circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MCF-7; MDA-MB-231
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: promotes EMT, suppresses apoptosis, and is associated with drug resistance
Molecular mechanism: not specified
Biological pathway or process:

EMT (promotes); apoptosis (inhibits); drug resistance (promotes); PI3K/AKT (other)
Detected method:
Q
Validation methods:

RT-qPCR
Clinical significance:

associated with cancer progression and drug-resistance
Description:

circHIPK3 is drug-responsive in breast cancer cell lines, often becoming upregulated after treatment. It is linked in the paper to EMT promotion, apoptosis suppression, and drug resistance, and is discussed as connected to PI3K/AKT-related context in MCF-7 cells.
Confidence score:

0.1155
Other information
Title:

Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.

Journal: Non-coding RNA
Published: 2023
PubMed ID: 37218992
Study type:

biological research
Data availability: All data used to support the conclusions are included in the manuscript.
Code availability: -