circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1-AS
Synonym: ciRS-7 / CDR1as
Host Gene: LINC00632
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary tumour tissue
Cell lines:

EA.hy926; M92-19T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: EGFR
Associated microRNA: hsa-miR-7
Biological function: Not prognostic or predictive of clinical outcomes in breast cancer cohorts; may be mainly expressed in stromal cells and potentially modulate miR-7 activity in stroma.
Molecular mechanism: Acts as a microRNA sponge for hsa-miR-7 (contains multiple binding sites) and shows inverse correlation with hsa-miR-7 expression; associated with stromal signature.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis
Clinical significance:

CDR1-AS was neither prognostic nor predictive of relevant outcomes in the studied breast cancer cohorts.
Description:

This study quantified CDR1-AS (ciRS-7) in breast cancer cohorts and found it inversely correlated with hsa-miR-7, consistent with a miRNA-sponge relationship. Clinically, CDR1-AS was not prognostic or predictive for outcomes, and its expression appeared enriched in stromal components rather than tumor cells or TILs.
Confidence score:

0.4758
Other information
Title:

Association of microRNA-7 and its binding partner CDR1-AS with the prognosis and prediction of 1st-line tamoxifen therapy in breast cancer.

Journal: Scientific reports
Published: 2018
PubMed ID: 29941867
Study type:

clinical study
Data availability: The full data sets used in this paper are available upon request.
Code availability: -