| Expression pattern: |
UP |
| Associated gene: |
messenger RNAs |
| Associated microRNA: |
miR-375 |
| Biological function: |
May participate in signal transduction and cell communication during LUAD development; proposed to act as a miRNA sponge. |
| Molecular mechanism: |
Predicted ceRNA/miRNA sponge mechanism involving miR-375 and downstream target genes (mRNAs). |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
ROC curve analysis suggested biomarker potential (AUC=0.815) for discriminating LUAD from normal controls; expression associated with clinical stage and distant metastasis. |
| Description: |
hsa_circ_0000792 is up-regulated in LUAD tissues (validated by qRT-PCR) and is proposed to act as a ceRNA by competitively binding miR-375, thereby affecting miR-375-associated target mRNAs. It shows diagnostic biomarker potential (ROC AUC ~0.815) and correlates with clinical parameters such as stage and distant metastasis. |
| Confidence score: |
0.5047 |