| Expression pattern: |
UP |
| Associated gene: |
SIRT4, Ago2 |
| Associated microRNA: |
miR-1276 |
| Biological function: |
Promotes viability/proliferation, migration and invasion; inhibits apoptosis in breast cancer cells. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-1276, relieving repression of SIRT4; associates with Ago2 and validated by reporter/pull-down/RIP assays. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circOMA1 expression is associated with tumor size and lymph node metastasis; discriminates BC tissues from adjacent normal tissues (ROC AUC 0.8296); high expression predicts poorer overall survival. |
| Description: |
circOMA1 (hsa_circRNA_0000073, derived from OMA1) is up-regulated in breast cancer and associated with larger tumor size, lymph node metastasis, and poorer overall survival. It mainly localizes in the cytoplasm and promotes malignant phenotypes by sponging miR-1276 to increase SIRT4 expression, forming a circOMA1/miR-1276/SIRT4 ceRNA axis. |
| Confidence score: |
0.8761 |