| Expression pattern: |
UP |
| Associated gene: |
BAG5 |
| Associated microRNA: |
miR-660, miR-660-5p |
| Biological function: |
Promotes HCC cell proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-660/miR-660-5p, thereby increasing BAG5 expression and promoting HCC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0008305 expression was elevated in stage II-III of HCC tissues compared to stage I; upregulated levels of circ_0008305 were observed in metastatic samples. |
| Description: |
circ_0008305 is up-regulated in HCC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion, tumor growth) while suppressing apoptosis. Mechanistically, it functions as a ceRNA sponging miR-660/miR-660-5p to upregulate BAG5, forming a circ_0008305-miR-660-BAG5 axis driving HCC progression. |
| Confidence score: |
0.6917 |