| Expression pattern: |
UP |
| Associated gene: |
UCHL3, MTA2, exosomes |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation, migration, invasion, and metastasis; inhibits apoptosis; stabilizes MTA2 protein to facilitate tumor progression; exosomal circMTA2 enhances cancer cell progression |
| Molecular mechanism: |
circMTA2 interacts with UCHL3 to restrain MTA2 ubiquitination and stabilize MTA2 protein expression; circMTA2 enhances UCHL3-MTA2 interaction; circMTA2 is transported by exosomes to promote GC progression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ubiquitination (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; TUNEL; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
may serve as a prognosis marker |
| Description: |
circMTA2 (hsa_circ_0022462), derived from MTA2, is up-regulated in gastric cancer tissues and cell lines and promotes GC proliferation, migration/invasion, and metastasis while inhibiting apoptosis. Mechanistically, circMTA2 binds UCHL3 to reduce MTA2 ubiquitination and stabilize MTA2 protein, and it can be delivered via exosomes to enhance GC progression. |
| Confidence score: |
0.8794 |