circRNA basic information
circBase ID: hsa_circ_0053881
Name: hsa_circ_TTC27
Synonym: hsa_circ_0053881_CBC1 / circ_0053881
Host Gene: TTC27
Genomic location(hg19): chr2:32958894-33046118:+
Genomic location(hg38): chr2:32733827-32821051:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008383
MONDO name: rheumatoid arthritis
Disease details: rheumatoid arthritis / RA
Disease DO ID:
 7148
Disease MeSH ID:
 D001172
Disease NCIt ID:
 C2884
Disease ICD11 ID:
 576319925
Disease OMIM ID:
 180300
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells / PBMCs
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RICTOR
Associated microRNA: hsa-miR-141-5p, hsa-miR-646
Biological function: unknown
Molecular mechanism: Putative ceRNA/miRNA sponge mechanism affecting RICTOR expression.
Biological pathway or process:

ceRNA regulation (other); immune regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Expression level correlates with inflammation/laboratory indices (ESR, CRP, RF).
Description:

hsa_circ_0053881 is up-regulated in RA PBMCs and validated by RT-qPCR. It is predicted to bind miRNAs (e.g., hsa-miR-141-5p and hsa-miR-646) in a ceRNA network that may influence RICTOR expression, and its level correlates positively with ESR/CRP/RF.
Confidence score:

0.4032
Other information
Title:

Profiling of differentially expressed circRNAs and functional prediction in peripheral blood mononuclear cells from patients with rheumatoid arthritis.

Journal: Annals of medicine
Published: 2023
PubMed ID: 36661308
Study type:

combined biological and clinical study
Data availability: The datasets used and analysed during this study are available from the corresponding author on reasonable request.
Code availability: -