| Expression pattern: |
UP |
| Associated gene: |
MEF2D, MEF2D mRNA, HNRNPUL1 |
| Associated microRNA: |
miR-361-3p |
| Biological function: |
Promotes gastric cancer cell proliferation, migration, and invasion; drives gastric cancer progression; shows diagnostic and prognostic biomarker potential. |
| Molecular mechanism: |
Acts through ceRNA and RBP-dependent mechanisms: hsa_circ_0013729 sponges miR-361-3p to regulate MEF2D and interacts with HNRNPUL1 to stabilize MEF2D mRNA. |
| Biological pathway or process: |
ceRNA regulation (promotes); mRNA stability (promotes); proliferation (promotes); migration (promotes); invasion (promotes); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Cohort Study |
| Clinical significance: |
Upregulated hsa_circ_0013729 showed diagnostic significance with ROC-AUC = 0.94 and prognostic value; higher expression correlated with TNM III-IV stages, positive lymphovascular invasion, neural invasion, and adverse overall survival. |
| Description: |
Hsa_circ_0013729 is upregulated in gastric cancer tissues and cell lines and is associated with diagnostic performance and poor overall survival. Functionally, it promotes gastric cancer cell proliferation, migration, and invasion. Mechanistically, it regulates MEF2D through both a miR-361-3p-dependent ceRNA axis and an HNRNPUL1-dependent RBP/mRNA-stabilization mechanism. |
| Confidence score: |
0.8197 |