| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential diagnostic biomarker for CAD; shows antagonistic interaction with alcohol consumption in CAD subjects. |
| Molecular mechanism: |
ceRNA mechanism (predicted circRNA-miRNA-mRNA network). |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
Down-regulated in CAD and shows diagnostic value (ROC AUC 0.662). Antagonistic interaction between hsa_circHERPUD2 expression and alcohol consumption was observed in CAD subjects. |
| Description: |
hsa_circHERPUD2 is significantly down-regulated in PBMCs of CAD patients and has moderate diagnostic value (ROC AUC 0.662). Its expression shows a significant antagonistic interaction with alcohol consumption in CAD subjects, and it is part of a predicted circRNA-miRNA-mRNA ceRNA network linked to CAD. |
| Confidence score: |
0.6895 |