| Expression pattern: |
UP |
| Associated gene: |
ALK7/ACVR1C, FZD3, WNT5A |
| Associated microRNA: |
miR-140-3p, miR-382-5p, miR-579-3p |
| Biological function: |
promotes cancer stem cell properties, cell proliferation, spheroid formation, colony formation, and tumor growth |
| Molecular mechanism: |
acts as a miRNA sponge (ceRNA-like) for miR-140-3p, miR-382-5p and miR-579-3p to increase ALK7/ACVR1C, FZD3 and WNT5A expression |
| Biological pathway or process: |
proliferation (promotes); stemness (promotes); ceRNA regulation (promotes); tumor growth (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Sanger Sequencing; RNA Pull-Down; Transfection; EdU Staining; Colony Formation Assay; In Vivo Animal Model; FISH / smFISH; IF (Immunofluorescence); Flow Cytometry（Non-apoptosis/cycle）; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
may be used as a predictive marker for tumor progression |
| Description: |
circZNF800 (hsa_circ_0082096), derived from the host gene ZNF800, is up-regulated in late-stage colorectal cancer tumor tissues and CRC stem cell-enriched spheroids. It promotes cancer stem cell properties and tumor growth by sponging miR-140-3p/miR-382-5p/miR-579-3p and increasing ALK7/ACVR1C, FZD3, and WNT5A expression. |
| Confidence score: |
0.7977 |