circRNA basic information
circBase ID: -
Name: hsa_circ_FOXO3
Synonym: circFOXO3
Host Gene: FOXO3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: triple-negative breast cancer
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

BT-20; MDA-MB-231; MDA-MB-468
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: May be a robust component of universal DNA damage response and dose-responsive circRNA regulation after irradiation.
Molecular mechanism: Radiation-induced upregulation associated with cell cycle regulation and DNA damage response; specific downstream axis not experimentally defined.
Biological pathway or process:

cell cycle (other); radioresistance (other); other pathway/process (other)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR
Clinical significance:

Potential radiation sensitivity biomarker and therapeutic target to improve TNBC treatment efficacy.
Description:

circFOXO3 shows gradual dose- and time-dependent upregulation after irradiation in all tested TNBC cell lines. The authors suggest that it may be part of a universal DNA damage response network and may reflect the magnitude of cellular stress.
Confidence score:

0.279
Other information
Title:

Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.

Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Published: 2026
PubMed ID: 41746541
Study type:

biological research
Data availability: All data produced in the current study are available from the corresponding author upon reasonable request; supplementary material available at https://doi.org/10.1007/s12094-026-04280-1
Code availability: -