| Expression pattern: |
UP |
| Associated gene: |
HN1 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
promotes HCC cell proliferation, migration, invasion and angiogenesis; promotes tumour growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0000092 sponges miR-338-3p to up-regulate HN1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Northern Blot; FISH / smFISH; Luciferase Reporter Assay; RNA Pull-Down; Transfection; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Tube Formation Assay; In Vivo Animal Model; ISH (In Situ Hybridization); IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0000092 expression was positively correlated with tumour node metastasis (TNM) stage and metastasis; potential candidate marker and therapeutic target for HCC |
| Description: |
hsa_circ_0000092 is up-regulated in HCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes HCC progression by acting as a ceRNA that sponges miR-338-3p, thereby up-regulating HN1 and enhancing proliferation, migration, invasion and angiogenesis, and its silencing suppresses tumour growth in vivo. |
| Confidence score: |
0.7489 |