| Expression pattern: |
UP |
| Associated gene: |
Bax, Bcl-2, caspase 3, caspase 7 |
| Associated microRNA: |
- |
| Biological function: |
circFOXO3 protects cardiomyocytes from radiation-induced cardiotoxicity by reducing DNA damage and apoptosis; knockdown increases DNA damage and apoptosis after radiation, whereas overexpression reduces DNA damage and apoptosis. |
| Molecular mechanism: |
circFOXO3 suppresses the apoptotic pathway after radiation by decreasing Bax, caspase 3 and caspase 7 expression and increasing Bcl-2 expression; circFOXO3 also reduces radiation-induced DNA damage. |
| Biological pathway or process: |
apoptosis (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Transfection; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
circFOXO3 may be a potential therapeutic target against radiation-induced cardiotoxicity. |
| Description: |
circFOXO3 is up-regulated in irradiated human AC16 cardiomyocytes and acts protectively against radiation-induced cardiotoxicity. Knockdown increases DNA damage and apoptosis, while overexpression reduces these effects by suppressing pro-apoptotic Bax, caspase 3 and caspase 7 and increasing anti-apoptotic Bcl-2. The study suggests circFOXO3 as a potential therapeutic target for radiation-induced cardiotoxicity. |
| Confidence score: |
0.4469 |