circRNA basic information
circBase ID: hsa_circ_0025288
Name: -
Synonym: circ_0025288
Host Gene: -
Genomic location(hg19): chr12:7027103-7032859:+
Genomic location(hg38): chr12:6917939-6923696:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HCT116; FHC
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-181a-3p, miR-455-5p
Biological function: Potential molecular target for colorectal cancer treatment; closely related to the pathogenesis of CRC.
Molecular mechanism: Predicted circRNA-miRNA interaction; circ_0025288 may bind multiple miRNAs including miR-181a-3p and miR-455-5p.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis
Clinical significance:

Potential molecular target for colorectal cancer treatment in the future.
Description:

hsa_circ_0025288/circ_0025288 was identified as an up-regulated circRNA in HCT116 colorectal cancer cells compared with FHC colorectal epithelial cells, with expression supported by microarray and RT-qPCR. Bioinformatics analysis predicted that circ_0025288 may interact with miRNAs such as miR-181a-3p and miR-455-5p, suggesting a potential circRNA-miRNA regulatory role in CRC pathogenesis and a possible therapeutic target value.
Confidence score:

0.2465
Other information
Title:

Integrated Analysis of mRNAs, lncRNAs, and circRNAs Expression Profile in Human Colorectal Cancer.

Journal: Alternative therapies in health and medicine
Published: 2025
PubMed ID: 39960277
Study type:

combined biological and bioinformatics study
Data availability: -
Code availability: -