| Expression pattern: |
UP |
| Associated gene: |
ERBB2, PI3K, AKT, mTOR |
| Associated microRNA: |
miR-940 |
| Biological function: |
promotes proliferation, migration and vasculogenic mimicry (VM) formation in nasopharyngeal carcinoma cells |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-940 to upregulate ERBB2 and activate the PI3K/AKT/mTOR signaling pathway |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); proliferation (promotes); migration (promotes); angiogenesis (other); metastasis (other); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; EdU Staining; Wound Healing Assay; Transwell Assay; In Vivo Animal Model |
| Clinical significance: |
may become a biomarker and therapeutic target for anti-angiogenic therapy in patients with nasopharyngeal carcinoma |
| Description: |
circMAN1A2 is highly expressed in NPC and promotes proliferation, migration, and vasculogenic mimicry. It functions as a ceRNA by sponging miR-940, thereby relieving miR-940-mediated repression of ERBB2 and activating PI3K/AKT/mTOR signaling. |
| Confidence score: |
0.5679 |