| Expression pattern: |
UP |
| Associated gene: |
SATB1 |
| Associated microRNA: |
miR-590-5p |
| Biological function: |
promotes glioma proliferation, migration/invasion, tumor growth and pulmonary metastasis; promotes EMT-related protein changes (increases N-cadherin and decreases E-cadherin). |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0010889 sponges miR-590-5p to upregulate SATB1. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes); glycolysis (other) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0010889 is a promising marker for glioma diagnostics. |
| Description: |
hsa_circ_0010889 is up-regulated in glioma tissues and cell lines and promotes malignant behaviors. Its knockdown suppresses glioma proliferation, migration/invasion and in vivo tumor growth/metastasis by sponging miR-590-5p to increase SATB1 (miR-590-5p/SATB1 axis), and is suggested as a diagnostic marker/therapeutic target. |
| Confidence score: |
0.6975 |