| Expression pattern: |
DN |
| Associated gene: |
AGO2 |
| Associated microRNA: |
hsa-miR-34a-3p, hsa-miR-330-5p |
| Biological function: |
Suppresses gastric cancer cell proliferation, migration, and invasion in vitro. |
| Molecular mechanism: |
Acts as a miRNA-binding circRNA and directly binds hsa-miR-34a-3p and hsa-miR-330-5p (validated by luciferase reporter assay and AGO2-RIP). |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
Downregulation in GC tissues; associated with tumor size, vascular invasion, and lymph node metastasis; potential biomarker for diagnosing and predicting LNM in GC. |
| Description: |
hsa_circ_0072309 is down-regulated in gastric cancer tissues and cell lines and functions as a tumor-suppressive circRNA by inhibiting GC cell proliferation, migration and invasion in vitro. Mechanistically, it binds hsa-miR-34a-3p and hsa-miR-330-5p as a miRNA-interacting circRNA and is proposed as a biomarker related to lymph node metastasis. |
| Confidence score: |
0.7745 |