| Expression pattern: |
UN |
| Associated gene: |
IRF7 |
| Associated microRNA: |
miR-762 |
| Biological function: |
Attenuates gastric cancer progression by inhibiting survival/proliferation, migration, invasion, and stemness and promoting apoptosis. |
| Molecular mechanism: |
Acts as a cytoplasmic sponge for miR-762, thereby indirectly increasing IRF7 expression and suppressing malignant phenotypes. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); stemness (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Diagnostic and therapeutic values (proposed); prognostic marker potential (proposed). |
| Description: |
circ0007360 acts as a cytoplasmic tumor-suppressive circRNA in gastric cancer models. It sponges miR-762 to indirectly upregulate IRF7, thereby inhibiting proliferation/survival, migration, invasion, and stemness while promoting apoptosis; knockdown enhances tumor growth in xenografts. |
| Confidence score: |
0.8004 |