| Expression pattern: |
UP |
| Associated gene: |
AQP1, TUBA1A, LPAR1, EMP1, DHTK1, GINS2, DI03, ITK |
| Associated microRNA: |
miR-6884-3p |
| Biological function: |
Potential diagnostic biomarker for prostate cancer; may be associated with lipid metabolism and may promote prostate cancer growth through regulation of lipid metabolism. |
| Molecular mechanism: |
Predicted ceRNA mechanism involving circ_0057558 acting on miR-6884-3p to regulate target genes; possible regulation of lipid metabolism. |
| Biological pathway or process: |
ceRNA regulation (other); lipid metabolism (other); proliferation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
AUC of circ_0057558 was 0.729; combined detection with circ_0062019 and PSA improved diagnostic performance for distinguishing PCa from BPH; circ_0057558 was positively correlated with total cholesterol. |
| Description: |
circ_0057558 was up-regulated in prostate cancer cell lines and tissues and was validated by qRT-PCR. It may function as a diagnostic biomarker, and the study suggests a predicted circ_0057558/miR-6884-3p/target-gene ceRNA relationship potentially linked to lipid metabolism in prostate cancer. |
| Confidence score: |
0.5047 |