circRNA basic information
circBase ID: -
Name: hsa_circ_CCT3
Synonym: circCCT3
Host Gene: CCT3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

A549; Calu-1; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: Wnt3a, FGF7
Associated microRNA: miR-107
Biological function: promotes invasion and epithelial-mesenchymal transition (EMT) of NSCLC cells
Molecular mechanism: circCCT3 acts as a competing endogenous RNA (ceRNA) of miR-107, regulating Wnt3a and downstream FGF7 to affect invasion and EMT
Biological pathway or process:

invasion (promotes); EMT (promotes); Wnt/beta-catenin (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; Transwell Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

In NSCLC cell lines, circCCT3 promotes invasion and EMT. Mechanistically, circCCT3 functions as a ceRNA for miR-107, thereby regulating Wnt3a/Wnt signaling and downstream FGF7 to drive metastatic phenotypes.
Confidence score:

0.3963
Other information
Title:

circCCT3 Enhances Invasion and Epithelial-Mesenchymal Transition (EMT) of Non-Small-Cell Lung Cancer (NSCLC) via the miR-107/Wnt/FGF7 Axis.

Journal: Journal of oncology
Published: 2022
PubMed ID: 35783154
Study type:

biological research
Data availability: The underlying data supporting the results of this study can be obtained from the corresponding author.
Code availability: -