| Expression pattern: |
UP |
| Associated gene: |
CST1 |
| Associated microRNA: |
miR-339-3p |
| Biological function: |
promotes CRC cell proliferation, migration, invasion, EMT, stemness, and tumor growth in vivo |
| Molecular mechanism: |
circ_0001821 acts as a miR-339-3p sponge to regulate CST1 expression through a ceRNA mechanism |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); stemness (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0001821 might be a potential therapeutic target for CRC |
| Description: |
circ_0001821 is up-regulated in colorectal cancer tissues and cells and mainly localizes in the cytoplasm. It promotes CRC proliferation, migration, invasion, EMT, stemness, and xenograft tumor growth by sponging miR-339-3p and regulating CST1 expression, suggesting potential therapeutic relevance. |
| Confidence score: |
0.7855 |