| Expression pattern: |
DN |
| Associated gene: |
VIM |
| Associated microRNA: |
- |
| Biological function: |
Potential noninvasive serum biomarker for HCC diagnosis and prognostic evaluation; associated with relapse-free survival and identified as an independent prognostic factor of RFS. |
| Molecular mechanism: |
Bioinformatics-based selection suggested involvement of the selected circRNA panel in Wnt signalling, IKK/NF-kappaB signaling, and cell proliferation; a proposed miRNA-sponge role targeting VIM was discussed but considered inconsistent with the study results and was not experimentally validated. |
| Biological pathway or process: |
Wnt/beta-catenin (other); NF-kappaB (other); proliferation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Strong serum biomarker potential with relatively high sensitivity and specificity compared with AFP; expression associated with relapse-free survival and reported as an independent prognostic factor of RFS. |
| Description: |
hsa_circ_000520 was selected as part of a bioinformatics-derived serum circRNA biomarker panel and validated by RT-qPCR in clinical serum samples. It was down-regulated in HCC, showed strong diagnostic biomarker potential, and was associated with worse relapse-free survival when positive/high, including independent prognostic value in Cox analysis. |
| Confidence score: |
0.6023 |