| Expression pattern: |
DN |
| Associated gene: |
PPARA, Ago2 |
| Associated microRNA: |
miR-18a-3p |
| Biological function: |
inhibits proliferation, invasion, migration, and colony formation; promotes apoptosis; suppresses tumor formation in vivo |
| Molecular mechanism: |
acts as a miRNA sponge for miR-18a-3p, thereby increasing PPARA expression |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); migration (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; divergent primers PCR; FISH / smFISH; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Colony Formation Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot; IHC (Immunohistochemistry) |
| Clinical significance: |
low expression of hsa_circ_0098181 was related to poor prognosis |
| Description: |
hsa_circ_0098181 is down-regulated in HCC tissues/cell lines and acts as a tumor suppressor. It mainly localizes in the cytoplasm and inhibits malignant phenotypes by sponging miR-18a-3p to derepress PPARA, reducing tumor growth in a xenograft model; low expression is associated with poor prognosis. |
| Confidence score: |
0.8657 |