| Expression pattern: |
UP |
| Associated gene: |
FN1 |
| Associated microRNA: |
miR-508-5p, miR-885-3p |
| Biological function: |
promotes proliferation and invasion; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0081534 sponges miR-508-5p to increase FN1 expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
could be a novel therapeutic target for the treatment of NPC patients |
| Description: |
hsa_circ_0081534 is up-regulated in nasopharyngeal carcinoma tissues and cell lines and promotes NPC cell proliferation and invasion. Mechanistically, it mainly localizes in the cytoplasm and acts as a ceRNA by sponging miR-508-5p, thereby increasing FN1 expression; knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.822 |