circRNA basic information
circBase ID: hsa_circ_0007401
Name: hsa_circ_NUP98
Synonym: -
Host Gene: NUP98
Genomic location(hg19): chr11:3789810-3797251:-
Genomic location(hg38): chr11:3768580-3776021:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009831
MONDO name: malignant pancreatic neoplasm
Disease details: pancreatic cancer
Disease DO ID:
 1793
Disease MeSH ID:
 -
Disease NCIt ID:
 C9005
Disease ICD11 ID:
 542147910
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

PANC-1; PANC-1-GR; PK-9; PK-9-GR; BXPC-3; BXPC-3-GR
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: FLI1
Associated microRNA: hsa-miR-6509-3p
Biological function: regulates gemcitabine resistance in pancreatic cancer (ceRNA network involvement)
Molecular mechanism: ceRNA mechanism via negative regulation between hsa_circ_0007401 and hsa-miR-6509-3p affecting FLI1
Biological pathway or process:

ceRNA regulation (other); drug resistance (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

This study identified hsa_circ_0007401 as down-regulated in gemcitabine-resistant pancreatic cancer cell-line datasets and proposed it participates in a ceRNA network. The inferred regulatory axis is hsa_circ_0007401-hsa-miR-6509-3p-FLI1, potentially related to gemcitabine resistance.
Confidence score:

0.1768
Other information
Title:

Hsa_circ_0007401 regulates gemcitabine resistance of pancreatic cancer through the hsa-miR-6509-3p/fli1 axis.

Journal: Medicine
Published: 2023
PubMed ID: 37233428
Study type:

bioinformatics study
Data availability: GSE110580; GSE79234; GSE35141; GSE140077; CTR_RNAseq_202
Code availability: https://cran.r-project.org/; https://cytoscape.org/