circRNA basic information
circBase ID: -
Name: hsa_circ_HMGCS1
Synonym: circ-HMGCS1
Host Gene: HMGCS1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Circ-HMGCS1 is associated with larger tumor size, lymph node metastasis, advanced FIGO stage, worse disease-free survival, and worse overall survival in cervical cancer patients; it serves as a diagnostic and prognostic biomarker.
Molecular mechanism: Downstream molecular mechanism was not explored in cervical cancer; the study primarily reports clinical expression, diagnostic value, and prognostic association.
Biological pathway or process:

not specified (other)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis
Clinical significance:

Circ-HMGCS1 has good diagnostic value for distinguishing cervical cancer tumor tissues from adjacent normal tissues, is positively correlated with tumor size, lymph node metastasis, and FIGO stage, and high expression independently predicts poor DFS and OS.
Description:

In cervical cancer, circ-HMGCS1 is up-regulated in tumor tissues and shows strong diagnostic ability to distinguish tumor from adjacent normal tissues. High circ-HMGCS1 expression is associated with tumor size, lymph node metastasis, FIGO stage, and independently predicts worse DFS and OS, supporting its value as a disease monitoring and prognostic biomarker. The downstream molecular mechanism in cervical cancer was not investigated in this study.
Confidence score:

0.5918
Other information
Title:

Circ-HMGCS1, an Indicator of Survival and Prognosis in Cervical Cancer Patients.

Journal: Clinical laboratory
Published: 2023
PubMed ID: 37560864
Study type:

clinical study
Data availability: -
Code availability: -