circRNA basic information
circBase ID: hsa_circ_0007534
Name: hsa_circ_DDX42
Synonym: -
Host Gene: DDX42
Genomic location(hg19): chr17:61869771-61877977:+
Genomic location(hg38): chr17:63792411-63800617:+
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; tumor tissue; non-tumorous adjacent tissue; blood samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: DDX42
Associated microRNA: -
Biological function: Serves as a potential blood-based diagnostic and prognostic biomarker for colorectal cancer; increased expression is associated with clinical classifications, metastatic phenotype, poor differentiation, aggressive characteristics, and poor prognosis.
Molecular mechanism: -
Biological pathway or process:

metastasis (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis
Clinical significance:

hsa_circ_0007534 could distinguish CRC patients from healthy controls with AUC 0.780, sensitivity 0.92 and specificity 0.522; high expression is associated with progression of clinical classifications, metastatic phenotype, poor differentiation, and poor prognosis.
Description:

This study reports that hsa_circ_0007534 is up-regulated in colorectal cancer tumor tissues and plasma. Plasma hsa_circ_0007534 has diagnostic value for CRC and its high expression is associated with advanced clinical features, metastasis-related phenotype, poor differentiation, and poorer overall survival.
Confidence score:

0.5918
Other information
Title:

Hsa_circ_0007534 as a blood-based marker for the diagnosis of colorectal cancer and its prognostic value.

Journal: International journal of clinical and experimental pathology
Published: 2018
PubMed ID: 31938236
Study type:

clinical study
Data availability: circBase database, http://www.circbase.org/
Code availability: -