circRNA basic information
circBase ID: hsa_circ_0060762
Name: hsa_circ_CSE1L
Synonym: hsa_circRNA_060762
Host Gene: CSE1L
Genomic location(hg19): chr20:47707278-47711500:+
Genomic location(hg38): chr20:49090741-49094963:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004976
MONDO name: amyotrophic lateral sclerosis
Disease details: amyotrophic lateral sclerosis / ALS
Disease DO ID:
 332
Disease MeSH ID:
 D000690
Disease NCIt ID:
 C34373
Disease ICD11 ID:
 1982355687
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: CSE1L
Associated microRNA: has-miR-9, hsa-miR-125a/b, hsa-miR-153, has-miR-192, has-miR-371b, has-miR-1275, has-miR-4695
Biological function: Potential ALS biomarker; may act as a miRNA sponge.
Molecular mechanism: Putative miRNA-sponging (ceRNA-like) mechanism based on predicted binding sites in circBank; reduced expression in ALS PBMCs.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Reduced in ALS PBMCs and shows diagnostic potential by ROC analysis (AUC ~0.75).
Description:

hsa_circ_0060762 is significantly down-regulated in PBMCs from ALS patients versus controls and shows diagnostic potential (ROC AUC ~0.75). The study suggests it may have miRNA-binding capacity (miRNA-sponge-like role) based on circBank predictions, supporting its candidacy as a peripheral blood biomarker for ALS.
Confidence score:

0.5963
Other information
Title:

Aberrantly Expressed Hsa_circ_0060762 and CSE1L as Potential Peripheral Blood Biomarkers for ALS.

Journal: Biomedicines
Published: 2023
PubMed ID: 37238987
Study type:

combined biological and clinical study
Data availability: The datasets during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -