| Expression pattern: |
DN |
| Associated gene: |
SOCS2 |
| Associated microRNA: |
miR-578 |
| Biological function: |
inhibits proliferation, migration, invasion, glycolysis, and tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circ_0006677 sponges miR-578 to increase SOCS2 expression |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); glycolysis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
Lower expression of circ_0006677 was significantly associated with poorer patient survival. |
| Description: |
circ_0006677 is down-regulated in NSCLC and its low expression is associated with worse overall survival. Functionally, circ_0006677 suppresses NSCLC cell proliferation, migration, invasion, and glycolysis and inhibits xenograft tumor growth. Mechanistically, it acts as a miR-578 sponge to upregulate SOCS2 (circ_0006677/miR-578/SOCS2 axis). |
| Confidence score: |
0.8423 |