| Expression pattern: |
UP |
| Associated gene: |
KHDRBS3 |
| Associated microRNA: |
- |
| Biological function: |
Promotes gastric cancer cell migration and invasion; GC-MSC-induced upregulation of circ_0024107 facilitates gastric cancer cell migration and invasion; does not influence proliferative capacity in the colony formation assay. |
| Molecular mechanism: |
KHDRBS3-mediated upregulation of circ_0024107 in gastric cancer cells and GC-MSCs; KHDRBS3 may enhance circ_0024107 expression by binding to its flanking regions. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; Transwell Assay; Colony Formation Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential therapeutic target for mitigating gastric cancer progression and metastasis. |
| Description: |
This study shows that hsa_circ_0024107/circ_0024107 is upregulated in gastric cancer cells and promotes migration and invasion, but not proliferation. GC-MSCs further induce circ_0024107 expression in gastric cancer cells to enhance these pro-migratory and pro-invasive effects. KHDRBS3 is identified as an upstream RBP regulator that increases circ_0024107 levels in both gastric cancer cells and GC-MSCs, forming a KHDRBS3-circ_0024107 axis with potential therapeutic relevance. |
| Confidence score: |
0.4546 |