| Expression pattern: |
UP |
| Associated gene: |
FZD4, beta-catenin, Cyclin D1, C-myc, PCNA, MMP9, MMP2 |
| Associated microRNA: |
miR-195-5p |
| Biological function: |
CircRASSF2 functions as a tumor promoter in CRC, promoting proliferation, migration, invasion, metastasis and tumor growth while inhibiting apoptosis. |
| Molecular mechanism: |
CircRASSF2 acts as a ceRNA by sponging miR-195-5p, thereby regulating FZD4 and activating the Wnt/beta-catenin signaling pathway. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circRASSF2 expression was associated with poor overall survival of CRC patients and circRASSF2 showed diagnostic value for CRC. |
| Description: |
CircRASSF2 is upregulated in colorectal cancer tissues and cell lines, and high expression is associated with poor overall survival and diagnostic potential. Functionally, circRASSF2 promotes CRC proliferation, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it sponges miR-195-5p to regulate FZD4 and activate the Wnt/beta-catenin pathway. |
| Confidence score: |
0.8066 |