circRNA basic information
circBase ID: hsa_circ_0064559
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr3:19190016-19389457:+
Genomic location(hg38): chr3:19148524-19347965:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumors; adjacent normal tissues
Cell lines:

RKO; SW620
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: STAT1, ATF2, TNFRSF10B, TGFBR2, BAX, SQSTM1, SLC4A7, CD274
Associated microRNA: -
Biological function: promotes CRC cell proliferation and tumor growth; inhibits apoptosis; increases G1 phase arrest when knocked down
Molecular mechanism: Knockdown alters expression of apoptosis- and proliferation-related genes (upregulates STAT1, ATF2, TNFRSF10B, TGFBR2, BAX, SQSTM1; downregulates SLC4A7, CD274), potentially involving multiple signaling pathways
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); cell cycle (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Cell Cycle Assay; In Vivo Animal Model
Clinical significance:

may be a potential biomarker for early diagnosis or prognosis of CRC and a novel drug target for CRC therapy
Description:

hsa_circ_0064559 is up-regulated in colorectal cancer. Its knockdown suppresses CRC cell proliferation, increases apoptosis and G1-phase accumulation in vitro, and inhibits tumor growth in a nude-mouse xenograft model, accompanied by broad changes in apoptosis/proliferation-related gene expression (e.g., STAT1, BAX, CD274).
Confidence score:

0.5802
Other information
Title:

Circular RNA hsa_circ_0064559 affects tumor cell growth and progression of colorectal cancer.

Journal: World journal of surgical oncology
Published: 2023
PubMed ID: 37280630
Study type:

combined biological and clinical study
Data availability: GSE209892; GSE226489
Code availability: -