| Expression pattern: |
UP |
| Associated gene: |
CORO1C, Ago2 |
| Associated microRNA: |
miR-1305 |
| Biological function: |
circ_0003028 promotes NSCLC malignant behaviors (proliferation, migration, invasion) and inhibits apoptosis; propofol suppresses NSCLC growth partly by downregulating circ_0003028. |
| Molecular mechanism: |
ceRNA mechanism: circ_0003028 sponges miR-1305 to upregulate CORO1C. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_0003028 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes. Propofol suppresses NSCLC growth partly by downregulating circ_0003028, which functions as a ceRNA to sponge miR-1305 and thereby increase CORO1C expression. |
| Confidence score: |
0.7856 |