circRNA basic information
circBase ID: hsa_circ_0000069
Name: -
Synonym: circ_0000069
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue specimens; adjacent normal tissue specimens
Cell lines:

BT549; MCF-7; SK-BR-3; T47D; MDA-MB-231; MCF-10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-432
Biological function: promotes breast cancer cell proliferation, migration, and invasion
Molecular mechanism: ceRNA (miRNA sponge) mechanism via miR-432
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

High has_circ_0000069 expression was associated with shorter overall survival and was an independent prognostic risk factor in breast cancer.
Description:

has_circ_0000069 is up-regulated in breast cancer tissues/cell lines and promotes proliferation, migration and invasion. Mechanistically, it functions as a ceRNA by sponging miR-432, and high expression predicts poorer overall survival.
Confidence score:

0.6987
Other information
Title:

Has_circ_0000069 expression in breast cancer and its influences on prognosis and cellular activities.

Journal: Oncology research
Published: 2023
PubMed ID: 37303741
Study type:

combined biological and clinical study
Data availability: Corresponding author may provide data and materials.
Code availability: -