| Expression pattern: |
UP |
| Associated gene: |
KLK8, PKD1, Ago2 |
| Associated microRNA: |
miR-6820-5p |
| Biological function: |
circSSPO promotes ESCC cell proliferation, colony formation, invasion, migration, tumorigenesis and lung metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
circSSPO functions as a ceRNA that sponges miR-6820-5p, thereby increasing KLK8 and PKD1 expression to promote ESCC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher circSSPO expression was associated with shorter overall survival in ESCC patients. |
| Description: |
circSSPO is an up-regulated oncogenic circRNA in ESCC. It acts as a ceRNA for miR-6820-5p, increasing KLK8 and PKD1 expression and thereby promoting malignant ESCC cell behaviors, tumor growth, and metastasis. Higher circSSPO expression is associated with shorter overall survival. |
| Confidence score: |
0.8961 |