senescence, ECM disruption, and impaired mitochondrial respiration." unclear 1516 38533181 Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization. hsa_circ_0007909 circATXN1 hsa_circ_ATXN1 ATXN1 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 aging hNPCs down-regulated "In aging hNPCs, SDTET nanogel-mediated siRNA treatment reduced circATXN1 expression as measured by RT-qPCR. This circATXN1 silencing was associated with reduced senescence features and improved mitochondrial function in aging hNPCs." 1517 38540291 Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus. hsa_circ_0006404 hsa_circ_FOXO3 FOXO3 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 nucleus pulposus cells (NPCs) up-regulated "In primary cultured human nucleus pulposus cells, circFOXO3 was up-regulated after TBHP-induced oxidative stress/oxeiptosis. Knockdown of circFOXO3 attenuated TBHP-induced oxeiptosis-related changes in NPCs." 1518 38570000 Super enhancer-associated circRNA-circLrch3 regulates hypoxia-induced pulmonary arterial smooth muscle cells pyroptosis by formation of R-loop with host gene. circLrch3 mmu_circ_Lrch3 Lrch3 Mus musculus pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 pulmonary arterial smooth muscle cells; PASMCs up-regulated circLrch3 is up-regulated in hypoxic pulmonary arterial smooth muscle cells in the context of pulmonary hypertension. Functional experiments showed that circLrch3 knockdown mitigated hypoxia-induced PASMC pyroptosis. 1519 38571815 Biomarker potential of competing endogenous RNA networks in Polycystic Ovary Syndrome (PCOS). hsa_circ_0023942 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 PCOS OGCs down-regulated "circ_0023942 expression is decreased in ovarian granulosa cells from PCOS compared with normal controls, with RT-qPCR evidence summarized for GCs." 1520 38572093 Engagement of N6-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2. mmu_circ_0000041 circHECW2 mmu_circ_HECW2 HECW2 Mus musculus major depressive disorder MONDO:0002009 major depressive disorder DOID:1470 astrocytes up-regulated "In the CUS mouse model of depression, circHECW2 was upregulated in sorted astrocytes compared with microglia, neurons, and endothelial cells, and FISH with GFAP immunostaining supported its accumulation in astrocytes. The study further linked astrocytic circHECW2 upregulation to astrocyte dysfunction in depression." 1521 38575112 Functional role of circRNA CHRC through miR-431-5p/KLF15 signaling axis in the progression of heart failure. circ_0014834 mmu_circ_Sorbs2 Sorbs2 Mus musculus heart failure MONDO:0005252 heart failure primary mouse cardiomyocytes down-regulated "circRNA CHRC was down-regulated in Ang-II-induced primary mouse cardiomyocytes, as detected by qPCR. Functional experiments in pmCMs showed that CHRC knockdown promoted hypertrophic phenotypes, while CHRC overexpression attenuated Ang-II-induced cardiomyocyte hypertrophy." 1522 38580662 Statins improve cardiac endothelial function to prevent heart failure with preserved ejection fraction through upregulating circRNA-RBCK1. hsa_circ_0059151 hsa_circRNA_102979 hsa_circ_RBCK1 RBCK1 Homo sapiens heart failure MONDO:0005252 heart failure endocardium up-regulated "In HFpEF mouse hearts, lovastatin increased circRNA-RBCK1 expression in the endocardium, with FISH signal shown together with the endothelial marker vWF." 1523 38580662 Statins improve cardiac endothelial function to prevent heart failure with preserved ejection fraction through upregulating circRNA-RBCK1. mm9_circ_003522 mmu_circ_Rbck1 Rbck1 Mus musculus heart failure MONDO:0005252 heart failure MCECs isolated from HFpEF mice up-regulated "In myocardial capillary endothelial cells isolated from HFpEF mice, lovastatin dramatically upregulated circRNA-RBCK1 expression. This upregulation was abolished when AP-2¦Á or circRNA-RBCK1 was deficient." 1524 38587436 Role of Hsa_circ_0000880 in the Regulation of High Glucose-Induced Apoptosis of Retinal Microvascular Endothelial Cells. hsa_circ_0000880 Homo sapiens diabetic retinopathy MONDO:0005266 diabetic retinopathy DOID:8947 retinal microvascular endothelial cells (RMECs) up-regulated "hsa_circ_0000880 was up-regulated in primary human retinal microvascular endothelial cells treated with high glucose compared with normal glucose. Silencing hsa_circ_0000880 affected RMEC viability, migration, tube formation, ROS production, and apoptosis under high-glucose conditions." 1525 38600344 Circular RNA-GRIN2B Suppresses Neuropathic Pain by Targeting the NF-¦ÊB/SLICK Pathway. Rno_circ_011726 rno_circ_GRIN2B GRIN2B Rattus norvegicus neuropathic pain MONDO:0021667 neuralgia DRG neurons up-regulated "circGRIN2B was up-regulated in primary cultured DRG neurons after IL-1¦Â stimulation compared with control neurons, as measured by RT-qPCR. In situ hybridization also showed cytoplasmic circGRIN2B expression in DRG neurons, with circGRIN2B-labeled neurons positive for CGRP." 1526 38638425 Altered circular RNA expressions in extracellular vesicles from bronchoalveolar lavage fluids in mice after bacterial infections. circ006620 Mus musculus lung inflammation MONDO:0043905 pneumonitis alveolar macrophages (AMs) dys-regulated "circ006620 showed differential expression between isolated alveolar macrophages and neutrophils from LPS-exposed mouse lung, measured by RT-qPCR." 1527 38638425 Altered circular RNA expressions in extracellular vesicles from bronchoalveolar lavage fluids in mice after bacterial infections. circ006620 Mus musculus lung inflammation MONDO:0043905 pneumonitis neutrophils dys-regulated "circ006620 showed differential expression between isolated neutrophils and alveolar macrophages from LPS-exposed mouse lung, measured by RT-qPCR." 1528 38638425 Altered circular RNA expressions in extracellular vesicles from bronchoalveolar lavage fluids in mice after bacterial infections. circ25900 Mus musculus lung inflammation MONDO:0043905 pneumonitis alveolar macrophages (AMs) dys-regulated "circ25900 showed differential expression between isolated alveolar macrophages and neutrophils from LPS-exposed mouse lung, measured by RT-qPCR." 1529 38638425 Altered circular RNA expressions in extracellular vesicles from bronchoalveolar lavage fluids in mice after bacterial infections. circ25900 Mus musculus lung inflammation MONDO:0043905 pneumonitis neutrophils dys-regulated "circ25900 showed differential expression between isolated neutrophils and alveolar macrophages from LPS-exposed mouse lung, measured by RT-qPCR." 1530 38649946 CircPRKD3/miR-6783-3p responds to mechanical force to facilitate the osteogenesis of stretched periodontal ligament stem cells. hsa_circ_0000992 circPRKD3 hsa_circ_PRKD3 PRKD3 Homo sapiens others others others periodontal ligament stem cells (PDLSCs) up-regulated "In primary cultured periodontal ligament stem cells, circPRKD3 expression was increased after mechanical stretch compared with non-stretched controls. Functional experiments in mechanically stimulated PDLSCs indicated that circPRKD3 promoted osteogenic differentiation." 1531 38691277 "Circular RNA KIAA0564 Serves as a Competitive Endogenous RNA for MicroRNA-424-5p, Mediating the Expression of Lysine Demethylase 4a, Thereby Facilitating Intervertebral Disc Degeneration." hsa_circ_0030120 CircKIAA0564 hsa_circ_KIAA0564 KIAA0564 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 NP cells up-regulated "CircKIAA0564 is up-regulated in primary human NP cells after IL-1¦Â treatment, an in vitro IDD model. Functional experiments in NP cells indicate that circKIAA0564 knockdown mitigates IL-1¦Â-induced inflammation, apoptosis, oxidative stress, and ECM degradation." 1532 38724419 Exploring the prognostic value of circular RNAs in pancreatic ductal adenocarcinoma using genome-wide expression profiling. hsa_circ_0001946 ciRS-7 / CDR1as hsa_circ_CDR1-AS CDR1-AS Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 PDAC cancer cells down-regulated CISH followed by digital imaging analysis showed ciRS-7 was absent in PDAC cancer cells while enriched in stromal cells within the tumor microenvironment. 1533 38724419 Exploring the prognostic value of circular RNAs in pancreatic ductal adenocarcinoma using genome-wide expression profiling. hsa_circ_0001946 ciRS-7 / CDR1as hsa_circ_CDR1-AS CDR1-AS Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 stromal cells within the tumor microenvironment up-regulated CISH followed by digital imaging analysis showed ciRS-7 was highly expressed in stromal cells within the PDAC tumor microenvironment and absent in PDAC cancer cells. 1534 38724502 circCDK13-loaded small extracellular vesicles accelerate healing in preclinical diabetic wound models. hsa_circ_0079929 circCDK13 hsa_circ_CDK13 CDK13 Homo sapiens diabetic wounds MONDO:0005015 diabetes mellitus DOID:9351 human dermal fibroblasts (HDFs) down-regulated "circCDK13 was downregulated in AGE-BSA-treated human dermal fibroblasts, an in vitro diabetic wound-related condition. Functional experiments showed circCDK13 promoted proliferation and migration of HDFs." 1535 38724502 circCDK13-loaded small extracellular vesicles accelerate healing in preclinical diabetic wound models. hsa_circ_0079929 circCDK13 hsa_circ_CDK13 CDK13 Homo sapiens diabetic wounds MONDO:0005015 diabetes mellitus DOID:9351 human epidermal keratinocytes (HEKs) down-regulated "circCDK13 was downregulated in AGE-BSA-treated human epidermal keratinocytes, an in vitro diabetic wound-related condition. Functional experiments showed circCDK13 promoted proliferation and migration of HEKs." 1536 38727863 CircCOX6A1 suppresses osteogenic differentiation and aggravates osteoporosis via miR-512-3p/DYRK2 axis. mmu_circ_COX6A1 COX6A1 Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 BMSCs down-regulated "In primary mouse BMSCs undergoing osteogenic differentiation, circCOX6A1 expression was significantly down-regulated from day 7 and continued to decrease with longer osteogenic stimulation. Functional experiments in BMSCs indicated that circCOX6A1 suppresses osteogenic differentiation through the miR-512-3p/DYRK2 axis." 1537 38754565 Whole-transcriptome sequencing of phagocytes reveals a ceRNA network contributing to natural resistance to tuberculosis infection. hsa_circ_XXbac-BPG248L24 XXbac-BPG248L24 Homo sapiens tuberculosis MONDO:0018076 tuberculosis DOID:399 phagocytes up-regulated hsa-XXbac-BPG248L24_0001 was up-regulated in sorted BCG-phagocytosing phagocytes from Resisters compared with LTBI patients based on whole-transcriptome sequencing. PRJNA963069 1538 38754565 Whole-transcriptome sequencing of phagocytes reveals a ceRNA network contributing to natural resistance to tuberculosis infection. hsa-LILRB1_0011 hsa_circ_LILRB1 LILRB1 Homo sapiens tuberculosis MONDO:0018076 tuberculosis DOID:399 phagocytes down-regulated hsa-LILRB1_0011 was down-regulated in sorted BCG-phagocytosing phagocytes from Resisters compared with LTBI patients based on whole-transcriptome sequencing. PRJNA963069 1539 38754565 Whole-transcriptome sequencing of phagocytes reveals a ceRNA network contributing to natural resistance to tuberculosis infection. hsa-ATAD3A_0003 hsa_circ_ATAD3A ATAD3A Homo sapiens tuberculosis MONDO:0018076 tuberculosis DOID:399 phagocytes dys-regulated hsa-ATAD3A_0003 was identified in the circRNA-miRNA-mRNA network from sorted BCG-phagocytosing phagocytes and showed significantly different expression between Resisters and LTBI patients. The paper suggests the hsa-ATAD3A_0003-CYP17A1 association may contribute to resistance to TB infection through immune metabolism-related ceRNA mechanisms. PRJNA963069 1540 38755265 M2 macrophage-derived exosomal circTMCO3 acts through miR-515-5p and ITGA8 to enhance malignancy in ovarian cancer. hsa_circ_0000772 Homo sapiens ovarian cancer MONDO:0008170 ovarian cancer DOID:2394 TAMs up-regulated hsa_circ_0000772 was upregulated in tumor-associated macrophages isolated from ovarian cancer tissues compared with normal tissue macrophages. 1541 38755265 M2 macrophage-derived exosomal circTMCO3 acts through miR-515-5p and ITGA8 to enhance malignancy in ovarian cancer. hsa_circ_0084335 Homo sapiens ovarian cancer MONDO:0008170 ovarian cancer DOID:2394 TAMs up-regulated hsa_circ_0084335 was upregulated in tumor-associated macrophages isolated from ovarian cancer tissues compared with normal tissue macrophages. 1542 38755265 M2 macrophage-derived exosomal circTMCO3 acts through miR-515-5p and ITGA8 to enhance malignancy in ovarian cancer. hsa_circ_0031017 circTMCO3 hsa_circ_TMCO3 TMCO3 Homo sapiens ovarian cancer MONDO:0008170 ovarian cancer DOID:2394 TAMs up-regulated "hsa_circ_0031017 / circTMCO3 was upregulated in tumor-associated macrophages isolated from ovarian cancer tissues compared with normal tissue macrophages. M2 macrophage-derived exosomal circTMCO3 promoted ovarian cancer cell proliferation, migration, and invasion through the miR-515-5p/ITGA8 axis." 1543 38755265 M2 macrophage-derived exosomal circTMCO3 acts through miR-515-5p and ITGA8 to enhance malignancy in ovarian cancer. hsa_circ_0091577 Homo sapiens ovarian cancer MONDO:0008170 ovarian cancer DOID:2394 TAMs up-regulated hsa_circ_0091577 was upregulated in tumor-associated macrophages isolated from ovarian cancer tissues compared with normal tissue macrophages. 1544 38760544 CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/¦Â-catenin signaling pathway. circ-0000465 mmu_circ_NSD1 NSD1 Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 primary cultured mouse cardiac fibroblasts up-regulated "circNSD1 was up-regulated in TGF-¦Â1-induced primary mouse cardiac fibroblasts, an in vitro cardiac fibrogenesis model. Functional experiments in CFs showed circNSD1 promoted fibrotic marker expression and proliferation." 1545 38760544 CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/¦Â-catenin signaling pathway. circ-0000465 mmu_circ_NSD1 NSD1 Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 CFs up-regulated circNSD1 was more abundant in mouse cardiac fibroblasts than in cardiomyocytes by qRT-PCR. Functional experiments in CFs showed circNSD1 promoted fibrotic marker expression and proliferation. 1546 38787942 A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli. circTulp4 mmu_circ_Tulp4 Tulp4 Mus musculus others others others primary forebrain neuronal cultures up-regulated "circTulp4 shows increased circular-to-linear predominance during maturation of primary mouse forebrain neuronal cultures, measured by RT-qPCR. Functional experiments in neurons indicate that circTulp4 regulates excitatory synaptic transmission." 1547 38787942 A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli. circTulp4 mmu_circ_Tulp4 Tulp4 Mus musculus others others others primary neuronal and astrocytic cultures up-regulated Primary neuronal and astrocytic culture qRT-PCR showed that circTulp4 circular-to-linear predominance is present in neurons but not astrocytes. The cultures were characterized using neuronal and glial markers. 1548 38795544 circMIRIAF aggravates myocardial ischemia-reperfusion injury via targeting miR-544/WDR12 axis. mmu_circ_0011688 mmu_circ_RAD23B RAD23B Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury mouse primary cardiomyocytes up-regulated circMIRIAF/mmu_circ_0011688 was increased in isolated mouse primary cardiomyocytes under H/RI conditions. The study links circMIRIAF to oxidative stress and inflammation in MI/RI through the miR-544/WDR12/Notch1 axis. 1549 38798702 Research progress of circRNA as a biomarker of osteoporosis. hsa_circ_0021739 circle_0021739 Homo sapiens postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis PBMC up-regulated circle_0021739 was significantly increased in PBMCs from postmenopausal osteoporosis patients and was assessed by chip sequencing and qPCR. The review also reports that circle_0021739 can target miR-502-5p to regulate osteoclastogenesis. 1550 38802299 circMTO1/miR-30c-5p/SOCS3 axis alleviates oral submucous fibrosis through inhibiting fibroblast-myofibroblast transition. circMTO1 hsa_circ_MTO1 MTO1 Homo sapiens oral submucous fibrosis MONDO:0018166 oral submucous fibrosis DOID:5773 buccal mucosal fibroblasts (BMFs) down-regulated "circMTO1 expression was decreased in arecoline-stimulated buccal mucosal fibroblasts derived from OSF tissues. circMTO1 overexpression restrained arecoline-induced migration, invasion, and fibroblast-myofibroblast transition in BMFs." 1551 38805063 CircZFR promotes colorectal cancer progression via stabilizing BCLAF1 and regulating the miR-3127-5p/RTKN2 axis. hsa_circ_0072088 circZFR hsa_circ_ZFR ZFR Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 primary CAFs and paired normal fibroblasts (NFs) no change "After isolation of primary cancer-associated fibroblasts and paired normal fibroblasts from CRC patient tissues, circZFR levels showed no significant difference between CAFs and NFs." 1552 38828010 CircRNA SEC24A promotes osteoarthritis through miR-107-5p/CASP3 axis. hsa_circ_0073966 circSEC24A hsa_circ_SEC24A SEC24A Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary chondrocytes up-regulated "circSEC24A was up-regulated in IL-1¦Â-stimulated human primary chondrocytes, an in vitro osteoarthritis model, based on qRT-PCR after primary chondrocyte isolation. Functional experiments in chondrocytes showed that circSEC24A knockdown promoted proliferation and suppressed apoptosis, ECM degradation, and inflammation." 1553 38828320 Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes in vitro endothelial cell angiogenesis by regulating the miR-140-3p/HIF-1¦Á/VEGF signaling axis. hsa_circ_0084043 circ_0084043 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 endothelial cells up-regulated "circ_0084043 was increased in endothelial cells after treatment with colorectal CAF-derived exosomes, and the authors concluded that this reflected exosomal transfer from CAFs to endothelial cells. Functional assays showed that circ_0084043 contributed to CAF exosome-induced endothelial proliferation, migration, and angiogenesis." 1554 38840551 Exposure of benzo[a]pyrene induces HCC exosome-circular RNA to activate lung fibroblasts and trigger organotropic metastasis. hsa_circ_0011496 hsa_circ_CSMD2 CSMD2 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 vimentin_positive fibroblasts up-regulated "In an exosome-educated mouse lung model of HCC metastasis, ISH for circ_0011496 combined with vimentin IHC showed circ_0011496 signal in vimentin-positive fibroblasts. The study links exosomal circ_0011496 delivery to fibroblast activation and pre-metastatic niche formation." 1555 38842177 Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-¦ÊB. circPVT1 hsa_circ_PVT1 PVT1 Homo sapiens age-dependent tendon diseases others others late-TSPCs (L-TSPCs) up-regulated "In primary human late-passage tendon stem/progenitor cells, circPVT1 levels were markedly increased after incubation with circPVT1-overexpressing TSPC-derived exosomes compared with NC-exo. circPVT1-exo improved proliferation, reduced senescence, and supported tenogenic differentiation in L-TSPCs." 1556 38904677 CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation. hsa_circ_HIPK3 HIPK3 Homo sapiens early-onset preeclampsia MONDO:0005041 glaucoma DOID:1686 primary human umbilical vein ECs (HUVECs) down-regulated "In primary HUVECs used as endothelial cells, qRT-PCR showed circHIPK3 downregulation after sh-circHIPK3 treatment. circHIPK3 knockdown decreased FAO activity, endothelial cell proliferation, and tube formation in the EOPE-related angiogenesis model." 1557 38907258 Platelet-derived circFAM13B associated with anti-platelet responsiveness of ticagrelor in patients with acute coronary syndrome. hsa_circ_0001535 hsa_circ_FAM13B FAM13B Homo sapiens acute coronary syndrome MONDO:0005542 acute coronary syndrome platelets up-regulated "In isolated platelets from ticagrelor-treated ACS patients, circFAM13B expression was higher in patients with ADP% < 76%, a group defined as high on-treatment platelet reactivity under ticagrelor treatment." 1558 38918838 M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis. hsa_circ_0043949 circBRCA1 hsa_circ_BRCA1 BRCA1 Homo sapiens Premature ovarian insufficiency MONDO:0005387 primary ovarian failure DOID:5426 ovarian granulosa cells (GCs) down-regulated "circBRCA1/hsa_circ_0043949 is down-regulated in ovarian granulosa cells from patients with POI compared with granulosa cells from women with normal ovarian reserve function, as measured by RT-qPCR. The study further links exosomal circBRCA1 to protection from oxidative stress-related granulosa cell mitochondrial dysfunction through the miR-642a-5p/FOXO1 axis." GSE97193 1559 38927017 CircInpp5b Ameliorates Renal Interstitial Fibrosis by Promoting the Lysosomal Degradation of DDX1. circInpp5b mmu_circ_Inpp5b Inpp5b Mus musculus renal interstitial fibrosis MONDO:0000494 renal fibrosis DOID:0050855 renal tubular epithelial cells up-regulated FISH showed that circInpp5b was mainly expressed in renal tubular epithelial cells of mouse kidney tissues in the renal interstitial fibrosis study. 1560 38936057 Identification of novel biomarker hsa_circ_0003914 for rheumatoid arthritis from plasma exosomes. hsa_circ_0003914 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 FLSs down-regulated "Primary RA patient-derived FLSs were transfected with siR-hsa_circ_0003914, resulting in knockdown of hsa_circ_0003914 in FLSs. Knockdown was associated with reduced FLS proliferation, migration, invasion and inflammatory cytokine secretion through NF-¦ÊB/p65 signaling." 1561 38936066 circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization. hsa_circ_0072688 circ_0072688 hsa_circ_ADAMTS6 ADAMTS6 Homo sapiens smoking-related emphysema MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 macrophages up-regulated "circADAMTS6 is up-regulated in CSE-treated macrophages, including primary BMDMs, in a concentration-dependent manner. Functional experiments indicate that circADAMTS6 participates in CSE-induced M2 macrophage polarization and proteinase/anti-proteinase imbalance." 1562 38936066 circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization. mmu_circ_Adamts6 Adamts6 Mus musculus smoking-related emphysema MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 macrophages up-regulated "circADAMTS6 is up-regulated in CSE-treated macrophages, including primary BMDMs, in a concentration-dependent manner. Functional experiments indicate that circADAMTS6 participates in CSE-induced M2 macrophage polarization and proteinase/anti-proteinase imbalance." 1563 38936066 circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization. hsa_circ_0072688 circ_0072688 hsa_circ_ADAMTS6 ADAMTS6 Homo sapiens smoking-related emphysema MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 CD68 + macrophages up-regulated "FISH combined with immunofluorescence showed elevated circADAMTS6 expression in lung tissues of smokers and COPD smokers, with circADAMTS6 mainly localized in CD68+ macrophages." 1564 38945954 Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions. hsa_circ_0000284 circHIPK3 hsa_circ_HIPK3 HIPK3 Homo sapiens Calcific aortic valve disease MONDO:0005463 aortic valve calcification aortic valve interstitial cells (AVICs) unknown "In primary human aortic valve interstitial cells, qRT-PCR after nuclear/cytoplasmic fractionation and FISH showed that circHIPK3 is primarily cytoplasmic. Functional experiments in AVICs indicated that circHIPK3 inhibited the osteogenic response." 1565 38963941 Circular RNA circPHF16 enhances IL-17A expression and secretion by sequestering miR-378a-3p to activate the IL6ST axis in Graves' disease. mmu_circ_0001581 circPHF16 mmu_circ_PHF16 PHF16 Mus musculus Graves' disease MONDO:0005364 Graves disease DOID:12361 splenic CD4 + T lymphocytes up-regulated circPHF16 was significantly upregulated in isolated splenic CD4+ T lymphocytes from Graves' disease model mice compared with control mice. The evidence was based on isolated mouse CD4+ T lymphocytes followed by gene expression analysis. 1566 38977695 CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation. mmu_circ_0011319 circCDC42 mmu_circ_CDC42 CDC42 Mus musculus Klebsiella pneumoniae infection MONDO:0030602 Klebsiella pneumonia DOID:13272 alveolar macrophages up-regulated circCDC42/mmu_circ_0011319 is increased in KP-infected murine alveolar macrophages and localizes to AMs by FISH with the AM marker SiglcF. Its encoded CDC42-165aa promotes Pyrin inflammasome-mediated macrophage pyroptosis and inflammatory responses. PRJNA984001 1567 38977695 CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation. mmu_circ_0011319 circCDC42 mmu_circ_CDC42 CDC42 Mus musculus Klebsiella pneumoniae infection MONDO:0030602 Klebsiella pneumonia DOID:13272 AMs up-regulated "circCDC42/mmu_circ_0011319 is mainly expressed in alveolar macrophages compared with neutrophils, T cells, and NK cells, especially after KP infection. FISH with SiglcF supports localization of circCDC42 in AMs." PRJNA984001 1568 38993677 CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1. hsa_circ_0003973 circSMAD3 hsa_circ_SMAD3 SMAD3 Homo sapiens heart failure MONDO:0005252 heart failure cardiomyocytes down-regulated "circSMAD3 was downregulated in cardiomyocytes isolated from TAC mouse hearts compared with control hearts, and immunofluorescence with cardiomyocyte marker TnT further supported cell-type localization." 1569 38993677 CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1. hsa_circ_0003973 circSMAD3 hsa_circ_SMAD3 SMAD3 Homo sapiens heart failure MONDO:0005252 heart failure cardiac fibroblasts down-regulated "circSMAD3 was downregulated in cardiac fibroblasts isolated from TAC mouse hearts compared with control hearts, and immunofluorescence with fibroblast marker Vimentin further supported cell-type localization." 1570 38993677 CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1. hsa_circ_0003973 circSMAD3 hsa_circ_SMAD3 SMAD3 Homo sapiens cardiac remodeling MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 primary cardiomyocytes (MCM) down-regulated "circSMAD3 was decreased in primary cardiomyocytes after Ang II stimulation, a treatment used to model cardiac remodeling-related cardiomyocyte hypertrophy." 1571 38993677 CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1. hsa_circ_0003973 circSMAD3 hsa_circ_SMAD3 SMAD3 Homo sapiens cardiac remodeling MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiac fibroblasts (MCF) down-regulated "circSMAD3 was decreased in primary cardiac fibroblasts after TGF¦Â1 stimulation, a treatment used to model cardiac remodeling-related fibroblast activation." 1572 38994030 Microglial circ-UBE2K exacerbates depression by regulating parental gene UBE2K via targeting HNRNPU. hsa_circ_0009154 circ-UBE2K hsa_circ_UBE2K UBE2K Homo sapiens major depressive disorder MONDO:0002009 major depressive disorder DOID:1470 microglia up-regulated "circ-UBE2K was most highly expressed in microglia compared with neurons and astrocytes in mouse brain, supported by in situ hybridization and MACS-isolated cell qPCR." 1573 38994030 Microglial circ-UBE2K exacerbates depression by regulating parental gene UBE2K via targeting HNRNPU. mmu_circ_Ube2k Ube2k Mus musculus major depressive disorder MONDO:0002009 major depressive disorder DOID:1470 microglia up-regulated "circ-UBE2K expression is increased in microglia after external stress in depression model mice. The study links this increase to UBE2K regulation, abnormal microglial activation, and neuroinflammation." 1574 39007896 Silencing of CircTRIM25/miR-138-5p/CREB1 axis promotes chondrogenesis in osteoarthritis. hsa_circ_0044719 circTRIM25 hsa_circ_TRIM25 TRIM25 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes isolated from normal or OA participants up-regulated "circTRIM25 was up-regulated in chondrocytes isolated from osteoarthritis participants compared with normal participants, based on primary chondrocyte isolation followed by qRT-PCR." 1575 39007896 Silencing of CircTRIM25/miR-138-5p/CREB1 axis promotes chondrogenesis in osteoarthritis. hsa_circ_0044719 circTRIM25 hsa_circ_TRIM25 TRIM25 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 IL-1¦Â-stimulated chondrocytes up-regulated circTRIM25 was up-regulated in IL-1¦Â-stimulated chondrocytes compared with untreated chondrocytes. Knockdown of circTRIM25 suppressed inflammatory readouts in IL-1¦Â-induced chondrocytes. 1576 39028686 CircARCN1 aggravates atherosclerosis by regulating HuR-mediated USP31 mRNA in macrophages. hsa_circ_0005589 circARCN1 hsa_circ_ARCN1 ARCN1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 CD68 + macrophages up-regulated "circARCN1 is mainly localized in CD68+ macrophages within human atherosclerotic plaques, compared with endothelial cells and smooth muscle cells. The study links macrophage-expressed circARCN1 to plaque inflammation through the HuR-USP31-NF-¦ÊB axis." 1577 39028686 CircARCN1 aggravates atherosclerosis by regulating HuR-mediated USP31 mRNA in macrophages. hsa_circ_0005589 circARCN1 hsa_circ_ARCN1 ARCN1 Homo sapiens coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 monocytes up-regulated "After PBMC subset separation by plastic adherence, circARCN1 decreased when monocytes were removed and increased when monocytes were enriched, supporting monocyte-enriched expression. The study associates circulating circARCN1 with stable angina and acute coronary syndrome." 1578 39039600 Hsa_circ_0043532 contributes to PCOS through upregulation of CYP19A1 by acting as a ceRNA for hsa-miR-1270. Hsa_circ_0043532 circ_0043532 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 GCs up-regulated circ_0043532 was up-regulated in granulosa cells from patients with PCOS compared with non-PCOS controls. The study links circ_0043532 to aberrant steroidogenesis through the miR-1270/CYP19A1 axis. 1579 39048814 CircARAP2 controls sMICA-induced NK cell desensitization by erasing CTCF/PRC2-induced suppression in early endosome marker RAB5A. hsa_circ_0069396 circARAP2 hsa_circ_ARAP2 ARAP2 Homo sapiens cancer MONDO:0004992 cancer DOID:0050686; DOID:0050687; DOID:162 human primary activated NK cells up-regulated circARAP2 was upregulated in human primary activated NK cells after rsMICA treatment in an sMICA-induced NK cell desensitization model. Knockdown of circARAP2 alleviated NKG2D endocytosis and NK cell desensitization. 1580 39082269 CircCHSY1 protects hearts against ischaemia/reperfusion injury by enhancing heme oxygenase 1 expression via miR-24-3p. mmu_circ_chsy1 chsy1 Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury NRCMs; AMCMs up-regulated "circCHSY1 was detected by RT-qPCR in isolated primary rat neonatal ventricular cardiomyocytes and adult mouse cardiomyocytes, and its expression increased after OGD/R injury. Functional experiments in NRCMs showed that circCHSY1 overexpression protected cardiomyocytes and mitochondrial function during OGD/R." 1581 39082269 CircCHSY1 protects hearts against ischaemia/reperfusion injury by enhancing heme oxygenase 1 expression via miR-24-3p. rno_circ_chsy1 chsy1 Rattus norvegicus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury NRCMs; AMCMs up-regulated "circCHSY1 was detected by RT-qPCR in isolated primary rat neonatal ventricular cardiomyocytes and adult mouse cardiomyocytes, and its expression increased after OGD/R injury. Functional experiments in NRCMs showed that circCHSY1 overexpression protected cardiomyocytes and mitochondrial function during OGD/R." 1582 39102213 CircNAP1L4 regulates pulmonary artery smooth muscle cell proliferation via the NAP1L4-mediated super-enhancer-driven glycolysis gene hexokinase II (HK II) in pulmonary hypertension. hsa_circ_0020816 circNAP1L4 hsa_circ_NAP1L4 NAP1L4 Homo sapiens pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 hypoxic HPASMCs down-regulated circNAP1L4 is down-regulated in hypoxia-treated human pulmonary artery smooth muscle cells. Functional experiments showed that circNAP1L4 overexpression inhibited hypoxia-induced HPASMC proliferation and glycolysis. 1583 39102213 CircNAP1L4 regulates pulmonary artery smooth muscle cell proliferation via the NAP1L4-mediated super-enhancer-driven glycolysis gene hexokinase II (HK II) in pulmonary hypertension. hsa_circ_0020816 circNAP1L4 hsa_circ_NAP1L4 NAP1L4 Homo sapiens pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 HPAECs cocultured with HPASMCs down-regulated "In a HPASMC-HPAEC coculture model, circNAP1L4 was decreased in HPAECs under hypoxia. circNAP1L4 inhibited HPAEC glycolysis and proliferation but did not regulate migration in this coculture system." 1584 39107881 A novel peptide encoded by circ-SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac-mediated CD36 transcription in NAFLD. mmu_circ_0016305 circ_SLC9A6 mmu_circ_SLC9A6 SLC9A6 Mus musculus nonalcoholic fatty liver disease / NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 primary hepatocytes up-regulated "circ_SLC9A6 was increased in isolated primary hepatocytes in the NAFLD/steatosis context, based on qRT-PCR after primary hepatocyte isolation." GSE94841 1585 39107958 Exosomal circ-0100519 promotes breast cancer progression via inducing M2 macrophage polarisation by USP7/NRF2 axis. hsa_circ_0100519 circ_0100519 hsa_circ_EPSTI1 EPSTI1 Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 macrophages up-regulated Breast cancer cell-derived exosomal circ_0100519 was detected in macrophages and was shown by cell-type co-localization with macrophage markers in tumour sections. Elevated circ_0100519 promoted M2-like macrophage polarization through the USP7/NRF2 axis. 1586 39126922 Bu-Shen-Ning-Xin decoction ameliorates premature ovarian insufficiency by suppressing oxidative stress through rno_circRNA_012284/rno_miR-760-3p/HBEGF pathway. rno_circRNA_012284 Rattus norvegicus premature ovarian insufficiency MONDO:0005387 primary ovarian failure DOID:5426 POI ovarian granulosa cells (OGCs) up-regulated "In POI ovarian granulosa cells from rats, rno_circRNA_012284 was up-regulated after BSNXD administration. Functional experiments in OGCs indicated that rno_circRNA_012284 overexpression alleviated excessive ROS generation." 1587 39139001 Cancer-associated fibroblast-derived circFARP1 modulates non-small cell lung cancer invasion and metastasis through the circFARP1/miR-338-3p/SOX4 axis. circFARP1 hsa_circ_FARP1 FARP1 Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 cancer-associated fibroblasts up-regulated "circFARP1 was up-regulated in primary cultured cancer-associated fibroblasts compared with paired normal fibroblasts from NSCLC patients, as measured by qRT-PCR. Functional experiments in CAFs and CAF-conditioned medium linked circFARP1 to CAF migration and invasion and to effects on NSCLC cell proliferation, migration and invasion." 1588 39157602 ciRS-7 circular RNA overexpression in plasma cells is a promising molecular biomarker of unfavorable prognosis in multiple myeloma. ciRS_7 / CDR1_AS Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 CD138+ plasma cells down-regulated "ciRS_7 expression was measured by qPCR after CD138+ plasma cell selection from patient bone marrow aspirates, and was downregulated in MM plasma cells compared with SMM and MGUS patient samples." 1589 39164758 Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1highCD206+ pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis. hsa_circ_0034880 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 CD206+ pro-tumor TAMs up-regulated FISH for circ-0034880 combined with immunofluorescence staining of TAM markers CD86 and CD206 supported circ-0034880 detection in TAMs from clinical CRC primary and liver metastatic lesions. Higher circ-0034880 in CRC liver metastatic lesions correlated positively with CD206+ pro-tumor TAM infiltration. 1590 39164758 Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1highCD206+ pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis. mmu-circ-0034880 Mus musculus colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 BMDMs up-regulated "Primary mouse BMDMs showed increased circ-0034880 after co-culture with murine colon cancer cell-derived TEVs, while circ-0034880-silenced TEVs had minimal effect. The authors concluded that circ-0034880 was transferred to macrophages from cancer cells in TEVs and promoted CD206+ pro-tumor macrophage activation." 1591 39183944 Aggravated Ulcerative Colitis via circNlgn-Mediated Suppression of Nuclear Actin Polymerization. circNlgn mmu_circ_Nlgn Nlgn Mus musculus colitis MONDO:0005292 colitis DOID:0060180 primary mouse colonic epithelial cells (mCECs) up-regulated "Primary mouse colonic epithelial cells isolated from circNlgn-transgenic mice showed high circNlgn expression. In this epithelial-cell system, circNlgn/Nlgn173 was linked to decreased PIAS3 expression and altered actin polymerization signaling in colitis-related models." 1592 39187041 Endonuclear Circ-calm4 regulates ferroptosis via a circR-Loop of the COMP gene in pulmonary artery smooth muscle cells. mmu_circ_calm4 calm4 Mus musculus pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 pulmonary arterial smooth muscle cells (PASMCs) up-regulated "circ-calm4 was upregulated in hypoxic pulmonary arterial smooth muscle cells, with FISH showing co-localization with the smooth muscle marker ¦Á-SMA. The study reports that increased endonuclear circ-calm4 promoted ferroptosis in PASMCs under hypoxic conditions." 1593 39187566 circNDUFA13 stimulates adipogenesis of bone marrow-derived mesenchymal stem cells via interaction with STAT3. hsa_circ_0050243 circNDUFA13 hsa_circ_NDUFA13 NDUFA13 Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 BMSCs and AD induction 7d BMSCs up-regulated circNDUFA13 is up-regulated in primary human BMSCs after 7 days of adipogenic induction and increases progressively during adipogenic differentiation. Functional experiments in BMSCs indicate that circNDUFA13 promotes adipogenic differentiation through interaction with STAT3 and activation of C/EBP¦Â transcription. 1594 39193132 Circular RNA IGF1R Promotes Cardiac Repair via Activating ¦Â-Catenin Signaling by Interacting with DDX5 in Mice after Ischemic Insults. rnoCirc_000455 rno_circ_Igf1r Igf1r Rattus norvegicus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 cardiomyocytes up-regulated circIGF1R/rnoCirc_000455 was identified from circRNA sequencing data comparing neonatal and adult cardiomyocytes and was higher in the neonatal regenerative state. Functional experiments in cardiomyocytes showed that circIGF1R promoted proliferation and reduced apoptosis. unclear 1595 39229866 CircPWWP2A promotes renal interstitial fibrosis through modulating miR-182/ROCK1 axis. Hsa_circ_0074837 hsa_circ_PWWP2A PWWP2A Homo sapiens renal interstitial fibrosis MONDO:0000494 renal fibrosis DOID:0050855 renal tubular cells up-regulated "circPWWP2A is increased in renal tubular cells in renal fibrosis models, with in situ hybridization/FISH localizing the induction primarily to renal tubules or renal tubule cells. Functional experiments support a pro-fibrotic role involving mitochondrial dysfunction and ROS production." 1596 39236286 Circular RNA-Cacna1d Plays a Critical Role in Sepsis-induced Lung Injury by Sponging microRNA-185-5p. mmu_circ_0005172 mmu_circ_Cacna1d Cacna1d Mus musculus sepsis-induced lung injury MONDO:0015796 acute lung injury vascular endothelium up-regulated FISH with a circRNA-Cacna1d probe and CD31 endothelial marker showed circRNA-Cacna1d overexpression in the pulmonary vascular wall of mice with sepsis-induced lung injury. Functional experiments indicated circRNA-Cacna1d knockdown reduced inflammatory responses and endothelial permeability in this context. 1597 39253079 CircRNAs expression profile and potential roles of circRERE-PMN in pre-metastatic lungs. chr4:150406196-150406664 mmu_circ_RERE RERE Mus musculus pre-metastatic lung niche in melanoma MONDO:0005191 metastatic melanoma MDSCs up-regulated circRERE-PMN was detected at high expression in MDSCs in pre-metastatic mouse lung tissue by FISH/immunofluorescence co-localization with cell-specific markers. 1598 39253079 CircRNAs expression profile and potential roles of circRERE-PMN in pre-metastatic lungs. chr4:150406196-150406664 mmu_circ_RERE RERE Mus musculus pre-metastatic lung niche in melanoma MONDO:0005191 metastatic melanoma alveolar epithelial cells up-regulated "circRERE-PMN was highly expressed in alveolar epithelial cells in pre-metastatic mouse lung tissue, with higher AOD than MDSCs and macrophages. In alveolar epithelial cells, circRERE-PMN was linked to inhibition of apoptosis and regulation of chemokine/cytokine expression." 1599 39253079 CircRNAs expression profile and potential roles of circRERE-PMN in pre-metastatic lungs. chr4:150406196-150406664 mmu_circ_RERE RERE Mus musculus pre-metastatic lung niche in melanoma MONDO:0005191 metastatic melanoma macrophages up-regulated circRERE-PMN was detected at high expression in macrophages in pre-metastatic mouse lung tissue by FISH/immunofluorescence co-localization with cell-specific markers. 1600 39268977 Circular RNA_0003489 reflects unfavorable treatment response and shortened survival in newly diagnosed multiple myeloma patients who receive bortezomib-based induction therapy. hsa_circ_0003489 Homo sapiens multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 BM plasma cells up-regulated circ_0003489 expression was measured by RT-qPCR in isolated bone marrow plasma cells and was increased in newly diagnosed multiple myeloma patients compared with donor controls. 1601 39328024 Physical exercise-induced circAnks1b upregulation promotes protective endoplasmic reticulum stress and suppresses apoptosis via miR-130b-5p/Pak2 signaling in an ischemic stroke model. rno_circ_Anks1b Anks1b Rattus norvegicus ischemic stroke MONDO:1060198 ischemic stroke neurons up-regulated circAnks1b was mainly expressed in neurons rather than astrocytes or microglia in peri-infarct cortex and was up-regulated in neurons of tMCAO rats after physical exercise. 1602 39328024 Physical exercise-induced circAnks1b upregulation promotes protective endoplasmic reticulum stress and suppresses apoptosis via miR-130b-5p/Pak2 signaling in an ischemic stroke model. rno_circ_Anks1b Anks1b Rattus norvegicus ischemic stroke MONDO:1060198 ischemic stroke primary rat neurons up-regulated "circAnks1b was markedly up-regulated in primary rat neurons exposed to OGD/R, an in vitro ischemia model. In primary neurons, circAnks1b was linked to miR-130b-5p/Pak2 regulation and reduced apoptosis." 1603 39329462 Integrin ¦Á6-containing extracellular vesicles promote lymphatic remodelling for pre-metastatic niche formation in lymph nodes via interplay with CD151. hsa_circ_0045334 hsa_circ_PLEKHM1P PLEKHM1P Homo sapiens bladder cancer MONDO:0004986 urinary bladder carcinoma DOID:4007 Human lymphatic endothelial cells (HLECs) up-regulated "BCa-derived ITGA6+EVs deliver LIPAR to human lymphatic endothelial cells, increasing LIPAR levels in these cells compared with control EV treatment. Delivered LIPAR activates SELE transcription and promotes lymphatic remodeling-associated pre-metastatic niche formation." GSE246659 1604 39342687 Hsa_circ_0043533 modulates apoptosis and viability of granulosa cells via miR-409-3p/BCL2 and EMT signalling in PCOS: Providing novel perspective of metformin. hsa_circ_0043533 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 GCs up-regulated "hsa_circ_0043533 was reported to be significantly higher in granulosa cells from PCOS than non-PCOS, validated by qPCR." 1605 39351864 CircTMTC1 Mediates Nucleocytoplasmic Translocation of DDX3X to Regulate Osteogenic Differentiation of Human Ligamentum Flavum Cells. hsa_circ_0025768 circTMTC1 hsa_circ_TMTC1 TMTC1 Homo sapiens ossification of the ligamentum flavum MONDO:0002081 musculoskeletal system disorder DOID:17 human LF cells up-regulated "circTMTC1 / hsa_circ_0025768 is up-regulated in primary human ligamentum flavum cells during osteogenic differentiation, supported by circRNA RNA-seq and RT-qPCR. Functional experiments in human LF cells indicate that circTMTC1 promotes osteogenic differentiation through DDX3X-mediated NLRP3 inflammasome signaling." 1606 39354521 Radiation-sensitive circRNA hsa_circ_0096498 inhibits radiation-induced liver fibrosis by suppressing EIF4A3 nuclear translocation to decrease CDC42 expression in hepatic stellate cells. hsa_circ_0096498 circ96498 hsa_circ_RSF1 RSF1 Homo sapiens radiation-induced liver injury MONDO:0043459 radiation-induced disorder HSCs up-regulated "hsa_circ_0096498/circ96498 was significantly upregulated and primarily localized in HSCs in paracancerous liver tissues from patients with radiation-induced liver injury, supported by FISH-based localization." 1607 39354521 Radiation-sensitive circRNA hsa_circ_0096498 inhibits radiation-induced liver fibrosis by suppressing EIF4A3 nuclear translocation to decrease CDC42 expression in hepatic stellate cells. mmu_circ_0013678 circ13678 Mus musculus radiation-induced liver fibrosis MONDO:0043459 radiation-induced disorder mouse HSCs up-regulated The mouse conserved circRNA mmu_circ_0013678/circ13678 was upregulated in irradiated mouse HSCs. HSC-specific circ13678 knockdown promoted inflammatory and fibrotic phenotypes in the RILF mouse model. 1608 39357702 Circ_0104873 promotes osteoarthritis progression via miR-875-5p/NOTCH3/Notch signaling pathway. hsa_circ_0104873 circ_0104873 hsa_circ_IQGAP1 IQGAP1 Homo sapiens Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 bone marrow mesenchymal stem cells (BMSCs) up-regulated "circ_0104873 was up-regulated in BMSCs during osteogenic differentiation, especially at day 7 in osteogenic medium compared with day 0. Functional assays in BMSCs indicated that circ_0104873 promoted proliferation and osteogenic differentiation." 1609 39370077 "Immune infiltration related circular RNA, circGLIS2, facilitated progression of endometriosis through miR-4731-5p/IL-1¦Â axis." circGLIS2 hsa_circ_GLIS2 GLIS2 Homo sapiens endometriosis MONDO:0005133 endometriosis DOID:289 primary endometrial cells unknown "circGLIS2 was detected in isolated primary endometrial cells and was predominantly cytoplasmic. In this primary endometrial cell system, circGLIS2 regulated IL-1¦Â and influenced immune cell infiltration through the miR-4731-5p/IL-1¦Â axis." 1610 39370077 "Immune infiltration related circular RNA, circGLIS2, facilitated progression of endometriosis through miR-4731-5p/IL-1¦Â axis." mmu_circ_0006310 Mus musculus endometriosis MONDO:0005133 endometriosis DOID:289 mouse endometrial cells down-regulated "In mouse endometrial cells, siRNA treatment reduced mmu-circ-0006310 expression and decreased IL-1¦Â mRNA. In the mouse endometriosis model, suppression of mmu-circ-0006310 reduced immune cell infiltration in endometriotic lesions." 1611 39384750 CircMETTL3-156aa reshapes the glycolytic metabolism of macrophages to promote M1 polarization and induce cytokine storms in sHLH. circMETTL3 hsa_circ_METTL3 METTL3 Homo sapiens Secondary Hemophagocytic lymphohistiocytosis MONDO:0015542 secondary hemophagocytic lymphohistiocytosis CD11b-labeled mononuclear macrophages up-regulated "circMETTL3 expression is increased in CD11b-labeled mononuclear macrophages from sHLH patients compared with healthy controls, supported by fluorescence colocalization. The study further links circMETTL3 to macrophage glycolysis and M1 polarization." 1612 39398229 Downregulation of Circular RNA Gla Reduced Astrocyte Inflammatory Status by Regulating miR-488/MEKK1 Levels and Promoted Functional Recovery After Spinal Cord Injury. circGla mmu_circ_Gla Gla Mus musculus spinal cord injury MONDO:0043797 spinal cord injury astrocytes up-regulated "circGla was increased after spinal cord injury and was detected in the cytoplasm of mouse astrocytes by RT-qPCR of nuclear/cytoplasmic fractions and FISH. In astrocytes, circGla regulated inflammatory mediator levels through the miR-488/MEKK1 pathway." 1613 39403796 Host combats porcine reproductive and respiratory syndrome virus infection at non-coding RNAs level. "circAFF3(L4,5,6).1" ssc_circ_AFF3 AFF3 Sus scrofa Porcine Reproductive and Respiratory Syndrome MONDO:0025494 porcine reproductive and respiratory syndrome PAMs dys-regulated "circAFF3(L4,5,6).1 was identified in RNA-seq analysis of PAMs isolated from PRRSV-infected pig lungs, within a differentially expressed circRNA landscape. It was predicted to regulate THBS2, DDX60, and FGFR1 via interaction with ssc-miR-149." 1614 39403796 Host combats porcine reproductive and respiratory syndrome virus infection at non-coding RNAs level. "circNBR1(14,L15).1" ssc_circ_NBR1 NBR1 Sus scrofa Porcine Reproductive and Respiratory Syndrome MONDO:0025494 porcine reproductive and respiratory syndrome PAMs dys-regulated "circNBR1(14,L15).1 was identified in RNA-seq analysis of PAMs isolated from PRRSV-infected pig lungs, within a differentially expressed circRNA landscape. It was predicted to manipulate SHANK2, FOXJ1, and RHBDD2 expression by binding ssc-miR-7135-3p." 1615 39403796 Host combats porcine reproductive and respiratory syndrome virus infection at non-coding RNAs level. circSPECC1 (2).1 ssc_circ_SPECC1 SPECC1 Sus scrofa Porcine Reproductive and Respiratory Syndrome MONDO:0025494 porcine reproductive and respiratory syndrome PAMs dys-regulated "circSPECC1 (2).1 was identified in RNA-seq analysis of PAMs isolated from PRRSV-infected pig lungs, within a differentially expressed circRNA landscape. It was predicted to interact with SCART1, NTN1, CASKIN2, and SULF2 through binding ssc-miR-4332." 1616 39407304 Identification of circRNA CDR1as/miR-214-3p regulatory axis in Legg-Calv¨¦-Perthes disease. circCDR1as Homo sapiens Legg-Calv¨¦-Perthes disease MONDO:0007885 Legg-Calve-Perthes disease DOID:14415 chondrocytes up-regulated "circCDR1as was up-regulated in primary chondrocytes collected from LCPD patients compared with healthy controls, based on qRT-PCR after primary chondrocyte isolation." 1617 39407304 Identification of circRNA CDR1as/miR-214-3p regulatory axis in Legg-Calv¨¦-Perthes disease. circCDR1as Homo sapiens Legg-Calv¨¦-Perthes disease MONDO:0007885 Legg-Calve-Perthes disease DOID:14415 primary chondrocytes up-regulated "circCDR1as was up-regulated in DEX-treated primary chondrocytes in an in vitro LCPD model, and siRNA treatment reduced its expression." 1618 39422230 "Circular RNA circASH1L(4,5) protects microRNA-129-5p from target-directed microRNA degradation in human skin wound healing." hsa_circ_0003247 hsa_circ_ASH1L ASH1L Homo sapiens skin wound healing MONDO:0000001 disease DOID:4 W7 keratinocytes up-regulated "circASH1L(4,5) was up-regulated in isolated wound-edge keratinocytes compared with skin keratinocytes during human skin wound healing, based on rRNA-depleted long RNA sequencing of isolated keratinocytes. Functional experiments in human primary keratinocytes showed that circASH1L promotes migration and proliferation." GSE174661 1619 39422230 "Circular RNA circASH1L(4,5) protects microRNA-129-5p from target-directed microRNA degradation in human skin wound healing." hsa_circ_0003247 hsa_circ_ASH1L ASH1L Homo sapiens skin wound healing MONDO:0000001 disease DOID:4 human primary keratinocytes up-regulated "TGF-¦Â2 treatment up-regulated circASH1L expression in human primary keratinocytes, linking wound-healing TGF-¦Â signaling to circASH1L induction. Functional assays showed circASH1L enhances keratinocyte growth and migration." 1620 39442967 [Serum from Xinfeng Capsule-treated rats affect the proliferation and apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by regulating circular RNA Cbl proto-oncogene B (circ-CBLB)]. hsa_circ_0066715 hsa_circ_CBLB CBLB Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 fibroblast-like synoviocytes / £ÒA-FLS down-regulated "In primary RA-FLS, TNF-¦Á stimulation used to establish the inflammatory model reduced circ-CBLB expression compared with untreated control cells, as measured by qRT-PCR." 1621 39442967 [Serum from Xinfeng Capsule-treated rats affect the proliferation and apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by regulating circular RNA Cbl proto-oncogene B (circ-CBLB)]. hsa_circ_0066715 hsa_circ_CBLB CBLB Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 fibroblast-like synoviocytes / £ÒA-FLS up-regulated "In primary RA-FLS, XFC-containing serum increased circ-CBLB expression compared with the TNF-¦Á model group, as measured by qRT-PCR. The study also linked circ-CBLB overexpression in RA-FLS to reduced proliferation, increased apoptosis, and altered inflammatory cytokines." 1622 39444078 Membrane Associated RNA-Containing Vesicles Regulate Cortical Astrocytic Microdomain Calcium Transients in Awake Ischemic Stroke Mice. circSCMH1 SCMH1 Homo sapiens ischemic stroke MONDO:1060198 ischemic stroke primary astrocytes unknown circSCMH1 was detected in primary astrocytes by FISH/immunofluorescence and RIP-qPCR evidence showing interaction with DDX1 and MARV formation. The paper does not report a clear endogenous up- or down-regulation direction for circSCMH1 in astrocytes. 1623 39467260 CircFndc3b Mediates Exercise-Induced Neuroprotection by Mitigating Microglial/Macrophage Pyroptosis via the ENO1/KLF2 Axis in Stroke Mice. mmu_circ_0001113 circFndc3b mmu_circ_Fndc3b Fndc3b Mus musculus ischemic stroke MONDO:1060198 ischemic stroke microglia/macrophages up-regulated "In MCAO mice, exercise increased circFndc3b expression in isolated peri-infarct microglia/macrophages, and FISH showed predominant colocalization with Iba1-positive microglia/macrophages. Functional experiments linked microglia/macrophage circFndc3b to reduced NLRP3 inflammasome-mediated pyroptosis and neuroinflammation." 1624 39467260 CircFndc3b Mediates Exercise-Induced Neuroprotection by Mitigating Microglial/Macrophage Pyroptosis via the ENO1/KLF2 Axis in Stroke Mice. mmu_circ_0001113 circFndc3b mmu_circ_Fndc3b Fndc3b Mus musculus ischemic stroke MONDO:1060198 ischemic stroke primary microglia down-regulated "In primary mouse microglia, OGD/R treatment significantly decreased circFndc3b expression, with FISH also showing reduced circFndc3b fluorescence intensity. Overexpression experiments in primary microglia showed circFndc3b mitigated NLRP3 inflammasome-mediated pyroptosis after OGD/R." 1625 39473004 Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus. circ-CAMTA1 hsa_circ_CAMTA1 CAMTA1 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 T cells down-regulated "circ-CAMTA1 was significantly reduced in purified T cells from patients with SLE compared with healthy controls, based on magnetic bead T-cell purification followed by RT-PCR." 1626 39473004 Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus. circ-CAMTA1 hsa_circ_CAMTA1 CAMTA1 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 T cells down-regulated circ-CAMTA1 expression was lower in purified T cells from SLE patients with higher disease activity than in those with lower disease activity. 1627 39473004 Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus. circ-ASH1L hsa_circ_ASH1L ASH1L Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 T cells down-regulated "circ-ASH1L was significantly reduced in purified T cells from patients with SLE compared with healthy controls, based on magnetic bead T-cell purification followed by RT-PCR." 1628 39473004 Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus. circ-ASH1L hsa_circ_ASH1L ASH1L Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 T cells down-regulated circ-ASH1L expression was lower in purified T cells from SLE patients with higher disease activity than in those with lower disease activity. 1629 39473004 Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus. circ-ASAP1 hsa_circ_ASAP1 ASAP1 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 T cells down-regulated "circ-ASAP1 was significantly reduced in purified T cells from patients with SLE compared with healthy controls, based on magnetic bead T-cell purification followed by RT-PCR." 1630 39473004 Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus. circ-ASAP1 hsa_circ_ASAP1 ASAP1 Homo sapiens systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 T cells down-regulated circ-ASAP1 expression was lower in purified T cells from SLE patients with higher disease activity than in those with lower disease activity. 1631 39488792 Endosomal Trafficking Bypassed by the RAB5B-CD109 Interplay Promotes Axonogenesis in KRAS-Mutant Pancreatic Cancer. hsa_circ_0007006 circPNIT hsa_circ_DYM DYM Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 DRG cells up-regulated "EV-packaged circPNIT from KRASG12D PDAC cells was delivered to DRG neurons and increased circPNIT expression in these cells, as measured by qRT-PCR after primary DRG isolation and EV treatment. CD109 blockade reduced delivery of EV-packaged circPNIT to DRG cells." 1632 39499344 Circular RNA circ_0022707 impedes the progression of preeclampsia via the miR-3135b/GHR/PI3K/Akt axis. hsa_circ_0022707 circ_0022707 hsa_circ_MAP4K2 MAP4K2 Homo sapiens Preeclampsia MONDO:0005081 preeclampsia DOID:10591 villous trophoblast cells down-regulated ISH showed that circ_0022707 was mainly expressed in placental villous trophoblast cells and its signal was reduced in PE placentas. Functional experiments in trophoblast cells indicated that circ_0022707 promoted proliferation and cell cycle progression while suppressing apoptosis. 1633 39511561 FUS/circZEB1/miR-128-3p/LBH feedback loop contributes to the malignant phenotype of GSCs via TNF-¦Á-mediated NF-¦ÊB signaling pathway. hsa_circ_0000230 circZEB1 hsa_circ_ZEB1 ZEB1 Homo sapiens glioblastoma MONDO:0018177 glioblastoma DOID:3068 glioma stem cells (GSCs) unknown "circZEB1/hsa_circ_0000230 expression was detected by qPCR in primary patient-derived GSC cultures from GBM specimens, with variable expression among GSC isolates. Functional assays in GSCs showed that circZEB1 promoted malignant phenotype and stemness via LBH." 1634 39533214 m6A-modified circCacna1c regulates necroptosis and ischemic myocardial injury by inhibiting Hnrnpf entry into the nucleus. mmu_circ_0001511 circCacna1c mmu_circ_Cacna1c Cacna1c Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 primary cardiomyocytes down-regulated "circCacna1c is decreased in primary cardiomyocytes during H2O2-induced necroptosis, a cell state relevant to myocardial infarction injury. Overexpression of circCacna1c protected primary cardiomyocytes from H2O2-induced necroptotic injury." 1635 39533214 m6A-modified circCacna1c regulates necroptosis and ischemic myocardial injury by inhibiting Hnrnpf entry into the nucleus. mmu_circ_0001511 circCacna1c mmu_circ_Cacna1c Cacna1c Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 neonatal rat cardiomyocytes up-regulated Primary-cell qRT-PCR showed that circCacna1c is more abundant in neonatal rat cardiomyocytes than in cardiac fibroblasts under physiological conditions in a myocardial infarction-focused study. 1636 39538329 Analysis of hsa_circ_0136256 as a biomarker for fibrosis in systemic sclerosis. hsa_circ_0136256 hsa_circ_FZD3 FZD3 Homo sapiens systemic sclerosis MONDO:0005100 systemic sclerosis DOID:418 PBMCs down-regulated "hsa_circ_0136256 was significantly decreased in PBMCs from patients with systemic sclerosis compared with healthy controls, based on RT-qPCR. The study suggests hsa_circ_0136256 may serve as a biomarker for clinical diagnosis of SSc." 1637 39542245 The circular RNA circNFIX regulates MEF2C expression in muscle satellite cells in spastic cerebral palsy. hsa_circ_0005660 hsa_circ_NFIX NFIX Homo sapiens spastic cerebral palsy MONDO:0000396 spastic cerebral palsy DOID:0050669 Human satellite cells-derived myoblasts (SC-MBs) down-regulated "circNFIX was down-regulated in satellite cell-derived myoblasts isolated from spastic cerebral palsy patient muscle biopsies compared with control satellite cell-derived myoblasts, as measured by qRT-PCR. Functional data in this cell-derived system support a role in myogenic differentiation through regulation of MEF2C." 1638 39542245 The circular RNA circNFIX regulates MEF2C expression in muscle satellite cells in spastic cerebral palsy. hsa_circ_0005660 hsa_circ_NFIX NFIX Homo sapiens spastic cerebral palsy MONDO:0000396 spastic cerebral palsy DOID:0050669 SC-MTs down-regulated circNFIX was down-regulated in satellite cell-derived myotubes generated from spastic cerebral palsy patient-derived satellite cell myoblasts compared with control-derived myotubes. The study links reduced circNFIX in this cell-derived system to impaired MEF2C regulation and reduced myotube fusion capacity. 1639 39543767 "Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2." hsa_circ_0001810 hsa_circ_NCOA2 NCOA2 Homo sapiens schizophrenia MONDO:0005090 schizophrenia DOID:5419 primary neurons up-regulated "ERVWE1 overexpression increased circ_0001810 production in neuronal cells, with validation in primary neurons, in the context of schizophrenia-related ERVWE1 signaling." 1640 39546192 Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying Circ-Tulp4 Attenuate Diabetes Mellitus with Nonalcoholic Fatty Liver Disease by Inhibiting Cell Pyroptosis through the HNRNPC/ABHD6 Axis. mmu_circ_Tulp4 Tulp4 Mus musculus Diabetes mellitus with nonalcoholic fatty liver disease / DM-NAFLD MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 hepatocytes up-regulated "In primary mouse hepatocytes under DM-NAFLD-like high-glucose conditions, EV treatment increased circ-Tulp4 expression, including delivery by circ-Tulp4-overexpressing UCMSC-EVs. This was associated with reduced lipid droplet accumulation and suppression of pyroptosis markers in hepatocytes." 1641 39549809 circAGO3 facilitates NF-¦ÊB pathway-mediated inflammatory atrophy in chicken skeletal muscle via the miR-34b-5p/TRAF3 axis. circAGO3 gga_circ_AGO3 AGO3 Gallus gallus skeletal muscle atrophy MONDO:0003939 muscle tissue disorder DOID:0080000; DOID:66 chicken skeletal muscle satellite cells (SMSCs) up-regulated "In primary cultured chicken skeletal muscle satellite cells, qPCR showed that pcDNA25-circAGO3 markedly upregulated circAGO3 expression. circAGO3 overexpression was associated with impaired differentiation, myotube atrophy, and inflammatory responses in SMSCs." 1642 39572284 Circ_0003072 Mediates the Pro-osteogenic Differentiation Effect of Betulinic Acid on Human Periodontal Ligament Stem Cells. hsa_circ_0003072 Homo sapiens Periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 human periodontal ligament stem cells up-regulated "In primary cultured hPDLSCs under osteogenic induction, circ_0003072 expression was increased after BetA treatment compared with untreated control cells. Functional assays showed that circ_0003072 knockdown weakened the pro-osteogenic differentiation effect of BetA in hPDLSCs." 1643 39572643 Circular RNA HIPK3 mediates epithelial-mesenchymal transition of retinal pigment epithelial cells by sponging multiple microRNAs. mmu_circ_HIPK3 HIPK3 Mus musculus vitreoretinal diseases MONDO:0020248 vitreoretinal degeneration retinal pigment epithelial (RPE) cells up-regulated "In primary mouse retinal pigment epithelial cells, circHIPK3 was significantly up-regulated after TGF-¦Â1-induced RPE-EMT compared with untreated control conditions. Functional perturbation showed that circHIPK3 regulates EMT and migration in RPE cells." 1644 39601144 CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation. mmu_circ_0001052 CircHipk3 mmu_circ_Hipk3 Hipk3 Mus musculus abdominal aortic aneurysm MONDO:0005350 abdominal aortic aneurysm DOID:7693 macrophage up-regulated "circHipk3 is increased in CD68-positive macrophages in AAA samples compared with normal/non-diseased aorta, supported by co-staining in murine and human aortic tissues. The study links circHipk3 in macrophages to pyroptosis and inflammatory mediator/MMP induction in AAA." 1645 39601341 The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells. circMAN1A2 hsa_circ_MAN1A2 MAN1A2 Homo sapiens Multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 CD138_purified plasma cells up-regulated "circMAN1A2 was detected in CD138-purified plasma cells from multiple myeloma patients by RNA-seq after cell sorting, and higher expression was associated with better outcome." 1646 39601341 The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells. circPCMTD1 hsa_circ_PCMTD1 PCMTD1 Homo sapiens Multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 CD138_purified plasma cells up-regulated "circPCMTD1 was detected in CD138-purified plasma cells from multiple myeloma patients by RNA-seq after cell sorting, and higher expression was associated with better outcome." 1647 39601341 The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells. circZNF609 hsa_circ_ZNF609 ZNF609 Homo sapiens Multiple myeloma MONDO:0009693 plasma cell myeloma DOID:9538 CD138_purified plasma cells up-regulated "circZNF609 was detected in CD138-purified plasma cells from multiple myeloma patients by RNA-seq after cell sorting, and higher expression was associated with better outcome." 1648 39612054 Circular RNA circVAPA mediates alveolar macrophage activation by modulating miR-212-3p/Sirt1 axis in acute respiratory distress syndrome. circVAPA hsa_circ_VAPA VAPA Homo sapiens acute respiratory distress syndrome MONDO:0006502 acute respiratory distress syndrome alveolar macrophages up-regulated circVAPA was up-regulated in alveolar macrophages isolated from BALF samples of ARDS patients compared with healthy controls. The study links this up-regulation to inflammatory activation of macrophages in ARDS. 1649 39626448 Exploring the mechanism of Taohong Siwu Decoction in treating ischemic stroke injury via the circDnajc1/miR-27a-5p/C1qc signaling axis. circDnajc1 rno_circ_Dnajc1 Dnajc1 Rattus norvegicus ischemic stroke MONDO:1060198 ischemic stroke microglial cells up-regulated "In primary rat microglial cells subjected to OGD/R, circDnajc1 expression was increased compared with the negative control group by RT-qPCR." 1650 39626448 Exploring the mechanism of Taohong Siwu Decoction in treating ischemic stroke injury via the circDnajc1/miR-27a-5p/C1qc signaling axis. circDnajc1 rno_circ_Dnajc1 Dnajc1 Rattus norvegicus ischemic stroke MONDO:1060198 ischemic stroke microglial cells down-regulated "In primary rat microglial cells subjected to OGD/R, THSWD-containing serum decreased circDnajc1 expression compared with OGD/R plus normal control serum by RT-qPCR." 1651 39636111 The neurological damage caused by enterovirus 71 infection is associated with hsa_circ_0069335/miR-29b/PMP22 pathway. hsa_circ_0069335 Homo sapiens EV71 infection-induced neurological damage MONDO:0005747 enterovirus infectious disease Schwann cells up-regulated "In primary cultured Schwann cells, circRNA expression was detected by qRT-PCR after EV71 infection, and cicrRNA expression was significantly increased in EV71-infected cells. The study identified hsa_circ_0069335 as a miR-29b-related circRNA and reported its co-localization with miR-29b." 1652 39647239 Macrophage metabolic reprogramming ameliorates diabetes-induced microvascular dysfunction. circSPECC1 SPECC1 Mus musculus diabetes-induced microvascular dysfunction MONDO:0000960 diabetic peripheral angiopathy DOID:11713 bone marrow-derived monocytes (BMDMs) up-regulated cSPECC1 expression is increased in isolated BMDMs after high-glucose diabetic stress. The study further links cSPECC1 in macrophages to macrophage polarization and macrophage-endothelial crosstalk. 1653 39667547 Circ-SPATA13 regulates the osteogenic differentiation of human periodontal ligament stem cells through the miR-485-5p_R + 1/BMP7 axis. hsa_circ_SPATA13 SPATA13 Homo sapiens periapical periodontitis MONDO:0004508 periapical periodontitis DOID:823 human periodontal ligament stem cells (PDLSCs) up-regulated circ-SPATA13 was detected in isolated human PDLSCs and was positively associated with their osteogenic differentiation. Functional assays showed that circ-SPATA13 promotes PDLSCs osteogenesis through the miR-485-5p_R + 1/BMP7 axis. 1654 39667599 A read-through circular RNA RCRIN inhibits metabolic dysfunction-associated steatotic liver disease. hsa_circ_RB1-ITM2B ITM2B; RB1 Homo sapiens metabolic dysfunction-associated steatotic liver disease MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 hepatocytes down-regulated "RCRIN is localized in hepatocyte cytoplasm and is reduced in MASLD hepatocytes compared with normal hepatocytes. The study links lower hepatocyte RCRIN to RPL8-containing ribosomes, lipid accumulation, and endoplasmic reticulum stress." GSE212739; GSE212741 1655 39667599 A read-through circular RNA RCRIN inhibits metabolic dysfunction-associated steatotic liver disease. mmu_circ_Rb1-Itm2b Itm2b; Rb1 Mus musculus metabolic dysfunction-associated steatotic liver disease MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 hepatocytes up-regulated "Mouse Rcrin is enriched in hepatocytes compared with other isolated mouse liver cells. Hepatocyte Rcrin deletion promotes lipid accumulation and MASLD progression, while Rcrin overexpression reduces hepatic steatosis." GSE212739; GSE212741 1656 39695793 Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA. hsa_circ_0002142 hsa_circ_Dennd2a Dennd2a Homo sapiens Premature ovarian insufficiency MONDO:0005387 primary ovarian failure DOID:5426 GCs down-regulated "circDennd2a was decreased in granulosa cells from POI patients compared with granulosa cells from patients with normal ovarian function, as measured by qRT-PCR. The study further linked HM-Exs-circDennd2a to LDHA-mediated glycolysis, proliferation, and apoptosis regulation in granulosa cell models." 1657 39707013 CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis. hsa_circ_IRAK3 IRAK3 Homo sapiens sepsis MONDO:0005229 bacterial infectious disease with sepsis DOID:0040085 peripheral blood neutrophils up-regulated circIRAK3 is up-regulated in isolated peripheral blood neutrophils from sepsis patients based on whole transcriptome sequencing and RT-qPCR validation. Elevated circIRAK3 in neutrophils is positively correlated with plasma NET levels and promotes NET formation in neutrophil-like dHL-60 cells. 1658 39709098 CircMETTL9 targets CCAR2 to induce neuronal oxidative stress and apoptosis via mitochondria-mediated pathways following traumatic brain injury. rno_circ_METTL9 METTL9 Rattus norvegicus Traumatic brain injury MONDO:0858950 traumatic brain injury DOID:0081292 neuronal marker NeuN up-regulated "circMETTL9 was elevated in the injured rat cerebral cortex after TBI and colocalized with the neuronal marker NeuN, with more extensive NeuN colocalization than GFAP. The study links circMETTL9 to neuronal oxidative stress and apoptosis through CCAR2-related mitochondrial pathways." 1659 39709098 CircMETTL9 targets CCAR2 to induce neuronal oxidative stress and apoptosis via mitochondria-mediated pathways following traumatic brain injury. rno_circ_METTL9 METTL9 Rattus norvegicus Traumatic brain injury MONDO:0858950 traumatic brain injury DOID:0081292 astrocyte-specific marker GFAP up-regulated circMETTL9 was elevated in the injured rat cerebral cortex after TBI and colocalized with the astrocyte marker GFAP in the injured cortex. The neuronal colocalization was reported as more extensive than GFAP colocalization. 1660 39713717 Hsa_circRNA_100791 Modulates Trim13 Through Sponging miR-487b-5p to Facilitate Inflammation in Allergic Rhinitis. hsa_circ_0004851 hsa_circ_100791 hsa_circ_CAPRIN1 CAPRIN1 Homo sapiens allergic rhinitis MONDO:0011786 allergic rhinitis DOID:4481 peripheral blood mononuclear cells (PBMCs) up-regulated "hsa_circRNA_100791 was significantly up-regulated in isolated PBMCs from allergic rhinitis patients compared with healthy controls, as measured by qRT-PCR." 1661 39716795 Inhibition of Circ0001679 Alleviates Ischemia/Reperfusion-induced Brain Injury via miR-216/TLR4 Regulatory Axis. circ0001679 Mus musculus ischemia reperfusion injury / IRI MONDO:0005203 ischemia reperfusion injury primary mouse astrocytes up-regulated "circ0001679 expression increased in OGD/R-treated primary mouse astrocytes as measured by qRT-PCR. Silencing circ0001679 attenuated OGD/R-induced apoptosis, inflammation, and oxidative stress in these astrocytes." 1662 39738128 Fast and sensitive multivalent spatial pattern-recognition for circular RNA detection. circSCMH1 mmu_circ_Scmh1 Scmh1 Mus musculus photothrombotic stroke MONDO:0005098 stroke disorder neurons down-regulated "In mouse photothrombotic stroke brain sections, TDF-based in situ imaging co-labeled with NeuN showed that circSCMH1 fluorescence was significantly reduced in neurons after stroke." 1663 39738128 Fast and sensitive multivalent spatial pattern-recognition for circular RNA detection. circSCMH1 mmu_circ_Scmh1 Scmh1 Mus musculus photothrombotic stroke MONDO:0005098 stroke disorder astrocytes down-regulated "In mouse photothrombotic stroke brain sections, TDF-based in situ imaging co-labeled with GFAP showed that circSCMH1 fluorescence was significantly reduced in astrocytes after stroke." 1664 39744434 CircMVP promotes METTL3 activation mediated CTNNB1 m6A modification in the inhibition of colorectal cancer in B7-H3 dependence antitumor immunity. hsa_circ_0000688 Alias_000014 hsa_circ_MVP MVP Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 epithelial cells (CRC cells) up-regulated "Single-cell RNA sequencing of CRC samples showed that circMVP was mainly expressed in the epithelial cells (CRC cells) cluster. Functional experiments in CRC cells showed circMVP promoted proliferation, invasion, migration and tumorigenicity." 1665 39747873 The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment. hsa_circ_0049398 circPETH hsa_circ_LDLR LDLR Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 tumor-associated macrophages up-regulated "In hepatocellular carcinoma, MACS-isolated tumor-associated macrophages showed approximately 8-fold higher circPETH expression than monocyte-derived macrophages by qRT-PCR. The authors further reported that TAM-derived EV-loaded circPETH is transferred to HCC cells and promotes metastatic and metabolic phenotypes." GSE241868 1666 39755856 CircRNA CDR1AS promotes cardiac ischemia-reperfusion injury in mice by triggering cardiomyocyte autosis. CDR1AS Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury cardiomyocytes up-regulated "CDR1AS was up-regulated in primary mouse cardiomyocytes after hypoxia-reoxygenation compared with control, supporting cell-type-resolved expression change in a myocardial ischemia/reperfusion injury model. The study further links CDR1AS to cardiomyocyte autosis and autophagy-related injury." 1667 39759393 EIF4A3 Enhances the Proliferation and Cell Cycle Progression of Keloid Fibroblasts by Inducing the hsa_circ_0002198 Expression. hsa_circ_0002198 hsa_circ_PDE7B PDE7B Homo sapiens keloid MONDO:0005348 keloid keloid fibroblasts (KFs) up-regulated "circ_0002198 is up-regulated in keloid fibroblasts compared with normal fibroblasts based on qRT-PCR of primary cultured fibroblasts from patient-derived skin tissues. Knockdown experiments in KFs showed effects on proliferation, migration, invasion, cell cycle progression, and apoptosis." 1668 39762891 Exosomal circ_0006896 promotes AML progression via interaction with HDAC1 and restriction of antitumor immunity. hsa_circ_0006896 circ_0006896 hsa_circ_KIAA1429 KIAA1429 Homo sapiens acute myeloid leukemia MONDO:0018874 acute myeloid leukemia DOID:9119 CD8+ T cells up-regulated "In sorted and activated CD8+ T cells, AML-derived exosomes increased circ_0006896 levels compared with PBS control, and exosomes with circ_0006896 knockdown weakened this upregulation. Functional experiments showed that reducing exosomal circ_0006896 enhanced CD8+ T cell cytotoxic function and reduced CD8+ T cell apoptosis." 1669 39774281 Hsa_circ_0109623 regulates the progression of autoimmune liver disease through Hsa_miR_146b-3p/Sortilin 1-mediated activation of CD4+ T cells. hsa_circ_0109623 Circ_0109623 hsa_circ_FCGBP FCGBP Homo sapiens autoimmune hepatitis MONDO:0016264 autoimmune hepatitis DOID:2048 PBMCs up-regulated hsa_circ_0109623 was reported to be highly expressed in PBMCs from patients with autoimmune hepatitis. Functional experiments in PBMCs linked hsa_circ_0109623 to CD4+ T-cell activation and inflammatory cytokine release. 1670 39774281 Hsa_circ_0109623 regulates the progression of autoimmune liver disease through Hsa_miR_146b-3p/Sortilin 1-mediated activation of CD4+ T cells. hsa_circ_0109623 Circ_0109623 hsa_circ_FCGBP FCGBP Homo sapiens autoimmune hepatitis MONDO:0016264 autoimmune hepatitis DOID:2048 PBMCs up-regulated "In primary PBMC cultures stimulated with ConA to induce CD4+ T-cell activation, hsa_circ_0109623 expression increased over time and peaked at 48 hours. Knockdown experiments in PBMCs showed reduced CD4+ T-cell activation markers and inflammatory cytokines." 1671 39796015 CircTEC Inhibits the Follicular Atresia in Buffalo (Bubalus bubalis) via Targeting miR-144-5p/FZD3 Signaling Axis. circ-002750 / circTEC TEC Bubalus bubalis follicular atresia MONDO:0000001 disease DOID:4 granulosa cells down-regulated "circTEC/circ-002750 is down-regulated in buffalo granulosa cells from atretic follicles compared with healthy follicles, supported by RNA-seq and RT-qPCR. Functional assays in buffalo granulosa cells showed that circTEC promotes proliferation and inhibits apoptosis." GSE157686 1672 39799463 Renal Tubular Epithelial Cell-Derived hsa_circ_0008925 From Urine Is Related to Chronic Renal Fibrosis. hsa_circ_0008925 hsa_circ_SEC63 SEC63 Homo sapiens renal fibrosis MONDO:0000494 renal fibrosis DOID:0050855 urinary renal tubular epithelial cells up-regulated hsa_circ_0008925 was measured by RT-qPCR in magnetic bead-sorted urinary renal tubular epithelial cells from CKD patients and was higher in moderate-severe renal fibrosis than in no-mild renal fibrosis. 1673 39800017 5-Methylcytosine-modified circRNA-CCNL2 regulates vascular remdeling in hypoxic pulmonary hypertension through binding to FXR2. hsa_circ_0003926 circCCNL2 hsa_circ_CCNL2 CCNL2 Homo sapiens hypoxic pulmonary hypertension MONDO:0017157 pulmonary hypertension owing to lung disease and/or hypoxia pulmonary artery smooth muscle cells (PASMCs) down-regulated circCCNL2 was detected in pulmonary artery smooth muscle cells by FISH co-localization with ¦Á-SMA and was reduced in PASMCs under hypoxic conditions. Functional assays in PASMCs showed that circCCNL2 overexpression inhibited hypoxia-induced PASMC proliferation. 1674 39863188 CircXYLT1 suppresses oxidative stress and promotes vascular remodeling in aging mice carotid artery injury model of atherosclerosis via PTBP1. CircXYLT1 mmu_circ_XYLT1 XYLT1 Mus musculus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 vascular smooth muscle cells (VSMCs) up-regulated "CircXYLT1 was up-regulated in vascular smooth muscle cells from aged mouse atherosclerosis models compared with controls, based on RNA sequencing and qPCR validation. Functional assays in VSMCs linked CircXYLT1 to oxidative stress regulation and proliferation." 1675 39863188 CircXYLT1 suppresses oxidative stress and promotes vascular remodeling in aging mice carotid artery injury model of atherosclerosis via PTBP1. CircXYLT1 mmu_circ_XYLT1 XYLT1 Mus musculus aortic aneurysm MONDO:0005160 aortic aneurysm DOID:3627 vascular smooth muscle cells (VSMCs) up-regulated "CircXYLT1 was up-regulated in vascular smooth muscle cells from aged mouse aortic aneurysm models compared with controls, based on RNA sequencing and qPCR validation. Functional assays in VSMCs linked CircXYLT1 to oxidative stress regulation and proliferation." 1676 39868042 Mechanism of hsa_circ_0069443 promoting early pregnancy loss through ALKBH5/FN1 axis in trophoblast cells. hsa_circ_0069443 Homo sapiens early pregnancy loss MONDO:0006774 habitual spontaneous abortion primary trophoblast cells down-regulated "Primary trophoblast cells isolated and cultured from early pregnancy loss and normal pregnancy chorionic villi were used to collect exosomes, and qRT-PCR showed decreased hsa_circ_0069443 in trophoblast cell-derived exosomes from early pregnancy loss patients." 1677 39868921 CircPRKD3-loaded exosomes concomitantly elicit tumor growth inhibition and glioblastoma microenvironment remodeling via inhibiting STAT3 signaling. hsa_circ_0000992 hsa_circ_PRKD3 PRKD3 Homo sapiens glioblastoma MONDO:0018177 glioblastoma DOID:3068 glioma stem cells down-regulated "circPRKD3/hsa_circ_0000992 was downregulated in exosomes derived from primary glioma stem cells compared with normal-cell-derived exosomes, based on RNA-seq screening and RT-qPCR validation. The study further linked circPRKD3 to reduced GSC stemness and GBM progression." 1678 39873909 The role of circular RNAs in autoimmune diseases: Potential diagnostic biomarkers and therapeutic targets. hsa_circ_0012919 hsa_circ_GNG12 GNG12 Homo sapiens Systemic lupus erythematosus MONDO:0007915 systemic lupus erythematosus DOID:9074 CD4+ T cells down-regulated "hsa_circ_0012919 was reduced in isolated CD4+ T cells from SLE individuals compared with healthy controls. The study evaluated DNMT1, CD11a, CD70 and methylation changes after hsa_circ_0012919-targeted siRNA, supporting a role in immune regulation in CD4+ T cells." 1679 39873909 The role of circular RNAs in autoimmune diseases: Potential diagnostic biomarkers and therapeutic targets. hsa_circ_0003738 hsa_circ_LRRC16A LRRC16A Homo sapiens Psoriasis MONDO:0005083 psoriasis DOID:8893 psoriatic regulatory T cells (Tregs) up-regulated circ_0003738 / hsa_circ_0003738 was elevated in psoriatic regulatory T cells and validated by RT-PCR. Knockout of circ_0003738 restored Treg inhibitory function and suppressed pro-inflammatory cytokine secretion. 1680 39901821 Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease. circCOL4A1 hsa_circ_COL4A1 COL4A1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 combined cluster of ECs and SMCs up-regulated "In SmartSeq2 single-cell data from human carotid atherosclerotic plaques, circCOL4A1 was enriched in the combined endothelial cell and smooth muscle cell cluster compared with other detected plaque cell types." GSE280608 1681 39901821 Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease. circCOL4A2 hsa_circ_COL4A2 COL4A2 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 combined cluster of ECs and SMCs up-regulated "In SmartSeq2 single-cell data from human carotid atherosclerotic plaques, circCOL4A2 was enriched in the combined endothelial cell and smooth muscle cell cluster compared with other detected plaque cell types." GSE280608 1682 39901821 Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease. circHSPG2 hsa_circ_HSPG2 HSPG2 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 combined cluster of ECs and SMCs up-regulated "In SmartSeq2 single-cell data from human carotid atherosclerotic plaques, circHSPG2 was enriched in the combined endothelial cell and smooth muscle cell cluster compared with other detected plaque cell types." GSE280608 1683 39914785 Exonic CircGUCY1A2 inhibits pulmonary artery smooth muscle cells phenotypic switching via regulating O-glycosylation of COL3A1 in pulmonary hypertension. hsa_circ_GUCY1A2 GUCY1A2 Homo sapiens pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 human pulmonary artery smooth muscle cells (PASMCs) down-regulated "circGUCY1A2 is significantly down-regulated in hypoxia-exposed human pulmonary artery smooth muscle cells compared with normoxic conditions. Functional experiments in human PASMCs indicate that circGUCY1A2 inhibits hypoxia-induced synthetic phenotypic switching, proliferation, and migration through COL3A1-related mechanisms." 1684 39937418 miR-758-3p Interferes with Neuronal Apoptosis in Cerebral Ischemia-Reperfusion by Inhibiting ILK. Novel_circ_0000964 Rattus norvegicus cerebral ischemia reperfusion injury MONDO:0005203 ischemia reperfusion injury rat cerebral cortical neurons down-regulated circRNA (0000964) was down-regulated in OGD-treated primary rat cerebral cortical neurons used as an in vitro CIRI model. The study links this neuronal circRNA to miR-758-3p/ILK regulation and neuronal viability/apoptosis. 1685 39944836 "CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation." circMERTK hsa_circ_MERTK MERTK Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 macrophage up-regulated "ISH showed circMERTK was more abundant in CRC tissues than comparable normal tissues and largely overlapped with the macrophage marker CD68, supporting macrophage localization in CRC." 1686 39948045 circNR3C2 promotes chondrogenic differentiation and cartilage repair of human adipose-derived stem cells via the hsa-miR-647/SOX9 pathway. circNR3C2 hsa_circ_NR3C2 NR3C2 Homo sapiens cartilage-related disorders MONDO:0000001 disease DOID:4 human adipose-derived stem cells up-regulated circNR3C2 was significantly increased in primary cultured hADSCs during chondrogenic differentiation after induction. Functional experiments in hADSCs showed that circNR3C2 regulates chondrogenic differentiation via the hsa-miR-647/SOX9 pathway. 1687 39948068 CircFUNDC1 interacts with CDK9 to promote mitophagy in nucleus pulposus cells under oxidative stress and ameliorates intervertebral disc degeneration. hsa_circ_0007290 hsa_circ_FUNDC1 FUNDC1 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 nucleus pulposus cells (NPCs) down-regulated "circFUNDC1 is downregulated in nucleus pulposus cells from high-grade/end-stage IVDD patients compared with low-grade IVDD, supported by qPCR after NPC isolation and confirmed by FISH. Functional experiments in NPCs indicate circFUNDC1 protects against oxidative stress by promoting mitophagy and reducing senescence." 1688 39953602 Circular RNA APP contributes to Alzheimer's disease pathogenesis by modulating microglial polarization via miR-1906/CLIC1 axis. circAPP mmu_circ_APP APP Mus musculus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 primary neurons up-regulated circAPP showed a slightly upregulated trend in A¦Â-treated primary neurons compared with untreated control conditions in an Alzheimer¡¯s disease-related model. 1689 39953602 Circular RNA APP contributes to Alzheimer's disease pathogenesis by modulating microglial polarization via miR-1906/CLIC1 axis. circAPP mmu_circ_APP APP Mus musculus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 glial cells up-regulated circAPP was significantly upregulated in A¦Â-treated primary glial cells compared with untreated control conditions in an Alzheimer¡¯s disease-related model. 1690 39973750 SRSF4-Associated ca-circFOXP1 Regulates Hypoxia-Induced PASMC Proliferation by the Formation of R Loop With Host Gene. mmu_circ_0013639 ca-circFOXP1 mmu_circ_FOXP1 FOXP1 Mus musculus pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 mouse pulmonary arterial smooth muscle cells (mPASMCs) up-regulated ca-circFOXP1 is significantly upregulated in hypoxic mouse pulmonary arterial smooth muscle cells compared with normoxic controls. Functional assays in mPASMCs support a role for ca-circFOXP1 in hypoxia-induced proliferation and migration. 1691 39973750 SRSF4-Associated ca-circFOXP1 Regulates Hypoxia-Induced PASMC Proliferation by the Formation of R Loop With Host Gene. mmu_circ_0013639 ca-circFOXP1 mmu_circ_FOXP1 FOXP1 Mus musculus pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 mouse pulmonary arterial endothelial cells (mPAECs) no change ca-circFOXP1 showed no significant expression change in hypoxic mouse pulmonary arterial endothelial cells. 1692 39973830 Adipose-derived stem cells exosomal circHIPK3 protects ovarian function by regulating MAPK signaling. circHIPK3 HIPK3 Homo sapiens ovarian aging MONDO:0005387 primary ovarian failure DOID:5426 primary granulosa cells (pGCs) up-regulated "ADSC-derived exosomes delivered circHIPK3 to primary granulosa cells, and circHIPK3 expression was detected in exosome-treated pGCs. Depletion of circHIPK3 in ADSC-derived exosomes impaired their protective effects on pGC viability and apoptosis." 1693 39982455 Profile of circular RNAs in bovine mammary tissues infected with Staphylococcus aureus. novel_circ_0016220 bta_circ_STAT6 STAT6 Bos taurus bovine mastitis MONDO:0025100 "mastitis, bovine" bMECs up-regulated novel_circ_0016220 was significantly increased in LTA-treated primary bovine mammary epithelial cells compared with untreated cells in an inflammatory model related to bovine mastitis. 1694 39982455 Profile of circular RNAs in bovine mammary tissues infected with Staphylococcus aureus. novel_circ_0001807 bta_circ_UGP2 UGP2 Bos taurus bovine mastitis MONDO:0025100 "mastitis, bovine" bMECs up-regulated novel_circ_0001807 was significantly increased in LTA-treated primary bovine mammary epithelial cells compared with untreated cells in an inflammatory model related to bovine mastitis. 1695 39982455 Profile of circular RNAs in bovine mammary tissues infected with Staphylococcus aureus. novel_ circ_0009731 bta_circ_LTF LTF Bos taurus bovine mastitis MONDO:0025100 "mastitis, bovine" bMECs up-regulated novel_ circ_0009731 was significantly increased in LTA-treated primary bovine mammary epithelial cells compared with untreated cells in an inflammatory model related to bovine mastitis. 1696 39982455 Profile of circular RNAs in bovine mammary tissues infected with Staphylococcus aureus. novel_circ_0016953 bta_circ_SLC39A8 SLC39A8 Bos taurus bovine mastitis MONDO:0025100 "mastitis, bovine" bMECs up-regulated novel_circ_0016953 was significantly increased in LTA-treated primary bovine mammary epithelial cells compared with untreated cells in an inflammatory model related to bovine mastitis. 1697 39982455 Profile of circular RNAs in bovine mammary tissues infected with Staphylococcus aureus. novel_circ_0015099 bta_circ_CD36 CD36 Bos taurus bovine mastitis MONDO:0025100 "mastitis, bovine" bMECs up-regulated novel_circ_0015099 was significantly increased in LTA-treated primary bovine mammary epithelial cells compared with untreated cells in an inflammatory model related to bovine mastitis. 1698 39982455 Profile of circular RNAs in bovine mammary tissues infected with Staphylococcus aureus. novel_circ_0008169 bta_circ_PIK3CA PIK3CA Bos taurus bovine mastitis MONDO:0025100 "mastitis, bovine" bMECs up-regulated novel_circ_0008169 was significantly increased in LTA-treated primary bovine mammary epithelial cells compared with untreated cells in an inflammatory model related to bovine mastitis. 1699 39982455 Profile of circular RNAs in bovine mammary tissues infected with Staphylococcus aureus. novel_circ_0001266 bta_circ_XDH XDH Bos taurus bovine mastitis MONDO:0025100 "mastitis, bovine" bMECs up-regulated novel_circ_0001266 was significantly increased in LTA-treated primary bovine mammary epithelial cells compared with untreated cells in an inflammatory model related to bovine mastitis. 1700 39982754 Circ-Sirt6 promotes the stability and expression of m6A modified Sirt6 mRNA by recruiting IGF2BP2. hsa_circ_0048584 hsa_circ_SIRT6 SIRT6 Homo sapiens Coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 vascular smooth muscle cells (VSMCs) down-regulated circ-Sirt6 is downregulated in PDGF-BB-induced proliferative vascular smooth muscle cells in a CAD-related phenotypic switching model. Overexpression of circ-Sirt6 inhibited VSMC proliferation and migration. 1701 39982754 Circ-Sirt6 promotes the stability and expression of m6A modified Sirt6 mRNA by recruiting IGF2BP2. rno_circ_Sirt6 Sirt6 Rattus norvegicus Coronary artery disease MONDO:0005010 coronary artery disorder DOID:3393 vascular smooth muscle cells (VSMCs) down-regulated circ-Sirt6 is downregulated in PDGF-BB-induced proliferative vascular smooth muscle cells in a CAD-related phenotypic switching model. Overexpression of circ-Sirt6 inhibited VSMC proliferation and migration. 1702 39988592 Glycolysis reprogramming in CAFs promotes oxaliplatin resistance in pancreatic cancer through circABCC4 mediated PKM2 nuclear translocation. hsa_circ_0030582 circABCC4 hsa_circ_ABCC4 ABCC4 Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 CAFs up-regulated "circABCC4 is highly expressed in patient-derived CAFs compared with other examined cell populations including paired normal fibroblasts, based on circRNA-seq and qRT-PCR after primary CAF isolation/purification. Functional experiments indicate circABCC4 in CAFs promotes glycolytic reprogramming and oxaliplatin resistance in PDAC cells." GSE172096 1703 39988592 Glycolysis reprogramming in CAFs promotes oxaliplatin resistance in pancreatic cancer through circABCC4 mediated PKM2 nuclear translocation. hsa_circ_0030582 circABCC4 hsa_circ_ABCC4 ABCC4 Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 CAFs up-regulated circABCC4 is up-regulated in CAFs isolated from oxaliplatin-resistant PDAC patients compared with CAFs from oxaliplatin-sensitive patients. Functional data support that circABCC4-positive CAFs enhance oxaliplatin resistance through glycolysis reprogramming and IL-8 secretion. 1704 39998739 CircTBCK protects against osteoarthritis by regulating extracellular matrix and autophagy. circTBCK mmu_circ_TBCK TBCK Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary chondrocytes down-regulated "circTBCK was significantly downregulated in IL-1¦Â-treated primary mouse chondrocytes compared with untreated control chondrocytes, based on qRT-PCR after primary chondrocyte isolation and culture. Functional assays in the same chondrocyte system linked circTBCK to proliferation, extracellular matrix regulation, and autophagy." 1705 40010553 Jianpi Qingre Tongluo Prescription (Huangqin Qingrechubi Capsule) alleviates inflammation and hypercoagulability by inhibiting the JAK2/STAT3 pathway via CircRNA 104633 downregulation in gouty arthritis. CircRNA 104633 Homo sapiens gouty arthritis MONDO:0005393 gout DOID:13189 peripheral blood mononuclear cells (PBMCs) up-regulated CircRNA 104633 was up-regulated in isolated PBMCs from gouty arthritis patients compared with normal controls. 1706 40010553 Jianpi Qingre Tongluo Prescription (Huangqin Qingrechubi Capsule) alleviates inflammation and hypercoagulability by inhibiting the JAK2/STAT3 pathway via CircRNA 104633 downregulation in gouty arthritis. CircRNA 104633 Homo sapiens gouty arthritis MONDO:0005393 gout DOID:13189 peripheral blood mononuclear cells (PBMCs) down-regulated CircRNA 104633 expression decreased in isolated PBMCs from gouty arthritis patients after HQC treatment. 1707 40010553 Jianpi Qingre Tongluo Prescription (Huangqin Qingrechubi Capsule) alleviates inflammation and hypercoagulability by inhibiting the JAK2/STAT3 pathway via CircRNA 104633 downregulation in gouty arthritis. CircRNA 104633 Homo sapiens gouty arthritis MONDO:0005393 gout DOID:13189 fibroblast-like synoviocytes (FLSs) up-regulated "CircRNA 104633 was up-regulated in primary human FLSs co-cultured with GA-PBMCs compared with FLSs alone, accompanied by increased cell viability and inflammatory/coagulation factor abnormalities." 1708 40010553 Jianpi Qingre Tongluo Prescription (Huangqin Qingrechubi Capsule) alleviates inflammation and hypercoagulability by inhibiting the JAK2/STAT3 pathway via CircRNA 104633 downregulation in gouty arthritis. CircRNA 104633 Homo sapiens gouty arthritis MONDO:0005393 gout DOID:13189 fibroblast-like synoviocytes (FLSs) down-regulated HQC treatment down-regulated CircRNA 104633 in primary human FLSs co-cultured with GA-PBMCs and reduced inflammatory/coagulation factor abnormalities. 1709 40021969 Identification of the CeRNA axis of circ_0000006/miR-483-5p/KDM2B in the progression of aortic aneurysm to aorta dissection. hsa_circ_0000006 circ_0000006 Homo sapiens Aortic dissection MONDO:0022470 aortic dissection lentiginosis human vascular smooth muscle cells (VSMCs) up-regulated "In primary human VSMCs, PDGF treatment increased circ_0000006 expression, and siRNA-mediated circ_0000006 knockdown suppressed PDGF-induced phenotypic switch, proliferation, and migration." 1710 40041896 N 6-Methyladenosine modification of circDcbld2 in Kupffer cells promotes hepatic fibrosis via targeting miR-144-3p/Et-1 axis. mmu_circ_0000693 circDcbld2 mmu_circ_Dcbld2 Dcbld2 Mus musculus hepatic fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 KCs up-regulated "circDcbld2 was up-regulated in isolated Kupffer cells from mouse hepatic fibrosis models compared with controls, based on circRNA high-throughput sequencing. Functional evidence indicates circDcbld2 affects KC inflammatory factor production and HSC activation via the miR-144-3p/Et-1 axis." 1711 40041896 N 6-Methyladenosine modification of circDcbld2 in Kupffer cells promotes hepatic fibrosis via targeting miR-144-3p/Et-1 axis. mmu_circ_0000693 circDcbld2 mmu_circ_Dcbld2 Dcbld2 Mus musculus hepatic fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 BMDMs up-regulated "circDcbld2 was significantly elevated in bone marrow-derived macrophages in hepatic fibrosis. In BMDMs, circDcbld2 silencing reduced LPS-induced inflammation and oxidative stress and decreased HSC activation in co-culture experiments." 1712 40041896 N 6-Methyladenosine modification of circDcbld2 in Kupffer cells promotes hepatic fibrosis via targeting miR-144-3p/Et-1 axis. mmu_circ_0000693 circDcbld2 mmu_circ_Dcbld2 Dcbld2 Mus musculus hepatic fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 HSCs no change "circDcbld2 was detected in isolated hepatic stellate cells from CCl4-induced hepatic fibrosis mice, but its level did not differ significantly in hepatic fibrosis." 1713 40041896 N 6-Methyladenosine modification of circDcbld2 in Kupffer cells promotes hepatic fibrosis via targeting miR-144-3p/Et-1 axis. mmu_circ_0000693 circDcbld2 mmu_circ_Dcbld2 Dcbld2 Mus musculus hepatic fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 hepatocytes no change "circDcbld2 was detected in isolated hepatocytes from CCl4-induced hepatic fibrosis mice, but its level did not differ significantly in hepatic fibrosis." 1714 40052890 Analyzing the Role of CircSnx5 in an Animal Model of Multiple Sclerosis. mmu_circ_0001081 circSnx5 mmu_circ_Snx5 Snx5 Mus musculus experimental autoimmune encephalomyelitis MONDO:0005134 experimental autoimmune encephalomyelitis Th1 down-regulated "After MACS purification of na_ve CD4+ T cells and in vitro Th1 differentiation, circSnx5 expression was significantly decreased compared with Th0 control cells." 1715 40052890 Analyzing the Role of CircSnx5 in an Animal Model of Multiple Sclerosis. mmu_circ_0001081 circSnx5 mmu_circ_Snx5 Snx5 Mus musculus experimental autoimmune encephalomyelitis MONDO:0005134 experimental autoimmune encephalomyelitis Th17 down-regulated "After MACS purification of na_ve CD4+ T cells and in vitro Th17 differentiation, circSnx5 expression was significantly decreased compared with Th0 control cells." 1716 40052890 Analyzing the Role of CircSnx5 in an Animal Model of Multiple Sclerosis. mmu_circ_0001081 circSnx5 mmu_circ_Snx5 Snx5 Mus musculus experimental autoimmune encephalomyelitis MONDO:0005134 experimental autoimmune encephalomyelitis Treg down-regulated "After MACS purification of na_ve CD4+ T cells and in vitro Treg differentiation, circSnx5 expression was significantly decreased compared with Th0 control cells." 1717 40061587 Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease. hsa_circ_0004662 circSOD2 hsa_circ_SOD2 SOD2 Homo sapiens metabolic dysfunction-associated steatotic liver disease MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 primary hepatocytes up-regulated circSOD2 was up-regulated in primary hepatocytes from MAFLD subjects compared with controls. 1718 40061587 Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease. circSOD2 SOD2 Mus musculus metabolic dysfunction-associated steatotic liver disease MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 primary mouse hepatocytes up-regulated "circSOD2 was increased in primary hepatocytes from HFD-induced MAFLD mice compared with control hepatocytes, and NAC pretreatment reduced this increase." 1719 40061587 Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease. circSOD2 SOD2 Mus musculus metabolic dysfunction-associated steatotic liver disease MONDO:0013209 metabolic dysfunction-associated steatotic liver disease DOID:0080208 bone marrow mesenchymal stem cells up-regulated "circSOD2 was up-regulated in BMSCs from HFD-induced MAFLD mice compared with normal diet mice, and Vitamin C supplementation reduced this increase. In BMSCs, circSOD2 inhibited osteogenic differentiation and bone formation through miR-29b." 1720 40083007 Circ-AARS plays an important role during the odontogenic differentiation of dental pulp stem cells by modulating miR-24-3p/KLF6 expression. hsa_circ_0040158 circ-AARS hsa_circ_AARS AARS Homo sapiens others others others DPSCs up-regulated "In isolated and cultured human dental pulp stem cells, hsa_circ_0040158/circ-AARS was significantly increased during odontogenic differentiation compared with normal DPSCs. Functional assays showed that circ-AARS promotes odontogenic differentiation of DPSCs." 1721 40089857 Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ-PIAS1-5/miR-219a-2-3p/TEAD1 Axis. circ_PIAS1_5 hsa_circ_PIAS1 PIAS1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 monocytes in the peripheral blood down-regulated circ_PIAS1_5 was measured by qRT-PCR in peripheral blood monocytes and was lower in patients with HHcy-associated atherosclerosis than in healthy controls. 1722 40089857 Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ-PIAS1-5/miR-219a-2-3p/TEAD1 Axis. circ_PIAS1_5 PIAS1 Mus musculus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 F4/80 up-regulated RNA-FISH combined with F4/80 immunostaining showed circ_PIAS1_5 co-localization with macrophages in atherosclerotic plaques of high-methionine diet ApoE_/_ mice. The study also reports that circ_PIAS1_5 suppresses lipid accumulation in foam cells during Hcy-induced atherosclerosis. 1723 40091031 Teriparatide facilitates osteogenic differentiation of bone mesenchymal stem cells to alleviate idiopathic osteoporosis via the circFNDC3B-miR-125a-5p-GLS axis. hsa_circ_FNDC3B FNDC3B Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 primary hMSCs down-regulated "circFNDC3B expression was lower in primary hMSCs isolated from osteoporosis patients than in hMSCs from healthy controls, as detected by RT-qPCR." 1724 40091031 Teriparatide facilitates osteogenic differentiation of bone mesenchymal stem cells to alleviate idiopathic osteoporosis via the circFNDC3B-miR-125a-5p-GLS axis. circFNDC3B hsa_circ_FNDC3B FNDC3B Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 hMSCs up-regulated circFNDC3B expression increased in primary hMSCs as osteogenic differentiation progressed in an in vitro osteogenesis model. 1725 40091031 Teriparatide facilitates osteogenic differentiation of bone mesenchymal stem cells to alleviate idiopathic osteoporosis via the circFNDC3B-miR-125a-5p-GLS axis. circFNDC3B hsa_circ_FNDC3B FNDC3B Homo sapiens osteoporosis MONDO:0005298 osteoporosis DOID:11476 hMSCs up-regulated circFNDC3B expression was significantly increased in hMSCs after Teriparatide treatment. Functional assays indicated that circFNDC3B contributed to TPD-promoted osteogenic differentiation of hMSCs. 1726 40091520 ADAR1-HNRNPL-Mediated CircCANX Decline Promotes Autophagy in Chronic Obstructive Pulmonary Disease. hsa_circ_0001564 circCANX hsa_circ_CANX CANX Homo sapiens Chronic obstructive pulmonary disease MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 lymphocytes (CD3) unknown "circCANX was detected in CD3-marked lymphocytes by co-localization with a FITC-labeled circCANX probe in the COPD context, but the cell-specific direction of expression change was not reported." 1727 40091520 ADAR1-HNRNPL-Mediated CircCANX Decline Promotes Autophagy in Chronic Obstructive Pulmonary Disease. hsa_circ_0001564 circCANX hsa_circ_CANX CANX Homo sapiens Chronic obstructive pulmonary disease MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 macrophages (F4/80) unknown "circCANX was detected in F4/80-marked macrophages by co-localization with a FITC-labeled circCANX probe in the COPD context, but the cell-specific direction of expression change was not reported." 1728 40091520 ADAR1-HNRNPL-Mediated CircCANX Decline Promotes Autophagy in Chronic Obstructive Pulmonary Disease. hsa_circ_0001564 circCANX hsa_circ_CANX CANX Homo sapiens Chronic obstructive pulmonary disease MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 epithelial cells (CK18) unknown "circCANX was detected in CK18-marked epithelial cells by co-localization with a FITC-labeled circCANX probe in the COPD context, but the cell-specific direction of expression change was not reported." 1729 40093898 Microglial circDlg1 modulates neuroinflammation by blocking PDE4B ubiquitination-dependent degradation associated with Alzheimer's disease. mmu_circ_0000679 circDlg1 mmu_circ_Dlg1 Dlg1 Mus musculus Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 cortical microglia up-regulated "Mouse circDlg1/mmu_circ_0000679 is up-regulated in cortical microglia from APP/PS1 Alzheimer's disease model mice compared with WT mice, supported by sorted microglia qRT-PCR and FISH/immunostaining colocalization. Microglia-specific circDlg1 knockdown reduced neuroinflammation and altered microglial response in APP/PS1 mice." 1730 40093898 Microglial circDlg1 modulates neuroinflammation by blocking PDE4B ubiquitination-dependent degradation associated with Alzheimer's disease. hsa_circ_0123248 hsa_circ_0123248 hsa_circ_DLG1 DLG1 Homo sapiens Alzheimer's disease / AD MONDO:0004975 Alzheimer disease DOID:10652 microglia up-regulated "Human circDLG1 is increased in cortical microglia from AD patients compared with healthy controls, supported by FISH combined with microglial immunostaining in human cortex." 1731 40093901 Circular RNA CHACR is involved in the pathogenesis of cardiac hypertrophy. chr1: 53256629-53282092- mmu_circ_Pms1 Pms1 Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocytes down-regulated "CHACR was downregulated in Ang II-induced hypertrophic primary mouse cardiomyocytes compared with untreated cardiomyocytes, based on qRT-PCR after primary cardiomyocyte isolation. Functional experiments in cardiomyocytes showed that CHACR regulated CPT1b protein stability and Jak2/Stat3 signaling." 1732 40095343 EIF4A3-Induced circ_0029941 Promotes Astrocyte Activation Through Enhancing Autophagy via miR-224-5p/NFAT5 Axis. circ_0029941 mmu_circ_PDS5B PDS5B Mus musculus ischemic stroke MONDO:1060198 ischemic stroke primary mouse astrocyte (AS) up-regulated "circ_0029941 was increased in OGD/R-treated primary mouse astrocytes compared with untreated cells, and FISH combined with GFAP immunostaining showed co-localization in the cortex of tMCAO mice. Knockdown experiments supported a role in astrocyte activation and autophagy." 1733 40099364 "A Novel Hidden Protein p-414aa Encoded by circSETD2(14,15) Inhibits Vascular Remodeling." hsa_circ_0065149 hsa_circ_SETD2 SETD2 Homo sapiens vascular remodeling diseases MONDO:0005385 vascular disorder DOID:178 human aortic smooth muscle cells (HASMCs) down-regulated "circSETD2(14,15) was reduced in PDGF-BB-induced proliferative human aortic smooth muscle cells. Functional experiments in the same cell type showed that circSETD2(14,15) inhibited VSMC phenotypic switching, proliferation and migration." GSE77278 1734 40116870 Dioscin alleviates the dysfunction of fibroblast-like synoviocytes by circ_0008267/miR-942-5p/FKBP5 axis during rheumatoid arthritis. hsa_circ_0008267 hsa_circ_SDHAP2 SDHAP2 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLS up-regulated "circ_0008267 expression was increased in RA-FLS compared with normal FLS based on qRT-PCR after FLS isolation and culture. Functional assays in RA-FLS indicated that circ_0008267 deficiency suppressed proliferation, invasion, migration, and inflammation and induced apoptosis." 1735 40116870 Dioscin alleviates the dysfunction of fibroblast-like synoviocytes by circ_0008267/miR-942-5p/FKBP5 axis during rheumatoid arthritis. hsa_circ_0008267 hsa_circ_SDHAP2 SDHAP2 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLS down-regulated "Dioscin treatment decreased circ_0008267 expression in RA-FLS based on qRT-PCR. Overexpression of circ_0008267 reversed dioscin-mediated suppression of RA-FLS proliferation, invasion, migration, and inflammatory response and reversed apoptosis promotion." 1736 40131148 CircBTBD7-420aa Encoded by hsa_circ_0000563 Regulates the Progression of Atherosclerosis and Construction of circBTBD7-420aa Engineered Exosomes. hsa_circ_0000563 circBTBD7 hsa_circ_BTBD7 BTBD7 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 smooth muscle cells up-regulated "FISH evidence showed colocalization of circBTBD7 with vascular smooth muscle cells in human coronary arteries, indicating smooth muscle cell-associated expression in the atherosclerosis/CAD context." 1737 40143778 Nose-to-Brain Delivery of Circular RNA SCMH1-Loaded Lipid Nanoparticles for Ischemic Stroke Therapy. mmu_circ_0001254 circSCMH1 mmu_circ_SCMH1 SCMH1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke neurons (NeuN +) unknown "Cy5-labeled circSCMH1 delivered by LNP1 was co-localized with the neuronal marker NeuN in peri-infarct brain sections of PT stroke mice, with predominant localization in neurons." 1738 40143778 Nose-to-Brain Delivery of Circular RNA SCMH1-Loaded Lipid Nanoparticles for Ischemic Stroke Therapy. mmu_circ_0001254 circSCMH1 mmu_circ_SCMH1 SCMH1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke astrocytes (GFAP +) unknown Cy5-labeled circSCMH1 delivered by LNP1 was detected in GFAP-positive astrocytes in peri-infarct brain sections of PT stroke mice. 1739 40143778 Nose-to-Brain Delivery of Circular RNA SCMH1-Loaded Lipid Nanoparticles for Ischemic Stroke Therapy. mmu_circ_0001254 circSCMH1 mmu_circ_SCMH1 SCMH1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke microglia (Iba-1 +) unknown Cy5-labeled circSCMH1 delivered by LNP1 was detected in Iba-1-positive microglia in peri-infarct brain sections of PT stroke mice. 1740 40145839 A Novel Protein NAB1-356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis. circNAB1 hsa_circ_NAB1 NAB1 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 cardiomyocytes down-regulated "In situ hybridization combined with immunofluorescence showed circNAB1 expression in human atrial cardiomyocytes, and atriums without AF had higher circNAB1 levels than atriums with AF." 1741 40145839 A Novel Protein NAB1-356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis. circNAB1 hsa_circ_NAB1 NAB1 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 cardiac fibroblasts down-regulated "In situ hybridization combined with immunofluorescence showed circNAB1 expression in human atrial cardiac fibroblasts, and atriums without AF had higher circNAB1 levels than atriums with AF." 1742 40160441 Blocking circular RNA FNDC3B induces fibroblast-like synoviocytes dysfunction to ameliorate rheumatoid arthritis through regulating the miR-125a-5p-Hexokinase2 axis. hsa_circ_FNDC3B FNDC3B Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 fibroblast-like synoviocytes up-regulated "circFNDC3B is significantly up-regulated in human fibroblast-like synoviocytes from rheumatoid arthritis patients compared with FLSs from normal volunteers. In FLSs-RA, circFNDC3B promotes glucose metabolism and resistance to oxidative stress-induced cell injury through the miR-125a-5p-HK2 axis." 1743 40164374 "Construction of a competing endogenous RNA regulatory network in pterygium and role of hsa_circ_0081682 in fibroblast proliferation, migration, and apoptosis." hsa_circ_0081682 Homo sapiens pterygium MONDO:0005085 pterygium DOID:0002116 primary Human Pterygium Fibroblasts (HPF) down-regulated "hsa_circ_0081682 was expressed at lower levels in primary human pterygium fibroblasts than in human conjunctival fibroblasts. Knockdown experiments in HPFs indicated effects on proliferation, migration, and apoptosis." 1744 40171669 Small Extracellular Vesicles From Hypoxia-Neuron Maintain Blood-Brain Barrier Integrity. mmu_circ_OGDH OGDH Mus musculus ischemic stroke MONDO:1060198 ischemic stroke ECs down-regulated "In MCAO/R mouse brain, CircOGDH was colocalized with the endothelial marker CD34 in ECs, and this endothelial colocalization was significantly reduced after neuron-specific CircOGDH knockdown. The study links neuronal sEV-delivered CircOGDH to endothelial COL4A4 expression and BBB integrity." 1745 40189516 Intranasal delivery of R8-modified circNFXL1 liposomes ameliorates Su5416-induced pulmonary arterial hypertension in C57BL/6 mice. circNFXL1 NFXL1 Homo sapiens pulmonary arterial hypertension MONDO:0015924 pulmonary arterial hypertension vascular smooth muscle cells down-regulated "RNA-FISH/immunofluorescence staining of mouse lung sections showed circNFXL1 signal together with the smooth muscle marker ¦Á-SMA, and circNFXL1 levels were decreased in PAH compared with normal controls." 1746 40189516 Intranasal delivery of R8-modified circNFXL1 liposomes ameliorates Su5416-induced pulmonary arterial hypertension in C57BL/6 mice. circNFXL1 NFXL1 Homo sapiens pulmonary arterial hypertension MONDO:0015924 pulmonary arterial hypertension vascular smooth muscle cells up-regulated "RNA-FISH/immunofluorescence staining of mouse lung sections showed circNFXL1 signal together with ¦Á-SMA staining, and R8-circNFXL1 treatment increased circNFXL1 fluorescence intensity compared with untreated PAH mice." 1747 40191465 Circ_0088200 acts as a sponge for miR-127-5p to promote the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes. hsa_circ_0088200 hsa_circ_TNC TNC Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLS up-regulated "Circ_0088200 was significantly upregulated in patient-derived RA fibroblast-like synoviocytes compared with OA fibroblast-like synoviocytes, validated by qRT-PCR after primary FLS isolation. Functional experiments in RA-FLS showed Circ_0088200 promoted migration and invasion via the miR-127-5p/MMP1 axis." 1748 40192802 Circular RNA circSTX12 regulates osteo-adipogenic balance and proliferation of BMSCs in senile osteoporosis. hsa_circ_0008126 circSTX12 hsa_circ_STX12 STX12 Homo sapiens senile osteoporosis MONDO:0005298 osteoporosis DOID:11476 BMSCs up-regulated "circSTX12 is up-regulated in isolated BMSCs from osteopenia and osteoporotic patients compared with young controls, measured by qPCR after primary BMSC isolation. Functional experiments in BMSCs showed that circSTX12 regulates osteogenic and adipogenic differentiation and proliferation." 1749 40208437 Dysregulation of the circ-Hdac4/miR-30c/RBPJ axis in decidua impairs placental function in preeclampsia. circ-Hdac4 mmu_circ_Hdac4 Hdac4 Mus musculus preeclampsia MONDO:0005081 preeclampsia DOID:10591 primary mouse uterine endometrial stromal cells (mESCs) up-regulated "circ-Hdac4 was markedly upregulated in isolated primary mouse uterine endometrial stromal cells during in vitro decidualization. Knockdown of circ-Hdac4 in mESCs reduced decidualization marker expression, supporting a role in stromal cell decidualization relevant to preeclampsia-related placental dysfunction." 1750 40214644 Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling. hsa_circ_0131722 cKIF6 hsa_circ_KIF6 KIF6 Homo sapiens pathological lymphangiogenesis MONDO:0000001 disease DOID:4 lymphatic endothelial cells (LECs) up-regulated "cKIF6 was increased in LPS-treated lymphatic endothelial cells compared with LECs cultured under normal conditions. Functional experiments in LECs showed that cKIF6 regulates viability, proliferation, migration, tube formation, and cholesterol metabolism." 1751 40220480 hsa_circ_0095812 accelerates periodontitis progression by adsorbing miR-485-3p-mediated THBS1 expression. hsa_circ_0095812 circLRRC4C hsa_circ_LRRC4C LRRC4C Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 PDLCs up-regulated "circLRRC4C was up-regulated in primary human PDLCs after LPS treatment, an in vitro periodontitis injury model. Knockdown of circLRRC4C attenuated LPS-induced PDLC inflammation and apoptosis." 1752 40237951 CircGTF2H2C Regulates NLRP3 Dephosphorylation via Modulating PTPN11 Expression in Spinal Cord Injury. circGTF2H2C rno_circ_GTF2H2C GTF2H2C Rattus norvegicus spinal cord injury MONDO:0043797 spinal cord injury Astrocytes induced by LPS up-regulated circGTF2H2C was significantly up-regulated in primary astrocyte-derived SCI cells compared with control astrocytes by RT-qPCR. Knockdown experiments in SCI cells showed that circGTF2H2C promoted inflammatory cytokine release and necrosis marker expression. 1753 40242872 Novel Truncated Peptide Derived From circCDYL Exacerbates Cardiac Hypertrophy. circCDYL rno_circ_cdyl cdyl Rattus norvegicus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocytes up-regulated "circCDYL is mainly expressed in rat cardiomyocytes compared with cardiac fibroblasts, based on qPCR analysis of RNAs from neonatal rat cardiomyocytes and cardiac fibroblasts." 1754 40242872 Novel Truncated Peptide Derived From circCDYL Exacerbates Cardiac Hypertrophy. circCDYL rno_circ_cdyl cdyl Rattus norvegicus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 primary rat cardiomyocytes up-regulated "circCDYL is up-regulated in primary rat cardiomyocytes after Ang II treatment, a cellular model of pathologically stimulated cardiomyocyte hypertrophy. Functional experiments in cardiomyocytes showed that circCDYL promotes cardiomyocyte hypertrophy." 1755 40248098 Circ_0098181 binds PKM2 to attenuate liver fibrosis. circ_0098181 rno_circ_SOX5 SOX5 Rattus norvegicus liver fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 activated rat primary HSCs down-regulated "circ_0098181 is down-regulated in activated primary rat hepatic stellate cells compared with quiescent primary rat hepatic stellate cells. Functional assays in hepatic stellate cells indicate that circ_0098181 suppresses activation, proliferation, and migration." 1756 40250664 Circular RNA CDYL facilitates hepatocellular carcinoma stemness and PD-L1+ exosomes-mediated immunotherapy resistance via stabilizing hornerin protein by blocking synoviolin 1-mediated ubiquitination. Circ-CDYL hsa_circ_CDYL CDYL Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 HCC tumor cells up-regulated "FISH-IF in HCC tissue-derived organoids showed Circ-CDYL RNA localized in tumor cells, with greater Circ-CDYL-HRNR colocalization in Circ-CDYL-high organoids than Circ-CDYL-low organoids." 1757 40252715 Novel_circ_0004013 targeting miR-29a-3p affects age-related hearing loss in miR-29a mouse model by RNA-seq analysis. novel_circ_0004013 Mus musculus Age-related hearing loss MONDO:0043765 presbycusis hair cells (HCs) up-regulated FISH analysis of mouse cochlear frozen sections showed higher novel_circ_0004013 fluorescence intensity in hair cells of miR-29a-deficient mice than in corresponding regions of miR-29a +/+ mice. 1758 40252715 Novel_circ_0004013 targeting miR-29a-3p affects age-related hearing loss in miR-29a mouse model by RNA-seq analysis. novel_circ_0004013 Mus musculus Age-related hearing loss MONDO:0043765 presbycusis spiral ganglion neurons (SGNs) no change FISH analysis of mouse cochlear frozen sections showed no significant difference in novel_circ_0004013 fluorescence intensity in spiral ganglion neurons between miR-29a-deficient mice and miR-29a +/+ mice. 1759 40273295 A new protein isoform encoded by human circular RNA circSLC8a1 contributes to cardiac remodelling. hsa_circ_0005232 circSLC8a1 hsa_circ_SLC8A1 SLC8A1 Homo sapiens cardiac remodeling MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiomyocyte up-regulated "Immunofluorescent in situ hybridization showed circSLC8a1 staining overlapping with the cardiomyocyte marker cTNT in mouse heart tissue, and circSLC8a1 delivery increased staining in pressure-overload mouse hearts." 1760 40273295 A new protein isoform encoded by human circular RNA circSLC8a1 contributes to cardiac remodelling. hsa_circ_0005232 circSLC8a1 hsa_circ_SLC8A1 SLC8A1 Homo sapiens cardiac remodeling MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 cardiac fibroblasts up-regulated "Immunofluorescent in situ hybridization showed circSLC8a1 staining overlapping with the cardiac fibroblast marker vimentin in mouse heart tissue, and circSLC8a1 delivery increased staining in pressure-overload mouse hearts." 1761 40279507 Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair. hsa_circ_0002874 CircGLIS3(2) hsa_circ_GLIS3 GLIS3 Homo sapiens acute wound healing MONDO:0021178 injury CD90+ dermal fibroblasts up-regulated "CircGLIS3(2) is up-regulated in CD90+ dermal fibroblasts isolated from human acute wound tissues compared with donor-matched skin fibroblasts, supported by MACS followed by RNA-seq and qRT-PCR validation. The study reports that CircGLIS3(2) RNA promotes matrix-secreting fibroblast activation and its encoded protein promotes fibroblast proliferation." GSE174661 1762 40279507 Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair. hsa_circ_0002874 CircGLIS3(2) hsa_circ_GLIS3 GLIS3 Homo sapiens acute wound healing MONDO:0021178 injury CD45_ epidermal keratinocytes no change "CircGLIS3(2) showed no change in isolated CD45_ epidermal keratinocytes from human acute wound tissue compared with donor-matched skin, while it increased in wound fibroblasts." GSE174661 1763 40281642 circ_0002970 promotes fibroblast-like synoviocytes invasion and the inflammatory response through Hippo/YAP signaling to induce CTGF/CCN1 expression in rheumatoid arthritis. hsa_circ_0002970 circ_0002970 hsa_circ_CEMIP CEMIP Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLSs up-regulated "circ_0002970 was detected by circRNA sequencing of isolated FLSs and was up-regulated in RA-FLSs compared with OA and healthy-control FLSs. Functional experiments in RA-FLSs showed that circ_0002970 promotes migration, invasion, and inflammatory response through Hippo-YAP signaling." 1764 40286845 CircPAFAH1B2 induces chondrocytes mitochondrial dysfunction and promotes cartilage degeneration through binding molecular chaperone ClpB. hsa_circ_0007827 circPAFAH1B2 hsa_circ_PAFAH1B2 PAFAH1B2 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated circPAFAH1B2 is upregulated in OA human cartilage compared with control cartilage and is localized to the cytoplasm of chondrocytes. Functional experiments in OA-PHCs indicate that increased circPAFAH1B2 impairs mitochondrial function and promotes apoptosis-related cartilage degeneration. 1765 40286845 CircPAFAH1B2 induces chondrocytes mitochondrial dysfunction and promotes cartilage degeneration through binding molecular chaperone ClpB. hsa_circ_0007827 circPAFAH1B2 hsa_circ_PAFAH1B2 PAFAH1B2 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes up-regulated "circPAFAH1B2 is upregulated in IL-1¦Â-stimulated primary human chondrocytes, an inflammatory OA-related model. Functional experiments in PHCs and OA-PHCs support its role in mitochondrial dysfunction, metabolic dysregulation, and apoptosis." 1766 40286845 CircPAFAH1B2 induces chondrocytes mitochondrial dysfunction and promotes cartilage degeneration through binding molecular chaperone ClpB. mmu_circ_0001770 circPafah1b2 mmu_circ_Pafah1b2 Pafah1b2 Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes up-regulated "The mouse homolog mmu_circ_0001770, designated circPafah1b2, was detected by FISH in the C57BL/6J DMM-induced OA model, with results described as similar to the human upregulation findings. In vivo modulation of circPafah1b2 in DMM mice affected mitochondrial dysfunction, apoptosis, and OA phenotypes in cartilage." 1767 40321703 Expression patterns of circRFX3 and miR-587 in colorectal cancer patients. hsa_circ_RFX3 RFX3 Homo sapiens Colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 lymphocytes down-regulated circRFX3 was measured by qRT-PCR after peripheral blood lymphocyte isolation and was significantly lower in CRC patients than in healthy controls. 1768 40326973 Hsa_circ_0007905 as a modulator of miR-330-5p and VDAC1: Enhancing stemness and reducing apoptosis in cervical cancer stem cells. hsa_circ_0007905 circSTX6 hsa_circ_STX6 STX6 Homo sapiens cervical cancer MONDO:0002974 cervical cancer DOID:4362 CD133 + CaSki cells up-regulated "hsa_circ_0007905 was up-regulated in flow-sorted CD133+ CaSki cervical cancer stem cells compared with CaSki cells by RT-qPCR. Silencing hsa_circ_0007905 reduced proliferation, migration, invasion, and self-renewal while increasing apoptosis in these CSCs." 1769 40330565 Platelet-Derived circRNAs hsa_circ_0004771 and hsa_circ_0019120 Differentially Expressed in Colorectal Cancer and Polyps. hsa_circ_0004771 hsa_circNRIP1_007 hsa_circ_NRIP1 NRIP1 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 platelets up-regulated "Platelet-derived hsa_circ_0004771 was up-regulated in colorectal cancer patients compared with healthy individuals, measured after platelet isolation and RT-qPCR." 1770 40330565 Platelet-Derived circRNAs hsa_circ_0004771 and hsa_circ_0019120 Differentially Expressed in Colorectal Cancer and Polyps. hsa_circ_0004771 hsa_circNRIP1_007 hsa_circ_NRIP1 NRIP1 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 platelets up-regulated "Platelet-derived hsa_circ_0004771 was reported as up-regulated in individuals with advanced polyps compared with healthy individuals, but the difference was not statistically significant." 1771 40330565 Platelet-Derived circRNAs hsa_circ_0004771 and hsa_circ_0019120 Differentially Expressed in Colorectal Cancer and Polyps. hsa_circ_0019120 hsa_circBTAF1_002 hsa_circ_BTAF1 BTAF1 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 platelets up-regulated "Platelet-derived hsa_circ_0019120 was significantly up-regulated in colorectal cancer patients compared with healthy individuals, measured after platelet isolation and RT-qPCR." 1772 40330565 Platelet-Derived circRNAs hsa_circ_0004771 and hsa_circ_0019120 Differentially Expressed in Colorectal Cancer and Polyps. hsa_circ_0019120 hsa_circBTAF1_002 hsa_circ_BTAF1 BTAF1 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 platelets up-regulated "Platelet-derived hsa_circ_0019120 was significantly up-regulated in individuals with advanced polyps compared with healthy individuals, measured after platelet isolation and RT-qPCR." 1773 40336343 Atrial remodelling and atrial fibrillation self-sustaining: the role of circulating circDGCR8. hsa_circ_0001204 circDGCR8 hsa_circ_DGCR8 DGCR8 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 human cardiac fibroblast-atrial cells up-regulated "In human atrial fibroblasts, circDGCR8 was up-regulated after AngII treatment during fibroblast-to-myofibroblast phenotypic switch. Functional experiments indicated that circDGCR8 promoted fibroblast proliferation, collagen synthesis, and myofibroblast transition." 1774 40341878 Tumor cell-intrinsic circular RNA circFNDC3B attenuates CD8+ T cells infiltration in non-small cell lung cancer. circFNDC3B hsa_circ_FNDC3B FNDC3B Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 EPCAM+ tumor cells up-regulated "circFNDC3B was upregulated in NSCLC tumor tissue compared with adjacent normal lung tissue and was primarily localized in EPCAM+ tumor cells by in situ hybridization coupled with RT-qPCR quantification. Mechanistically, tumor cell-intrinsic circFNDC3B suppressed CXCL10/CXCL11-dependent CD8+ T cell recruitment." PRJNA863919 1775 40341878 Tumor cell-intrinsic circular RNA circFNDC3B attenuates CD8+ T cells infiltration in non-small cell lung cancer. circFNDC3B hsa_circ_FNDC3B FNDC3B Homo sapiens non-small cell lung cancer / NSCLC MONDO:0005233 non-small cell lung carcinoma DOID:3908 CD45_ non-immune cells up-regulated "circFNDC3B was detected primarily in CD45_ non-immune cells from NSCLC tumor specimens, together with EPCAM+ tumor-cell localization. The article links tumor cell-intrinsic circFNDC3B to reduced CXCL10/CXCL11 expression and impaired CD8+ T cell infiltration." PRJNA863919 1776 40342810 MiR-335-5p Escaped from CircKIAA0586 Adsorption Contributes to Mechanical Overloading-Induced Cartilage Degeneration by Targeting Lymphoid-Specific Helicase. hsa_circ_0102233 circ_0102233 hsa_circ_KIAA0586 KIAA0586 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human primary chondrocytes down-regulated circKIAA0586 is down-regulated in human primary chondrocytes after mechanical overloading compared with control cells. Functional experiments indicate that circKIAA0586 supplementation suppresses pro-senescent and pro-catabolic effects of mechanical overloading in chondrocytes. GSE274759; GSE274760; GSE274761 1777 40373256 CircRNA GRAMD4 induces NBR1 expression to promote autophagy and immune escape in renal cell carcinoma. hsa_circ_0001250 circGRAMD4 hsa_circ_GRAMD4 GRAMD4 Homo sapiens renal cell carcinoma MONDO:0005086 renal cell carcinoma DOID:4450 RCC cells up-regulated FISH-IF staining of RCC patient tumor tissue slices showed that circGRAMD4 is preferentially expressed in RCC tumor cells rather than immune cells. Functional experiments indicate that tumor-cell circGRAMD4 suppresses CD8+ T cell antitumor responses. 1778 40375961 PLGA microspheres loaded with si-circETS1 as a therapeutic strategy to delay intervertebral disc degeneration. hsa_circ_0002083 circETS1 hsa_circ_ETS1 ETS1 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 human NPCs up-regulated "In primary cultured human nucleus pulposus cells, TNF-¦Á induction to promote degeneration significantly upregulated circETS1 expression. Functional experiments in NPCs showed that inhibiting circETS1 alleviated TNF-¦Á-induced suppression of proliferation and apoptosis and promoted extracellular matrix-related protein expression." 1779 40384439 ca-circSCN8A Promotes HPASMCs Ferroptosis via LLPS Initiated R-Loop. ca-circSCN8A hsa_circ_SCN8A SCN8A Homo sapiens pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 human pulmonary arterial smooth muscle cells up-regulated ca-circSCN8A is up-regulated in hypoxic human pulmonary arterial smooth muscle cells. Functional experiments in HPASMCs support that ca-circSCN8A promotes hypoxia-related ferroptosis through regulation of SLC7A11. GSM5235379-GSM5235391 1780 40387410 Circ_0006646 Promotes the Progression of Osteoarthritis via Upregulating CDH11 Expression in an IGF2BP2-Dependent Manner. hsa_circ_0006646 circ_0006646 hsa_circ_PTK2 PTK2 Homo sapiens Osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human chondrocytes up-regulated "circ_0006646 was up-regulated in primary human chondrocytes treated with IL-1¦Â compared with untreated chondrocytes. Knockdown of circ_0006646 modulated proliferation, apoptosis, inflammation, and ECM degradation in IL-1¦Â-treated chondrocytes." 1781 40409233 CiR-EIS alleviates metabolic dysfunction-associated steatohepatitis by modulating macrophage polarization involving the miR-548m/IGF1 axis. hsa_circ_0008882 hsa_circ_MT-ND5 MT-ND5 Homo sapiens metabolic dysfunction-associated steatohepatitis MONDO:0007027 metabolic dysfunction-associated steatohepatitis DOID:0080547 macrophages down-regulated "IF-FISH in human liver sections showed ciR-EIS colocalization with the macrophage marker CD68, and macrophage ciR-EIS expression was decreased in MASH. Functional experiments in THP-1-derived macrophages indicated that ciR-EIS modulates macrophage polarization involving the miR-548m/IGF1 axis." 1782 40435734 Loss of circular EYA3 attenuates formaldehyde-induced cardiomyocyte pyroptosis and congenital heart defects by regulating Smad5 stability. rno_circ_009926 rno_circ_EYA3 EYA3 Rattus norvegicus congenital heart disease MONDO:0005453 congenital heart disease DOID:1682 rat cardiomyocytes (CM) up-regulated "circEYA3 was enriched in primary rat cardiomyocytes compared with cardiac fibroblasts isolated from adult rat hearts, measured by qRT-PCR. The study links circEYA3 to FA-induced cardiomyocyte pyroptosis and congenital heart defects." 1783 40446676 CircRALGPS2 modulates chicken follicle development through promotion of granulosa cell apoptosis and autophagy via the miR-200a-3p/TGF¦Â2/SMAD pathway. circRALGPS2 gga_circ_RALGPS2 RALGPS2 Gallus gallus follicular atresia MONDO:0000001 disease DOID:4 granulosa cells up-regulated "circRALGPS2 was reported to be significantly elevated in atretic follicles compared with normal follicles, and granulosa layers/primary chicken granulosa cells were used for downstream analyses. In primary chicken granulosa cells, circRALGPS2 promoted apoptosis through the miR-200a-3p/TGF¦Â2/SMAD pathway." PRJNA721929 1784 40455824 ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas. ciRS-7 / CDR1as hsa_circ_LINC00632 LINC00632 Homo sapiens adenocarcinomas MONDO:0004970 adenocarcinoma DOID:299 cancer cells down-regulated Single molecule chromogenic and fluorescent in situ hybridization showed that ciRS-7 was absent from cancer cells in most primary adenocarcinoma samples while present in stromal areas. 1785 40455824 ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas. ciRS-7 / CDR1as hsa_circ_LINC00632 LINC00632 Homo sapiens adenocarcinomas MONDO:0004970 adenocarcinoma DOID:299 stroma up-regulated "Single molecule chromogenic and fluorescent in situ hybridization showed that ciRS-7 was expressed in stromal regions of primary adenocarcinoma samples, contrasting with its absence from cancer cells in most cases." 1786 40455824 ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas. ciRS-7 / CDR1as hsa_circ_LINC00632 LINC00632 Homo sapiens colon adenocarcinoma MONDO:0002271 colon adenocarcinoma DOID:234 cancer cell fractions down-regulated Laser-capture microdissection followed by RT-qPCR showed lower ciRS-7 expression in colon adenocarcinoma cancer cell fractions than in stromal fractions. 1787 40455824 ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas. ciRS-7 / CDR1as hsa_circ_LINC00632 LINC00632 Homo sapiens colon adenocarcinoma MONDO:0002271 colon adenocarcinoma DOID:234 stromal cell fractions up-regulated Laser-capture microdissection followed by RT-qPCR showed higher ciRS-7 expression in colon adenocarcinoma stromal fractions than in cancer cell fractions. 1788 40457889 Exosomal circ_0003057 promotes osteo/odontogenic differentiation of hDPSCs by binding with EIF4A3 through upregulated parental gene ANKH. circ_0003057 hsa_circ_ANKH ANKH Homo sapiens others others others hDPSCs up-regulated "In primary cultured human dental pulp stem cells, circ_0003057 was upregulated during osteo/odontogenic differentiation and validated by qRT-PCR after candidate circRNA screening. Functional experiments showed that circ_0003057 promoted osteo/odontogenic differentiation of hDPSCs." 1789 40459649 Circular RNA role in Atherosclerosis Development and Progression. circDcbld1 rno_circ_Dcbld1 Dcbld1 Rattus norvegicus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 VSMCs up-regulated "circDcbld1 was elevated in injured rat carotid arteries with intimal hyperplasia and localized by FISH predominantly to medial and neointimal layers, especially VSMCs. Functional data linked circDcbld1 to VSMC migration and neointimal hyperplasia." 1790 40459649 Circular RNA role in Atherosclerosis Development and Progression. CircEsyt2(2-6) hsa_circ_ESYT2 ESYT2 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 VSMCs up-regulated "CircEsyt2(2-6) was upregulated in atherosclerotic aortic plaques and localized by FISH/immunofluorescence to VSMCs among other plaque cell types. Functional experiments linked it to VSMC proliferation, migration, apoptosis, and remodeling." 1791 40459649 Circular RNA role in Atherosclerosis Development and Progression. CircEsyt2(2-6) hsa_circ_ESYT2 ESYT2 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 ECs up-regulated CircEsyt2(2-6) was upregulated in atherosclerotic aortic plaques and localized by FISH/immunofluorescence to ECs among other plaque cell types. 1792 40459649 Circular RNA role in Atherosclerosis Development and Progression. CircEsyt2(2-6) hsa_circ_ESYT2 ESYT2 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 fibroblasts up-regulated CircEsyt2(2-6) was upregulated in atherosclerotic aortic plaques and localized by FISH/immunofluorescence to fibroblasts among other plaque cell types. 1793 40459649 Circular RNA role in Atherosclerosis Development and Progression. CircEsyt2(2-6) hsa_circ_ESYT2 ESYT2 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 macrophages up-regulated CircEsyt2(2-6) was upregulated in atherosclerotic aortic plaques and localized by FISH/immunofluorescence to macrophages among other plaque cell types. 1794 40459649 Circular RNA role in Atherosclerosis Development and Progression. CircEsyt2(2-6) mmu_circ_Esyt2 Esyt2 Mus musculus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 VSMCs up-regulated "CircEsyt2(2-6) was upregulated in atherosclerotic aortic plaques and localized by FISH/immunofluorescence to VSMCs among other plaque cell types. Functional experiments linked it to VSMC proliferation, migration, apoptosis, and remodeling." 1795 40459649 Circular RNA role in Atherosclerosis Development and Progression. CircEsyt2(2-6) mmu_circ_Esyt2 Esyt2 Mus musculus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 ECs up-regulated CircEsyt2(2-6) was upregulated in atherosclerotic aortic plaques and localized by FISH/immunofluorescence to ECs among other plaque cell types. 1796 40459649 Circular RNA role in Atherosclerosis Development and Progression. CircEsyt2(2-6) mmu_circ_Esyt2 Esyt2 Mus musculus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 fibroblasts up-regulated CircEsyt2(2-6) was upregulated in atherosclerotic aortic plaques and localized by FISH/immunofluorescence to fibroblasts among other plaque cell types. 1797 40459649 Circular RNA role in Atherosclerosis Development and Progression. CircEsyt2(2-6) mmu_circ_Esyt2 Esyt2 Mus musculus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 macrophages up-regulated CircEsyt2(2-6) was upregulated in atherosclerotic aortic plaques and localized by FISH/immunofluorescence to macrophages among other plaque cell types. 1798 40481048 CircRNA_1809 promotes the osteogenic differentiation of bone marrow mesenchymal stem cells through miR-370-3p. circRNA_1809 Rattus norvegicus others others others rat bone marrow mesenchymal stem cells (rBMMSCs) up-regulated "In primary cultured rat BMMSCs, circRNA_1809 was upregulated during osteogenic differentiation as measured by fluorescence quantitative PCR. Knockdown experiments indicated that circRNA_1809 promoted osteogenic differentiation of rBMMSCs through the miR-370-3p/Kitlg pathway." 1799 40487353 CircITSN1/EIF4A3/Itsn1 axis mediates postoperative cognitive dysfunction in aged mice: A novel mechanism and therapeutic target. mmu_circ_Itsn1 Itsn1 Mus musculus postoperative cognitive dysfunction / POCD MONDO:0002602 central nervous system disorder DOID:331 neuronal markers up-regulated "circITSN1 was increased in the hippocampus of aged mice after surgery and was reported to co-localize spatially with neuronal markers, supporting neuron-associated up-regulation in the POCD model. Knockdown of circITSN1 reduced pro-inflammatory cytokines and dendritic spine injury in the hippocampus." 1800 40513658 A novel peptide MIB1-223aa encoded by exosomal circMIB1 from cancer-associated fibroblasts drives triple-negative breast cancer metastasis and stemness via stabilizing MIB1 to activate Notch signaling. hsa_circ_0000835 hsa_circ_MIB1 MIB1 Homo sapiens triple-negative breast cancer / TNBC MONDO:0005494 triple-negative breast carcinoma DOID:0060081 CAFs up-regulated circMIB1 is up-regulated in patient-derived cancer-associated fibroblasts and their exosomes compared with normal fibroblasts from corresponding non-tumor tissues in TNBC. 1801 40521053 Circular RNA-Sirt1 sponges miR-27b-3p to protect vascular smooth muscle cell injury during atherosclerosis through regulating the glutamine metabolism pathway. hsa_circ_0093887 hsa_circ_SIRT1 SIRT1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 VSMCs down-regulated circSirt1 is down-regulated in VSMCs isolated from vessels surrounding atherosclerotic plaques compared with VSMCs from healthy blood vessels. Functional experiments in VSMCs/AoSMCs support a protective role against oxidative stress-induced injury through the miR-27b-3p-GLS axis. 1802 40521053 Circular RNA-Sirt1 sponges miR-27b-3p to protect vascular smooth muscle cell injury during atherosclerosis through regulating the glutamine metabolism pathway. hsa_circ_0093887 hsa_circ_SIRT1 SIRT1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 AoSMCs down-regulated circSirt1 is down-regulated in primary human aortic smooth muscle cells after H2O2-induced oxidative stress. Overexpression experiments indicate circSirt1 protects VSMCs from oxidative stress-induced injury and promotes glutamine metabolism. 1803 40528033 Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1. mmu_circ_42424 mmu_circ_Dhx32 Dhx32 Mus musculus cardiac ischemia-reperfusion injury MONDO:0005203 ischemia reperfusion injury neonatal mouse ventricular cardiomyocytes up-regulated circDhx32 was significantly upregulated in primary neonatal mouse ventricular cardiomyocytes after hypoxia-reoxygenation treatment. Silencing circDhx32 reduced inflammatory cytokine expression in H/R-treated cardiomyocytes through the AdipoR1-AMPK-NF-¦ÊB signaling pathway. 1804 40539039 Identification of the microglia-associated signature in experimental autoimmune encephalomyelitis. mmu_circ_0001569 mmu_circ_GAS2 GAS2 Mus musculus experimental autoimmune encephalomyelitis MONDO:0005134 experimental autoimmune encephalomyelitis microglia up-regulated "mmu-circ-0001569/circGAS2 was significantly upregulated in FACS-isolated microglia from EAE mice compared with control microglia, with validation by qRT-PCR." GSE253318 1805 40576192 Regulation of macrophage plasticity by circCCDC7 19-13 through HSP90 inhibition suppresses prostate cancer progression and metastasis: a translational study. circCCDC719-13 hsa_circ_CCDC7 CCDC7 Homo sapiens prostate cancer MONDO:0008315 prostate cancer DOID:10283 tumor-associated macrophages (TAMs) down-regulated circCCDC719-13 was decreased in sorted tumor-associated macrophages from prostate cancer tissues compared with macrophages from adjacent control tissues. Functional experiments in TAMs linked circCCDC719-13 overexpression to altered TAM polarization and reduced tumor-promoting effects. 1806 40576192 Regulation of macrophage plasticity by circCCDC7 19-13 through HSP90 inhibition suppresses prostate cancer progression and metastasis: a translational study. circCCDC719-13 hsa_circ_CCDC7 CCDC7 Homo sapiens prostate cancer MONDO:0008315 prostate cancer DOID:10283 macrophages down-regulated "Flow-sorted macrophages from prostate cancer bone metastases showed lower circCCDC719-13 than macrophages from primary prostate cancer, supported by transcriptome sequencing and RT-qPCR validation. The study links reduced circCCDC719-13 in macrophages to TAM polarization and metastatic prostate cancer progression." 1807 40583858 CircMAN1A2 Levels Determine GBM Susceptibility to TMZ in a Pathway Involving TEP1- and KEAP1-Mediated NRF2 Degradation Leading to Ferroptosis. hsa_circ_0000118 circMAN1A2 hsa_circ_MAN1A2 MAN1A2 Homo sapiens glioblastoma MONDO:0018177 glioblastoma DOID:3068 TMZ_resistant GSCs down-regulated circMAN1A2 was decreased in TMZ-resistant patient-derived glioma stem-like cells compared with their parental GSC lines. Functional experiments showed circMAN1A2 overexpression suppressed malignant GSC phenotypes and reversed TMZ resistance. 1808 40588510 PYRCR alleviates myocardial ischemia/reperfusion injury in mice via inhibiting DRG2-mediated cardiomyocyte pyroptosis. circRNA_45524 / PYRCR Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury cardiomyocytes down-regulated "PYRCR/circRNA_45524 was significantly decreased in primary neonatal mouse cardiomyocytes subjected to hypoxia/reoxygenation, a model related to myocardial ischemia/reperfusion injury. Functional experiments in cardiomyocytes showed that PYRCR overexpression suppressed H/R-induced pyroptotic and inflammatory responses." 1809 40588510 PYRCR alleviates myocardial ischemia/reperfusion injury in mice via inhibiting DRG2-mediated cardiomyocyte pyroptosis. circRNA_45524 / PYRCR Mus musculus myocardial ischemia/reperfusion injury MONDO:0005203 ischemia reperfusion injury cardiomyocytes up-regulated "PYRCR showed higher expression in isolated primary cardiomyocytes than in cardiac fibroblasts, indicating cardiomyocyte-enriched expression within the heart." 1810 40596955 Diagnostic value of hsa_circ_0012138 in the chronic progression of obstructive nephropathy. hsa_circ_0012138 hsa_circ_ERI3 ERI3 Homo sapiens Obstructive nephropathy MONDO:0056796 obstructive nephropathy DOID:0070314 human tubular epithelial cells up-regulated "RNA-FISH showed cytoplasmic hsa_circ_0012138 signal in human tubular epithelial cells, with enhanced fluorescence intensity in obstructive nephropathy kidneys compared with normal kidney tissue." 1811 40601689 circRNA_BMPR2 affects the progression of polycystic ovary syndrome by regulating the expression of Rab43. hsa_circ_0003218 hsa_circ_BMPR2 BMPR2 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 ovarian granulosa cells up-regulated "circ_BMPR2 is significantly up-regulated in isolated ovarian granulosa cells from PCOS patients compared with non-PCOS patients, as assessed by RT-qPCR after primary cell isolation from follicular fluid." 1812 40640166 Regulation of partial endothelial-to-mesenchymal transition by circATXN1 in ischemic diseases. circATXN1 mmu_circ_ATXN1 ATXN1 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 CD31-positive cells up-regulated "In a mouse myocardial infarction model, circATXN1 expression was elevated in CD31-positive endothelial cells in ischemic heart tissue. Functional experiments linked circATXN1 knockdown in endothelial cells to enhanced partial EndMT, angiogenesis, and recovery after ischemic injury." 1813 40640166 Regulation of partial endothelial-to-mesenchymal transition by circATXN1 in ischemic diseases. circATXN1 mmu_circ_ATXN1 ATXN1 Mus musculus hindlimb ischemia MONDO:0000491 limb ischemia DOID:0050852 CD31-positive cells up-regulated "In a mouse hindlimb ischemia model, circATXN1 was elevated in ischemic gastrocnemius tissue and showed increased expression in CD31-positive endothelial cells in the ischemic disease model. CircATXN1 knockdown promoted partial EndMT and improved blood flow recovery after ischemic injury." 1814 40649761 The Involvement of LvSRSF2 in Circular RNA Biogenesis and Its Role in Immunity Against White Spot Syndrome Virus (WSSV) in Litopenaeus vannamei. circ-Alpha2 Alpha2 Litopenaeus vannamei White spot syndrome virus infection MONDO:0005108 viral infectious disease DOID:934 hemocytes up-regulated "circ-Alpha2 was up-regulated in WSSV-infected shrimp hemocyte-derived samples after LvSRSF2 knockdown compared with dsGFP control, as measured by qPCR." 1815 40649761 The Involvement of LvSRSF2 in Circular RNA Biogenesis and Its Role in Immunity Against White Spot Syndrome Virus (WSSV) in Litopenaeus vannamei. circ-Anillin Anillin Litopenaeus vannamei White spot syndrome virus infection MONDO:0005108 viral infectious disease DOID:934 hemocytes up-regulated "circ-Anillin was up-regulated in WSSV-infected shrimp hemocyte-derived samples after LvSRSF2 knockdown compared with dsGFP control, as measured by qPCR." 1816 40649761 The Involvement of LvSRSF2 in Circular RNA Biogenesis and Its Role in Immunity Against White Spot Syndrome Virus (WSSV) in Litopenaeus vannamei. circ-Calpain Calpain Litopenaeus vannamei White spot syndrome virus infection MONDO:0005108 viral infectious disease DOID:934 hemocytes up-regulated "circ-Calpain was up-regulated in WSSV-infected shrimp hemocyte-derived samples after LvSRSF2 knockdown compared with dsGFP control, as measured by qPCR." 1817 40649761 The Involvement of LvSRSF2 in Circular RNA Biogenesis and Its Role in Immunity Against White Spot Syndrome Virus (WSSV) in Litopenaeus vannamei. circ-Hemocytin Hemocytin Litopenaeus vannamei White spot syndrome virus infection MONDO:0005108 viral infectious disease DOID:934 hemocytes up-regulated "circ-Hemocytin was up-regulated in hemocytes after WSSV infection, remaining elevated up to 48 hpi by qRT-PCR." 1818 40649761 The Involvement of LvSRSF2 in Circular RNA Biogenesis and Its Role in Immunity Against White Spot Syndrome Virus (WSSV) in Litopenaeus vannamei. circ-Nephrin Nephrin Litopenaeus vannamei White spot syndrome virus infection MONDO:0005108 viral infectious disease DOID:934 hemocytes up-regulated "circ-Nephrin was up-regulated in WSSV-infected shrimp hemocyte-derived samples after LvSRSF2 knockdown compared with dsGFP control, as measured by qPCR." 1819 40649761 The Involvement of LvSRSF2 in Circular RNA Biogenesis and Its Role in Immunity Against White Spot Syndrome Virus (WSSV) in Litopenaeus vannamei. circ-Toll Toll Litopenaeus vannamei White spot syndrome virus infection MONDO:0005108 viral infectious disease DOID:934 hemocytes up-regulated "circ-Toll was up-regulated in WSSV-infected shrimp hemocyte-derived samples after LvSRSF2 knockdown compared with dsGFP control, as measured by qPCR." 1820 40661956 circ-0001875 downregulation is associated with M1 macrophage activation and lung inflammation in severe asthma. hsa_circ_0001875 hsa_circ_FAM120A FAM120A Homo sapiens asthma MONDO:0004979 asthma DOID:2841 monocytes isolated from peripheral blood down-regulated circ-0001875 was downregulated in peripheral-blood monocytes in the severe asthma context. The study further links circ-0001875 downregulation to M1 macrophage polarization and airway inflammation. 1821 40662732 Interferon-stimulated circHOMER1 attenuates antiviral innate immunity. mmu_circ_0000491 circHomer1 mmu_circ_Homer1 Homer1 Mus musculus viral infection MONDO:0005108 viral infectious disease DOID:934 primary peritoneal macrophages up-regulated "Mouse circHomer1 was upregulated in primary peritoneal macrophages after DNA or RNA viral stimulation, as measured by qRT-PCR after primary macrophage isolation." 1822 40663488 NSD1-916aa encoded by CircNSD1 contributes to AKI-to-CKD transition through inducing ferroptosis in tubular epithelial cells. mmu_circ_0000465 CircNsd1 mmu_circ_Nsd1 Nsd1 Mus musculus AKI-to-CKD transition MONDO:0002492 acute kidney injury DOID:3021 tubular epithelial cells down-regulated CircNsd1 is predominantly localized in tubular epithelial cells and is decreased in mouse kidney injury models related to AKI-to-CKD transition. 1823 40691637 Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study. circCSNK1G3 hsa_circ_CSNK1G3 CSNK1G3 Homo sapiens Chronic Lymphocytic Leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 leukemic B cells down-regulated "circCSNK1G3 was decreased in purified leukemic B cells from CLL patients compared with B cells from healthy donors, based on circRNA RNA-seq and RT-qPCR validation." E-MTAB-15004 1824 40691637 Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study. circEXOC6B(3-5) hsa_circ_EXOC6B EXOC6B Homo sapiens Chronic Lymphocytic Leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 leukemic B cells down-regulated circEXOC6B(3-5) was depleted in purified malignant B cells from CLL patients compared with healthy donor B cells. E-MTAB-15004 1825 40691637 Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study. circZNF609 hsa_circ_ZNF609 ZNF609 Homo sapiens Chronic Lymphocytic Leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 leukemic B cells up-regulated circZNF609 was overexpressed in purified malignant B cells from CLL patients compared with healthy donor B cells. E-MTAB-15004 1826 40691637 Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study. circLPAR3 hsa_circ_LPAR3 LPAR3 Homo sapiens Chronic Lymphocytic Leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 leukemic B cells up-regulated "circLPAR3 was increased in purified leukemic B cells from CLL patients compared with B cells from healthy donors, based on circRNA RNA-seq and RT-qPCR validation." E-MTAB-15004 1827 40691637 Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study. circCDK14(3-4) hsa_circ_CDK14 CDK14 Homo sapiens chronic lymphocytic leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 leukemic B cells up-regulated circCDK14(3-4) was upregulated in purified leukemic B cells and showed significantly higher expression in t(14;19) CLL B cells than in CLL without t(14;19). E-MTAB-15004 1828 40691637 Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study. circCORO1C hsa_circ_CORO1C CORO1C Homo sapiens chronic lymphocytic leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 leukemic B cells up-regulated circCORO1C was significantly overexpressed in purified leukemic B cells from t(14;19) CLL compared with healthy donor B cells; high circCORO1C expression was associated with shorter TTFT and OS. E-MTAB-15004 1829 40691637 Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study. circCLEC2D hsa_circ_CLEC2D CLEC2D Homo sapiens chronic lymphocytic leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 leukemic B cells up-regulated circCLEC2D was significantly overexpressed in purified leukemic B cells from t(14;19) CLL compared with healthy donor B cells; high circCLEC2D expression was associated with shorter TTFT and OS. E-MTAB-15004 1830 40691637 Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study. circEMB hsa_circ_EMB EMB Homo sapiens chronic lymphocytic leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 leukemic B cells up-regulated circEMB was significantly overexpressed in purified leukemic B cells from t(14;19) CLL compared with healthy donor B cells. E-MTAB-15004 1831 40691637 Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study. circCEP70(3-6) hsa_circ_CEP70 CEP70 Homo sapiens chronic lymphocytic leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 leukemic B cells down-regulated circCEP70(3-6) showed lower expression in purified leukemic B cells from t(14;19) CLL compared with healthy donor B cells. E-MTAB-15004 1832 40696949 CircRNA_26782 Regulates Axonal Growth via Inhibiting the Autophagy Pathway in a Rat Model of Spinal Cord Injury. circRNA_26782 rno_circ_Akap6 Akap6 Rattus norvegicus spinal cord injury MONDO:0043797 spinal cord injury spinal neurons down-regulated "In primary rat E14 spinal neurons, circ_26782 was detected in neuronal cytoplasm by FISH and its expression was reduced after circ_26782-specific siRNA treatment as measured by qRT-PCR. Knockdown of circ_26782 promoted axonal elongation in these neurons." 1833 40702555 Hypoxic cancer-associated fibroblast exosomal circSTAT3 drives triple negative breast cancer stemness via miR-671-5p/NOTCH1 signaling. hsa_circ_0043800 circSTAT3 hsa_circ_STAT3 STAT3 Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 hypoxia-conditioned CAFs up-regulated "In primary breast cancer-derived CAF cultures, circSTAT3/hsa_circ_0043800 was upregulated in hypoxia-conditioned CAFs and their exosomes compared with normoxic CAFs. The study links CAF-derived exosomal circSTAT3 to stromal-tumor communication promoting TNBC stemness and chemoresistance." 1834 40730119 Circular RNA PVT1 promotes osteoarthritis progression through the miR-550a-3p/CX3CR1 pathway: A mechanistic study. hsa_circ_0001821 hsa_circ_PVT1 PVT1 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 OA chondrocytes up-regulated "circPVT1 is significantly upregulated in OA chondrocytes compared with normal chondrocytes based on qRT-PCR after chondrocyte isolation and culture. Functional assays in OA chondrocytes indicate that circPVT1 affects proliferation, apoptosis, inflammatory mediator release, and extracellular matrix degradation." 1835 40735833 CircGLIS3 Inhibits Intramuscular Adipogenesis and Alleviates Skeletal Muscle Fat Infiltration. circRNA32 bta_circ_GLIS3 GLIS3 Bos taurus skeletal muscle fat infiltration MONDO:0020120 skeletal muscle disorder primary bovine intramuscular preadipocytes up-regulated "circGLIS3/circRNA32 was identified by circRNA-seq in primary bovine intramuscular preadipocytes and was increased during adipogenic differentiation, with about a 10-fold increase on day 3 versus pre-differentiation. Functional experiments in these primary cells showed that circGLIS3 inhibits intramuscular adipogenesis." 1836 40739999 Hsa_circ_0020491 promotes polycystic ovary syndrome by interacting with IGF2BP2 through regulation of granular cell autophagy and mitochondrial dysfunction. hsa_circ_0020491 hsa_circ_MKI67 MKI67 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells (Gcs) up-regulated "hsa_circ_0020491 was up-regulated in isolated granulosa cells from PCOS patients compared with non-PCOS patients, as measured by RT-qPCR. The study further linked hsa_circ_0020491 to autophagy dysregulation and mitochondrial dysfunction in granulosa-cell-related PCOS models." GSE145296 1837 40742571 CircZNF418 alleviates oxidative stress-induced cartilage endplate degeneration by stabilizing Sox9 through HuR. circZNF418 hsa_circ_ZNF418 ZNF418 Homo sapiens Intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 human endplate chondrocytes down-regulated circZNF418 was down-regulated in isolated human endplate chondrocytes from degenerative CEP tissues compared with normal CEP cells. Functional experiments in CEP cells indicated that circZNF418 overexpression promoted cell viability and reduced oxidative stress-induced degeneration-related changes. 1838 40742571 CircZNF418 alleviates oxidative stress-induced cartilage endplate degeneration by stabilizing Sox9 through HuR. circZNF418 hsa_circ_ZNF418 ZNF418 Homo sapiens Intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 CEP cells down-regulated circZNF418 was down-regulated in primary cultured human CEP cells treated with TBHP to induce oxidative stress compared with untreated control cells. Overexpression of circZNF418 increased CEP cell viability and mitigated oxidative stress-induced ECM-related degenerative changes. 1839 40750918 circANKRD12/circTIMMDC1 synergistically regulates enteric neural crest cell migration via miR-181b-5p-PROX1-NOTCH1 axis in Hirschsprung's disease. hsa_circ_0003865 circANKRD12 hsa_circ_ANKRD12 ANKRD12 Homo sapiens Hirschsprung's disease MONDO:0018309 Hirschsprung disease DOID:10487 colonic enteric neurons down-regulated "circANKRD12 was reported as significantly downregulated in HSCR, and FISH localized it within colonic enteric neurons. Functional explant data indicated that circANKRD12 affects ENCC migration and proliferation." 1840 40750918 circANKRD12/circTIMMDC1 synergistically regulates enteric neural crest cell migration via miR-181b-5p-PROX1-NOTCH1 axis in Hirschsprung's disease. circTIMMDC1 hsa_circ_TIMMDC1 TIMMDC1 Homo sapiens Hirschsprung's disease MONDO:0018309 Hirschsprung disease DOID:10487 colonic enteric neurons down-regulated "circTIMMDC1 was reported as significantly downregulated in HSCR, and FISH localized it within colonic enteric neurons. Functional explant data indicated that circTIMMDC1 affects ENCC migration and proliferation." 1841 40760232 KHDRBS3-mediated upregulation of circ_0024107 in gastric cancer cells and GC-MSCs synergistically drives gastric cancer cell migration and invasion. hsa_circ_0024107 Homo sapiens gastric cancer MONDO:0001056 gastric cancer DOID:10534 GC-MSCs down-regulated "In isolated gastric cancer tissue-derived mesenchymal stem cells, qPCR showed that KHDRBS3 knockdown decreased circ_0024107 levels. The study links this KHDRBS3-circ_0024107 axis to interactions between GC-MSCs and gastric cancer cells." 1842 40767364 CircZNF418 Prevents Intervertebral Disc Degeneration by Targeting the HuR/SIRT6 Axis to Protect Against Oxidative Stress-Induced Ferroptosis and Senescence. hsa_circ_0052318 circZNF418 hsa_circ_ZNF418 ZNF418 Homo sapiens Intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 NPCs down-regulated "In isolated and cultured human nucleus pulposus cells, TBHP-induced oxidative stress reduced circZNF418 expression as measured by qPCR. Functional experiments in the same NPC model showed that circZNF418 overexpression suppressed oxidative stress-induced ferroptosis and senescence, while knockdown had the opposite effect." 1843 40781640 Circular RNA GCLC promotes osteogenic differentiation of bone marrow mesenchymal stem cells via modulating miR-516b-5p/GNAS axis. hsa_circ_GCLC GCLC Homo sapiens Osteoporosis MONDO:0005298 osteoporosis DOID:11476 bone marrow mesenchymal stem cells (BMSCs) up-regulated "In primary cultured human BMSCs, circGCLC expression increased during osteogenic differentiation as measured by qPCR. Functional perturbation experiments in BMSCs supported a role for circGCLC in promoting osteogenic differentiation through the miR-516b-5p/GNAS axis and MAPK signalling." 1844 40784956 CAFs exosomal circFOXO1 promotes TNBC autophagy and radioresistance via miR-27a-3p/BNIP3 axis. hsa_circ_FOXO1 FOXO1 Homo sapiens triple-negative breast cancer / TNBC MONDO:0005494 triple-negative breast carcinoma DOID:0060081 Cancer-associated fibroblasts (CAFs) up-regulated "In primary TNBC-derived CAF cultures, exosomal circRNA-FOXO1/FOXO1 expression was significantly upregulated after radiotherapy compared with untreated control. The study links CAF-derived exosomal circRNA-FOXO1 to TNBC autophagy and reduced radiosensitivity through the miR-27a-3p/BNIP3 axis." 1845 40823777 "Hsa_circ_0026782 Acts as a ""Molecular Break"" of CREB1-Mediated Transcription by Promoting Its Phosphorylation at Ser142 That Prevents Keloid Progression." hsa_circ_0026782 hsa_circ_ITGA7 ITGA7 Homo sapiens keloid MONDO:0005348 keloid primary human keloid fibroblasts (hKFs) unknown "hsa_circ_0026782 was detected in primary human keloid fibroblasts isolated from keloid tissues, with RT-qPCR showing predominant nuclear localization. Functional experiments in hKFs showed effects on proliferation, migration, invasion, apoptosis, and cell cycle." 1846 40840702 CircFGFR2 induces astrocyte pyroptosis to promote ischemic stroke. circFGFR2 hsa_circ_FGFR2 FGFR2 Homo sapiens ischemic stroke MONDO:1060198 ischemic stroke astrocytes up-regulated "IF/FISH co-localization in the human cerebral organoid ischemic stroke model showed that circFGFR2 was highly expressed in astrocytes, with GFAP showing stronger co-localization than NeuN or Iba1." 1847 40840702 CircFGFR2 induces astrocyte pyroptosis to promote ischemic stroke. circFGFR2 hsa_circ_FGFR2 FGFR2 Homo sapiens ischemic stroke MONDO:1060198 ischemic stroke astrocyte cells up-regulated "In an OGD/R-induced human astrocyte model, RT-qPCR showed that circFGFR2 was significantly upregulated compared with control astrocytes. Knockdown experiments indicated that circFGFR2 promoted astrocytic pyroptosis-associated inflammatory signaling." 1848 40842453 Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis. hsa-circRNA-087631 Homo sapiens intracranial atherosclerotic stenosis MONDO:0011057 cerebrovascular disorder DOID:6713 peripheral neutrophils up-regulated hsa-circRNA-087631 was up-regulated in isolated peripheral neutrophils from ICAS patients compared with healthy controls and was validated by qRT-PCR. 1849 40842453 Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis. hsa_circ_0005785 hsa-circRNA-101141 anaphsae promoting complex subunit 7 Homo sapiens intracranial atherosclerotic stenosis MONDO:0011057 cerebrovascular disorder DOID:6713 peripheral neutrophils up-regulated hsa-circRNA-101141 was up-regulated in isolated peripheral neutrophils from ICAS patients compared with healthy controls and was validated by qRT-PCR. 1850 40842453 Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis. hsa-circRNA-100914 Homo sapiens intracranial atherosclerotic stenosis MONDO:0011057 cerebrovascular disorder DOID:6713 peripheral neutrophils down-regulated hsa-circRNA-100914 was down-regulated in isolated peripheral neutrophils from ICAS patients compared with healthy controls and was validated by qRT-PCR. 1851 40842453 Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis. hsa-circRNA-001082 Homo sapiens intracranial atherosclerotic stenosis MONDO:0011057 cerebrovascular disorder DOID:6713 peripheral neutrophils down-regulated hsa-circRNA-001082 was down-regulated in isolated peripheral neutrophils from ICAS patients compared with healthy controls and was validated by qRT-PCR. 1852 40842453 Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis. hsa-circRNA-087631 Homo sapiens intracranial atherosclerotic stenosis MONDO:0011057 cerebrovascular disorder DOID:6713 peripheral neutrophils down-regulated "In isolated peripheral neutrophils from ICAS patients, hsa-circRNA-087631 levels were significantly reduced 24 hours after endovascular treatment compared with before treatment." 1853 40842453 Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis. hsa_circ_0005785 hsa-circRNA-101141 anaphsae promoting complex subunit 7 Homo sapiens intracranial atherosclerotic stenosis MONDO:0011057 cerebrovascular disorder DOID:6713 peripheral neutrophils down-regulated "In isolated peripheral neutrophils from ICAS patients, hsa-circRNA-101141 levels were significantly reduced 24 hours after endovascular treatment compared with before treatment." 1854 40842453 Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis. hsa-circRNA-087631 Homo sapiens intracranial atherosclerotic stenosis MONDO:0011057 cerebrovascular disorder DOID:6713 peripheral neutrophils up-regulated hsa-circRNA-087631 was significantly higher in peripheral neutrophils from ICAS patients with perioperative AE/SAE than in those without perioperative AE/SAE. 1855 40842453 Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis. hsa_circ_0005785 hsa-circRNA-101141 anaphsae promoting complex subunit 7 Homo sapiens intracranial atherosclerotic stenosis MONDO:0011057 cerebrovascular disorder DOID:6713 peripheral neutrophils up-regulated hsa-circRNA-101141 was significantly higher in peripheral neutrophils from ICAS patients with perioperative AE/SAE than in those without perioperative AE/SAE. 1856 40883663 Radiation-sensitive circRNA promotes intestinal regeneration. "circDmbt1(3,4,5,6)" mmu_circ_Dmbt1 Dmbt1 Mus musculus radiation-induced intestinal injury MONDO:0043459 radiation-induced disorder Lgr5+ intestinal epithelial stem cells up-regulated "circDmbt1(3,4,5,6) was enriched in sorted Lgr5+ intestinal epithelial stem cells compared with Lgr5_ intestinal epithelial cells in a mouse RIII study." 1857 40883663 Radiation-sensitive circRNA promotes intestinal regeneration. "circDmbt1(3,4,5,6)" mmu_circ_Dmbt1 Dmbt1 Mus musculus radiation-induced intestinal injury MONDO:0043459 radiation-induced disorder Lgr5+ intestinal stem cells down-regulated "circDmbt1(3,4,5,6) was downregulated in sorted Lgr5+ intestinal stem cells 2 days after irradiation in a mouse model of radiation-induced intestinal injury." 1858 40886783 "Circular RNAs accumulate in aging human placental tissue and in stillbirth, leading to DNA damage and cellular senescence." hsa_circ_0000284 circ_0000284 hsa_circ_HIPK3 HIPK3 Homo sapiens stillbirth MONDO:0013727 "pregnancy loss, recurrent, susceptibility to, 1" syncytiotrophoblasts up-regulated "In patient-derived trophoblast stem cell cultures differentiated into placental trophoblast lineages, circ_0000284 was primarily detected in syncytiotrophoblasts and not detected in extravillous trophoblasts. Knockdown experiments in primary syncytiotrophoblasts linked circ_0000284 to circR-loop formation, DNA damage, and senescence-associated gene expression." 1859 40915343 CircTTC3 regulates the osteogenic differentiation of adipose-derived mesenchymal stem cells via miR-205/Smad3 axis. circ_000584 rno_circ_TTC3 TTC3 Rattus norvegicus cranial bone defect MONDO:0002081 musculoskeletal system disorder DOID:17 ADSCs up-regulated "In primary cultured rat ADSCs, WTS followed by qRT-PCR showed that circ_000584, named circTTC3, was up-regulated after 14 days of osteogenic induction compared with conventional culture. Functional experiments indicated that circTTC3 promotes osteogenic differentiation of ADSCs through the miR-205/Smad3 axis." 1860 40915343 CircTTC3 regulates the osteogenic differentiation of adipose-derived mesenchymal stem cells via miR-205/Smad3 axis. circ_006422 Rattus norvegicus cranial bone defect MONDO:0002081 musculoskeletal system disorder DOID:17 ADSCs up-regulated "In primary cultured rat ADSCs, WTS followed by qRT-PCR showed that circ_006422 was up-regulated after 14 days of osteogenic induction compared with conventional culture." 1861 40950872 Circular RNA circFTO promotes pressure overload-induced cardiac hypertrophy by encoding a novel protein FTO-36aa. mmu_circ_0001717 circFTO mmu_circ_FTO FTO Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 hypertrophic NRCMs up-regulated circFTO was upregulated in PE-treated hypertrophic neonatal cardiomyocytes based on RT-PCR after primary cardiomyocyte isolation and culture. Knockdown of circFTO attenuated PE-induced hypertrophic phenotypes in cardiomyocytes. 1862 40955561 Circular RNA Cdr1as Modulates Macrophage-Mediated Cardiac Reparative Function. circ-cdr1as / circ-Cdr1as mmu_circ_CDR1 CDR1 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 macrophages down-regulated circ-cdr1as was significantly downregulated in F4/80+ sorted cardiac macrophages from mouse post-MI left ventricular tissue compared with sham controls. Functional experiments support a role for circ-cdr1as in regulating anti-inflammatory macrophage phenotype through the miR-7/Klf4 pathway. 1863 40955561 Circular RNA Cdr1as Modulates Macrophage-Mediated Cardiac Reparative Function. circ-cdr1as / circ-Cdr1as mmu_circ_CDR1 CDR1 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 cardiomyocytes down-regulated circ-cdr1as was significantly downregulated in isolated cardiomyocytes from mouse post-MI left ventricular tissue compared with sham controls. Cardiac overexpression experiments showed reduced cardiomyocyte apoptosis after MI. 1864 40955561 Circular RNA Cdr1as Modulates Macrophage-Mediated Cardiac Reparative Function. circ-cdr1as / circ-Cdr1as mmu_circ_CDR1 CDR1 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 endothelial cells no change circ-cdr1as showed no change in isolated endothelial cells from mouse post-MI left ventricular tissue compared with sham controls. 1865 40955561 Circular RNA Cdr1as Modulates Macrophage-Mediated Cardiac Reparative Function. circ-cdr1as / circ-Cdr1as mmu_circ_CDR1 CDR1 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 fibroblasts no change circ-cdr1as showed no change in isolated fibroblasts from mouse post-MI left ventricular tissue compared with sham controls. 1866 40956561 CircRNA circ_0004058 Modulates Early Brain Injury in Subarachnoid Hemorrhage Through miR-221-3p and VE1 Activation Pathway. circ_0004058 Rattus norvegicus subarachnoid hemorrhage MONDO:0005099 subarachnoid hemorrhage primary rat brain microvascular endothelial cells (rBMECs) down-regulated "circ_0004058 was down-regulated in primary rat brain microvascular endothelial cells isolated from SAH rats compared with Sham rats, based on RT-qPCR." 1867 40962208 Combination of circular RNA-miRNA-mRNA expression profiles and bioinformatic analysis in ovarian endometriosis. hsa_circ_0005918 hsa_circ_FCHSD2 FCHSD2 Homo sapiens ovarian endometriosis MONDO:0006337 ovarian endometriosis DOID:11432 ectopic stromal cells up-regulated hsa_circ_0005918 was upregulated in ectopic endometrial stromal cells compared with eutopic stromal cells from patients with endometriosis. Functional assays indicated that hsa_circ_0005918 promoted migration and invasion of endometrial stromal cells. 1868 40986450 CircGNAQ Promotes Intracranial Aneurysm Formation by Facilitating Vascular Smooth Muscle Cell Phenotypic Switching and Apoptosis. hsa_circ_0006459 circGNAQ hsa_circ_GNAQ GNAQ Homo sapiens Intracranial aneurysm MONDO:0005291 brain aneurysm DOID:10941 VSMCs up-regulated circGNAQ is up-regulated in intracranial aneurysm tissues compared with normal arterial tissues and is predominantly localized within VSMCs based on FISH with ACTA2 immunofluorescence. Functional experiments indicate that circGNAQ regulates VSMC phenotypic switching and apoptosis. 1869 41006753 IL6ST participates in the development of adolescent idiopathic scoliosis by regulating bone marrow mesenchymal stem cells. circSCAF8 hsa_circ_SCAF8 SCAF8 Homo sapiens adolescent idiopathic scoliosis MONDO:0005488 adolescent idiopathic scoliosis BMSCs dys-regulated circSCAF8 was identified as a differentially expressed circRNA in primary BMSCs from AIS patients versus non-AIS controls and was validated by qPCR in primary BMSCs. Functional experiments showed that circSCAF8 knockdown inhibited BMSC proliferation and osteogenic differentiation through IL6ST regulation. PRJNA1289347 1870 41006753 IL6ST participates in the development of adolescent idiopathic scoliosis by regulating bone marrow mesenchymal stem cells. circANKRD17 hsa_circ_ANKRD17 ANKRD17 Homo sapiens adolescent idiopathic scoliosis MONDO:0005488 adolescent idiopathic scoliosis BMSCs dys-regulated "circANKRD17 was identified among differentially expressed circRNAs in primary BMSCs from AIS patients versus non-AIS controls, and its expression was assessed by qPCR in primary BMSCs." PRJNA1289347 1871 41006753 IL6ST participates in the development of adolescent idiopathic scoliosis by regulating bone marrow mesenchymal stem cells. circFOXP1 hsa_circ_FOXP1 FOXP1 Homo sapiens adolescent idiopathic scoliosis MONDO:0005488 adolescent idiopathic scoliosis BMSCs dys-regulated "circFOXP1 was identified among differentially expressed circRNAs in primary BMSCs from AIS patients versus non-AIS controls, and its expression was assessed by qPCR in primary BMSCs." PRJNA1289347 1872 41006753 IL6ST participates in the development of adolescent idiopathic scoliosis by regulating bone marrow mesenchymal stem cells. circSLAIN2 hsa_circ_SLAIN2 SLAIN2 Homo sapiens adolescent idiopathic scoliosis MONDO:0005488 adolescent idiopathic scoliosis BMSCs dys-regulated "circSLAIN2 was identified among differentially expressed circRNAs in primary BMSCs from AIS patients versus non-AIS controls, and its expression was assessed by qPCR in primary BMSCs." PRJNA1289347 1873 41006753 IL6ST participates in the development of adolescent idiopathic scoliosis by regulating bone marrow mesenchymal stem cells. circCCSER2 hsa_circ_CCSER2 CCSER2 Homo sapiens adolescent idiopathic scoliosis MONDO:0005488 adolescent idiopathic scoliosis BMSCs dys-regulated circCCSER2 was identified among differentially expressed circRNAs in primary BMSCs from AIS patients versus non-AIS controls by high-throughput sequencing. PRJNA1289347 1874 41006753 IL6ST participates in the development of adolescent idiopathic scoliosis by regulating bone marrow mesenchymal stem cells. circHIPK2 hsa_circ_HIPK2 HIPK2 Homo sapiens adolescent idiopathic scoliosis MONDO:0005488 adolescent idiopathic scoliosis BMSCs dys-regulated circHIPK2 was identified among differentially expressed circRNAs in primary BMSCs from AIS patients versus non-AIS controls by high-throughput sequencing. PRJNA1289347 1875 41017455 Extracellular Vesicle-Packaged circTAX1BP1 from Cancer-Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells. hsa_circ_0134036 circTAX1BP1 hsa_circ_TAX1BP1 TAX1BP1 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 CAFs up-regulated circTAX1BP1 is up-regulated in isolated cancer-associated fibroblasts compared with normal fibroblasts from colorectal cancer patient tissues. CAF-derived EV-packaged circTAX1BP1 is transferred to CRC cells and promotes malignant progression. 1876 41017455 Extracellular Vesicle-Packaged circTAX1BP1 from Cancer-Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells. hsa_circ_0134036 circTAX1BP1 hsa_circ_TAX1BP1 TAX1BP1 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 ITGA11+ myCAF up-regulated Flow-sorted ITGA11+ myCAFs show higher intracellular and EV-packaged circTAX1BP1 than iCAFs or ITGA11+-d myCAFs. This supports ITGA11+ myCAFs as a major source of EV-packaged circTAX1BP1 in the CRLM feedback loop. 1877 41017455 Extracellular Vesicle-Packaged circTAX1BP1 from Cancer-Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells. hsa_circ_0134036 circTAX1BP1 hsa_circ_TAX1BP1 TAX1BP1 Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 ITGA11+ myCAF up-regulated "In flow-sorted ITGA11+ myCAFs, co-culture with circTAX1BP1-EV-induced CRC cells increased intracellular and EV-packaged circTAX1BP1, and this induction was blocked by a TGF-¦Â inhibitor. The evidence supports a TGF-¦Â-dependent feedback loop between CRC cells and ITGA11+ myCAFs." 1878 41037850 Experimental investigation of adipose-derived mesenchymal stem cell-derived exosomes in the treatment of osteoporosis via the hsa_circ_0028877/miR-4728-3p/PTCH1 axis. hsa_circ_0028877 Homo sapiens postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis BMSCs up-regulated hsa_circ_0028877 was up-regulated in BMSCs isolated from OVX rats compared with normal control BMSCs. Functional experiments in BMSCs indicated that hsa_circ_0028877 suppresses osteogenesis and proliferation. 1879 41037850 Experimental investigation of adipose-derived mesenchymal stem cell-derived exosomes in the treatment of osteoporosis via the hsa_circ_0028877/miR-4728-3p/PTCH1 axis. hsa_circ_0028877 Homo sapiens postmenopausal osteoporosis MONDO:0008159 postmenopausal osteoporosis OVX cells no change "In OVX rat BMSCs, ADSCs-exos did not change total hsa_circ_0028877 expression but altered its subcellular distribution, reducing cytoplasmic hsa_circ_0028877 and increasing nuclear localization. This was linked to obstruction of the hsa_circ_0028877/miR-4728-3p/PTCH1 axis." 1880 41041073 Hsa_circ_0058495-mediated IGF2BP2 ubiquitination and m6A modification of MEKK1 promote the progression of PDAC. hsa_circ_0058495 circRHBDD1 hsa_circ_RHBDD1 RHBDD1 Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 M2 macrophages up-regulated "FISH evidence in patient-derived PDAC tissues showed that hsa_circ_0058495 was abundant in M2 macrophages, and the authors reported higher abundance in M2 macrophages than M1 macrophages. Exosomal hsa_circ_0058495 was reported to facilitate M2 macrophage polarization through the IGF2BP2-MEKK1 axis." 1881 41057949 Cancer-associated fibroblast-derived circKLHL24 drives perineural invasion in pancreatic cancer via dual regulation of the sec31a-CXCL12 axis. hsa_circ_0001369 circKLHL24 hsa_circ_KLHL24 KLHL24 Homo sapiens pancreatic ductal adenocarcinoma MONDO:0005184 pancreatic ductal adenocarcinoma DOID:3498; DOID:3587 cancer-associated fibroblasts (CAFs) up-regulated "circKLHL24 is up-regulated in cancer-associated fibroblasts compared with adjacent normal fibroblasts in PDAC, supported by circRNA high-throughput sequencing and qRT-PCR after primary fibroblast isolation. ISH with a CAF marker also showed spatial co-localization between circKLHL24 signal and PDPN-positive stromal areas." GSE172096 1882 41062012 circ-0007006 attenuates fibrosis in thyroid-associated ophthalmopathy by stabilizing HBEGF expression in vitro. hsa_circ_0007006 hsa_circ_DYM DYM Homo sapiens Thyroid-associated ophthalmopathy MONDO:0001509 endocrine exophthalmos DOID:12359 Primary orbital fibroblasts (OFs) down-regulated "In primary orbital fibroblasts isolated from type II TAO patients, IGF-1 stimulation was associated with dynamic hsa_circ_0007006 expression and a fluctuating decreasing trend by qRT-PCR. Functional assays in orbital fibroblasts showed that circ-0007006 suppresses fibrotic activation." 1883 41075359 Hsa_circ_0007349 upregulates glutamate-ammonia ligase to modulate gingival fibroblast wound healing. hsa_circ_0007349 hsa_circ_USP3 USP3 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 Human gingival fibroblasts (HGFs) up-regulated "In primary human gingival fibroblasts, hsa_circ_0007349 was markedly increased after P. gingivalis LPS treatment. Functional assays in HGFs showed that hsa_circ_0007349 regulates proliferation and migration through the miR-127-5p/GLUL axis." 1884 41078288 Circular RNA Rftn1 Promotes Cardiac Hypertrophy In Vitro and In Vivo by Sponging miRNA-1192 to Upregulate Tripartite Motif Protein 25 and 41. mmu_circ_0004641 mmu_circ_Rftn1 Rftn1 Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 neonatal mouse ventricular cardiomyocytes (NMVCs) up-regulated "In primary neonatal mouse ventricular cardiomyocytes, Ang II-induced hypertrophy was associated with increased circRftn1 expression by qPCR. Knockdown of circRftn1 in NMVCs reversed cardiomyocyte enlargement and reduced hypertrophy markers, supporting a role in cardiomyocyte hypertrophic remodeling." 1885 41084478 [Mechanism of Tougu Xiaotong Capsules in alleviating glycolytic metabolism disorder of chondrocytes in osteoarthritis by modulating circFOXO3]. circFOXO3 mmu_circ_FOXO3 FOXO3 Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes down-regulated "In mouse chondrocytes used as an IL-1¦Â-induced OA model, circFOXO3 was decreased compared with blank chondrocytes, supported by FISH localization and RT-qPCR detection." 1886 41084478 [Mechanism of Tougu Xiaotong Capsules in alleviating glycolytic metabolism disorder of chondrocytes in osteoarthritis by modulating circFOXO3]. circFOXO3 mmu_circ_FOXO3 FOXO3 Mus musculus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 IL-1¦Â-induced chondrocytes up-regulated "TGXTC treatment increased circFOXO3 expression in IL-1¦Â-induced mouse chondrocytes, as shown by FISH and RT-qPCR evidence. Silencing circFOXO3 weakened TGXTC regulation of glycolysis-related proteins in chondrocytes." 1887 41087791 Exosomes from hypoxic pre-treated BMSCs protect against lipopolysaccharide-induced acute lung injury via delivery of circ-LRP6. circ_0001529 mmu_circ_LRP6 LRP6 Mus musculus acute lung injury MONDO:0015796 acute lung injury hypoxic BM-MSC-derived exosomes up-regulated circ-LRP6 was up-regulated in exosomes derived from hypoxia-pretreated primary mouse BM-MSCs compared with normoxic BM-MSC exosomes. Knockdown of circ-LRP6 in hypoxic BM-MSC-derived exosomes reduced their protective effects in LPS-induced acute lung injury models. 1888 41107944 A novel protein cRERE encoded by a circular RNA directly targets ERK signaling to alleviate chemotherapy-induced neuropathic pain. chr5:167547693-167581074 rno_circ_Rere Rere Rattus norvegicus chemotherapy-induced neuropathic pain MONDO:0800390 chemotherapy-induced toxicity dorsal horn neurons / CaMKII¦Á-positive excitatory neurons down-regulated "circRere is reduced after vincristine treatment in the rat spinal dorsal horn and is localized mainly to dorsal horn neurons, especially CaMKII¦Á-positive excitatory neurons, by FISH with cell marker co-localization. The circRere-encoded protein cRERE modulates neuronal central sensitization and pain behavior through ERK1/CREB/IL-1¦Â signaling." PRJNA1328743 1889 41117932 A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling. mmu_circ_0000431 mmu_circ_RYR2 RYR2 Mus musculus cardiac hypertrophy MONDO:0005045 hypertrophic cardiomyopathy DOID:11984 neonatal mouse cardiomyocytes (NMCMs) down-regulated "In isolated neonatal mouse cardiomyocytes, hypertrophic stimulation reduced circRYR2 abundance, indicating down-regulation in hypertrophic cardiomyocytes." 1890 41132846 A novel feedback loop: CELF1/circ-CELF1/BRPF3/KAT7 in cardiac fibrosis. mmu_circ_Celf1 Celf1 Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 CFs up-regulated "circ-CELF1 was significantly up-regulated in isolated cardiac fibroblasts from MI model mice compared with normal adult mice. Functional experiments in cardiac fibroblasts supported profibrotic roles including proliferation, migration, fibrosis-related marker expression, and effects on cardiomyocytes through conditioned medium." 1891 41132846 A novel feedback loop: CELF1/circ-CELF1/BRPF3/KAT7 in cardiac fibrosis. mmu_circ_Celf1 Celf1 Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 CFs up-regulated "circ-CELF1 was significantly up-regulated in primary mouse cardiac fibroblasts after TGF-¦Â1 treatment. In the same cell type, circ-CELF1 promoted fibrosis-related marker expression, proliferation, migration, and cardiomyocyte injury through conditioned medium." 1892 41132846 A novel feedback loop: CELF1/circ-CELF1/BRPF3/KAT7 in cardiac fibrosis. hsa_circ_CELF1 CELF1 Homo sapiens cardiac fibrosis MONDO:0005267 heart disorder DOID:114 HCFs up-regulated hsa-circ-CELF1 was validated by junction-site sequencing and RNase R resistance and was up-regulated in human cardiac fibroblasts treated with TGF-¦Â1. Silencing hsa-circ-CELF1 reduced fibrosis-related expression and proliferation in HCFs. 1893 41146880 The significance of m6A-circFOXK2 in CD4+T cells from patients with rheumatoid arthritis and circFOXK2 correlates with Th17 % and autophagy. hsa_circ_0000817 hsa_circRNA_102239 hsa_circ_FOXK2 FOXK2 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 CD4+T cells up-regulated "circFOXK2 expression was increased in isolated CD4+ T cells from new-onset rheumatoid arthritis patients compared with healthy controls, as measured by RT-qPCR after CD4+ T-cell isolation. Its expression in RA CD4+ T cells positively correlated with Th17% and CD4+ T-cell autophagy level." 1894 41146880 The significance of m6A-circFOXK2 in CD4+T cells from patients with rheumatoid arthritis and circFOXK2 correlates with Th17 % and autophagy. hsa_circ_0000817 hsa_circRNA_102239 hsa_circ_FOXK2 FOXK2 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 CD4+T cells up-regulated circFOXK2 expression was higher in isolated CD4+ T cells from new-onset RA patients than in revisiting RA patients. The paper describes new-onset RA patients as having no prior immunosuppressive drugs or corticosteroids before recruitment. 1895 41146880 The significance of m6A-circFOXK2 in CD4+T cells from patients with rheumatoid arthritis and circFOXK2 correlates with Th17 % and autophagy. hsa_circ_0001931 hsa_circRNA_001931 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 CD4+T cells no change "hsa_circ_0001931 expression showed no significant difference in isolated CD4+ T cells from new-onset RA patients compared with healthy controls, despite differential m6A-related findings reported elsewhere in the paper." 1896 41157579 Comparative Transcriptomics Reveals Novel and Differential Circular RNA Responses Underlying Interferon-Mediated Antiviral Regulation in Porcine Alveolar Macrophages. novel_circ_0000028 Sus scrofa Porcine Reproductive and Respiratory Syndrome MONDO:0025494 porcine reproductive and respiratory syndrome porcine alveolar macrophages up-regulated "In primary porcine alveolar macrophages, novel_circ_0000028 was detected only after IFN-¦Ø5 treatment, indicating treatment-specific up-regulation in the PRRSV-swine model context." PRJNA882823 1897 41157579 Comparative Transcriptomics Reveals Novel and Differential Circular RNA Responses Underlying Interferon-Mediated Antiviral Regulation in Porcine Alveolar Macrophages. novel_circ_0000006 Sus scrofa Porcine Reproductive and Respiratory Syndrome MONDO:0025494 porcine reproductive and respiratory syndrome porcine alveolar macrophages up-regulated "In primary porcine alveolar macrophages, novel_circ_0000006 was present across groups but had its highest TPM value after IFN-¦Á1 treatment, supporting treatment-specific up-regulation in the PRRSV-swine model context." PRJNA882823 1898 41162865 CircAASS alleviates renal injury and fibrosis by regulating mitochondrial homeostasis in tubular epithelial cells. mmu_circ_Aass Aass Mus musculus acute kidney injury MONDO:0002492 acute kidney injury DOID:3021 primary TECs down-regulated "circAASS/circAass is decreased in injured tubular epithelial cells under AKI-related injury conditions. Functional experiments indicate that restoring circAass/circAASS improves mitochondrial homeostasis and reduces apoptosis, inflammation, and fibrosis-related responses in TEC-associated AKI models." 1899 41163590 Circ_0000756 Mediates Oxidative Stress and Metabolic Memory in Diabetic Neuropathy via miR-7b Suppression of NRF2/ARE Pathway. rno_circ_0000756 chr10:67435246|67453577 rno_circ_Atad5 Atad5 Rattus norvegicus diabetic peripheral neuropathy MONDO:0006626 diabetic neuropathy DOID:9743 Schwann cells up-regulated "In primary rat Schwann cells, circ_0000756 was upregulated under the HG_NG metabolic memory condition compared with normal glucose by RT-qPCR. Functional experiments indicated that circ_0000756 modulation affected Schwann cell apoptosis, inflammatory cytokines, oxidative stress, and metabolic memory-related changes." 1900 41169933 Aerobic exercise alleviates allergic airway inflammation by suppressing circMETTL9-mediated formation of macrophage extracellular traps. mmu_circ_0001624 circRNA 3941 mmu_circ_METTL9 METTL9 Mus musculus asthma MONDO:0004979 asthma DOID:2841 airway epithelial cells up-regulated "circMETTL9/mmu_circ_0001624 is increased in airway epithelial cells in OVA-induced asthma compared with control, supported by RNA FISH and circRNA validation. The study links airway epithelial circMETTL9 to epithelial-macrophage communication and MET formation." 1901 41169933 Aerobic exercise alleviates allergic airway inflammation by suppressing circMETTL9-mediated formation of macrophage extracellular traps. mmu_circ_0001624 circRNA 3941 mmu_circ_METTL9 METTL9 Mus musculus asthma MONDO:0004979 asthma DOID:2841 airway epithelial cells down-regulated "Aerobic exercise reduces circMETTL9 expression in airway epithelial cells in OVA-induced asthma, reversing the OVA-induced increase. This downregulation is associated with reduced epithelial-macrophage communication driving MET formation." 1902 41178597 MSC Membrane-Coated circPROSC-siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification. hsa_circ_0001788 circPROSC hsa_circ_PROSC PROSC Homo sapiens craniosynostosis MONDO:0015469 craniosynostosis DOID:2340 hMSCs up-regulated "circPROSC expression gradually increases during osteogenic differentiation of primary human MSCs, a disease-relevant cell state for craniosynostosis." 1903 41187421 CircP4HA3/miR-5001-5p/THBS2 axis promotes chondrocyte senescence and cartilage degradation during osteoarthritis progression. hsa_circ_1539 hsa_circ_P4HA3 P4HA3 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes (HCs) up-regulated "CircP4HA3/hsa_circ_1539 is up-regulated in primary human chondrocytes exposed to TNF-¦Á or IL-1¦Â inflammatory stimulation, and RT-qPCR/FISH showed cytoplasmic expression in human chondrocytes. Functional assays in chondrocytes indicated that CircP4HA3 knockdown affected proliferation, migration, ECM-related genes, and senescence markers." 1904 41187421 CircP4HA3/miR-5001-5p/THBS2 axis promotes chondrocyte senescence and cartilage degradation during osteoarthritis progression. hsa_circ_0000412 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes (HCs) up-regulated hsa_circ_0000412 was up-regulated in primary human chondrocytes exposed to TNF-¦Á or IL-1¦Â inflammatory stimulation. 1905 41187421 CircP4HA3/miR-5001-5p/THBS2 axis promotes chondrocyte senescence and cartilage degradation during osteoarthritis progression. hsa_circ_0039783 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes (HCs) up-regulated hsa_circ_0039783 was up-regulated in primary human chondrocytes exposed to TNF-¦Á or IL-1¦Â inflammatory stimulation. 1906 41187421 CircP4HA3/miR-5001-5p/THBS2 axis promotes chondrocyte senescence and cartilage degradation during osteoarthritis progression. hsa_circ_0065147 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes (HCs) up-regulated hsa_circ_0065147 was up-regulated in primary human chondrocytes exposed to TNF-¦Á or IL-1¦Â inflammatory stimulation. 1907 41187421 CircP4HA3/miR-5001-5p/THBS2 axis promotes chondrocyte senescence and cartilage degradation during osteoarthritis progression. hsa_circ_0004340 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes (HCs) up-regulated hsa_circ_0004340 was up-regulated in primary human chondrocytes exposed to TNF-¦Á or IL-1¦Â inflammatory stimulation. 1908 41203147 Circular RNA Gsr-0002 promotes schistosomiasis-induced liver fibrosis by regulating the DNMT3A/PTEN pathway. mmu-Gsr_0002 mmu_circ_Gsr Gsr Mus musculus schistosomiasis-induced liver fibrosis MONDO:0005155 cirrhosis of liver DOID:5082 primary hepatic stellate cells (HSCs) up-regulated "circGsr-0002 is up-regulated in primary hepatic stellate cells isolated from S. japonicum-infected mice compared with healthy control mice, supported by circRNA high-throughput sequencing and qRT-PCR validation. Knockdown experiments indicate that circGsr-0002 promotes HSC activation and proliferation and reduces apoptosis through the miR-383-3p/DNMT3A/PTEN pathway." 1909 41206418 Prefrontal circHomer1 regulates synaptic and behavioral adaptations induced by cocaine. rno_circ_Homer1 Homer1 Rattus norvegicus cocaine use disorder MONDO:0005186 cocaine dependence DOID:9975 excitatory neurons down-regulated BaseScope in situ hybridization combined with neuronal marker immunostaining showed that repeated cocaine exposure reduced circHomer1 co-labeling with CamKII-positive excitatory neurons in the rat PrL. The study further reports that circHomer1 in PrL excitatory neurons regulates cocaine-induced behavioral and synaptic responses. 1910 41208880 Dysregulation of SRSF3/circSAMD4/CIRBP Axis Promotes Iodinated Contrast-induced Acute Kidney Injury. mmu_circ_005305 mmu_circ_Samd4 Samd4 Mus musculus contrast-induced acute kidney injury MONDO:0002492 acute kidney injury DOID:3021 RTECs up-regulated "Mouse circSamd4 was up-regulated in renal tubular epithelial cells of iohexol-induced CI-AKI mice, with FISH and tubular marker co-staining showing localization mainly in renal tubules, particularly proximal tubules. CircSamd4 knockdown alleviated tubular injury and cell death in CI-AKI mice." 1911 41208880 Dysregulation of SRSF3/circSAMD4/CIRBP Axis Promotes Iodinated Contrast-induced Acute Kidney Injury. hsa_circ_0004846 circSAMD4 hsa_circ_SAMD4A SAMD4A Homo sapiens contrast-induced acute kidney injury MONDO:0002492 acute kidney injury DOID:3021 human primary RTECs up-regulated "Human primary renal tubular epithelial cells showed increased circSAMD4 expression after iohexol exposure, measured by qRT-PCR after primary cell isolation and culture." 1912 41208880 Dysregulation of SRSF3/circSAMD4/CIRBP Axis Promotes Iodinated Contrast-induced Acute Kidney Injury. hsa_circ_0004846 circSAMD4 hsa_circ_SAMD4A SAMD4A Homo sapiens acute tubular injury MONDO:0006637 acute kidney tubular necrosis DOID:12556 RTECs up-regulated "In biopsy-confirmed acute tubular injury patient kidney tissue, circSAMD4 was significantly elevated in renal tubular epithelial cells, and co-staining showed extensive co-localization in renal tubules, particularly proximal tubules." 1913 41310793 Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway. novel_circ_0012677 hsa_circ_NLRP12 NLRP12 Homo sapiens pulmonary arterial hypertension MONDO:0015924 pulmonary arterial hypertension human pulmonary arterial smooth muscle cells (hPASMCs) up-regulated circNLRP12 was upregulated in hypoxia-exposed human pulmonary arterial smooth muscle cells. Silencing circNLRP12 attenuated hypoxia-induced hPASMC proliferation and migration and reversed apoptosis resistance. 1914 41328340 PTBP1-mediated inhibition of circular RNA SCMH1 biogenesis impairs brain recovery after ischemic stroke. mmu_circ_Scmh1 Scmh1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke primary mouse astrocytes down-regulated "In primary mouse astrocytes, OGD, used as a model for ischemic stroke, significantly reduced circSCMH1 levels as measured by real-time PCR." 1915 41328340 PTBP1-mediated inhibition of circular RNA SCMH1 biogenesis impairs brain recovery after ischemic stroke. mmu_circ_Scmh1 Scmh1 Mus musculus ischemic stroke MONDO:1060198 ischemic stroke primary mouse astrocytes up-regulated "In primary mouse astrocytes, shRNA-mediated Ptbp1 knockdown substantially increased circSCMH1 levels without changing linear Scmh1 mRNA expression." 1916 41340590 Identifying Circ-RNF216 as a Regulator of Renal Tubular Epithelial Cell Proliferation Via the TGF-¦¢1/Smad3-Mediated Pathway in Chronic Kidney Disease. mmu_circ_Rnf216 Rnf216 Mus musculus chronic kidney disease MONDO:0005300 chronic kidney disease DOID:784 tubular epithelial cells up-regulated circ-RNF216 was detected by in situ hybridization in mouse kidneys and was markedly upregulated in tubular epithelial cells in UUO kidney. Functional experiments in mTECs indicated that circ-RNF216 knockdown reduced fibrosis-related Vimentin expression and TGF-¦Â1-induced cell migration. 1917 41351065 The novel circular RNA circG6pc attenuates oxidative stress and mitochondrial damage through miR-7018-5p/Aldh6a1 axis in kidney fibrosis. mmu_circ_G6pc G6pc Mus musculus renal fibrosis MONDO:0000494 renal fibrosis DOID:0050855 tubular epithelial cells down-regulated "circG6pc was detected by ISH/FISH in mouse kidney tissue, was mainly localized to tubular/tubular epithelial cells, and was decreased in UUO fibrotic kidneys compared with normal kidneys. Functional experiments linked circG6pc to reduced fibrosis, mitochondrial dysfunction, and oxidative stress through the miR-7018-5p/Aldh6a1 axis." 1918 41362724 Circular RNA circPLXNC1 functions as an inhibitor of senescence by regulating autophagy in osteoarthritis. hsa_circ_0099504 hsa_circ_PLXNC1 PLXNC1 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 human primary chondrocytes up-regulated "Primary human chondrocytes were isolated and profiled by RNA-seq after Rapamycin treatment, identifying circPLXNC1 among differentially expressed circRNAs. The authors state that circPLXNC1 expression in senescent chondrocytes was reversed by Rapamycin-promoted autophagy flux." 1919 41362724 Circular RNA circPLXNC1 functions as an inhibitor of senescence by regulating autophagy in osteoarthritis. hsa_circ_0099504 hsa_circ_PLXNC1 PLXNC1 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 primary human chondrocytes down-regulated "In isolated primary human chondrocytes, qRT-PCR showed lower circPLXNC1 expression after 3-MA treatment than in controls, supporting reduced circPLXNC1 under low-autophagy conditions relevant to OA." 1920 41376162 Methylated circPTK2 as a driver of fibroblast activation in pulmonary fibrosis. hsa_circ_0002483 hsa_circ_PTK2 PTK2 Homo sapiens pulmonary fibrosis MONDO:0002771 pulmonary fibrosis DOID:3770 fibroblast up-regulated "circPTK2/circPTK2-m + is upregulated in fibroblast-marker-positive lung tissue regions from pulmonary fibrosis patients versus non-diseased controls, supported by fluorescent co-staining with vimentin. Functional experiments in fibroblasts indicate that circPTK2-m + promotes fibroblast activation, proliferation, and migration." 1921 41380930 circCacna1c modulates osteogenic differentiation of BMSCs via miR-7669-3p/Ciart axis in osteoporosis. mmu_circ_0001511 circCacna1c mmu_circ_Cacna1c Cacna1c Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 bone marrow stromal cells (BMSCs) down-regulated circCacna1c is significantly downregulated in BMSCs isolated from ovariectomized osteoporosis-model mice compared with sham-operated controls. 1922 41380930 circCacna1c modulates osteogenic differentiation of BMSCs via miR-7669-3p/Ciart axis in osteoporosis. mmu_circ_0001511 circCacna1c mmu_circ_Cacna1c Cacna1c Mus musculus osteoporosis MONDO:0005298 osteoporosis DOID:11476 BMSCs up-regulated circCacna1c is upregulated during osteogenic differentiation of primary mouse BMSCs and is positively associated with the osteogenic marker Alp. 1923 41390174 Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn's disease. circPLCE1 hsa_circ_PLCE1 PLCE1 Homo sapiens Crohn's disease MONDO:0005011 Crohn disease DOID:8778 HIMFs; fibroblasts down-regulated "circPLCE1 is downregulated in fibroblasts/HIMFs from strictured Crohn's disease intestinal segments compared with adjacent non-strictured Crohn's disease segments, supported by circRNA transcriptomics of isolated HIMFs and FISH co-localization with vimentin. Functional experiments in HIMFs indicate that reduced circPLCE1 promotes PPP activation and extracellular matrix deposition." PRJCA049983 1924 41390174 Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn's disease. CircPlce1 mmu_circ_Plce1 Plce1 Mus musculus Crohn's disease MONDO:0005011 Crohn disease DOID:8778 fibroblasts down-regulated "Mouse CircPlce1/circPLCE1 is decreased in fibroblasts in the DSS-induced intestinal fibrotic model, supported by FISH. Fibroblast-specific circPLCE1 knockdown in mice increased susceptibility to DSS-induced intestinal fibrosis and promoted PPP-related changes." 1925 41391036 Circular RNA PTPN4 Contributes to Blood-Brain Barrier Disruption during Early Epileptogenesis. mmu_circ_0000069 Circ_0004696 / CircPTPN4 mmu_circ_PTPN4 PTPN4 Mus musculus temporal lobe epilepsy MONDO:0005115 temporal lobe epilepsy DOID:3328 BMECs / cerebral vascular endothelial cells up-regulated CircPTPN4 was detected in primary BMECs and localized to cerebral vascular endothelial cells by FISH; qRT-PCR showed CircPTPN4 upregulation in BMECs exposed to epileptic neurons. Functional experiments indicated CircPTPN4 contributes to tight junction disruption and BBB impairment in epilepsy models. 1926 41391036 Circular RNA PTPN4 Contributes to Blood-Brain Barrier Disruption during Early Epileptogenesis. mmu_circ_0000069 Circ_0004696 / CircPTPN4 mmu_circ_PTPN4 PTPN4 Mus musculus temporal lobe epilepsy MONDO:0005115 temporal lobe epilepsy DOID:3328 neurons no change "CircPTPN4 was detected in primary neurons by FISH, but its expression did not significantly differ between epileptic and control neurons, supporting endothelial-specific upregulation under epileptic conditions." 1927 41397666 Tumor cell exosome circ-0023919 promotes EMT through the miR-197-5p/ICAM5 axis and enhances the drug resistance of colorectal cancer to 5-fu. hsa_circ_0023919 hsa_circ_PICALM PICALM Homo sapiens colorectal cancer MONDO:0005575 colorectal cancer DOID:5672; DOID:9256 primary CRC cells; CRC/5-Fu resistant cells up-regulated "circ-0023919 was identified from primary CRC tumor-cell-derived resistant cells and exosomes and was upregulated in CRC/5-Fu drug-resistant cells compared with parental primary CRC cells. Functional experiments in CRC/5-Fu cells linked circ-0023919 to EMT, migration, invasion, stemness and 5-Fu drug resistance." 1928 41405748 Circ_0043582 promotes dental pulp cell injury via miR-940/TRAF3/NF-¦ÊB axis in pulpitis. hsa_circ_0043582 Homo sapiens pulpitis MONDO:0006937 pulpitis DOID:11121 human dental pulp cells (HDPCs) up-regulated "circ_0043582 was up-regulated in LPS-treated primary human dental pulp cells used as an in vitro pulpitis model. Knockdown of circ_0043582 attenuated LPS-induced HDPC injury, inflammation, oxidative stress, apoptosis, and proliferation inhibition through the miR-940/TRAF3/NF-¦ÊB axis." 1929 41407226 circSCYL2 antagonizes hnRNPA2B1-mediated m6A-chromatin crosstalk to promote ferroptosis and inhibit metastasis of breast cancer to brain. hsa_circ_SCYL2 SCYL2 Homo sapiens breast cancer MONDO:0007254 breast cancer DOID:1612 cancer cells from brain metastases down-regulated "circSCYL2 was down-regulated in breast cancer cells isolated from brain metastases in a GFP-labeled MDA-MB-231 mouse metastasis model, based on GFP flow cytometry purification and RT-qPCR. circSCYL2 overexpression promoted ferroptosis in brain metastatic breast cancer cells and inhibited brain metastasis." 1930 41439030 Circular RNA MALAT1 as a potential target for antimetastatic therapy. hsa_circ_0002082 circ2082 hsa_circ_MALAT1 MALAT1 Homo sapiens hepatocellular carcinoma MONDO:0007256 hepatocellular carcinoma DOID:684; DOID:686 cancer stem-like cells (CSCs) up-regulated circ-MALAT1 is significantly higher in HCC cancer stem-like cells than in adherent HCC cells based on quantitative RT-qPCR. The text links circ-MALAT1 to CSC self-renewal through PAX5/TP53 inhibition and JAK2/STAT3 activation. 1931 41439030 Circular RNA MALAT1 as a potential target for antimetastatic therapy. hsa_circ_0002082 circ2082 hsa_circ_MALAT1 MALAT1 Homo sapiens esophageal squamous cell carcinoma MONDO:0005580 esophageal squamous cell carcinoma DOID:3748 CSCs up-regulated "circ-MALAT1 is higher in ESCC CSCs than in other ESCC cells based on quantitative RT-qPCR. The text links circ-MALAT1 to stemness, migration, invasion and cisplatin resistance in ESCC." 1932 41439564 Recombinant human granulocyte colony-stimulating factor improves implantation partly by downregulating Hsa_circ_0001550_. hsa_circ_0001550 hsa circRNA 104001 hsa_circ_RARS RARS Homo sapiens recurrent implantation failure MONDO:0021124 female infertility hESCs down-regulated "rhG-CSF treatment downregulated hsa circ 0001550 expression in primary human endometrial stromal cells, with concomitant upregulation of endometrial receptivity markers HOXA10 and LIF." 1933 41439564 Recombinant human granulocyte colony-stimulating factor improves implantation partly by downregulating Hsa_circ_0001550_. hsa_circ_0001550 hsa circRNA 104001 hsa_circ_RARS RARS Homo sapiens recurrent implantation failure MONDO:0021124 female infertility hEECs down-regulated "rhG-CSF treatment downregulated hsa circ 0001550 expression in primary human endometrial epithelial cells, with concomitant upregulation of endometrial receptivity markers HOXA10 and LIF." 1934 41477335 IGF2BP1 positively regulates CircOGDH accumulation in hypoxia induced stress granules. CircOGDH OGDH Mus musculus ischemic stroke MONDO:1060198 ischemic stroke primary cortical neurons down-regulated "In primary cortical neurons, RT-qPCR after actinomycin D treatment showed that IGF2BP1 knockdown reduced CircOGDH stability under hypoxic conditions. This supports IGF2BP1-dependent maintenance of CircOGDH in hypoxic neurons relevant to acute ischemic stroke." 1935 41486887 CircTspan3 Promotes Cartilage Development Through ANNEXIN A2-Mediated Ferroptosis and Apoptosis Inhibition and Exosome-Mediated Paracrine Signaling. mmu_circ_0001775 circTspan3 mmu_circ_Tspan3 Tspan3 Mus musculus chondrodysplasia MONDO:0022723 chondrodysplasia primary chondrocytes (P0) down-regulated "circTspan3 is down-regulated in isolated primary chondrocytes from Xbp1 conditional knockout mice with chondrodysplasia compared with littermate controls. The study links circTspan3 to chondrocyte anabolism, apoptosis suppression, ferroptosis suppression, and exosome-mediated paracrine signaling." 1936 41487094 CircZBTB44-Encoded Peptide ZBTB44-342aa Alleviates Aortic Valve Calcification Via cGAS-STING Inhibition. hsa_circ_0002484 circZBTB44 hsa_circ_ZBTB44 ZBTB44 Homo sapiens Calcific aortic valve disease MONDO:0005463 aortic valve calcification human aortic valve interstitial cells down-regulated circZBTB44 was downregulated in osteogenically differentiated human aortic valve interstitial cells exposed to osteogenic medium. Functional experiments in HAVICs indicated that circZBTB44 negatively regulates osteogenic differentiation and calcification. 1937 41503997 Dual-Modified Mannose/RVG29 Peptide-Functionalized Lipid Nanoparticles Loaded With circHIPK2 siRNA Ameliorate Hypoxic-Ischemic Brain Damage in Neonatal Mice by Suppressing Astrocyte Activation. mmu_circ_HIPK2 HIPK2 Mus musculus neonatal hypoxic-ischemic encephalopathy MONDO:0006663 perinatal asphyxia DOID:11088 primary astrocytes down-regulated "In isolated and cultured primary mouse astrocytes, qRT-PCR showed that circHIPK2 siRNAs reduced circHIPK2 expression compared with untreated control cells, with siRNA-3 producing an 80.13% decrease. The study links astrocyte-targeted circHIPK2 silencing to reduced astrocyte activation and neuroinflammation in HIE/HIBD models." 1938 41510160 Mechanosensitive snoRNA-like circular RNA sno-circCNOT1 drives endothelial dysfunction and atherosclerosis. hsa_circ_0000705 sno-circCNOT1 hsa_circ_CNOT1 CNOT1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 endothelial cells up-regulated sno-circCNOT1/hsa_circ_0000705 is upregulated in endothelial cells exposed to pro-atherogenic IL-1¦Â or oscillatory shear stress. Functional assays indicate that sno-circCNOT1 promotes endothelial inflammation and monocyte adhesion. 1939 41510160 Mechanosensitive snoRNA-like circular RNA sno-circCNOT1 drives endothelial dysfunction and atherosclerosis. hsa_circ_0000705 sno-circCNOT1 hsa_circ_CNOT1 CNOT1 Homo sapiens atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 endothelial cells down-regulated sno-circCNOT1/hsa_circ_0000705 is downregulated in endothelial cells under anti-atherogenic laminar shear stress. This contrasts with its induction by pro-atherogenic IL-1¦Â and oscillatory shear stress. 1940 41510160 Mechanosensitive snoRNA-like circular RNA sno-circCNOT1 drives endothelial dysfunction and atherosclerosis. sno-circCNOT1 mmu_circ_Cnot1 CNOT1 Mus musculus atherosclerosis MONDO:0005311 atherosclerosis DOID:1936 Endothelial cells up-regulated "In mouse aorta, FISH combined with endothelial marker staining showed elevated endothelial sno-circCNOT1 in disturbed-flow aortic arch regions compared with laminar-flow thoracic aorta. This supports endothelial cell-associated upregulation of sno-circCNOT1 under atheroprone shear stress." 1941 41519399 CircCramp1l targets the miR-532-3p/HMGB1/Drp1 axis to regulate allergic rhinitis. hsa_circ_0003592 hsa_circ_Cramp1l Cramp1l Homo sapiens allergic rhinitis MONDO:0011786 allergic rhinitis DOID:4481 human nasal epithelial cell(HNEpCs) up-regulated "hsa_circ_0003592, referred to as circCramp1l, is upregulated in HDM-stimulated primary human nasal mucosal epithelial cells in an allergic rhinitis model. Functional experiments in HNEpCs indicate that circCramp1l promotes epithelial cell apoptosis." 1942 41520563 Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1. mmu_circ_Samd4 Samd4 Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 cardiac fibroblasts up-regulated "mmu_circSamd4/circSamd4 is enriched in mouse cardiac fibroblasts compared with cardiomyocytes, supported by isolated-cell qRT-PCR and FISH with fibroblast marker co-localization." 1943 41520563 Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1. mmu_circ_Samd4 Samd4 Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 CFs up-regulated circSamd4 is up-regulated in cardiac fibroblasts isolated from TAC-induced fibrotic mouse hearts compared with sham hearts. 1944 41520563 Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1. mmu_circ_Samd4 Samd4 Mus musculus cardiac fibrosis MONDO:0005267 heart disorder DOID:114 CFs up-regulated circSamd4 expression increases in primary mouse cardiac fibroblasts activated with TGF-¦Â1 compared with untreated fibroblasts. 1945 41548986 A highly abundant circular RNA from the RMST locus plays a role in posterior fossa ependymoma pathogenesis. hsa_circ_0099634 circRMST hsa_circ_RMST RMST Homo sapiens posterior fossa ependymoma MONDO:0850339 posterior fossa ependymoma DOID:0080889 cancer cells up-regulated Single-molecule in situ hybridization targeting the circRMST back-splice junction in EPN patient samples showed that circRMST is highly expressed in cancer cells throughout the tumors and predominantly cytoplasmic. 1946 41555117 CircRNA HIPK2-mediated metabolic reprogramming restores mitochondrial homeostasis in chondrocytes through the miR-206/Sirt3 signaling axis attenuating osteoarthritis-induced nociception. circHIPK2 hsa_circ_HIPK2 HIPK2 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 articular chondrocytes down-regulated circHIPK2 is down-regulated in primary articular chondrocytes isolated from OA patient cartilage compared with normal-control chondrocytes. Functional experiments in chondrocytes support roles in metabolic regulation and apoptosis. 1947 41555117 CircRNA HIPK2-mediated metabolic reprogramming restores mitochondrial homeostasis in chondrocytes through the miR-206/Sirt3 signaling axis attenuating osteoarthritis-induced nociception. circHIPK2 HIPK2 Rattus norvegicus osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 Articular chondrocytes down-regulated circHIPK2 is down-regulated in articular chondrocytes isolated from rat osteoarthritis models compared with corresponding control/sham conditions. In vivo AAV-mediated circHIPK2 overexpression attenuated pain behaviors and cartilage degeneration in these OA models. 1948 41564714 Human Left Ventricle circRNA-miRNA-mRNA Network Analyses Reveal a Novel Proangiogenic Role for circNPHP1 Under Ischemic Conditions. circNPHP1 hsa_circ_NPHP1 NPHP1 Homo sapiens ischemic heart disease MONDO:0005053 ischemic disease DOID:326 human cardiac microvascular endothelial cells; human umbilical vein endothelial cells up-regulated circNPHP1 was up-regulated in cultured human endothelial cells under hypoxia used to mimic ischemic conditions. Functional assays indicated that circNPHP1 promotes endothelial proliferation and angiogenic cord formation. PRJNA1336212 1949 41564714 Human Left Ventricle circRNA-miRNA-mRNA Network Analyses Reveal a Novel Proangiogenic Role for circNPHP1 Under Ischemic Conditions. circNPHP1 hsa_circ_NPHP1 NPHP1 Homo sapiens ischemic heart disease MONDO:0005053 ischemic disease DOID:326 human cardiac microvascular endothelial cells; human umbilical vein endothelial cells up-regulated circNPHP1 was up-regulated in cultured human endothelial cells under combined hypoxia and high glucose used to mimic IHD with diabetes. Functional assays indicated that circNPHP1 promotes endothelial proliferation and angiogenic cord formation. PRJNA1336212 1950 41605366 Circ_0075691 regulates lipid metabolism in granulosa cells by interacting with EIF4A3 to promote PTGS2 mRNA stability. circ_0075691 hsa_circ_ATXN1 ATXN1 Homo sapiens polycystic ovary syndrome / PCOS MONDO:0008487 polycystic ovary syndrome DOID:11612 granulosa cells up-regulated circ_0075691 was up-regulated in isolated granulosa cells from PCOS patients compared with normal controls by RT-PCR. Functional assays in granulosa-cell systems linked circ_0075691 to altered lipid metabolism and oxidative stress. 1951 41610425 circPCMTD1: A protein-coding circular RNA that regulates DNA damage response in BCR/ABL1-positive leukemias. circPCMTD1 hsa_circ_PCMTD1 PCMTD1 Homo sapiens chronic lymphocytic leukemia MONDO:0004948 B-cell chronic lymphocytic leukemia DOID:1040 CD34-positive blasts down-regulated "In CD34-positive blasts from BP-CML patients, circPCMTD1 was efficiently depleted after circPCMTD1 knock-down. This depletion reduced colony formation by leukemic blasts." 1952 41610425 circPCMTD1: A protein-coding circular RNA that regulates DNA damage response in BCR/ABL1-positive leukemias. circPCMTD1 hsa_circ_PCMTD1 PCMTD1 Homo sapiens acute myeloid leukemia / AML MONDO:0018874 acute myeloid leukemia DOID:9119 leukemic blasts down-regulated "In AML patient leukemic blasts, circPCMTD1 was expressed and efficiently depleted after circPCMTD1 knock-down. The article reports no DDR effect in AML samples." 1953 41619923 Circ_Mkrn2 facilitates the progression of atrial fibrillation via sponging miR-10b-5p. circRNA_4760 hsa_circ_MKRN2 MKRN2 Homo sapiens atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 HAFs; RAFs; atrial fibroblasts up-regulated "circ_Mkrn2 expression was increased in primary human and rat atrial fibroblasts under chronic intermittent hypoxia compared with normoxia. Functional experiments in rat atrial fibroblasts showed circ_Mkrn2 promoted atrial fibroblast activation, proliferation and migration through the miR-10b-5p/SMURF1 axis." 1954 41641542 circMFN2 Regulates the IGF2BP3-PDK4 to Ameliorate Pulmonary Hypertension. hsa_circ_MFN2 MFN2 Homo sapiens pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 ¦Á-SMA + smooth muscle layers / pulmonary artery smooth muscle cells down-regulated "RNA-FISH with ¦Á-SMA immunostaining showed that circMFN2 signal is reduced in pulmonary arteriolar smooth muscle layers in pulmonary hypertension models, with minimal overlap in CD31+ endothelial cells. Functional experiments in hPASMCs indicate that circMFN2 suppresses hypoxia-induced proliferation, migration, and metabolic dysfunction." 1955 41619923 Circ_Mkrn2 facilitates the progression of atrial fibrillation via sponging miR-10b-5p. circRNA_4760 rno_circ_Mkrn2 Mkrn2 Rattus norvegicus atrial fibrillation MONDO:0004981 atrial fibrillation DOID:0060224 HAFs; RAFs; atrial fibroblasts up-regulated "circ_Mkrn2 expression was increased in primary human and rat atrial fibroblasts under chronic intermittent hypoxia compared with normoxia. Functional experiments in rat atrial fibroblasts showed circ_Mkrn2 promoted atrial fibroblast activation, proliferation and migration through the miR-10b-5p/SMURF1 axis." 1956 41641542 circMFN2 Regulates the IGF2BP3-PDK4 to Ameliorate Pulmonary Hypertension. circMFN2 mmu_circ_Mfn2 Mfn2 Mus musculus pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 ¦Á-SMA + smooth muscle layers / pulmonary artery smooth muscle cells down-regulated "RNA-FISH with ¦Á-SMA immunostaining showed that circMFN2 signal is reduced in pulmonary arteriolar smooth muscle layers in pulmonary hypertension models, with minimal overlap in CD31+ endothelial cells. Functional experiments in hPASMCs indicate that circMFN2 suppresses hypoxia-induced proliferation, migration, and metabolic dysfunction." 1957 41654728 hsa_circ_0006168 drives microglial activation in TNC via miR-99b-5p/KDM6B axis to promote central sensitization in migraine. hsa_circ_0006168 Homo sapiens migraine MONDO:0005277 migraine disorder DOID:6364 microglia up-regulated "In NTG-induced migraine mice, mmu_circ_0012878 was detected by FISH and showed pronounced co-localization with the microglial marker Iba1 in the TNC compared with sham mice. Knockdown of mmu_circ_0012878 suppressed microglial activation, reduced M1 polarization, and promoted M2 polarization." 1958 41654728 hsa_circ_0006168 drives microglial activation in TNC via miR-99b-5p/KDM6B axis to promote central sensitization in migraine. hsa_circ_0006168 Homo sapiens migraine MONDO:0005277 migraine disorder DOID:6364 neuronal nuclei (NeuN) up-regulated "In NTG-induced migraine mice, mmu_circ_0012878 was detected by FISH in the TNC and partially co-localized with the neuronal marker NeuN compared with sham mice. The paper emphasizes a more pronounced co-localization with Iba1 and a microglial mechanism." 1959 41654728 hsa_circ_0006168 drives microglial activation in TNC via miR-99b-5p/KDM6B axis to promote central sensitization in migraine. mmu_circ_0012878 Mus musculus migraine MONDO:0005277 migraine disorder DOID:6364 microglia up-regulated "In NTG-induced migraine mice, mmu_circ_0012878 was detected by FISH and showed pronounced co-localization with the microglial marker Iba1 in the TNC compared with sham mice. Knockdown of mmu_circ_0012878 suppressed microglial activation, reduced M1 polarization, and promoted M2 polarization." 1960 41654728 hsa_circ_0006168 drives microglial activation in TNC via miR-99b-5p/KDM6B axis to promote central sensitization in migraine. mmu_circ_0012878 Mus musculus migraine MONDO:0005277 migraine disorder DOID:6364 neuronal nuclei (NeuN) up-regulated "In NTG-induced migraine mice, mmu_circ_0012878 was detected by FISH in the TNC and partially co-localized with the neuronal marker NeuN compared with sham mice. The paper emphasizes a more pronounced co-localization with Iba1 and a microglial mechanism." 1961 41655237 Mitochondrial CircRNA CircMT-RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair. circMT-RNR2 hsa_circ_MT-RNR2 MT-RNR2 Homo sapiens diabetic foot ulcer MONDO:0005015 diabetes mellitus DOID:9351 dermal fibroblasts up-regulated "circMT-RNR2 is enriched in dermal fibroblasts compared with epidermal keratinocytes in human skin/DFU-related samples, supported by qRT-PCR of isolated cells." 1962 41655237 Mitochondrial CircRNA CircMT-RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair. circMT-RNR2 hsa_circ_MT-RNR2 MT-RNR2 Homo sapiens diabetic foot ulcer MONDO:0005015 diabetes mellitus DOID:9351 human adult dermal fibroblasts down-regulated "In primary human adult dermal fibroblasts, high glucose and hypoxic conditions reduced circMT-RNR2 expression, conditions described as characteristic of DFU." 1963 41655237 Mitochondrial CircRNA CircMT-RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair. mmu_circ_MT-RNR2 MT-RNR2 Mus musculus Diabetic foot ulcer / DFU MONDO:0005015 diabetes mellitus DOID:9351 wound fibroblasts up-regulated "In a murine wound healing model, CircMT-RNR2 was upregulated in purified wound fibroblasts compared with skin fibroblasts, as measured by qRT-PCR after fibroblast purification." 1964 41665194 Circular RNA circFNDC3B Modulates M2 Macrophage Activation and Intestinal Inflammation in Crohn's Disease. CircRNA_103516 hsa_circ_FNDC3B FNDC3B Homo sapiens Crohn's disease MONDO:0005011 Crohn disease DOID:8778 CD14 + monocytes up-regulated circFNDC3B is up-regulated in sorted peripheral blood CD14+ monocytes from active Crohn's disease patients compared with healthy controls. Functional assays linked circFNDC3B to monocyte adhesion to vascular endothelial cells. 1965 41665194 Circular RNA circFNDC3B Modulates M2 Macrophage Activation and Intestinal Inflammation in Crohn's Disease. CircRNA_103516 hsa_circ_FNDC3B FNDC3B Homo sapiens Crohn's disease MONDO:0005011 Crohn disease DOID:8778 CD14 + monocytes down-regulated "In sorted peripheral blood CD14+ monocytes, circFNDC3B expression was lower/restored in remission Crohn's disease compared with active Crohn's disease." 1966 41665194 Circular RNA circFNDC3B Modulates M2 Macrophage Activation and Intestinal Inflammation in Crohn's Disease. CircRNA_103516 hsa_circ_FNDC3B FNDC3B Homo sapiens Crohn's disease MONDO:0005011 Crohn disease DOID:8778 neutrophils down-regulated circFNDC3B is down-regulated in peripheral blood neutrophils from Crohn's disease patients compared with healthy controls based on isolated-cell qRT-PCR. 1967 41666156 Penumbra-derived small extracellular vesicles carry pathogenic RNA driving remote damage after cortical infarction. CircOGDH mmu_circ_OGDH OGDH Mus musculus ischemic stroke MONDO:1060198 ischemic stroke thalamic neurons up-regulated "CircOGDH accumulated after MCAO and was predominantly localized in ipsilateral thalamic neurons by FISH, supporting neuron-associated CircOGDH up-regulation in focal cortical infarction." 1968 41667113 "Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction." mmu_circ_0001468 circHIPK2 mmu_circ_Hipk2 Hipk2 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 pro-inflammatory macrophages up-regulated circHIPK2 is upregulated in primary cardiac pro-inflammatory macrophages isolated from mouse hearts at Day 1 after myocardial infarction compared with non-MI control macrophages. The study links circHIPK2 to macrophage polarization and inflammatory responses. 1969 41667113 "Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction." mmu_circ_0001468 circHIPK2 mmu_circ_Hipk2 Hipk2 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 macrophage fractions up-regulated Cardiac fractionation of mouse left ventricular tissue after myocardial infarction showed that circHIPK2 expression increased specifically in macrophage fractions among major cardiac cell types. This supports macrophage-enriched circHIPK2 expression in post-MI hearts. 1970 41667113 "Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction." mmu_circ_0001468 circHIPK2 mmu_circ_Hipk2 Hipk2 Mus musculus myocardial infarction MONDO:0005068 myocardial infarction DOID:5844 GFP + CD68 + populations down-regulated FACS-defined GFP+CD68+ macrophages from post-MI mice showed selective downregulation of circHIPK2 after macrophage-targeted AAV9-circHIPK2-shR treatment compared with scramble control. This cell-specific inhibition was associated with reduced inflammatory gene expression in macrophages. 1971 41667834 BMSCs exosomes regulate pulmonary microvascular endothelial apoptosis via circRNA_43350/miR-342-5p in COPD. mmu_circRNA_43350 mmu_circ_Ciapin1 Ciapin1 Mus musculus chronic obstructive pulmonary disease / COPD MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 BMSCs down-regulated mmu_circRNA_43350 was decreased in BMSC-derived exosomes from COPD mice compared with normal mice. The study links BMSC exosomal circRNA_43350 to regulation of CSE-induced PMVEC apoptosis via miR-342-5p. 1972 41667834 BMSCs exosomes regulate pulmonary microvascular endothelial apoptosis via circRNA_43350/miR-342-5p in COPD. mmu_circRNA_43350 mmu_circ_Ciapin1 Ciapin1 Mus musculus chronic obstructive pulmonary disease / COPD MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 PMVECs down-regulated "In primary mouse PMVECs, CSE treatment inhibited circRNA_43350 expression compared with untreated control conditions. Overexpression of circRNA_43350 attenuated CSE-induced apoptosis in PMVECs through interaction with miRNA-342-5p." 1973 41671376 Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs. circHomer1 rno_circ_Homer1 Homer1 Rattus norvegicus others others others primary cortical neurons up-regulated "circHomer1 was up-regulated in primary cortical neurons after 14 days in vitro, a stage when neurons begin to present mature dendritic spines." 1974 41671376 Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs. circHomer1 rno_circ_Homer1 Homer1 Rattus norvegicus others others others hippocampal neurons up-regulated "Bicuculline treatment increased circHomer1 expression in primary hippocampal neurons, including both somatic and dendritic compartments." 1975 41671376 Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs. circHomer1 mmu_circ_Homer1 Homer1 Mus musculus others others others CA1 neurons up-regulated "In mouse hippocampal CA1 neurons, environmental enrichment induced activity-associated circHomer1 expression detected by smFISH; circHomer1 peaked in the somatic layer and remained elevated in MAP2-labeled neuropil." 1976 41673675 Decreased expression of circ-CCDC134 mediated by TNF-¦Á in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A. circ-UBXN7 hsa_circ_UBXN7 UBXN7 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 T cells down-regulated circ-UBXN7 was downregulated in magnetically purified T cells from patients with rheumatoid arthritis compared with healthy controls. 1977 41673675 Decreased expression of circ-CCDC134 mediated by TNF-¦Á in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A. circ-CCDC134 hsa_circ_CCDC134 CCDC134 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 T cells down-regulated circ-CCDC134 was downregulated in magnetically purified T cells from patients with rheumatoid arthritis compared with healthy controls. Functional experiments in activated T cells/Jurkat cells showed that circ-CCDC134 promotes IL-2 and IFN-¦Ã expression or secretion and reverses chronic TNF-¦Á-related suppression of cytokine secretion. 1978 41673675 Decreased expression of circ-CCDC134 mediated by TNF-¦Á in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A. circ-CCDC88C hsa_circ_CCDC88C CCDC88C Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 T cells down-regulated circ-CCDC88C was downregulated in magnetically purified T cells from patients with rheumatoid arthritis compared with healthy controls. 1979 41673675 Decreased expression of circ-CCDC134 mediated by TNF-¦Á in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A. circ-MORC3 hsa_circ_MORC3 MORC3 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 T cells down-regulated circ-MORC3 was downregulated in magnetically purified T cells from patients with rheumatoid arthritis compared with healthy controls. 1980 41673675 Decreased expression of circ-CCDC134 mediated by TNF-¦Á in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A. circ-PDXDC1 hsa_circ_PDXDC1 PDXDC1 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 T cells down-regulated circ-PDXDC1 was downregulated in magnetically purified T cells from patients with rheumatoid arthritis compared with healthy controls. 1981 41673675 Decreased expression of circ-CCDC134 mediated by TNF-¦Á in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A. circ-PRRC2B hsa_circ_PRRC2B PRRC2B Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 T cells down-regulated circ-PRRC2B was downregulated in magnetically purified T cells from patients with rheumatoid arthritis compared with healthy controls. 1982 41673675 Decreased expression of circ-CCDC134 mediated by TNF-¦Á in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A. circ-G3BP1 hsa_circ_G3BP1 G3BP1 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 T cells down-regulated circ-G3BP1 was downregulated in magnetically purified T cells from patients with rheumatoid arthritis compared with healthy controls. 1983 41673675 Decreased expression of circ-CCDC134 mediated by TNF-¦Á in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A. circ-SRBD1 hsa_circ_SRBD1 SRBD1 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 T cells down-regulated circ-SRBD1 was downregulated in magnetically purified T cells from patients with rheumatoid arthritis compared with healthy controls. 1984 41673675 Decreased expression of circ-CCDC134 mediated by TNF-¦Á in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A. circ-WDR59 hsa_circ_WDR59 WDR59 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 T cells down-regulated circ-WDR59 was downregulated in magnetically purified T cells from patients with rheumatoid arthritis compared with healthy controls. 1985 41673675 Decreased expression of circ-CCDC134 mediated by TNF-¦Á in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A. circ-RAB11FIP1 hsa_circ_RAB11FIP1 RAB11FIP1 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 T cells down-regulated circ-RAB11FIP1 was downregulated in magnetically purified T cells from patients with rheumatoid arthritis compared with healthy controls. 1986 41673675 Decreased expression of circ-CCDC134 mediated by TNF-¦Á in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A. circ-PHF14 hsa_circ_PHF14 PHF14 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 T cells down-regulated circ-PHF14 was downregulated in magnetically purified T cells from patients with rheumatoid arthritis compared with healthy controls. 1987 41679563 Silencer-regulated circLSM14A inhibits autophagy of pulmonary artery smooth muscle cells through parental protein LSM14A. circLSM14A hsa_circ_LSM14A LSM14A Homo sapiens Pulmonary hypertension MONDO:0005149 pulmonary hypertension DOID:6432 HPASMCs down-regulated "circLSM14A is down-regulated in hypoxic human pulmonary artery smooth muscle cells, and FISH supports its cytoplasmic localization in HPASMCs. Functional experiments indicate that circLSM14A inhibits hypoxia-induced autophagy in HPASMCs." 1988 41703266 A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants. CDR1as Homo sapiens Major Depressive Disorder MONDO:0002009 major depressive disorder DOID:1470 leukocytes up-regulated "In leukocytes collected from venous blood of patients with MDD treated with SSRIs, CDR1as levels were higher in non-remitters than remitters at 30 weeks after treatment." NCT02209142 1989 41703266 A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants. Cdr1as Mus musculus Major Depressive Disorder MONDO:0002009 major depressive disorder DOID:1470 mouse cortical neurons down-regulated "In primary mouse cortical neurons, Cdr1as expression was reduced after TrkB inhibition and after CBP/CREB or ERK inhibition, indicating regulation by BDNF/TrkB and ERK/CREB signaling." 1990 41711097 Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression. hsa_circ_0000228 circZEB1 hsa_circ_ZEB1 ZEB1 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ HSPCs up-regulated "circZEB1 / hsa_circ_0000228 was upregulated in sorted CD34+ cells from patients with MDS compared with healthy controls, based on total RNA-seq." 1991 41711097 Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression. hsa_circ_0000228 circZEB1 hsa_circ_ZEB1 ZEB1 Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ HSPCs up-regulated circZEB1 / hsa_circ_0000228 showed SF3B1 mutation-associated upregulation in sorted CD34+ cells from patients with MDS. 1992 41711097 Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression. circARID1B hsa_circ_ARID1B ARID1B Homo sapiens myelodysplastic neoplasms MONDO:0006311 myelodysplastic/myeloproliferative neoplasm DOID:4972 CD34+ HSPCs up-regulated "circARID1B was among the MDS-associated upregulated circRNAs detected by total RNA-seq in sorted CD34+ HSPCs, and its high expression was associated with AML risk." 1993 41716226 Abnormal circ-CDK8 expression affects periodontitis development by regulating let-7b-5p/MAP4K3 signaling. circ-CDK8 hsa_circ_CDK8 CDK8 Homo sapiens periodontitis MONDO:0005076 periodontitis DOID:824; DOID:9893 I-PDLSCs down-regulated "In primary human periodontal ligament stem cells cultured under inflammatory conditions, circ-CDK8 expression was reported as decreased compared with control PDLSCs by qRT-PCR. Functional experiments in I-PDLSCs linked circ-CDK8 knockdown to altered autophagy and osteogenic differentiation via the let-7b-5p/MAP4K3 pathway." 1994 41739298 CircRNA_02540 alleviated the migration and ligament differentiation capacities of SM-MSCs suppressed by chronic inflammation via regulating miR-203a-3p/ZIC1 pathway. circRNA_02540 Homo sapiens anterior cruciate ligament injury MONDO:0043895 ankle injury SM-MSCs down-regulated circRNA_02540 was decreased in human synovial membrane-derived MSCs after TNF-¦Á treatment used to model chronic inflammation. Overexpression of circRNA_02540 enhanced migration and ligament differentiation capacities of SM-MSCs under chronic inflammatory conditions. 1995 41759746 Sevoflurane aggravated neuroinflammation and oxidative stress in neonatal mice by modulating microglia phenotype via circRNA2092/miR-873a-5p/KEAP1. circRNA2092 Mus musculus anterior cruciate ligament injury MONDO:0043895 ankle injury microglia up-regulated "Primary cultured mouse microglia were examined with or without sevoflurane exposure by qPCR validation of DEcircRNAs, and circRNA2092 was reported to be significantly upregulated in the sevoflurane group. Knockdown experiments in microglia supported a role for circRNA2092 in microglial inflammatory and oxidative stress responses." 1996 41775938 METTL3-Mediated m6A Regulation of CircINTS4/miR-146b-3p Axis in Rheumatoid Arthritis. hsa_circ_0002476 circINTS4 hsa_circ_INTS4 INTS4 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLS down-regulated "circINTS4 is endogenously downregulated in rheumatoid arthritis fibroblast-like synoviocytes compared with healthy FLS-derived controls. Functional experiments in RA-FLS indicate that circINTS4 limits cell viability and migration, promotes apoptosis, and influences macrophage polarization through the FLS secretome." 1997 41775938 METTL3-Mediated m6A Regulation of CircINTS4/miR-146b-3p Axis in Rheumatoid Arthritis. hsa_circ_0002476 circINTS4 hsa_circ_INTS4 INTS4 Homo sapiens rheumatoid arthritis MONDO:0008383 rheumatoid arthritis DOID:7148 RA-FLS up-regulated "In RA-FLS, METTL3 knockdown significantly increased circINTS4 abundance, indicating that METTL3-mediated m6A modification negatively regulates circINTS4 expression in this cell type." 1998 41809636 Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability. hsa_circ_0006896 circKIAA1429 hsa_circ_VIRMA VIRMA Homo sapiens carotid atherosclerotic plaque MONDO:1060134 atherosclerotic cardiovascular disease PBMCs up-regulated "circVIRMA(3-4) was significantly increased in isolated PBMCs from patients with vulnerable carotid plaques compared with stable plaques, based on RT-qPCR." 1999 41809636 Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability. hsa_circ_0044073 hsa_circ_GRN GRN Homo sapiens carotid atherosclerotic plaque MONDO:1060134 atherosclerotic cardiovascular disease PBMCs up-regulated "circGRN(12-13) was significantly upregulated in isolated PBMCs from patients with vulnerable carotid plaques compared with stable plaques, based on RT-qPCR." 2000 41809636 Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability. hsa_circ_0001946 CDR1as hsa_circ_CDR1 CDR1 Homo sapiens carotid atherosclerotic plaque MONDO:1060134 atherosclerotic cardiovascular disease PBMCs up-regulated "CDR1as(1) was markedly upregulated in isolated PBMCs from patients with vulnerable carotid plaques compared with stable plaques, based on RT-qPCR, and showed strong predictive value among the circRNAs studied." 2001 41809636 Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability. hsa_circ_0008574 hsa_circ_ANRIL ANRIL Homo sapiens carotid atherosclerotic plaque MONDO:1060134 atherosclerotic cardiovascular disease PBMCs no change circANRIL(5-7) showed no significant differential expression in isolated PBMCs between patients with vulnerable and stable carotid plaques. 2002 41809636 Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability. hsa_circ_0004297 hsa_circ_ANRIL ANRIL Homo sapiens carotid atherosclerotic plaque MONDO:1060134 atherosclerotic cardiovascular disease PBMCs no change circANRIL(4-14) showed no significant differential expression in isolated PBMCs between patients with vulnerable and stable carotid plaques. 2003 41826685 HIV-1-encoded circular RNA enhances viral transcription through Tat binding. "circHIV: 5,390-6,044" Human immunodeficiency virus 1 HIV-1 infection MONDO:0005109 HIV infectious disease DOID:526 primary CD4_ T cells up-regulated HIV-1-encoded circHIV was detected by TaqMan RT-qPCR in RNase R-treated RNA from primary CD4+ T cells infected with wild-type NL4-3. 2004 41844577 M6A-modified circArhgap26 attenuates cardiac ischemia_reperfusion injury by suppressing plakophilin-1 palmitoylation. circRNA_018468 mmu_circ_Arhgap26 Arhgap26 Mus musculus cardiac ischemia-reperfusion injury MONDO:0005203 ischemia reperfusion injury cardiomyocytes down-regulated circRNA_018468 (CircArhgap26) was significantly decreased in primary mouse cardiomyocytes subjected to H2O2 or H/R stimulation. Functional assays in cardiomyocytes showed that circArhgap26 overexpression reduced apoptosis-related injury phenotypes. 2005 41851080 K48 and K63 linkage-competed ubiquitination of BECN1 promotes circPDE4D-mediated autophagy in chronic obstructive pulmonary disease. hsa_circ_0072568 circPDE4D hsa_circ_PDE4D PDE4D Homo sapiens chronic obstructive pulmonary disease / COPD MONDO:0005002 chronic obstructive pulmonary disease DOID:3083 primary bronchial epithelial cells down-regulated "circPDE4D (hsa_circ_0072568) was downregulated in primary bronchial epithelial cells isolated from COPD patients compared with normal primary bronchial epithelial cells, as measured by RT-qPCR." 2006 41894117 YTH N6-methyladenosine RNA binding protein 2 mediated m6A modification of circHIPK2 promotes cellular senescence and osteoarthritis progression by inhibiting autophagy. circHIPK2 hsa_circ_HIPK2 HIPK2 Homo sapiens osteoarthritis MONDO:0005178 osteoarthritis DOID:8398 chondrocytes down-regulated "circHIPK2 was significantly downregulated in osteoarthritis chondrocytes compared with normal articular chondrocytes, based on qRT-PCR analysis of isolated primary chondrocytes. Functional experiments in chondrocytes showed that circHIPK2 overexpression suppresses chondrocyte senescence, whereas circHIPK2 knockdown promotes senescence." 2007 41895673 Circ_0068481 promotes pulmonary arterial smooth muscle cell remodeling via PTEN degradation and PI3K/AKT signaling activation. hsa_circ_0068481 circ_0068481 Homo sapiens pulmonary arterial hypertension MONDO:0015924 pulmonary arterial hypertension human pulmonary arterial smooth muscle cells (hPASMCs) up-regulated "circ_0068481 is up-regulated in hypoxia-treated human pulmonary arterial smooth muscle cells compared with normoxic conditions. Functional assays indicate that circ_0068481 promotes hPASMC proliferation, migration, and phenotypic switching while inhibiting apoptosis under hypoxia." 2008 41907223 Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression. hsa_circ_0101645 hsa_circ_AKAP6 AKAP6 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 endplate chondrocytes (EPC) up-regulated hsa_circ_0101645 was overexpressed in primary endplate chondrocytes derived from IVDD patients compared with control EPCs. Functional assays in EPCs linked hsa_circ_0101645 to reduced viability and increased apoptosis. 2009 41907223 Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression. hsa_circ_0101557 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 EPCs up-regulated hsa_circ_0101557 was reported as significantly overexpressed in IVDD-derived primary EPCs compared with control EPCs. 2010 41907223 Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression. hsa_circ_0102116 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 EPCs up-regulated hsa_circ_0102116 was reported as significantly overexpressed in IVDD-derived primary EPCs compared with control EPCs. 2011 41907223 Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression. hsa_circ_0103838 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 EPCs up-regulated hsa_circ_0103838 was reported as significantly overexpressed in IVDD-derived primary EPCs compared with control EPCs. 2012 41907223 Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression. hsa_circ_0104508 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 EPCs up-regulated hsa_circ_0104508 was reported as significantly overexpressed in IVDD-derived primary EPCs compared with control EPCs. 2013 41907223 Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression. hsa_circ_0101852 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 EPCs down-regulated hsa_circ_0101852 was reported as significantly down-expressed in IVDD-derived primary EPCs compared with control EPCs. 2014 41907223 Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression. hsa_circ_0101853 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 EPCs down-regulated hsa_circ_0101853 was reported as significantly down-expressed in IVDD-derived primary EPCs compared with control EPCs. 2015 41907223 Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression. hsa_circ_0100019 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 EPCs down-regulated hsa_circ_0100019 was reported as significantly down-expressed in IVDD-derived primary EPCs compared with control EPCs. 2016 41907223 Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression. hsa_circ_0101139 Homo sapiens intervertebral disc degeneration MONDO:0011385 intervertebral disk degenerative disorder DOID:90 EPCs down-regulated hsa_circ_0101139 was reported as significantly down-expressed in IVDD-derived primary EPCs compared with control EPCs. 2017 41929494 Comprehensive circRNA profiling of platelets and exosomes identifies hsa_circ_0061274 as a novel biomarker for lung adenocarcinoma. hsa_circ_0061274 Homo sapiens lung adenocarcinoma MONDO:0005061 lung adenocarcinoma DOID:3910 platelets down-regulated "hsa_circ_0061274 is down-regulated in isolated platelets from lung adenocarcinoma patients compared with healthy donor platelets, supported by platelet circRNA sequencing and qRT-PCR validation." PRJCA052366 2018 41929494 Comprehensive circRNA profiling of platelets and exosomes identifies hsa_circ_0061274 as a novel biomarker for lung adenocarcinoma. hsa_circ_0061274 Homo sapiens lung adenocarcinoma MONDO:0005061 lung adenocarcinoma DOID:3910 platelets down-regulated "hsa_circ_0061274 is down-regulated in isolated platelets from lung adenocarcinoma patients compared with benign pulmonary nodule patients, based on qRT-PCR validation." PRJCA052366 2019 41929494 Comprehensive circRNA profiling of platelets and exosomes identifies hsa_circ_0061274 as a novel biomarker for lung adenocarcinoma. hsa_circ_0061274 Homo sapiens lung adenocarcinoma MONDO:0005061 lung adenocarcinoma DOID:3910 platelets down-regulated "hsa_circ_0061274 is down-regulated in isolated platelets from stage I lung adenocarcinoma patients compared with benign pulmonary nodule patients, based on qRT-PCR validation." PRJCA052366 2020 41940034 CircSMAD4 shapes matrix-remodeling TAMs in lung adenocarcinoma. hsa_circ_0047713 circSMAD4 hsa_circ_SMAD4 SMAD4 Homo sapiens lung adenocarcinoma MONDO:0005061 lung adenocarcinoma DOID:3910 tumor-associated macrophages / TAMs up-regulated "circSMAD4 / hsa_circ_0047713 is enriched in sorted LUAD tumor-associated macrophages compared with normal tissue-resident macrophages, with additional CD68 co-localization support in tumor sections. Functional experiments indicate that circSMAD4 promotes tumor-educated M2-like, matrix-remodeling macrophage programs and downstream protumor effects." 2021 41960189 CircAFF3 modulation of p53-ID2 signaling in the retinal pigment epithelium links inflammation with cell death in dry age-related macular degeneration. circAff3 / circAFF3 mmu_circ_Aff3 Aff3 Mus musculus dry AMD MONDO:0100114 dry age related macular degeneration RPE samples down-regulated "In isolated mouse RPE samples from a laser-induced CNV model used to screen dry AMD-related circRNAs, circAff3 was significantly reduced after laser injury. This reduction was not observed in RPE-excluded retina samples." 2022 41960189 CircAFF3 modulation of p53-ID2 signaling in the retinal pigment epithelium links inflammation with cell death in dry age-related macular degeneration. circAFF3 hsa_circ_AFF3 AFF3 Homo sapiens age-related macular degeneration / AMD MONDO:0005150 age-related macular degeneration DOID:10871 RPE down-regulated "Analysis of public GEO data from human RPE and RPE-excluded retina samples showed that circAFF3 was downregulated in RPE from AMD samples compared with healthy controls, with no change in retina samples." GSE99248 2023 41967708 The deficiency of circSLC8A1 fosters tubular partial EMT-induced renal fibrosis through upregulating Annexin A2 signaling. hsa_circ_0000994 hsa_circ_SLC8A1 SLC8A1 Homo sapiens chronic kidney disease MONDO:0005300 chronic kidney disease DOID:784 tubular down-regulated "Human circSLC8A1 is localized to proximal tubular regions by FISH combined with tubular marker immunostaining, and its in situ signal decreases in CKD kidneys as fibrosis becomes more severe." 2024 41967708 The deficiency of circSLC8A1 fosters tubular partial EMT-induced renal fibrosis through upregulating Annexin A2 signaling. mmu_circ_0000823 mmu_circ_Slc8a1 Slc8a1 Mus musculus renal fibrosis MONDO:0000494 renal fibrosis DOID:0050855 mouse primary proximal renal TECs down-regulated "Mouse circSlc8a1 is downregulated in TGF-¦Â-stimulated primary proximal renal tubular epithelial cells, supporting cell-resolved dysregulation in a profibrotic tubular epithelial model." 2025 41972134 The molecular mechanism of circRNA_0021727 in inflammation of eosinophilic chronic rhinosinusitis. hsa_circ_0021727 Homo sapiens Eosinophilic chronic rhinosinusitis MONDO:0006031 chronic rhinosinusitis Primary nasal epithelial cells (PNECs) up-regulated circRNA_0021727 was up-regulated in primary nasal epithelial cells/epithelium from ECRS patient nasal polyp samples compared with control inferior turbinate samples. Functional experiments in primary nasal epithelial cells indicated that circRNA_0021727 promotes ECRS-related inflammation under IL-13 treatment.