| Expression pattern: |
UP |
| Associated gene: |
NFAT5 |
| Associated microRNA: |
miR-625-5p |
| Biological function: |
promotes NSCLC cell growth, metastasis and glycolysis; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circCCDC134 sponges miR-625-5p to regulate NFAT5 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; EdU Staining; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circCCDC134 was highly expressed in the serum exosomes of NSCLC patients compared with healthy normal controls, suggesting exosomal circCCDC134 could act as a diagnostic indicator/target for NSCLC. |
| Description: |
circCCDC134 is up-regulated in NSCLC tissues/cells and enriched in patient serum exosomes. Functionally, circCCDC134 promotes proliferation, migration/invasion, tumor growth, and glycolysis while inhibiting apoptosis by acting as a ceRNA that sponges miR-625-5p and derepresses NFAT5. |
| Confidence score: |
0.8327 |