circRNA basic information
circBase ID: hsa_circ_0004771
Name: hsa_circ_NRIP1
Synonym: circ_00059_NRIP1
Host Gene: NRIP1
Genomic location(hg19): chr21:16386664-16415895:-
Genomic location(hg38): chr21:15014343-15043574:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005184
MONDO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Disease DO ID:
 3498, 3587
Disease MeSH ID:
 D021441
Disease NCIt ID:
 C9120
Disease ICD11 ID:
 581089833
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

frozen tumor tissue; FFPE surgical PDAC specimens; normal pancreas; peritumoral pancreatitis; autoimmune pancreatitis
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Independent prognostic biomarker candidate in surgically treated PDAC.
Molecular mechanism: Not mechanistically characterized; association based on differential expression profiling and survival analysis.
Biological pathway or process:

not specified (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; Clinical Sample Validation; Survival Analysis; ROC Analysis
Clinical significance:

High expression was associated with worse overall survival and circNRIP1 showed independent prognostic value in multivariate analysis.
Description:

circNRIP1 was up-regulated in PDAC versus controls and was one of three circRNAs with independent prognostic value. Its high expression was associated with poorer survival, but no molecular mechanism was experimentally investigated.
Confidence score:

0.5121
Other information
Title:

Exploring the prognostic value of circular RNAs in pancreatic ductal adenocarcinoma using genome-wide expression profiling.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
Published: 2024
PubMed ID: 38724419
Study type:

combined bioinformatics and clinical study
Data availability: Supplementary Table 4; Supplementary Table 5; https://doi.org/10.1016/j.pan.2024.04.004
Code availability: -