| Expression pattern: |
UP |
| Associated gene: |
CD47, LDHA, PDIA3, SLC16A1 |
| Associated microRNA: |
miR-154-5p |
| Biological function: |
Promotes G1/S transition and proliferation; inhibits apoptosis in cervical cancer cells. |
| Molecular mechanism: |
Directly binds (sponges) miR-154-5p and acts as a ceRNA to regulate downstream mRNAs (e.g., CD47, LDHA, PDIA3, SLC16A1), affecting immune infiltration-related processes. |
| Biological pathway or process: |
ceRNA regulation (promotes); cell cycle (promotes); proliferation (promotes); apoptosis (inhibits); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Bioinformatics Analysis |
| Clinical significance: |
Potential biomarker for HPV16-positive cervical cancer / cervical squamous cell carcinoma. |
| Description: |
hsa_circ_0000276 (circTRIM22) is up-regulated in HPV16-positive cervical cancer and directly binds miR-154-5p, functioning as a ceRNA. Its knockdown suppresses proliferation and G1/S progression and promotes apoptosis in SiHa and CaSki cells, with downstream effects involving genes such as CD47, LDHA, PDIA3 and SLC16A1 and links to immune infiltration. |
| Confidence score: |
0.6777 |