| Expression pattern: |
DN |
| Associated gene: |
AGO2, AKT1, Akt, P-Akt, E-cadherin, Snail, Bax, cleaved-caspase3 |
| Associated microRNA: |
- |
| Biological function: |
Suppresses invasion and migration, suppresses proliferation, reduces cisplatin resistance, and promotes H2O2-induced apoptosis in osteosarcoma cells. |
| Molecular mechanism: |
Inhibits Akt signaling by decreasing Akt phosphorylation; effects are rescued by Akt activator SC79. |
| Biological pathway or process: |
PI3K/AKT (inhibits); migration (inhibits); invasion (inhibits); proliferation (inhibits); apoptosis (promotes); drug resistance (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Western Blot; Annexin V/PI Flow Cytometry; Cell Cycle Assay |
| Clinical significance: |
Potential biomarker for predicting biological behavior and cisplatin sensitivity in osteosarcoma. |
| Description: |
hsa_circ_0088214 is down-regulated in osteosarcoma cell lines. Its overexpression suppresses invasion/migration and proliferation, reduces cisplatin resistance, and promotes H2O2-induced apoptosis, largely by inhibiting Akt signaling (reduced Akt phosphorylation), with SC79 rescuing these phenotypes. |
| Confidence score: |
0.5098 |