| Expression pattern: |
UP |
| Associated gene: |
STAT6, AGO2 |
| Associated microRNA: |
miR-1-3p |
| Biological function: |
Promotes gastric cancer proliferation, migration, invasion, tumor growth, and induces macrophage M2 polarization via exosomes. |
| Molecular mechanism: |
Exosomal circATP8A1 acts as a ceRNA to sponge miR-1-3p, thereby relieving miR-1-3p-mediated repression of STAT6 and activating the STAT6 pathway to drive macrophage M2 polarization, promoting gastric cancer progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); immune regulation (promotes); migration (promotes); invasion (promotes); proliferation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); ELISA |
| Clinical significance: |
Higher circATP8A1 expression is associated with advanced TNM stage and worse prognosis/poor survival in gastric cancer patients; elevated in plasma exosomes, suggesting prognostic biomarker potential. |
| Description: |
circATP8A1 is upregulated in gastric cancer tissues and plasma exosomes and promotes gastric cancer progression. It is delivered via exosomes to macrophages, where it sponges miR-1-3p to activate STAT6 signaling, inducing M2 polarization that enhances tumor growth and migration; high circATP8A1 is associated with worse prognosis. |
| Confidence score: |
0.8884 |