| Expression pattern: |
UP |
| Associated gene: |
EZH2 |
| Associated microRNA: |
miR-760 |
| Biological function: |
Promotes doxorubicin resistance and malignant behaviors (colony formation, migration, invasion) and inhibits apoptosis in DXR-resistant osteosarcoma cells; circPRDM2 silencing increases DXR sensitivity in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-760, relieving repression of EZH2 and elevating EZH2 expression, thereby enhancing doxorubicin resistance. |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model |
| Clinical significance: |
High circPRDM2 expression is associated with worse overall survival and disease free survival in osteosarcoma patients. |
| Description: |
circPRDM2 is up-regulated in doxorubicin-resistant osteosarcoma tissues and cells and promotes DXR resistance, proliferation/colony formation, migration and invasion while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-760 to elevate EZH2, and high circPRDM2 correlates with worse OS and DFS. |
| Confidence score: |
0.8034 |