circRNA basic information
circBase ID: hsa_circ_0087862
Name: hsa_circ_RAD23B
Synonym: circ-RAD23B
Host Gene: RAD23B
Genomic location(hg19): chr9:110068659-110081160:+
Genomic location(hg38): chr9:107306378-107318879:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; paired adjacent normal tissues; corresponding adjacent normal tissues
Cell lines:

NCM460; HCT116; LoVo
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: TRAF6, Ago2 protein
Associated microRNA: miR-149-5p
Biological function: Hsa_circ_0087862 functions as a tumor promoter in CRC cells; its knockdown reduces proliferation and invasion and triggers apoptosis.
Molecular mechanism: Hsa_circ_0087862 acts as a ceRNA/molecular sponge for miR-149-5p, thereby regulating TRAF6 expression in CRC cells.
Biological pathway or process:

proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis
Clinical significance:

Targeting hsa_circ_0087862/miR-149-5p/TRAF6 axis may be a promising anti-CRC therapeutic strategy.
Description:

Hsa_circ_0087862 is up-regulated in colorectal cancer tissues and cell lines and acts as an oncogenic circRNA. Its silencing suppresses CRC cell proliferation and invasion while promoting apoptosis, mainly through sponging miR-149-5p and relieving regulation of TRAF6. The study suggests the hsa_circ_0087862/miR-149-5p/TRAF6 axis as a potential anti-CRC therapeutic target.
Confidence score:

0.7435
Other information
Title:

The Role of Hsa_circ_0087862/miR-149-5p/TRAF6 Regulatory Axis in Colorectal Cancer Progression.

Journal: Applied biochemistry and biotechnology
Published: 2025
PubMed ID: 40366539
Study type:

combined bioinformatics and biological research
Data availability: GSE138589; GSE126094; Data are available from the corresponding author on reasonable request.
Code availability: -