| Expression pattern: |
DS |
| Associated gene: |
SMAD2, NRAS |
| Associated microRNA: |
miR-3692-5p, miR-4270 |
| Biological function: |
Might function as a ceRNA and play key roles in HCC by sponging miR-3692-5p and miR-4270 and regulating gene expression. |
| Molecular mechanism: |
ceRNA mechanism; hsa-circ-0011950 may sponge miR-3692-5p and miR-4270 to regulate SMAD2 and NRAS in HCC. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis |
| Clinical significance: |
May provide novel insight into pathogenesis, selection of therapeutic targets and prognostic factors for HCC. |
| Description: |
hsa-circ-0011950 was identified by microarray-based bioinformatics analysis as a dysregulated circRNA in HCC and a hub circRNA in a circRNA-miRNA-mRNA regulatory network. The study predicted that it may function as a ceRNA by sponging miR-3692-5p and miR-4270, regulating SMAD2 and NRAS-related axes in HCC, but no experimental validation was performed. |
| Confidence score: |
0.1768 |