| Expression pattern: |
DN |
| Associated gene: |
LDLR |
| Associated microRNA: |
miR-4644 |
| Biological function: |
Regulates lipid metabolism/cholesterol metabolism in ovarian granulosa cells and affects lipid secretion. |
| Molecular mechanism: |
ceRNA mechanism: circ_0008285 sponges miR-4644 to regulate LDLR, influencing cholesterol metabolism and lipid secretion. |
| Biological pathway or process: |
ceRNA regulation (promotes); lipid metabolism (other); cholesterol metabolism (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; Western Blot; Clinical Sample Validation; Cohort Study |
| Clinical significance: |
- |
| Description: |
In PCOS follicular-fluid exosomes, circ_0008285 is decreased and functions as a ceRNA in granulosa cells. It sponges miR-4644 to relieve repression of LDLR, thereby modulating cholesterol/lipid metabolism and lipid secretion (e.g., free fatty acids). |
| Confidence score: |
0.8111 |