| Expression pattern: |
UP |
| Associated gene: |
PRDX3 |
| Associated microRNA: |
miR-224-5p |
| Biological function: |
circSOD2 knockdown alleviates IL-1beta-induced chondrocyte injury by reducing apoptosis, inflammation, and ECM degradation and rescuing proliferation in an OA cell model. |
| Molecular mechanism: |
ceRNA mechanism: circSOD2 sponges miR-224-5p, thereby relieving miR-224-5p-mediated repression of PRDX3. |
| Biological pathway or process: |
apoptosis (inhibits); inflammation (inhibits); proliferation (promotes); other pathway/process (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; ELISA; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Higher circSOD2 expression is associated with more serious cartilaginous degeneration in OA patients. |
| Description: |
circSOD2 (hsa_circ_0004662) is up-regulated in OA knee cartilage and IL-1beta-treated CHON-001 chondrocytes. Silencing circSOD2 protects chondrocytes by reducing apoptosis, inflammation, and ECM degradation, via a ceRNA mechanism involving miR-224-5p and PRDX3. |
| Confidence score: |
0.7618 |