| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
microRNA-670-3p, miR-670-3p |
| Biological function: |
Promotes ESCC cell proliferation, migration, invasion and metastasis; knockdown suppresses proliferative capacity and invasiveness. |
| Molecular mechanism: |
Circ-ABCB10 binds to and adsorbs microRNA-670-3p, negatively regulating microRNA-670-3p expression to enhance ESCC cell proliferation and invasion. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
High circ-ABCB10 expression predicts poor prognosis and is correlated with malignant clinicopathological features in ESCC patients. |
| Description: |
Circ-ABCB10 is up-regulated in ESCC tissues and cell lines and its high expression is associated with advanced stage and poor overall survival. Functionally, circ-ABCB10 promotes ESCC cell proliferation, migration and invasion. Mechanistically, it directly binds microRNA-670-3p and inhibits its expression, forming a circ-ABCB10/microRNA-670-3p regulatory axis. |
| Confidence score: |
0.6987 |