| Expression pattern: |
UP |
| Associated gene: |
E2F7 |
| Associated microRNA: |
miR-379-5p |
| Biological function: |
promotes cisplatin resistance (DDP resistance), proliferation, invasion and migration; inhibits apoptosis; promotes tumor growth |
| Molecular mechanism: |
ceRNA sponge mechanism: circ_0010235 sponges miR-379-5p to upregulate E2F7, thereby enhancing cisplatin resistance |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_0010235 is up-regulated in cisplatin (DDP)-resistant lung cancer tissues/cells and promotes chemoresistance and malignant phenotypes. It primarily acts in the cytoplasm as a ceRNA, sponging miR-379-5p to de-repress E2F7, thereby enhancing DDP resistance and tumor growth. |
| Confidence score: |
0.786 |