circRNA basic information
circBase ID: hsa_circ_0001772
Name: hsa_circ_RBM33
Synonym: circRBM33
Host Gene: -
Genomic location(hg19): chr7:155465560-155473602:+
Genomic location(hg38): chr7:155672866-155680908:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

fresh CRC tissues; matched non-cancerous tissues; CRC tissues; normal tissues; tumor tissues; adjacent normal tissues; xenografts
Cell lines:

SW480; LoVo; HCT-116; NCM460
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: SLC1A5, C-myc, CyclinD1, Ki67
Associated microRNA: miR-512-5p
Biological function: CircRBM33 promotes CRC cell proliferation, migration, tumor growth and glutamine metabolism, and inhibits apoptosis.
Molecular mechanism: CircRBM33 acts as a ceRNA/miRNA sponge for miR-512-5p to increase SLC1A5 expression, thereby promoting CRC progression and glutamine metabolism.
Biological pathway or process:

proliferation (promotes); migration (promotes); apoptosis (inhibits); glutaminolysis (promotes); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis; Transfection; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay
Clinical significance:

providing a promising therapeutic target for CRC therapy
Description:

CircRBM33 is up-regulated in colorectal cancer tissues and cell lines. It promotes CRC cell proliferation, migration, xenograft tumor growth and glutamine metabolism while suppressing apoptosis, at least partly through a ceRNA mechanism involving miR-512-5p and SLC1A5. The study proposes circRBM33 as a potential therapeutic target for CRC.
Confidence score:

0.7859
Other information
Title:

CircRBM33 facilitates colorectal cancer progression by regulating the miR-512-5p/SLC1A5 axis.

Journal: Pathology, research and practice
Published: 2025
PubMed ID: 41086588
Study type:

combined biological and clinical study
Data availability: GSE138589; GEPIA-COAD; TCGA-COAD; Supplementary data associated with this article can be found in the online version at doi:10.1016/j.prp.2025.156248
Code availability: -