circRNA basic information
circBase ID: hsa_circ_0018905
Name: hsa_circ_SAMD8
Synonym: -
Host Gene: SAMD8
Genomic location(hg19): chr10:76910271-76928416:+
Genomic location(hg38): chr10:75150513-75168658:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005184
MONDO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma / PDAC
Disease DO ID:
 3498, 3587
Disease MeSH ID:
 D021441
Disease NCIt ID:
 C9120
Disease ICD11 ID:
 581089833
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum exosomes; tumor tissues; normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: 497 target mRNAs
Associated microRNA: hsa-miR-7845-5p, hsa-miR-4270, hsa-miR-4685-5p, hsa-miR-8052, hsa-miR-145-5p, hsa-miR-5195-3p, hsa-miR-1271-5p
Biological function: may be implicated in the development of PDAC
Molecular mechanism: circRNA-miRNA-mRNA regulatory network (miRNA sponge/ceRNA inference)
Biological pathway or process:

ceRNA regulation (other); PI3K/AKT (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0018905 is down-regulated in PDAC (validated by qRT-PCR) and was used to construct a PDAC-specific predicted circRNA-miRNA-mRNA network involving seven candidate miRNAs and hundreds of target mRNAs; enrichment of targets implicated pathways such as PI3K-AKT, AGE-RAGE, and ECM-receptor interaction.
Confidence score:

0.5135
Other information
Title:

Differential expression and bioinformatics analysis of exosome circRNAs in pancreatic ductal adenocarcinoma.

Journal: Translational oncology
Published: 2023
PubMed ID: 37182508
Study type:

combined biological and clinical study
Data availability: GSE79634; GSE163031; GSE15471
Code availability: -