| Expression pattern: |
UP |
| Associated gene: |
miR-203 precursor |
| Associated microRNA: |
miR-203 |
| Biological function: |
promotes maturation of miR-203 and increases LPS-induced apoptosis of chondrocytes, thereby promoting OA progression |
| Molecular mechanism: |
Circ_0038467 promotes miR-203 maturation by directly interacting with miR-203 precursor and affecting its processing/transport between nucleus and cytoplasm; apoptosis effects are miR-203-dependent |
| Biological pathway or process: |
apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; Annexin V/PI Flow Cytometry; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Clinical Sample Validation |
| Clinical significance: |
Measuring the expression of Circ_0038467 may reflect the treatment efficiency of OA. |
| Description: |
Circ_0038467 is up-regulated in osteoarthritis synovial fluid and can be induced by LPS in chondrocytes. It promotes maturation of miR-203 via direct interaction with the miR-203 precursor and increases LPS-induced chondrocyte apoptosis in a miR-203-dependent manner, suggesting potential value as a treatment-response indicator and therapeutic target. |
| Confidence score: |
0.6166 |