circRNA basic information
circBase ID: -
Name: hsa_circ_ANAPC7
Synonym: circ-ANAPC7 / hsa-circRNA-101141
Host Gene: ANAPC7
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018881
MONDO name: myelodysplastic syndrome
Disease details: Myelodysplastic syndrome / MDS
Disease DO ID:
 0050908
Disease MeSH ID:
 -
Disease NCIt ID:
 C3247
Disease ICD11 ID:
 -
Disease OMIM ID:
 614286
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Acts as a diagnostic biomarker and stratifies MDS risk (higher expression indicates higher IPSS-R risk group).
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

circ-ANAPC7 shows high diagnostic performance for differentiating MDS risk groups by ROC analysis and may be added to the scoring system for risk stratification.
Description:

In bone marrow samples from MDS patients, circ-ANAPC7 expression is higher than controls and increases stepwise across IPSS-R risk groups. circ-ANAPC7 provides strong ROC-based discrimination between adjacent risk strata, supporting its use as a diagnostic/risk-stratification biomarker.
Confidence score:

0.4187
Other information
Title:

The Circular RNA Circ-ANAPC7 as a Biomarker for the Risk Stratification of Myelodysplastic Syndrome.

Journal: Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
Published: 2023
PubMed ID: 37304473
Study type:

clinical study
Data availability: -
Code availability: -