circRNA basic information
circBase ID: hsa_circ_0020850
Name: hsa_circ_NUP98
Synonym: circ_0020850
Host Gene: NUP98
Genomic location(hg19): chr11:3697738-3789974:-
Genomic location(hg38): chr11:3676508-3768744:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; normal tissue samples
Cell lines:

A549; PC-9; BEAS-2B
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: IRS2
Associated microRNA: miR-195-5p
Biological function: promotes proliferation, migration and invasion and inhibits apoptosis in lung adenocarcinoma; its knockdown suppresses xenograft tumor growth
Molecular mechanism: ceRNA mechanism: circ_0020850 sponges miR-195-5p to relieve repression of IRS2
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model
Clinical significance:

-
Description:

In lung adenocarcinoma, circ_0020850 is up-regulated and functions as an oncogenic circRNA. Silencing circ_0020850 inhibits proliferation, migration and invasion, promotes apoptosis, and reduces xenograft tumor growth by sponging miR-195-5p to increase IRS2 expression.
Confidence score:

0.6835
Other information
Title:

circRNA Hsa_circ_0020850 Silence Represses the Development of Lung Adenocarcinoma via Regulating miR-195-5p/IRS2 Axis.

Journal: Cancer management and research
Published: 2020
PubMed ID: 33149675
Study type:

combined biological and clinical study
Data availability: GSE101684
Code availability: -