circRNA basic information
circBase ID: -
Name: hsa_circ_SMARCA5
Synonym: circSMARCA5
Host Gene: SMARCA5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tumors; adjacent non-tumorous tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: SMARCA5
Associated microRNA: -
Biological function: potential therapy-responsive, tumor-suppressive circRNA candidate; expression is lower in CRC tumors than in adjacent non-tumorous tissues
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation
Clinical significance:

-
Description:

circSMARCA5 was identified in the authors' circRNA microarray screening as a candidate down-regulated in CRC and up-regulated after chemotherapy. Its lower expression in CRC tumors versus adjacent non-tumorous tissues was validated by RT-PCR, but the article did not further define its mechanism, functional role, or clinical prognostic significance.
Confidence score:

0.3588
Other information
Title:

CircFLNB upregulated by chemotherapy via alternative splicing suppresses the progression of colorectal cancer.

Journal: Cancer letters
Published: 2025
PubMed ID: 40684838
Study type:

combined biological and clinical study
Data availability: Supplementary data; available from the corresponding author upon reasonable request
Code availability: -