circRNA basic information
circBase ID: hsa_circ_0059457
Name: hsa_circ_TASP1
Synonym: circ_0059457
Host Gene: TASP1
Genomic location(hg19): chr20:13398094-13514788:-
Genomic location(hg38): chr20:13417447-13534141:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; adjacent normal tissues; tumor tissues
Cell lines:

MCF10A; MB231; BT549
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: UBE2C, Ago2, TASP1
Associated microRNA: miR-140-3p
Biological function: promotes BC cell proliferation, migration, invasion, sphere formation ability, glycolysis, EMT and tumor growth in vivo
Molecular mechanism: circ_0059457 acts as a ceRNA sponge for miR-140-3p to regulate UBE2C expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); stemness (promotes); glycolysis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

provided potential target for the treatment of BC
Description:

circ_0059457 is up-regulated in breast cancer tissues and cells and promotes malignant progression. Mechanistically, it sponges miR-140-3p to regulate UBE2C, thereby promoting proliferation, migration, invasion, sphere formation, glycolysis, EMT-related changes, and xenograft tumor growth. The study proposes circ_0059457 as a potential therapeutic target for breast cancer.
Confidence score:

0.8399
Other information
Title:

Circ_0059457 Promotes Proliferation, Metastasis, Sphere Formation and Glycolysis in Breast Cancer Cells by Sponging miR-140-3p to Regulate UBE2C.

Journal: Biochemical genetics
Published: 2024
PubMed ID: 37284894
Study type:

combined biological and clinical study
Data availability: GSE165884; BRCA dataset; GEPIA
Code availability: -